Assembly and immunological properties of Newcastle disease virus-like particles containing the respiratory syncytial virus F and G proteins.

abstract：:The innate immune response is crucial for defense against viral infections. Cells recognize virus infection through pattern recognition receptors and induce type I interferons as well as proinflammatory cytokines to orchestrate an innate immune response. Herpes simplex virus 1 (HSV-1) triggers both the cyclic GMP-AMP ...

journal_title：Journal of virology

authors： Latif MB,Raja R,Kessler PM,Sen GC

更新日期：2020-02-28 00:00:00

abstract：:The HXLF (HindIII-X left reading frame) gene family is a group of five genes that share one or two regions of homology and are arranged in tandem within the short unique component of the human cytomegalovirus genome (K. Weston and B.G. Barrell, J. Mol. Biol. 192:177-208, 1986). These genes were cloned into an SP6 expr...

journal_title：Journal of virology

authors： Gretch DR,Kari B,Gehrz RC,Stinski MF

更新日期：1988-06-01 00:00:00

abstract：UNLABELLED:The possibility that vaccination with adenovirus (AdV) vectors increased mucosal T cell activation remains a central hypothesis to explain the potential enhancement of HIV acquisition within the Step trial. Modeling this within rhesus macaques is complicated because human adenoviruses, including human adenov...

journal_title：Journal of virology

authors： Bukh I,Calcedo R,Roy S,Carnathan DG,Grant R,Qin Q,Boyd S,Ratcliffe SJ,Veeder CL,Bellamy SL,Betts MR,Wilson JM

更新日期：2014-08-01 00:00:00

abstract：:We sequenced the genes coding for the two neutralization proteins, VP4 and VP7, of human rotavirus strains L26 and L27 with subgroup I specificity but the long RNA pattern. The deduced VP7 amino acid sequence of strains L26 and L27 showed a low homology (73.6 to 81.9%) to those of rotavirus strains of the established ...

journal_title：Journal of virology

authors： Taniguchi K,Urasawa T,Kobayashi N,Gorziglia M,Urasawa S

更新日期：1990-11-01 00:00:00

abstract：UNLABELLED:Development of a vaccine to prevent congenital cytomegalovirus infection is a major public health priority. Live vaccines attenuated through mutations targeting viral mechanisms responsible for evasion of host defense may be both safe and efficacious. Safety and vaccine efficacy were evaluated using a guinea...

journal_title：Journal of virology

authors： Schleiss MR,Bierle CJ,Swanson EC,McVoy MA,Wang JB,Al-Mahdi Z,Geballe AP

更新日期：2015-10-01 00:00:00

abstract：:A panel of 28 insertion mutants of the human immunodeficiency virus type 1 (HIV-1) Gag precursor (Pr55Gag) was constructed by linker-insertion mutagenesis and expressed in recombinant baculovirus-infected insect cells. One set of 14 mutants carried the normal N-myristylation signal; the other set constituted their non...

journal_title：Journal of virology

authors： Chazal N,Carrière C,Gay B,Boulanger P

更新日期：1994-01-01 00:00:00

abstract：:Poxviruses express proteins that limit host immune responses to infection. For example, the molluscum contagiosum virus MC160 protein inhibits tumor necrosis factor alpha (TNF-alpha)-induced NF-kappaB activation. This event correlates with MC160-induced IKK1 protein degradation, suggesting a mechanism for the above-me...

journal_title：Journal of virology

authors： Nichols DB,Shisler JL

更新日期：2009-04-01 00:00:00

abstract：:Utilizing the isolated left and right halves of both adenovirus type 2 and the nondefective adenovirus simian virus 40 hybrid (Ad2(+)ND(1)), studies were undertaken to find the site on the DNA molecules at which replication begins. The data are consistent with several models which include an initiation event at both e...

journal_title：Journal of virology

authors： Horwitz MS

更新日期：1974-05-01 00:00:00

abstract：:The Aichi virus 2A protein is not a protease, unlike many other picornavirus 2A proteins, and it is related to a cellular protein, H-rev107. Here, we examined the replication properties of two 2A mutants in Vero cells and a cell-free translation/replication system. In one mutant, amino acids 36 to 126 were replaced wi...

journal_title：Journal of virology

authors： Sasaki J,Taniguchi K

更新日期：2008-10-01 00:00:00

abstract：:Glycoprotein gIII of pseudorabies virus is a major antigen found in the envelopes of virus particles as well as in and on the surfaces of infected cells. It is not an essential gene product for virus growth in tissue culture. In this report, we provide evidence that, although it is not essential, the gIII protein is r...

