Isolation and preliminary characterization of bacteriophages for Bdellovibrio bacteriovorus.

abstract：:Electron micrographic studies of neuronal axons have produced contradictory conclusions on how alphaherpesviruses are transported from neuron cell bodies to axon termini. Some reports have described unenveloped capsids transported on axonal microtubules with separate transport of viral glycoproteins within membrane ve...

journal_title：Journal of virology

authors： Snyder A,Wisner TW,Johnson DC

更新日期：2006-11-01 00:00:00

abstract：:For human parainfluenza virus type 3 and many other paramyxoviruses, membrane fusion mediated by the fusion protein (F) has a stringent requirement for the presence of the homotypic hemagglutinin-neuraminidase protein (HN). With the goal of gaining further insight into the role of HN in the fusion process, we develope...

journal_title：Journal of virology

authors： Porotto M,Murrell M,Greengard O,Moscona A

更新日期：2003-03-01 00:00:00

abstract：UNLABELLED:Although the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) epidemic was controlled by nonvaccine measures, coronaviruses remain a major threat to human health. The design of optimal coronavirus vaccines therefore remains a priority. Such vaccines present major challenges: coronavirus im...

journal_title：Journal of virology

authors： Honda-Okubo Y,Barnard D,Ong CH,Peng BH,Tseng CT,Petrovsky N

更新日期：2015-03-01 00:00:00

abstract：:Genetic studies with immunocompetent mice show the importance of both T cells and gamma interferon (IFN-γ) for survival of a measles virus (MV) challenge; however, the direct role of T cells and IFN-γ within the MV-infected brain has not been addressed. Organotypic brain explants represent a successful ex vivo system ...

journal_title：Journal of virology

authors： Stubblefield Park SR,Widness M,Levine AD,Patterson CE

更新日期：2011-04-01 00:00:00

abstract：:Virus-specific RNA synthesized in monkey cells after infection by both wild-type simian virus 40 (SV40) and the early SV40 temperature-sensitive mutant tsA58 has been analyzed. The fraction of SV40-specific RNA increased throughout infection with either wild-type SV40 or with tsA58 in direct proportion to the accumula...

journal_title：Journal of virology

authors： Khoury G,May E

更新日期：1977-07-01 00:00:00

abstract：:The human polyomavirus JC virus (JCV) establishes persistent infections in most individuals and is the etiologic agent of progressive multifocal leukoencephalopathy. In this report, we describe the establishment of a soluble cell-free system that is capable of replicating exogenous plasmid DNA containing the JCV origi...

journal_title：Journal of virology

authors： Nesper J,Smith RW,Kautz AR,Sock E,Wegner M,Grummt F,Nasheuer HP

更新日期：1997-10-01 00:00:00

abstract：:Mouse cytomegalovirus (MCMV) encodes two potential seven-transmembrane-spanning proteins with homologies to cellular chemokine receptors, M33 and M78. While these virus-encoded chemokine receptors are necessary for the in vivo pathogenesis of MCMV, the function of these proteins is unknown. Since vascular smooth muscl...

journal_title：Journal of virology

authors： Melnychuk RM,Smith P,Kreklywich CN,Ruchti F,Vomaske J,Hall L,Loh L,Nelson JA,Orloff SL,Streblow DN

更新日期：2005-08-01 00:00:00

abstract：:The C-terminal half of the replicase ORF1a polyprotein of the arterivirus equine arteritis virus is processed by a chymotrypsinlike serine protease (SP) (E. J. Snijder et al., J. Biol. Chem. 271:4864-4871, 1996) located in nonstructural protein 4 (nsp4). Three probable SP cleavage sites had previously been identified ...

journal_title：Journal of virology

authors： Wassenaar AL,Spaan WJ,Gorbalenya AE,Snijder EJ

更新日期：1997-12-01 00:00:00

abstract：:RNA silencing is a conserved eukaryotic gene regulatory system in which sequence specificity is determined by small RNAs. Plant RNA silencing also acts as an antiviral mechanism; therefore, viral infection requires expression of a silencing suppressor. The mechanism and the evolution of silencing suppression are still...

journal_title：Journal of virology

authors： Mérai Z,Kerényi Z,Molnár A,Barta E,Válóczi A,Bisztray G,Havelda Z,Burgyán J,Silhavy D

更新日期：2005-06-01 00:00:00

abstract：:AV3 cells (continuous human amnion) infected with the Onderstepoort strain of canine distemper virus produced cell fusion within 2 to 5 hr when added to AV3 cell monolayers. An apparent requirement for intact, infected cells was demonstrated by showing that (i) frozen-and-thawed infected cells failed to induce fusion,...

