Signal peptidase cleavage at the flavivirus C-prM junction: dependence on the viral NS2B-3 protease for efficient processing requires determinants in C, the signal peptide, and prM.

abstract：:Previous studies have shown that serum interferon (IFN) production in mice is quantitatively influenced by If loci, whose alleles determine high or low production. Although different loci influence IFN production in response to different inducers, such as Newcastle disease virus, Sendai virus, herpes simplex virus typ...

journal_title：Journal of virology

authors： De Maeyer-Guignard J,Dandoy F,Bailey DW,De Maeyer E

更新日期：1986-06-01 00:00:00

abstract：:The Group B Staphylococcus phage P11-M15 is shown to be 51% protein and 49% deoxyribonucleic acid (DNA). The intact virion has a molecular weight of 66.7 x 10(6) daltons. The purified viral DNA has a molecular weight of 32.7 x 10(6) daltons. The intact virion is shown to be composed of a polyhedral head which is attac...

journal_title：Journal of virology

authors： Brown DT,Brown NC,Burlingham BT

更新日期：1972-04-01 00:00:00

abstract：:An effective vaccine for AIDS may require development of novel vectors capable of eliciting long-lasting immune responses. Here we report the development and use of replication-competent and replication-defective strains of recombinant herpes simplex virus (HSV) that express envelope and Nef antigens of simian immunod...

journal_title：Journal of virology

authors： Murphy CG,Lucas WT,Means RE,Czajak S,Hale CL,Lifson JD,Kaur A,Johnson RP,Knipe DM,Desrosiers RC

更新日期：2000-09-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) protease and its substrate, the assembly protein ICP35, are involved in virion maturation. Both proteins are encoded by a single open reading frame but are translated independently from 3'-coterminal mRNAs of different sizes and are in frame. The herpesvirus shell assembles arou...

journal_title：Journal of virology

authors： Robertson BJ,McCann PJ 3rd,Matusick-Kumar L,Preston VG,Gao M

更新日期：1997-02-01 00:00:00

abstract：:Infection of the chestnut blight fungus Cryphonectria parasitica with Cryphonectria hypovirus 1 (CHV1) causes disruption of virulence, pigmentation, and sporulation. Transcriptional downregulation of key developmentally regulated fungal genes occurs during infection, but vegetative growth is unaffected. Previous studi...

journal_title：Journal of virology

authors： Kazmierczak P,McCabe P,Turina M,Jacob-Wilk D,Van Alfen NK

更新日期：2012-06-01 00:00:00

abstract：:Vesicular stomatitis virus has the potential for very rapid evolution in the laboratory, but like many other arboviruses, it evolves at a relatively slow rate in the natural environment. Previous work showed that alternating replication in different cell types does not promote stasis. In order to determine whether oth...

journal_title：Journal of virology

authors： Zárate S,Novella IS

更新日期：2004-11-01 00:00:00

abstract：:PCR amplification of baboon endogenous virus (BaEV) long terminal repeat, reverse transcriptase gene, and env fragments from 24 different species of African monkeys indicates that BaEV is less widespread than was formerly thought. Instead of being present in every species of African primates, BaEV can be found only in...

journal_title：Journal of virology

authors： van der Kuyl AC,Dekker JT,Goudsmit J

更新日期：1995-12-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is a highly species-specific herpesvirus that targets sensory ganglionic neurons. This species specificity has limited the study of many aspects of VZV pathogenesis, including neuronal infection. We report development of a highly efficient neuroblastoma cell model to study productive VZV i...

journal_title：Journal of virology

authors： Christensen J,Steain M,Slobedman B,Abendroth A

更新日期：2011-08-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) sequences were generated from blood and from brain tissue obtained by stereotactic biopsy from six patients undergoing a diagnostic neurosurgical procedure. Proviral DNA was directly amplified by nested PCR, and 8 to 36 clones from each sample were sequenced. Phylogenetic an...

journal_title：Journal of virology

authors： Korber BT,Kunstman KJ,Patterson BK,Furtado M,McEvilly MM,Levy R,Wolinsky SM

更新日期：1994-11-01 00:00:00

abstract：:During studies of APOBEC3 (A3) anti-human immunodeficiency virus type 1 (anti-HIV-1) mechanisms, we identified a single cysteine at position 320 (C320) that disrupts A3DE activity. This residue is located in the recently identified DNA binding domain in A3G. Replacing C320 with a corresponding tyrosine from A3F (Y307)...