journal_title：Journal of virology

authors： Whealy ME,Robbins AK,Enquist LW

更新日期：1988-07-01 00:00:00

abstract：:VP16-H is an essential structural protein of herpes simplex virus type 1 (HSV-1) and is also a potent activator of virus immediate-early (IE) gene expression. Current models of functional determinants within VP16-H indicate that it consists of two domains, an N-terminal domain involved in recruiting VP16-H to a multic...

journal_title：Journal of virology

authors： Grapes M,O'Hare P

更新日期：2000-11-01 00:00:00

abstract：:The herpes simplex virus 1 infected cell protein 22 (ICP22), the product of the alpha22 gene, is a nucleotidylylated and phosphorylated nuclear protein with properties of a transcriptional factor required for the expression of a subset of viral genes. Here, we report the following. (i) ICP22 interacts with a previousl...

journal_title：Journal of virology

authors： Bruni R,Roizman B

更新日期：1998-11-01 00:00:00

abstract：:The molecular mechanism by which retroviral Gag proteins are directed to the plasma membrane for the formation of particles (budding) is unknown, but it is widely believed that the MA domain, located at the amino terminus, plays a critical role. Consistent with this idea, we found that small deletions in this segment ...

journal_title：Journal of virology

authors： Wills JW,Craven RC,Weldon RA Jr,Nelle TD,Erdie CR

更新日期：1991-07-01 00:00:00

abstract：:The temperature-sensitive and attenuated phenotypes of the Sabin type 1 vaccine strain of poliovirus result from numerous point mutations which occurred in the virulent Mahoney virus parent. One of these mutations is located in a 3D polymerase (3Dpol) codon (U-6203-->C, Tyr-73-->His) and is involved in attenuation in ...

journal_title：Journal of virology

authors： Georgescu MM,Tardy-Panit M,Guillot S,Crainic R,Delpeyroux F

更新日期：1995-09-01 00:00:00

abstract：:In order to clarify antigenic variations among various isolates of human herpesvirus 6 (HHV-6) and cross-reactivity among HHV-6, HHV-7, and human cytomegalovirus (HCMV) in the T-cell immune response, the antigenic specificity of the proliferative response mediated by 232 CD4+ human T-cell clones directed against HHV-6...

journal_title：Journal of virology

authors： Yasukawa M,Yakushijin Y,Furukawa M,Fujita S

更新日期：1993-10-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) glycoprotein B (gB), encoded by the UL55 open reading frame, is an essential envelope glycoprotein involved in cell attachment and entry. Previously, we identified residue serine 900 (Ser900) as a unique site of reversible casein kinase 2 phosphorylation in the cytoplasmic domain of HCMV g...

journal_title：Journal of virology

authors： Jarvis MA,Jones TR,Drummond DD,Smith PP,Britt WJ,Nelson JA,Baldick CJ

更新日期：2004-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most important cause of severe, lower respiratory tract infections in infants, and RSV infections have been associated with chronic wheezing and asthma during childhood. However, the mechanism of RSV-induced airway inflammation and airway hyperresponsiveness (AHR) is poorly und...

journal_title：Journal of virology

authors： Zang N,Xie X,Deng Y,Wu S,Wang L,Peng C,Li S,Ni K,Luo Y,Liu E

更新日期：2011-12-01 00:00:00

abstract：:Resistance to ectromelia (mousepox) virus-induced mortality was examined in crosses between susceptible DBA/2J, A/J, and BALB/cByJ mice and resistant C57BL/6J and AKR/J mice. Depending on the cross, resistance to mousepox virus was shown to be determined by one or more independently assorting autosomal loci with domin...

journal_title：Journal of virology

authors： Wallace GD,Buller RM,Morse HC 3rd

更新日期：1985-09-01 00:00:00

abstract：:The entire genome of the reference strain of bluetongue virus (BTV) serotype 16 (strain RSArrrr/16) was sequenced (a total of 23,518 base pairs). The virus was obtained from the Orbivirus Reference Collection (ORC) at IAH, Pirbright, United Kingdom. The virus strain, which was previously provided by the Onderstepoort ...

journal_title：Journal of virology

authors： Maan S,Maan NS,Singh KP,Belaganahalli MN,Guimera M,Pullinger G,Nomikou K,Mertens PP

更新日期：2012-09-01 00:00:00

abstract：:Monoclonal antibodies produced against the prototype cell-adapted Wyoming strain of equine infectious anemia virus (EIAV), a lentivirus, were studied for reactivity with the homologous prototype and 16 heterologous isolates. Eighteen hybridomas producing monoclonal antibodies (MAbs) were isolated. Western blot (immuno...

