Herpes simplex virus capsids are transported in neuronal axons without an envelope containing the viral glycoproteins.

abstract：UNLABELLED:The gastrointestinal mucosa is the primary site where human immunodeficiency virus type 1 (HIV-1) invades, amplifies, and becomes persistently established, and cell-to-cell transmission of HIV-1 plays a pivotal role in mucosal viral dissemination. Mast cells are widely distributed in the gastrointestinal tra...

journal_title：Journal of virology

authors： Jiang AP,Jiang JF,Wei JF,Guo MG,Qin Y,Guo QQ,Ma L,Liu BC,Wang X,Veazey RS,Ding YB,Wang JH

更新日期：2015-12-30 00:00:00

abstract：:Synthesis of cytoplasmic viral RNA was studied during infection of cultured human (KB) cells with adenovirus 2. At 6 h, before viral DNA synthesis began 5% of the poly(A)-containing RNA hybridized to viral DNA; by 12 h and at later times more than 80% was virus specified. At 18 h after infection, four major size class...

journal_title：Journal of virology

authors： Tal J,Craig EA,Raskas HJ

更新日期：1975-01-01 00:00:00

abstract：:Viruses efficiently block the host antiviral response in order to replicate and spread before host intervention. The mechanism initiating antiviral immunity during stealth viral replication is unknown, but recent data demonstrate that defective viral genomes generated at peak virus replication are critical for this pr...

journal_title：Journal of virology

authors： López CB

更新日期：2014-08-01 00:00:00

abstract：:The cell culture lines HTG2 and HTG3 were established from a transplantable hamster tumor induced by a murine sarcoma virus (strain Gz-MSV) after 17 and 60 in vivo passages, respectively. The viruses released by these two cell lines markedly differ in morphology, antigenic composition, infectivity, transforming abilit...

journal_title：Journal of virology

authors： Gazdar AF,Russell E,Sarma PS,Sarin PS,Hall W,Chopra HC

更新日期：1973-10-01 00:00:00

abstract：:Most patients infected with hepatitis C virus (HCV) become chronic carriers. Viruses that efficiently establish persistent infections must have effective ways of evading host defenses. In the case of HCV, little is known about how chronic infections are established or maintained. Besides hepatocytes, several reports s...

journal_title：Journal of virology

authors： Bergqvist A,Rice CM

更新日期：2001-01-01 00:00:00

abstract：:Intact, purified particles of the nodaviruses flock house virus and nodamura virus that were either transfected into cells that were resistant to infection or introduced into in vitro translation systems directed the synthesis of viral proteins. We infer that direct interaction of these nodavirus particles with cytopl...

journal_title：Journal of virology

authors： Hiscox JA,Ball LA

更新日期：1997-10-01 00:00:00

abstract：:Mus dunni endogenous virus (MDEV) is activated from cells of the Asian wild mouse M. dunni (also known as Mus terricolor) in response to treatment with either 5-iodo-2'-deoxyuridine or hydrocortisone. MDEV represents a new murine retrovirus interference group and thus appears to use a different receptor for entry into...

journal_title：Journal of virology

authors： Bonham L,Wolgamot G,Miller AD

更新日期：1997-06-01 00:00:00

abstract：:Rotavirus nonstructural protein 4 (NSP4) induces dramatic changes in cellular calcium homeostasis. These include increased endoplasmic reticulum (ER) permeability, resulting in decreased ER calcium stores and activation of plasma membrane (PM) calcium influx channels, ultimately causing a 2- to 4-fold elevation in cyt...

journal_title：Journal of virology

authors： Hyser JM,Utama B,Crawford SE,Broughman JR,Estes MK

更新日期：2013-12-01 00:00:00

abstract：:CH/S is a virulent porcine epidemic diarrhea virus (PEDV) strain and is used as the virulent strain to evaluate the protection rates of vaccines against PEDV infection in China. Here, we report the complete genome sequence of strain CH/S, which may aid in understanding the molecular characteristics of this strain. ...

journal_title：Journal of virology

authors： Chen J,Wang C,Shi H,Qiu HJ,Liu S,Shi D,Zhang X,Feng L

更新日期：2011-11-01 00:00:00

abstract：:The emerging porcine epidemic diarrhea virus (PEDV) requires trypsin supplementation to activate its S protein for membrane fusion and virus propagation in cell culture. By substitution of a single amino acid in the S protein, we created a recombinant PEDV with an artificial furin protease cleavage site N terminal of ...