journal_title：Journal of virology

authors： Dang Y,Abudu A,Son S,Harjes E,Spearman P,Matsuo H,Zheng YH

更新日期：2011-06-01 00:00:00

abstract：:Animal influenza viruses pose a clear threat to public health. Transmissibility among humans is a prerequisite for a novel influenza virus to cause a human pandemic. A novel reassortant swine influenza virus acquired sustained human-to-human transmissibility and caused the 2009 influenza pandemic. However, the molecul...

journal_title：Journal of virology

authors： Zhang Y,Zhang Q,Gao Y,He X,Kong H,Jiang Y,Guan Y,Xia X,Shu Y,Kawaoka Y,Bu Z,Chen H

更新日期：2012-09-01 00:00:00

abstract：:The objective of this investigation was to examine by electron microscopy the replicative ribonucleoprotein (RNP) structures synthesized in vesicular stomatitis virus-infected HeLa cells. Pulse-labeled in vivo products of vesicular stomatitis virus replication and transcription can be separated by centrifugation in Re...

journal_title：Journal of virology

authors： Naeve CW,Summers DF

更新日期：1980-06-01 00:00:00

abstract：:Antibody was raised against purified vaccinia virus RNA polymerase and used to screen a recombinant vaccinia virus-lambda gt11 library. The DNA from several immunopositive clones was shown by Southern hybridization to originate from the vaccinia virus HindIII E fragment. The nucleotide sequence of the RNA polymerase s...

journal_title：Journal of virology

authors： Broyles SS,Pennington MJ

更新日期：1990-11-01 00:00:00

abstract：:Hemagglutinin (HA) of influenza virus must be activated by proteolysis before the virus can become infectious. Previous studies indicated that HA cleavage is driven by membrane-bound or extracellular serine proteases in the respiratory tract. However, there is still uncertainty as to which proteases are critical for a...

journal_title：Journal of virology

authors： Magnen M,Gueugnon F,Guillon A,Baranek T,Thibault VC,Petit-Courty A,de Veer SJ,Harris J,Humbles AA,Si-Tahar M,Courty Y

更新日期：2017-07-27 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV-68) is a naturally occurring rodent pathogen with significant homology to human pathogens Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. T cells are essential for primary clearance of MHV-68 and survival of mice following intranasal infection. Previous reports have sugg...

journal_title：Journal of virology

authors： Giannoni F,Lyon AB,Wareing MD,Dias PB,Sarawar SR

更新日期：2005-06-01 00:00:00

abstract：:Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by IBD virus (IBDV). Although IBDV-induced host cell apoptosis has been established, the underlying molecular mechanism is still unclear. We report here that IBDV viral protein 5 (VP5) is a major apoptosis induce...

journal_title：Journal of virology

authors： Li Z,Wang Y,Xue Y,Li X,Cao H,Zheng SJ

更新日期：2012-02-01 00:00:00

abstract：:Feline panleukopenia virus (FPV) and its host range variant, canine parvovirus (CPV), can bind the feline transferrin receptor (TfR), while only CPV binds to the canine TfR. Introducing two CPV-specific changes into FPV (at VP2 residues 93 and 323) endowed that virus with the canine TfR binding property and allowed ca...

journal_title：Journal of virology

authors： Hueffer K,Govindasamy L,Agbandje-McKenna M,Parrish CR

更新日期：2003-09-01 00:00:00

abstract：:The entry of animal viruses into cells is associated with permeabilization of the infected cells to protein toxins such as alpha-sarcin (C. Fernández-Puentes and L. Carrasco, Cell 20:769-775, 1980). This phenomenon has been referred to as "the early permeabilization by animal viruses" (L. Carrasco, Virology 113:623-62...

journal_title：Journal of virology

authors： Almela MJ,González ME,Carrasco L

更新日期：1991-05-01 00:00:00

abstract：:Previous work on the strict late (gamma) UL38 promoter of herpes simplex virus type 1 identified three cis-acting elements required for wild-type levels of transcription: a TATA box at -31, a consensus mammalian initiator element at the transcription start site, and a downstream activation sequence (DAS) at +20 to +33...

journal_title：Journal of virology

authors： Petroski MD,Wagner EK

更新日期：1998-10-01 00:00:00

abstract：:Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction of the innate immune response to influenza virus infection results in hypercytokinemia, which is responsible for mortality and morbidity. However, the mechanism by which influenza induces hypercytokinemia is not fully understood...

