Abstract:
:Murine gammaherpesvirus 68 (MHV-68) is a naturally occurring rodent pathogen with significant homology to human pathogens Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. T cells are essential for primary clearance of MHV-68 and survival of mice following intranasal infection. Previous reports have suggested that protein kinase C theta (PKCtheta) is essential for T-cell activation and cytokine production in vitro. To determine the role of this molecule in vivo during the immune response to a viral infection, PKCtheta-/- mice were infected with MHV-68. Despite the essential role of T cells in viral clearance, PKCtheta-/- mice survived infection, cleared lytic virus, and maintained effective long-term control of latency. CD8 T-cell expansion, trafficking to the lung, and cytotoxic activity were similar in PKCtheta+/+ and PKCtheta-/- mice, whereas antiviral antibody and T-helper cell cytokine production were significantly lower in PKCtheta-/- mice than in PKCtheta+/+ mice. These studies demonstrate a differential requirement for PKCtheta in the immune response to MHV-68 and show that PKCtheta is not essential for the T-cell activation events leading to viral clearance.
journal_name
J Viroljournal_title
Journal of virologyauthors
Giannoni F,Lyon AB,Wareing MD,Dias PB,Sarawar SRdoi
10.1128/JVI.79.11.6808-6813.2005subject
Has Abstractpub_date
2005-06-01 00:00:00pages
6808-13issue
11eissn
0022-538Xissn
1098-5514pii
79/11/6808journal_volume
79pub_type
杂志文章abstract::Mouse-hamster somatic cell hybrids were used to show that the recombinant mink cell focus-forming murine leukemia viruses and their ecotropic virus progenitors require different mouse chromosomes for replication. Mouse chromosome 1 was shown to carry the genetic information necessary for the replication of six differe...
journal_title:Journal of virology
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更新日期:1983-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.40.1.276-284.1981
更新日期:1981-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.1.415-423.1991
更新日期:1991-01-01 00:00:00
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journal_title:Journal of virology
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更新日期:2015-11-25 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.10.5237-5243.1991
更新日期:1991-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.67.1.178-188.1993
更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.00505-12
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2019-04-17 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.3.1059-1068.1989
更新日期:1989-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.65.5.2757-2760.1991
更新日期:1991-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.38.3.886-894.1981
更新日期:1981-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.3.6.605-610.1969
更新日期:1969-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.01936-06
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pub_type: 杂志文章
doi:10.1128/jvi.74.14.6309-6315.2000
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pub_type: 杂志文章
doi:10.1128/JVI.45.1.73-79.1983
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更新日期:2007-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2018-01-02 00:00:00
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更新日期:2004-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1991-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2017-08-24 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.51.3.776-787.1984
更新日期:1984-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.66.10.6233-6236.1992
更新日期:1992-10-01 00:00:00