journal_title：Journal of virology

authors： Li W,Wicht O,van Kuppeveld FJ,He Q,Rottier PJ,Bosch BJ

更新日期：2015-08-01 00:00:00

abstract：:We have analyzed the mechanism by which the matrix (M1) protein associates with cellular membranes during influenza A virus assembly. Interaction of the M1 protein with the viral hemagglutinin (HA) or neuraminidase (NA) glycoprotein was extensively analyzed by using wild-type and transfectant influenza viruses as well...

journal_title：Journal of virology

authors： Enami M,Enami K

更新日期：1996-10-01 00:00:00

abstract：:Viruses actively interact with host metabolism because viral replication relies on host cells to provide nutrients and energy. Vaccinia virus (VACV; the prototype poxvirus) prefers glutamine to glucose for efficient replication to the extent that VACV replication is hindered in glutamine-free medium. Remarkably, our d...

journal_title：Journal of virology

authors： Pant A,Cao S,Yang Z

更新日期：2019-06-14 00:00:00

abstract：:Human cytomegalovirus (HCMV) encodes several proteins that inhibit major histocompatibility complex (MHC) class I-dependent antigen presentation. The HCMV products US2 and US11 are each sufficient for causing the dislocation of human and murine MHC class I heavy chains from the lumen of the endoplasmic reticulum to th...

journal_title：Journal of virology

authors： Rehm A,Engelsberg A,Tortorella D,Körner IJ,Lehmann I,Ploegh HL,Höpken UE

更新日期：2002-05-01 00:00:00

abstract：:Adenovirus types 5 and 3 (Ad5 and Ad3), two human adenovirus serotypes of evolutionarily divergent subgroups, show very different levels of E1A gene expression early after infection of permissive cells. Since adenovirus E1A gene expression is known to be transcriptionally autoregulated, we have investigated the differ...

journal_title：Journal of virology

authors： Jones SN,Tibbetts C

更新日期：1989-04-01 00:00:00

abstract：:The nuclear egress complex (NEC) is required for efficient translocation of newly synthesized herpesvirus nucleocapsids from the nucleus to the cytosol. It consists of the type II membrane protein pUL34 which interacts with pUL31 at the inner nuclear membrane (INM). To map regions within pUL34 required for nuclear mem...

journal_title：Journal of virology

authors： Paßvogel L,Trübe P,Schuster F,Klupp BG,Mettenleiter TC

更新日期：2013-04-01 00:00:00

abstract：:Precursor polyproteins containing translational products of the gag gene of Moloney murine leukemia virus were purified by gel electrophoresis and cleaved into large fragments by hydroxylamine, mild acid hydrolysis, or cyanogen bromide. The hydroxylamine cleavage method (specific for asparagine-glycine bonds) was adap...

journal_title：Journal of virology

authors： Saris CJ,van Eenbergen J,Liskamp RM,Bloemers HP

更新日期：1983-06-01 00:00:00

abstract：:We have selected neutralization escape mutants by using a monoclonal antibody (nt-MAb) against a sequential epitope between amino acids 93 through 104 (neutralization antigenic site I) of poliovirus type 1 Mahoney. The majority of mutants were also resistant against five strain-specific nt-MAbs which recognized confor...

journal_title：Journal of virology

authors： Wiegers K,Uhlig H,Dernick R

更新日期：1988-05-01 00:00:00

abstract：:Cells of the established MvlLu mink line spontaneously released a reverse transcriptase-containing virus after long-term passage in tissue culture. By molecular hybridization, DNA of normal mink cells was found to possess extensive nucleotide sequence homology with a reverse-transcription product of the viral genome, ...

journal_title：Journal of virology

authors： Barbacid M,Tronick SR,Aaronson SA

更新日期：1978-01-01 00:00:00

abstract：:Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for ...

journal_title：Journal of virology

authors： Rinaldo C,Huang XL,Fan ZF,Ding M,Beltz L,Logar A,Panicali D,Mazzara G,Liebmann J,Cottrill M

更新日期：1995-09-01 00:00:00

abstract：:Replicase gene expression by the human coronavirus 229E involves the synthesis of two large polyproteins, pp1a and pp1ab. Experimental evidence suggests that these precursor molecules are subject to extensive proteolytic processing. In this study, we show that a chymotrypsin-like enzyme, the virus-encoded 3C-like prot...

journal_title：Journal of virology

authors： Ziebuhr J,Siddell SG

更新日期：1999-01-01 00:00:00

abstract：:The first morphological evidence of African swine fever virus (ASFV) assembly is the appearance of precursor viral membranes, thought to derive from the endoplasmic reticulum, within the assembly sites. We have shown previously that protein p54, a viral structural integral membrane protein, is essential for the genera...

