Abstract:
:Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after infection. Our goal was to identify molecular changes in blood that are related to disease progression. Rhesus macaques (Macaca mulatta) infected intravenously with a lethal dose of lymphocytic choriomeningitis virus (LCMV) provide a model for Lassa virus infection of humans. Blood samples taken before and during the course of infection were used to monitor gene expression changes that paralleled disease onset. Changes in blood showed major disruptions in eicosanoid, immune response, and hormone response pathways. Approximately 12% of host genes alter their expression after LCMV infection, and a subset of these genes can discriminate between virulent and non-virulent LCMV infection. Major transcription changes have been given preliminary confirmation by quantitative PCR and protein studies and will be valuable candidates for future validation as biomarkers for arenavirus disease.
journal_name
J Viroljournal_title
Journal of virologyauthors
Djavani MM,Crasta OR,Zapata JC,Fei Z,Folkerts O,Sobral B,Swindells M,Bryant J,Davis H,Pauza CD,Lukashevich IS,Hammamieh R,Jett M,Salvato MSdoi
10.1128/JVI.00536-07subject
Has Abstractpub_date
2007-08-01 00:00:00pages
7960-73issue
15eissn
0022-538Xissn
1098-5514pii
JVI.00536-07journal_volume
81pub_type
杂志文章abstract:UNLABELLED:Semen enhances HIV infection in vitro, but how long it retains this activity has not been carefully examined. Immediately postejaculation, semen exists as a semisolid coagulum, which then converts to a more liquid form in a process termed liquefaction. We demonstrate that early during liquefaction, semen exh...
journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.2.1097-1106.1997
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01514-13
更新日期:2013-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.4.3176-3183.1999
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.7.4427-4431.1993
更新日期:1993-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.8.3661-3673.1990
更新日期:1990-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1998-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02514-09
更新日期:2010-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.23.11137-11144.2000
更新日期:2000-12-01 00:00:00
abstract::TR1.3 is a Friend murine leukemia virus (MLV) that induces selective syncytium induction (SI) of brain capillary endothelial cells (BCEC), intracerebral hemorrhage, and death. Syncytium induction by TR1.3 has been mapped to a single tryptophan-to-glycine conversion at position 102 of the envelope glycoprotein (Env102)...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.80.9.4601-4609.2006
更新日期:2006-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章,收录出版
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更新日期:2004-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.7.6073-6075.1999
更新日期:1999-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.12.7080-7088.1992
更新日期:1992-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章,收录出版
doi:10.1128/jvi.76.2.912-917.2002
更新日期:2002-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.5.3580-3587.1997
更新日期:1997-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.23.2.323-337.1977
更新日期:1977-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02060-07
更新日期:2008-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1979-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.20.9872-9884.2001
更新日期:2001-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02696-06
更新日期:2007-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.7.3343-3351.2001
更新日期:2001-04-01 00:00:00
abstract::Simian immunodeficiency virus (SIV) infection of rhesus macaques has become an important surrogate model for evaluating HIV vaccine strategies. The extreme resistance to neutralizing antibody (NAb) of many commonly used strains, such as SIVmac251/239 and SIVsmE543-3, limits their potential relevance for evaluating the...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00923-12
更新日期:2012-08-01 00:00:00