"Endless" viral DNA in cells infected with channel catfish virus.

abstract：:Interferon-induced proteins (IFPs) exert multiple functions corresponding to diverse interferon signals. However, the intracellular functions of many IFPs are not fully characterized. Here, we report that IFP35, a member of the IFP family with a molecular mass of 35 kDa, can interact with the bovine Tas (BTas) regulat...

journal_title：Journal of virology

authors： Tan J,Qiao W,Wang J,Xu F,Li Y,Zhou J,Chen Q,Geng Y

更新日期：2008-05-01 00:00:00

abstract：:Koala retrovirus (KoRV) is of an interest to virologists due to its currently active endogenization into the koala (Phascolarctos cinereus) genome. Although KoRV has frequently been isolated in wild and captive koala populations, its pathogenesis and transmission remain to be fully characterized, and most previous res...

journal_title：Journal of virology

authors： Hashem MA,Maetani F,Kayesh MEH,Eiei T,Mochizuki K,Ito A,Sakurai H,Asai T,Tsukiyama-Kohara K

更新日期：2020-05-18 00:00:00

abstract：:The adenovirus (Ad) E4 ORF3 protein is both necessary and sufficient to reorganize a nuclear subdomain, the PML nuclear body (PML-NB), from punctate structures into elongated nuclear tracks. PML-NB disruption is recapitulated by a variety of DNA viruses that encode proteins responsible for compromising PML-NB integrit...

journal_title：Journal of virology

authors： Ullman AJ,Hearing P

更新日期：2008-08-01 00:00:00

abstract：:Transcription of herpesviral late genes is stimulated after the onset of viral DNA replication but otherwise restricted. Late gene expression in gammaherpesviruses requires the coordination of six early viral proteins, termed viral transactivation factors (vTFs). Here, we mapped the organization of this protein comple...

journal_title：Journal of virology

authors： Davis ZH,Hesser CR,Park J,Glaunsinger BA

更新日期：2015-10-14 00:00:00

abstract：:Extracts from poliovirus-infected HeLa cells are unable to translate vesicular stomatitis virus or cellular mRNAs in vitro, probably reflecting the poliovirus-induced inhibition of host cell protein synthesis which occurs in vivo. Crude initiation factors from uninfected HeLa cells are able to restore translation of v...

journal_title：Journal of virology

authors： Hansen J,Etchison D,Hershey JW,Ehrenfeld E

更新日期：1982-04-01 00:00:00

abstract：UNLABELLED:Multiple cellular pathways are regulated by small ubiquitin-like modifier (SUMO) modification, including ubiquitin-mediated proteolysis, signal transduction, innate immunity, and antiviral defense. In the study described in this report, we investigated the effects of SUMO on the replication of two members of...

journal_title：Journal of virology

authors： Maarifi G,Hannoun Z,Geoffroy MC,El Asmi F,Zarrouk K,Nisole S,Blondel D,Chelbi-Alix MK

更新日期：2016-06-24 00:00:00

abstract：:We have measured growth of West Nile virus in mouse primary peritoneal macrophages (resident, thioglycolate elicited, and Mycobacterium bovis BCG activated) and in macrophagelike (P338D1) and nonmacrophage (L929, PS clone D) cell lines infected in the absence or presence of specific antibodies (immunoglobulin G ([IgG]...

journal_title：Journal of virology

authors： Cardosa MJ,Gordon S,Hirsch S,Springer TA,Porterfield JS

更新日期：1986-03-01 00:00:00

abstract：:The D4R gene of vaccinia virus encodes a functional uracil-DNA glycosylase that is essential for viral viability (D. T. Stuart, C. Upton, M. A. Higman, E. G. Niles, and G. McFadden, J. Virol. 67:2503-2513, 1993), and a D4R mutant, ts4149, confers a conditional lethal defect in viral DNA replication (A. K. Millns, M. S...

journal_title：Journal of virology

authors： Ellison KS,Peng W,McFadden G

更新日期：1996-11-01 00:00:00

abstract：:Candidate foot-and-mouth disease (FMD) DNA vaccines designed to produce viral capsids lacking infectious viral nucleic acid were evaluated. Plasmid DNAs containing a portion of the FMDV genome coding for the capsid precursor protein (P1-2A) and wild-type or mutant viral proteinase 3C (plasmids P12X3C or P12X3C-mut, re...

journal_title：Journal of virology

authors： Chinsangaram J,Beard C,Mason PW,Zellner MK,Ward G,Grubman MJ

更新日期：1998-05-01 00:00:00

abstract：:The hemagglutinin (HA), a glycoprotein on the surface of influenza A virus (IAV), initiates the virus life cycle by binding to terminal sialic acid (SA) residues on host cells. The HA gradually accumulates amino acid substitutions that allow IAV to escape immunity through a mechanism known as antigenic drift. We recen...

