De novo synthesis of N and P proteins as a key step in Sendai virus gene expression.

abstract：:A virus (M-7) isolated from baboon placental tissue demonstrates many similarities to endogenous feline virus RD-114. Immunodiffusion analysis shows a group-specific antigen (gs-1) line of identity between M-7 and RD-114. Anti-RD-114 DNA polymerase IgG inhibits M-7 polymerase by 57% compared to 97% for RD-114. M-7 vir...

journal_title：Journal of virology

authors： Hellman A,Peebles PT,Strickland JE,Fowler AK,Kalter SS,Oroszlan KS,Gilden RV

更新日期：1974-07-01 00:00:00

abstract：:The simian virus 40 large T antigen is a promiscuous transcriptional activator of many viral and cellular promoters. We show that the promoter structure necessary for T antigen-mediated transcriptional activation is very simple. A TATA or initiator element is required, in addition to an upstream factor-binding site, w...

journal_title：Journal of virology

authors： Gilinger G,Alwine JC

更新日期：1993-11-01 00:00:00

abstract：:Betapapillomavirus replication and transcription have not been studied in detail because of a lack of suitable cellular systems supporting human papillomavirus (HPV) genome replication. We have recently shown that the human osteosarcoma cell line U2OS provides a useful environment for the genome replication of many di...

journal_title：Journal of virology

authors： Sankovski E,Männik A,Geimanen J,Ustav E,Ustav M

更新日期：2014-01-01 00:00:00

abstract：:The recently emerged highly virulent variants of porcine epidemic diarrhea virus (PEDV) have caused colossal economic losses to the worldwide swine industry. In this study, we investigated the viral virulence determinants by constructing a series of chimeric mutants between the highly virulent strain BJ2011C and the a...

journal_title：Journal of virology

authors： Wang D,Ge X,Chen D,Li J,Cai Y,Deng J,Zhou L,Guo X,Han J,Yang H

更新日期：2018-06-13 00:00:00

abstract：:We isolated revertants of a polyomavirus whose origin of DNA replication contains a point mutation in the palindrome to which large T antigen binds. Four independent second-site revertants contain an Asp-286----Asn-286 substitution in large T antigen. This mutant large T antigen activates replication of DNAs containin...

journal_title：Journal of virology

authors： Tang WJ,Folk WR

更新日期：1989-01-01 00:00:00

abstract：:An R638A mutation of the polymerase acidic protein (PA) subunit of the RNA polymerase of influenza A/WSN/33 virus results in severe attenuation of viral growth in cell culture by promoting the synthesis of defective interfering RNAs. We propose that R638A is an "elongation" mutant that destabilizes PA-RNA template int...

journal_title：Journal of virology

authors： Fodor E,Mingay LJ,Crow M,Deng T,Brownlee GG

更新日期：2003-04-01 00:00:00

abstract：:Bovine leukemia virus (BLV) and human T-cell lymphotropic virus type 1 (HTLV-1) belong to the genus of deltaretroviruses. Their entry into the host cell is supposed to be mediated by interactions of the extracellular (SU) envelope glycoproteins with cellular receptors. To gain insight into the mechanisms governing thi...

journal_title：Journal of virology

authors： Gatot JS,Callebaut I,Van Lint C,Demonté D,Kerkhofs P,Portetelle D,Burny A,Willems L,Kettmann R

更新日期：2002-08-01 00:00:00

abstract：:Cultural changes that follow infection of rabbit kidney cells with fibroma virus were studied. Characteristic alterations of cell morphology and development of multilayered piles and cords of cells were found to occur in infected cultures in which cell division was blocked by gamma radiation or by cell crowding and se...

journal_title：Journal of virology

authors： Tompkins WA,Walker DL,Hinze HC

更新日期：1969-11-01 00:00:00

abstract：:The S1 gene nucleotide sequences of 10 type 3 (T3) reovirus strains were determined and compared with the T3 prototype Dearing strain in order to study sequence diversity in strains of a single reovirus serotype and to learn more about structure-function relationships of the two S1 translation products, sigma 1 and si...

journal_title：Journal of virology

authors： Dermody TS,Nibert ML,Bassel-Duby R,Fields BN

更新日期：1990-10-01 00:00:00

abstract：:Human immunodeficiency virus infection in humans and simian immunodeficiency virus (SIV) infection in rhesus macaques (RM) leads to a generalized loss of immune responses involving perturbations in T-cell receptor (TCR) signaling. In contrast, naturally SIV-infected sooty mangabeys (SM) remain asymptomatic and retain ...

journal_title：Journal of virology

authors： Bostik P,Wu P,Dodd GL,Villinger F,Mayne AE,Bostik V,Grimm BD,Robinson D,Kung HJ,Ansari AA