journal_title：Journal of virology

authors： Hussain KA,Issel CJ,Schnorr KL,Rwambo PM,Montelaro RC

更新日期：1987-10-01 00:00:00

abstract：:The full repertoire of hepatitis B virus (HBV) peptides that bind to the common HLA class I molecules found in areas with a high prevalence of chronic HBV infection has not been determined. This information may be useful for designing immunotherapies for chronic hepatitis B. We identified amino acid residues under pos...

journal_title：Journal of virology

authors： Abbott WG,Tsai P,Leung E,Trevarton A,Ofanoa M,Hornell J,Gane EJ,Munn SR,Rodrigo AG

更新日期：2010-01-01 00:00:00

abstract：:The replication of porcine circovirus type 1 (PCV1) is thought to occur by rolling-circle replication (RCR), whereby the introduction of a single-strand break generates a free 3'-hydroxyl group serving as a primer for subsequent DNA synthesis. The covalently closed, single-stranded genome of PCV1 replicates via a doub...

journal_title：Journal of virology

authors： Steinfeldt T,Finsterbusch T,Mankertz A

更新日期：2006-07-01 00:00:00

abstract：:GLUT1 has recently been suggested to be a binding receptor for human T-cell leukemia virus type 1 (HTLV-1). We used a novel, short-term assay to define the role of GLUT1 in cell-to-cell transmission. Although increasing cell surface levels of GLUT1 enhanced HTLV-I transfer, efficient virus spread correlated largely wi...

journal_title：Journal of virology

authors： Takenouchi N,Jones KS,Lisinski I,Fugo K,Yao K,Cushman SW,Ruscetti FW,Jacobson S

更新日期：2007-02-01 00:00:00

abstract：:Disulfide bonds reportedly stabilize the capsids of several viruses, including papillomavirus, polyomavirus, and simian virus 40, and have been detected in herpes simplex virus (HSV) capsids. In this study, we show that in mature HSV-1 virions, capsid proteins VP5, VP23, VP19C, UL17, and UL25 participate in covalent c...

journal_title：Journal of virology

authors： Szczepaniak R,Nellissery J,Jadwin JA,Makhov AM,Kosinski A,Conway JF,Weller SK

更新日期：2011-09-01 00:00:00

abstract：:Transduction of the liver with single-stranded adeno-associated virus serotype 2 (AAV2) vectors is inefficient; less than 10% of hepatocytes are permissive for stable transduction, and transgene expression is characterized by a lag phase of up to 6 weeks. AAV2-based vector genomes packaged inside AAV6 or AAV8 capsids ...

journal_title：Journal of virology

authors： Thomas CE,Storm TA,Huang Z,Kay MA

更新日期：2004-03-01 00:00:00

abstract：:The protein product of the v-myb oncogene of avian myeloblastosis virus, p48v-myb, differs structurally in several ways from its normal cellular homolog, p75c-myb. We demonstrated that the 11 specific amino acid substitutions found in two independent molecular clones of this virus were not required for the transformat...

journal_title：Journal of virology

authors： Stober-Grässer U,Lipsick JS

更新日期：1988-03-01 00:00:00

abstract：UNLABELLED:Crimean-Congo hemorrhagic fever virus (CCHFV; genus Nairovirus) is an extremely pathogenic member of the Bunyaviridae family. Since handling of the virus requires a biosafety level 4 (BSL-4) facility, little is known about pathomechanisms and host interactions. Here, we describe the establishment of a transc...

journal_title：Journal of virology

authors： Devignot S,Bergeron E,Nichol S,Mirazimi A,Weber F

更新日期：2015-06-01 00:00:00

abstract：:It is shown that gene 5 protein of bacteriophage M13 is one of the major proteins synthesized in vitro under the direction of M13 replicative-form DNA. By means of DNA-cellulose chromatography, this protein has been purified to homogeneity and its biological characteristics have been compared with those of its native ...

journal_title：Journal of virology

authors： Konings RN,Jansen J,Cuypers T,Schoenmakers JG

更新日期：1973-12-01 00:00:00

abstract：:The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics, and nature of the virus-specific T cell response using intrace...

journal_title：Journal of virology

authors： Hillaire ML,van Trierum SE,Bodewes R,van Baalen CA,van Binnendijk RS,Koopmans MP,Fouchier RA,Osterhaus AD,Rimmelzwaan GF

更新日期：2011-11-01 00:00:00

abstract：:Nonenveloped gastrointestinal viruses, such as human rotavirus, can exit infected cells from the apical surface without cell lysis. The mechanism of such nonlytic exit is poorly understood. The nonenveloped Orsay virus is an RNA virus infecting the intestine cells of the nematode Caenorhabditis elegans Dye staining re...

journal_title：Journal of virology

authors： Yuan W,Zhou Y,Fan Y,Tao YJ,Zhong W

更新日期：2018-06-29 00:00:00