journal_title：Journal of virology

authors： Santos JJS,Abente EJ,Obadan AO,Thompson AJ,Ferreri L,Geiger G,Gonzalez-Reiche AS,Lewis NS,Burke DF,Rajão DS,Paulson JC,Vincent AL,Perez DR

更新日期：2019-01-04 00:00:00

abstract：:There are two types of infectious vaccinia virus particles: intracellular naked virions and extracellular enveloped virions (EEV). To determine the biological role of the enveloped form of vaccinia virus, we produced and characterized a mutant that is defective in EEV formation. The strategy involved replacement by ho...

journal_title：Journal of virology

authors： Blasco R,Moss B

更新日期：1991-11-01 00:00:00

abstract：UNLABELLED:Human metapneumovirus (HMPV), a recently discovered paramyxovirus, infects nearly 100% of the world population and causes severe respiratory disease in infants, the elderly, and immunocompromised patients. We previously showed that HMPV binds heparan sulfate proteoglycans (HSPGs) and that HMPV binding requir...

journal_title：Journal of virology

authors： Klimyte EM,Smith SE,Oreste P,Lembo D,Dutch RE

更新日期：2016-09-29 00:00:00

abstract：:The members of Flaviviridae utilize several endocytic pathways to enter a variety of host cells. Our previous work showed that classical swine fever virus (CSFV) enters porcine kidney (PK-15) cells through a clathrin-dependent pathway that requires Rab5 and Rab7. The entry mechanism for CSFV into other cell lines rema...

journal_title：Journal of virology

authors： Zhang YN,Liu YY,Xiao FC,Liu CC,Liang XD,Chen J,Zhou J,Baloch AS,Kan L,Zhou B,Qiu HJ

更新日期：2018-07-17 00:00:00

abstract：:The activity of phosphatidylinositol 4-kinase class III beta (PI4KIIIβ) has been shown to be required for the replication of multiple picornaviruses; however, it is unclear whether a physical association between PI4KIIIβ and the viral replication machinery exists and, if it does, whether association is necessary. We e...

journal_title：Journal of virology

authors： Greninger AL,Knudsen GM,Betegon M,Burlingame AL,Derisi JL

更新日期：2012-04-01 00:00:00

abstract：:Artificial target sequences for tissue-specific miRNAs have recently been introduced as a new means for altering the tissue tropism of viral replication. This approach can be used to improve the safety of oncolytic viruses for cancer virotherapy by restricting their replication in unwanted tissues, such as the liver. ...

journal_title：Journal of virology

authors： Ylösmäki E,Martikainen M,Hinkkanen A,Saksela K

更新日期：2013-01-01 00:00:00

abstract：:Heron hepatitis B virus (HHBV) is an avian hepadnavirus that is closely related to duck hepatitis B virus (DHBV). To learn more about the mechanism of hepadnavirus replication, we characterized a clone of HHBV that contains a substitution of DHBV sequence from nucleotide coordinates 403 to 1364. This clone, named HDE1...

journal_title：Journal of virology

authors： Mueller-Hill K,Loeb DD

更新日期：1996-12-01 00:00:00

abstract：:Nonstructural protein 5B (NS5B) of bovine viral diarrhea virus (BVDV) contains sequence motifs that are predictive of an RNA-dependent RNA polymerase activity. We describe the expression and purification of the BVDV NS5B protein derived from an infectious cDNA clone of BVDV (NADL strain). BVDV NS5B protein was active ...

journal_title：Journal of virology

authors： Zhong W,Gutshall LL,Del Vecchio AM

更新日期：1998-11-01 00:00:00

abstract：:We recently discovered an expanded family of adeno-associated viruses (AAVs) that show promise as improved gene therapy vectors. In this study we evaluated the potential of vectors based on several of these novel AAVs as vaccine carriers for human immunodeficiency virus type 1 Gag. Studies with mice indicated that vec...

journal_title：Journal of virology

authors： Lin J,Zhi Y,Mays L,Wilson JM

更新日期：2007-11-01 00:00:00

abstract：:The virion host shutoff (vhs) protein encoded by herpes simplex virus type 1 (HSV-1) destabilizes both viral and host mRNAs. An HSV-1 strain with a mutation in vhs is attenuated in virulence and induces immune responses in mice that are protective against corneal infection with virulent HSV-1, but it has the capacity ...

journal_title：Journal of virology

authors： Geiss BJ,Smith TJ,Leib DA,Morrison LA

更新日期：2000-12-01 00:00:00

abstract：:During primary infection, the number of HIV-1 particles in plasma increases rapidly, reaches a peak, and then declines until it reaches a set point level. Understanding the kinetics of primary infection, and its effect on the establishment of chronic infection, is important in defining the early pathogenesis of HIV. W...