更新日期：2001-12-01 00:00:00

abstract：:Today, global attention is focused on two influenza virus strains: the current pandemic strain, swine origin influenza virus (H1N1-2009), and the highly pathogenic avian influenza virus, H5N1. At present, the infection caused by the H1N1-2009 is moderate, with mortality rates of less <1%. In contrast, infection with t...

journal_title：Journal of virology

authors： Achdout H,Meningher T,Hirsh S,Glasner A,Bar-On Y,Gur C,Porgador A,Mendelson M,Mandelboim M,Mandelboim O

更新日期：2010-04-01 00:00:00

abstract：:Recently, self-replicating and self-limiting RNA vaccines (RNA replicons) have emerged as an important form of nucleic acid vaccines. Self-replicating RNA eventually causes lysis of transfected cells and does not raise the concern associated with naked DNA vaccines of integration into the host genome. This is particul...

journal_title：Journal of virology

authors： Cheng WF,Hung CH,Chai CY,Hsu KF,He L,Ling M,Wu TC

更新日期：2001-03-01 00:00:00

abstract：:In vitro studies have suggested an important role for the minor capsid protein (VP1) unique region and the junction between VP1 and the major capsid protein (VP2) in the neutralizing immune response to B19 parvovirus. We investigated the role of the NH2-terminal region of the major structural protein in capsid structu...

journal_title：Journal of virology

authors： Kawase M,Momoeda M,Young NS,Kajigaya S

更新日期：1995-10-01 00:00:00

abstract：:Five gibbon ape leukemia virus substrains (two from gibbons with lymphocytic leukemia and three from gibbons with myelogenous leukemia) were examined for unique genomic sequences specific for each form of leukemia. By using sequential adsorption procedures, the genome from each gibbon ape leukemia virus was fractionat...

journal_title：Journal of virology

authors： Sun L,Kawakami TG

更新日期：1980-08-01 00:00:00

abstract：:Homo-oligomeric runs were inserted into a spleen necrosis virus-based retrovirus vector to determine the nature and rate of mutations within runs of 10 to 12 identical nucleotides during a single replication cycle. Clones of helper cells containing integrated copies of retroviral vectors were used to produce virus for...

journal_title：Journal of virology

authors： Burns DP,Temin HM

更新日期：1994-07-01 00:00:00

abstract：:The control of human immunodeficiency virus type 1 (HIV-1) associated with particular HLA class I alleles suggests that some CD8(+) T-cell responses may be more effective than others at containing HIV-1. Unfortunately, substantial diversities in the breadth, magnitude, and function of these responses have impaired our...

journal_title：Journal of virology

authors： Wang YE,Li B,Carlson JM,Streeck H,Gladden AD,Goodman R,Schneidewind A,Power KA,Toth I,Frahm N,Alter G,Brander C,Carrington M,Walker BD,Altfeld M,Heckerman D,Allen TM

更新日期：2009-02-01 00:00:00

abstract：:Herpes simplex virus DNA replication proteins localize in characteristic patterns corresponding to viral DNA replication structures in the infected cell nucleus. The intranuclear spatial organization of the HSV DNA replication structures and the factors regulating their nuclear location remain to be defined. We have u...

journal_title：Journal of virology

authors： de Bruyn Kops A,Knipe DM

更新日期：1994-06-01 00:00:00

abstract：:The small RNA segment (S segment) of Uukuniemi (UUK) virus encodes two proteins, the nucleocapsid protein (N) and a nonstructural protein (NSs), by an ambisense strategy. The function of NSs has not been elucidated for any of the bunyaviruses expressing this protein. We have now expressed the N and NSs proteins in Sf9...

journal_title：Journal of virology

authors： Simons JF,Persson R,Pettersson RF

更新日期：1992-07-01 00:00:00

abstract：:The unfolded-protein response (UPR), activated by sensor molecules PERK, ATF6, and IRE1 to resolve endoplasmic reticulum (ER) stress, has emerged as a key target for host cells and viruses to control the infection outcomes. The UPR regulates ER protein folding, controls cell fate upon ER stress, and plays an important...

journal_title：Journal of virology

authors： Qian Z,Xuan B,Chapa TJ,Gualberto N,Yu D

更新日期：2012-06-01 00:00:00

abstract：:Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampered the development of appropriate antiviral therapies. Here we show that the NoV NS3 protein, derived from murine NoV (MNV), is intimately associated with the MNV replication complex and the...

journal_title：Journal of virology

authors： Cotton BT,Hyde JL,Sarvestani ST,Sosnovtsev SV,Green KY,White PA,Mackenzie JM