journal_title：Journal of virology

authors： Ma N,Li X,Jiang H,Dai Y,Xu G,Zhang Z

更新日期：2021-01-13 00:00:00

abstract：:Both the RNase H domain of Moloney murine leukemia virus (Mo-MLV) reverse transcriptase (RT) and Escherichia coli RNase H possess a positively charged alpha-helix (C helix) and a loop that are not present in the RNase H domains of human immunodeficiency virus (HIV) RT or avian sarcoma virus RT. Although a mutant Mo-ML...

journal_title：Journal of virology

authors： Lim D,Orlova M,Goff SP

更新日期：2002-08-01 00:00:00

abstract：:Vif counteracts the host restriction factor APOBEC3G (A3G) and other APOBEC3s by preventing the incorporation of A3G into progeny virions. We previously identified Vif mutants with a dominant-negative (D/N) phenotype that interfered with the function of wild-type Vif, inhibited the degradation of A3G, and reduced the ...

journal_title：Journal of virology

authors： Miyagi E,Welbourn S,Sukegawa S,Fabryova H,Kao S,Strebel K

更新日期：2020-03-17 00:00:00

abstract：:Preferential integration into transcriptionally active regions of genomes has been observed for retroviral vectors based on gamma-retroviruses and lentiviruses. However, differences in the integration site preferences were detected, which might be explained by differences in viral components of the preintegration comp...

journal_title：Journal of virology

authors： Monse H,Laufs S,Kuate S,Zeller WJ,Fruehauf S,Uberla K

更新日期：2006-08-01 00:00:00

abstract：:HB-3, a temperate bacteriophage of Streptococcus pneumoniae, synthesizes its own murein hydrolase activity when multiplying on cultures of pneumococcus. The enzyme (HBL) was purified and biochemically characterized as an N-acetylmuramoyl-L-alanine amidase of 36,000 daltons, and a 2.1-kilobase DraI fragment containing ...

journal_title：Journal of virology

authors： Romero A,Lopez R,Garcia P

更新日期：1990-01-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (gammaHV68, or MHV-68) is a genetically tractable, small animal model for the analysis of gammaherpesvirus pathogenesis. The gammaHV68 genome is colinear with the genomes of other sequence gammaherpesviruses, containing large blocks of conserved genes interspersed by a number of putative gen...

journal_title：Journal of virology

authors： Clambey ET,Virgin HW 4th,Speck SH

更新日期：2000-02-01 00:00:00

abstract：:Inhibition of RNA synthesis of the LH strain of type 3 poliovirus at the restrictive temperature occurs concurrently with the breakdown of noncapsid virus-specific peptide 2. This finding, along with other reported data (B.D. Korant, In Proteases and Biological Control, p. 621-644, 1975), suggests that noncapsid virus...

journal_title：Journal of virology

authors： Bowles SA,Tershak DR

更新日期：1978-08-01 00:00:00

abstract：:We tested whether the selection of target sites can be manipulated by fusing retroviral integrase with a sequence-specific DNA-binding protein. A hybrid protein that has the Escherichia coli LexA protein fused to the C terminus of the human immunodeficiency virus type 1 integrase was constructed. The fusion protein, I...

journal_title：Journal of virology

authors： Goulaouic H,Chow SA

更新日期：1996-01-01 00:00:00

abstract：:Given the current difficulties generating vaccine-induced neutralizing antibodies to human immunodeficiency virus (HIV), the focus of the vaccine community has shifted toward creating cytotoxic-T-lymphocyte (CTL)-based vaccines. Recent reports of CTL-based vaccine trials in macaques challenged with simian/human immuno...

journal_title：Journal of virology

authors： Vogel TU,Reynolds MR,Fuller DH,Vielhuber K,Shipley T,Fuller JT,Kunstman KJ,Sutter G,Marthas ML,Erfle V,Wolinsky SM,Wang C,Allison DB,Rud EW,Wilson N,Montefiori D,Altman JD,Watkins DI

更新日期：2003-12-01 00:00:00

abstract：:The swine-specific coronavirus transmissible gastroenteritis virus (TGEV) uses pig aminopeptidase-N (pAPN) as a cellular receptor. We showed that the human aminopeptidase-N (hAPN) cannot substitute for pAPN in this respect, although the two enzymes have 80% amino acid sequence identity. In order to map the TGEV bindin...

journal_title：Journal of virology

authors： Delmas B,Gelfi J,Kut E,Sjöström H,Noren O,Laude H

更新日期：1994-08-01 00:00:00

abstract：:Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immuniz...

journal_title：Journal of virology

authors： Lewis AJ,Whitton JL,Hatalski CG,Weissenböck H,Lipkin WI

更新日期：1999-03-01 00:00:00