journal_title：Journal of virology

authors： Rankin AM,Fisher LE,Bussell RH

更新日期：1972-12-01 00:00:00

abstract：:Nipah virus (NiV) and Hendra virus (HeV) are emerging zoonotic viruses and the causative agents of severe respiratory disease and encephalitis in humans. Little is known about the mechanisms that govern the development of respiratory and neurological disease. Using a hamster model of lethal NiV and HeV infection, we d...

journal_title：Journal of virology

authors： Rockx B,Brining D,Kramer J,Callison J,Ebihara H,Mansfield K,Feldmann H

更新日期：2011-08-01 00:00:00

abstract：:Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccine-elicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the seme...

journal_title：Journal of virology

authors： Whitney JB,Luedemann C,Hraber P,Rao SS,Mascola JR,Nabel GJ,Letvin NL

更新日期：2009-10-01 00:00:00

abstract：:Restriction factors are intrinsic cellular defense proteins that have evolved to block microbial infections. Retroviruses such as HIV-1 are restricted by TRIM5 proteins, which recognize the viral capsid shell that surrounds, organizes, and protects the viral genome. TRIM5α uses a SPRY domain to bind capsids with low i...

journal_title：Journal of virology

authors： Wagner JM,Christensen DE,Bhattacharya A,Dawidziak DM,Roganowicz MD,Wan Y,Pumroy RA,Demeler B,Ivanov DN,Ganser-Pornillos BK,Sundquist WI,Pornillos O

更新日期：2018-01-30 00:00:00

abstract：:Proteasomes are critical for the processing of antigens for presentation through the major histocompatibility complex (MHC) class I pathway. HIV-1 Gag protein is a component of several experimental HIV-1 vaccines. Therefore, understanding the processing of HIV-1 Gag protein and the resulting epitope repertoire is esse...

journal_title：Journal of virology

authors： Steers NJ,Currier JR,Kijak GH,di Targiani RC,Saxena A,Marovich MA,Kim JH,Michael NL,Alving CR,Rao M

更新日期：2011-02-01 00:00:00

abstract：:Type III interferons ([IFNs] IFN-lambda and interleukin-28 and -29 [IL-28/29]) are recently recognized cytokines with innate antiviral effects similar to those of type I IFNs (IFN-alpha/beta). Like IFN-alpha/beta, IFN-lambda-expression can be induced by viruses, and it is believed that type I and III IFNs are regulate...

journal_title：Journal of virology

authors： Stoltz M,Klingström J

更新日期：2010-09-01 00:00:00

abstract：:Misfolded alpha-synuclein (αS) may exhibit a number of characteristics similar to those of the prion protein, including the apparent ability to spread along neuroanatomical connections. The demonstration for this mechanism of spread is largely based on the intracerebral injections of preaggregated αS seeds in mice, in...

journal_title：Journal of virology

authors： Ayers JI,Riffe CJ,Sorrentino ZA,Diamond J,Fagerli E,Brooks M,Galaleldeen A,Hart PJ,Giasson BI

更新日期：2018-08-29 00:00:00

abstract：UNLABELLED:The latent HIV reservoir is a major impediment to curing HIV infection. The contribution of CD4(+) T cell activation status to the establishment and maintenance of the latent reservoir was investigated by enumerating viral DNA components in a cohort of 12 individuals commencing antiretroviral therapy (ART) c...

journal_title：Journal of virology

authors： Murray JM,Zaunders JJ,McBride KL,Xu Y,Bailey M,Suzuki K,Cooper DA,Emery S,Kelleher AD,Koelsch KK,PINT Study Team.

更新日期：2014-03-01 00:00:00

abstract：:Meq is the major Marek's disease virus (MDV)-encoded oncoprotein and is essential for T-cell lymphomagenesis. Meq and several noncoding RNAs, including three microRNA (MiR) clusters, are expressed from the repeats of the MDV genome during latent infection of T cells. To investigate the state of the chromatin in this a...

journal_title：Journal of virology

authors： Brown AC,Nair V,Allday MJ

更新日期：2012-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a prominent risk factor for the development of hepatocellular carcinoma (HCC). Similar to most solid tumors, HCCs are believed to contain poorly differentiated cancer stem cell-like cells (CSCs) that initiate tumorigenesis and confer resistance to chemotherapy. In these studies, we...

journal_title：Journal of virology

authors： Ali N,Allam H,May R,Sureban SM,Bronze MS,Bader T,Umar S,Anant S,Houchen CW

更新日期：2011-12-01 00:00:00

abstract：:High rates of genetic variation ensure the survival of RNA viruses. Although this variation is thought to result from error-prone replication, RNA viruses must also maintain highly conserved genomic segments. A balance between conserved and variable viral elements is especially important in order for viruses to avoid ...