更新日期：2017-01-18 00:00:00

abstract：:We have previously reported that chimpanzees chronically infected with hepatitis C virus (HCV) could be reinfected, even with the original infecting strain. In this study we tested the hypothesis that this might reflect the presence of minor quasispecies to which there was little or no immunity. To evaluate this hypot...

journal_title：Journal of virology

authors： Wyatt CA,Andrus L,Brotman B,Huang F,Lee DH,Prince AM

更新日期：1998-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection causes not only intrahepatic diseases but also extrahepatic manifestations, including type 2 diabetes. We previously reported that HCV replication suppresses cellular glucose uptake by downregulation of cell surface expression of glucose transporter 2 (GLUT2) (D. Kasai et al., J. Hepa...

journal_title：Journal of virology

authors： Matsui C,Shoji I,Kaneda S,Sianipar IR,Deng L,Hotta H

更新日期：2012-12-01 00:00:00

abstract：UNLABELLED:Development of a vaccine to prevent congenital cytomegalovirus infection is a major public health priority. Live vaccines attenuated through mutations targeting viral mechanisms responsible for evasion of host defense may be both safe and efficacious. Safety and vaccine efficacy were evaluated using a guinea...

journal_title：Journal of virology

authors： Schleiss MR,Bierle CJ,Swanson EC,McVoy MA,Wang JB,Al-Mahdi Z,Geballe AP

更新日期：2015-10-01 00:00:00

abstract：:One hundred thirty-eight new Epstein-Barr virus (EBV) genome sequences have been determined. One hundred twenty-five of these and 116 from previous reports were combined to produce a multiple-sequence alignment of 241 EBV genomes, which we have used to analyze variation within the viral genome. The type 1/type 2 class...

journal_title：Journal of virology

authors： Correia S,Bridges R,Wegner F,Venturini C,Palser A,Middeldorp JM,Cohen JI,Lorenzetti MA,Bassano I,White RE,Kellam P,Breuer J,Farrell PJ

更新日期：2018-10-29 00:00:00

abstract：:Natural Killer (NK) cells are important in the immune response to a number of viruses; however, the mechanisms used by NK cells to discriminate between healthy and virus-infected cells are only beginning to be understood. Infection with vaccinia virus provokes a marked increase in the susceptibility of target cells to...

journal_title：Journal of virology

authors： Chisholm SE,Reyburn HT

更新日期：2006-03-01 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection is a major cause of liver disease. The HCV polyprotein contains a hypervariable region (HVR1) located at the N terminus of the second envelope glycoprotein E2. The strong variability of this 27-amino-acid region is due to its apparent tolerance of amino acid substitutions toge...

journal_title：Journal of virology

authors： Penin F,Combet C,Germanidis G,Frainais PO,Deléage G,Pawlotsky JM

更新日期：2001-06-01 00:00:00

abstract：:Adeno-associated virus (AAV) integrates very efficiently into a specific site (AAVS1) of human chromosome 19. Two elements of the AAV genome are sufficient: the inverted terminal repeats (ITRs) and the Rep78 or Rep68 protein. The incorporation of the AAV integration machinery in nonviral delivery systems is of great i...

journal_title：Journal of virology

authors： Lamartina S,Roscilli G,Rinaudo D,Delmastro P,Toniatti C

更新日期：1998-09-01 00:00:00

abstract：:The matrix domain of human immunodeficiency virus type 1 Gag polyprotein was studied for its role in virus assembly. Deletion and substitution mutations caused a dramatic reduction in virus production. Mutant Gag polyproteins were myristoylated and had a high affinity for membrane association. Immunofluorescence stain...

journal_title：Journal of virology

authors： Yuan X,Yu X,Lee TH,Essex M

更新日期：1993-11-01 00:00:00

abstract：:The relationship between NS protein phosphorylation and RNA polymerase activities was determined in nucleocapsids purified from vesicular stomatitis virus grown in BHK cells. Phosphate incorporation into endogenous NS protein under transcription conditions reached a maximum value of 0.06 mol/mol of NS within 20 to 30 ...

journal_title：Journal of virology

authors： Massey DM,Deans N,Lenard J

更新日期：1990-07-01 00:00:00

abstract：:We have selected an HXB2 variant which can replicate in the presence of a neutralizing human serum. Sequencing of the gp120 region of the env gene from the variant and parental viruses identified a single amino acid substitution in the third conserved region of gp120 at residue 375 (AGT-->AAT, Ser-->Asn; designated 37...

journal_title：Journal of virology

authors： McKeating JA,Bennett J,Zolla-Pazner S,Schutten M,Ashelford S,Brown AL,Balfe P

更新日期：1993-09-01 00:00:00