journal_title：Journal of virology

authors： Ribeiro RM,Qin L,Chavez LL,Li D,Self SG,Perelson AS

更新日期：2010-06-01 00:00:00

abstract：:Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) causes acute lung injury (ALI) that often leads to severe lung disease. A mouse model of acute SARS-CoV infection has been helpful in understanding the host response to infection; however, there are still unanswered questions concerning SARS-CoV p...

journal_title：Journal of virology

authors： Page C,Goicochea L,Matthews K,Zhang Y,Klover P,Holtzman MJ,Hennighausen L,Frieman M

更新日期：2012-12-01 00:00:00

abstract：:Rubella virus is an enveloped positive-strand RNA virus of the family TOGAVIRIDAE: Virions are composed of three structural proteins: a capsid and two membrane-spanning glycoproteins, E2 and E1. During virus assembly, the capsid interacts with genomic RNA to form nucleocapsids. In the present study, we have investigat...

journal_title：Journal of virology

authors： Law LM,Everitt JC,Beatch MD,Holmes CF,Hobman TC

更新日期：2003-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is the most common congenitally transmitted pathogen worldwide, impacting an estimated 1 million newborns annually. Congenital HCMV (cCMV) infection is a major global contributor to long-term neurologic deficits, including deafness, microcephaly, and neurodevelopmental delay, as well as to...

journal_title：Journal of virology

authors： Permar SR,Schleiss MR,Plotkin SA

更新日期：2018-03-14 00:00:00

abstract：:The four temperature-sensitive (ts) loci identified in the PB1 and PB2 gene segments of cold-adapted A/Ann Arbor/6/60 influenza virus, the master donor virus for influenza A virus (MDV-A) FluMist vaccines, were introduced into a divergent A/Puerto Rico/8/34 influenza virus strain. Recombinant A/Puerto Rico/8/34 virus ...

journal_title：Journal of virology

authors： Jin H,Zhou H,Lu B,Kemble G

更新日期：2004-01-01 00:00:00

abstract：:Forty isolates of herpes simplex virus were compared by means of cross-neutralization curves. The 11 oral isolates were serotype 1, and all 29 genital/anal isolates were serotype 2. The cytopathic effects of the two serotypes were consistently different. Passage of strains of type 1 and type 2 in mice and in rabbits y...

journal_title：Journal of virology

authors： Plummer G,Waner JL,Phuangsab A,Goodheart CR

更新日期：1970-01-01 00:00:00

abstract：:We have used Northern blot hybridization to study the accumulation of specific cellular mRNAs in Vero cells infected with herpes simplex virus (HSV) type 1 or type 2. HSV-1 infection decreased the cytoplasmic levels of beta- and gamma-actin, beta-tubulin, and histone H3 and H4 mRNAs, though not all at the same rate. H...

journal_title：Journal of virology

authors： Schek N,Bachenheimer SL

更新日期：1985-09-01 00:00:00

abstract：:We have examined the attachment and penetration phenotypes of several glycoprotein gIII mutants of pseudorabies virus (PRV) and have identified the first one-third of gIII as a region that mediates efficient virus attachment to PK15 and Vero cells. This portion of gIII, amino acids 25 through 157 of the wild-type sequ...

journal_title：Journal of virology

authors： Flynn SJ,Burgett BL,Stein DS,Wilkinson KS,Ryan P

更新日期：1993-05-01 00:00:00

abstract：:The recent advent of genome sequences as the only source available to classify many newly discovered viruses challenges the development of virus taxonomy by expert virologists who traditionally rely on extensive virus characterization. In this proof-of-principle study, we address this issue by presenting a computation...

journal_title：Journal of virology

authors： Lauber C,Gorbalenya AE

更新日期：2012-04-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is the causative agent of chickenpox and herpes zoster (shingles). After the primary infection, the virus remains latent in sensory ganglia and reactivates upon weakening of the cellular immune system due to various conditions, erupting from sensory neurons and infecting the corresponding ...

journal_title：Journal of virology

authors： Selariu A,Cheng T,Tang Q,Silver B,Yang L,Liu C,Ye X,Markus A,Goldstein RS,Cruz-Cosme RS,Lin Y,Wen L,Qian H,Han J,Dulal K,Huang Y,Li Y,Xia N,Zhu H

更新日期：2012-08-01 00:00:00

abstract：:Simian virus 40 (SV40) large T antigen (Tag) is a promiscuous transcriptional transactivator; however, its mechanism of transactivation remains unknown. Recent studies have suggested the possible involvement of protein-protein interactions with TBP, the TATA box-binding protein of TFIID, and TEF-1, an enhancer-binding...

journal_title：Journal of virology

authors： Johnston SD,Yu XM,Mertz JE

更新日期：1996-02-01 00:00:00