journal_title：Journal of virology

authors： Contreras AM,Hiasa Y,He W,Terella A,Schmidt EV,Chung RT

更新日期：2002-09-01 00:00:00

abstract：:Parvoviruses infect humans and a broad range of animals, from mammals to crustaceans, and generally are associated with a variety of acute and chronic diseases. However, many others cause persistent infections and are not known to be associated with any disease. Viral persistence is likely related to the ability to in...

journal_title：Journal of virology

authors： Liu H,Fu Y,Xie J,Cheng J,Ghabrial SA,Li G,Peng Y,Yi X,Jiang D

更新日期：2011-10-01 00:00:00

abstract：:Vpu is a 16-kDa membrane-associated phosphoprotein that is expressed from the same, singly spliced message as the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein precursor, gp160. Previous studies suggest that Vpu functions in the late stages of viral replication, possibly in virus egression from the...

journal_title：Journal of virology

authors： Geraghty RJ,Panganiban AT

更新日期：1993-07-01 00:00:00

abstract：:Sequence analysis of the short unique (Us) segment of the bovine herpesvirus 1 (BHV-1) genome predicted that the Us open reading frame (ORF) 4 encodes a protein with homology to glycoprotein G (gG) of other alpha-herpesviruses (P. Leung-Tack, J.-C. Audonnet, and M. Riviere, Virology 199:409-421, 1994). RNA analysis sh...

journal_title：Journal of virology

authors： Keil GM,Engelhardt T,Karger A,Enz M

更新日期：1996-05-01 00:00:00

abstract：:The majority of double-stranded DNA (dsDNA) viruses infecting eukaryotic organisms use host- or virus-expressed histones or protamine-like proteins to condense their genomes. In contrast, members of the Baculoviridae family use a protamine-like protein named P6.9. The dephosphorylated form of P6.9 binds to DNA in a no...

journal_title：Journal of virology

authors： Wang M,Tuladhar E,Shen S,Wang H,van Oers MM,Vlak JM,Westenberg M

更新日期：2010-09-01 00:00:00

abstract：:Apoptosis of virus-infected cells occurs either as a direct response to viral infection or upon recognition of infection by the host immune response. Apoptosis reduces production of new virus from these cells, and therefore viruses have evolved inhibitory mechanisms. We previously showed that laboratory strains of her...

journal_title：Journal of virology

authors： Jerome KR,Fox R,Chen Z,Sears AE,Lee Hy,Corey L

更新日期：1999-11-01 00:00:00

abstract：:The DNA of normal chicken embryos contains sequences related to the avian leukosis-sarcoma viruses. RNA-dependent DNA polymerase of these viruses is encoded by a genetic element known as the pol gene. The nature of the endogenous virus pol gene in chicken cells was investigated by testing its ability to participate in...

journal_title：Journal of virology

authors： Sawyer RC,Rettenmier CW,Hanafusa H

更新日期：1979-03-01 00:00:00

abstract：UNLABELLED:The gastrointestinal mucosa is the primary site where human immunodeficiency virus type 1 (HIV-1) invades, amplifies, and becomes persistently established, and cell-to-cell transmission of HIV-1 plays a pivotal role in mucosal viral dissemination. Mast cells are widely distributed in the gastrointestinal tra...

journal_title：Journal of virology

authors： Jiang AP,Jiang JF,Wei JF,Guo MG,Qin Y,Guo QQ,Ma L,Liu BC,Wang X,Veazey RS,Ding YB,Wang JH

更新日期：2015-12-30 00:00:00

abstract：:Neurotropic herpesviruses depend on long-distance axon transport for the initial establishment of latency in peripheral ganglia (retrograde transport) and for viral spread in axons to exposed body surfaces following reactivation (anterograde transport). Images of neurons infected with herpes simplex virus type 1 (HSV-...

journal_title：Journal of virology

authors： Antinone SE,Zaichick SV,Smith GA

更新日期：2010-12-01 00:00:00

abstract：:Retroviruses use RNA as their genetic material within viral particles and DNA (provirus) as their genetic material within cells. The rate of recombination during reverse transcription between two identical sequences within the same RNA molecule is very high. In this study, we have developed a sensitive system to study...

journal_title：Journal of virology

authors： Li T,Zhang J

更新日期：2000-08-01 00:00:00

abstract：:Infection with human T-cell leukemia virus type 1 (HTLV-1) can result in the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic inflammatory disease of the central nervous system (CNS). HTLV-2 is highly related to HTLV-1 at the genetic level and shares a high degree of sequen...

journal_title：Journal of virology

authors： Banerjee P,Rochford R,Antel J,Canute G,Wrzesinski S,Sieburg M,Feuer G

更新日期：2007-02-01 00:00:00