journal_title：Journal of virology

authors： Suárez C,Gutiérrez-Berzal J,Andrés G,Salas ML,Rodríguez JM

更新日期：2010-08-01 00:00:00

abstract：:T cells are central players in the immune response to infectious disease, with the specificity of their responses controlled by the T-cell receptor (TCR)/CD3 complex on the cell surface. Impairment of TCR/CD3-directed CD4(+) T-cell immune responses is frequently observed in individuals infected with human immunodefici...

journal_title：Journal of virology

authors： Segura I,Delmelle-Wibaut C,Janssens M,Cleuter Y,van den Broeke A,Kettmann R,Willard-Gallo KE

更新日期：1999-06-01 00:00:00

abstract：:It has been reported that gene expression directed by the long terminal repeat of Rous sarcoma virus (RSV) is trans activated by a protein encoded in an alternate reading frame within the RSV gag gene (S. Broome and W. Gilbert, Cell 40:537-546, 1985). We have made specific mutations to test the role of the putative tr...

journal_title：Journal of virology

authors： Carlberg K,Beemon K

更新日期：1988-11-01 00:00:00

abstract：:Hepatitis C virus (HCV) enters cells via a pH- and clathrin-dependent endocytic pathway. Scavenger receptor BI (SR-BI) and CD81 are important entry factors for HCV internalization into target cells. The SR-BI gene gives rise to at least two mRNA splice variants, SR-BI and SR-BII, which differ in their C termini. SR-BI...

journal_title：Journal of virology

authors： Grove J,Huby T,Stamataki Z,Vanwolleghem T,Meuleman P,Farquhar M,Schwarz A,Moreau M,Owen JS,Leroux-Roels G,Balfe P,McKeating JA

更新日期：2007-04-01 00:00:00

abstract：:We have studied the fate of CD4 in CEM T cells expressing a human immunodeficiency virus type 1 HIV-1 Nef protein. Nef triggered a rapid endocytosis and a degradation of CD4, while most of the p56lck was upheld at the cell membrane. In the presence of Nef, CD4 accumulated in acidic intracellular vesicles that were not...

journal_title：Journal of virology

authors： Schwartz O,Dautry-Varsat A,Goud B,Maréchal V,Subtil A,Heard JM,Danos O

更新日期：1995-01-01 00:00:00

abstract：:Polyoma virus complementary RNA, synthesized in vitro by using highly purified Escherichia coli RNA polymerase and nondefective form I polyoma DNA, was translated in a wheat germ cell-free system. Polypeptides were synthesized that comigrated on sodium dodecyl sulfate-polyacrylamide gels with the polyoma capsid protei...

journal_title：Journal of virology

authors： Mangel WF,Hewick RM,Bayley ST,Wheeler T,Harvey R,Waterfield MD,Smith AE

更新日期：1978-02-01 00:00:00

abstract：:Epithelial cells lining mucosal surfaces impose multiple barriers to viral infection. At the ocular surface, the carbohydrate-binding protein galectin-3 maintains barrier function by cross-linking transmembrane mucins on the apical glycocalyx. Despite these defense mechanisms, many viruses have evolved to exploit fund...

journal_title：Journal of virology

authors： Woodward AM,Mauris J,Argüeso P

更新日期：2013-05-01 00:00:00

abstract：UNLABELLED:The DNA damage response (DDR) that evolved to repair host cell DNA damage also recognizes viral DNA entering the nucleus during infections. Here, we investigated the modulation of DDR signaling during de novo infection of primary endothelial cells by Kaposi's sarcoma-associated herpesvirus (KSHV). Phosphoryl...

journal_title：Journal of virology

authors： Singh VV,Dutta D,Ansari MA,Dutta S,Chandran B

更新日期：2014-03-01 00:00:00

abstract：:Oncostatin M (OSM) is released together with type I interferon (IFN) by activated dendritic cells, suggesting a concerted action of these cytokines in the biological response against infection. We found that OSM increases the antiviral effect of IFN-alpha in Huh7 hepatoma cells infected with hepatitis A or hepatitis C...

journal_title：Journal of virology

authors： Larrea E,Aldabe R,Gonzalez I,Segura V,Sarobe P,Echeverria I,Prieto J

更新日期：2009-04-01 00:00:00

abstract：:Human respiratory syncytial virus (RSV) is a serious respiratory pathogen in infants and young children as well as elderly and immunocompromised populations. However, no RSV vaccines are available. We have explored the potential of virus-like particles (VLPs) as an RSV vaccine candidate. VLPs composed entirely of RSV ...

journal_title：Journal of virology

authors： McGinnes LW,Gravel KA,Finberg RW,Kurt-Jones EA,Massare MJ,Smith G,Schmidt MR,Morrison TG

更新日期：2011-01-01 00:00:00