Abstract:
:Cultural changes that follow infection of rabbit kidney cells with fibroma virus were studied. Characteristic alterations of cell morphology and development of multilayered piles and cords of cells were found to occur in infected cultures in which cell division was blocked by gamma radiation or by cell crowding and serum deprivation, thus indicating no dependence upon cell division. Fibroma virus infection did not remove blocks to cell division, but it did exert distinct effects upon nuclear deoxyribonucleic acid synthesis in cells blocked by radiation or cell crowding. Use of tritium-labeled thymidine and autoradiography demonstrated that after infection initial inhibition of nuclear incorporation was followed by sharply increased nuclear labeling at a time that coincided with beginning alterations of cell morphology and development of cell piling.
journal_name
J Viroljournal_title
Journal of virologyauthors
Tompkins WA,Walker DL,Hinze HCdoi
10.1128/JVI.4.5.603-609.1969subject
Has Abstractpub_date
1969-11-01 00:00:00pages
603-9issue
5eissn
0022-538Xissn
1098-5514journal_volume
4pub_type
杂志文章abstract::The coding capacity of human cytomegalovirus (HCMV) for glycoproteins by far exceeds that of other herpesviruses. Few of these proteins have been characterized so far. We have investigated the gene product of reading frame UL132. The putative protein product of UL132 is a glycoprotein with a theoretical mass of 29.8 k...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.18.11837-11847.2005
更新日期:2005-09-01 00:00:00
abstract::The replication of vaccinia virus is thought to take place exclusively in the cytoplasm of host cells. However, using DNA-DNA hybridization techniques, it can be shown that a significant fraction of the synthesis of vaccinia DNA takes place in the nucleus as well as the cytoplasm. The (3H) thymiding pulse-labeled vacc...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.15.2.305-315.1975
更新日期:1975-02-01 00:00:00
abstract::Hepatitis C virus (HCV) is a major causative agent of posttransfusion non-A, non-B hepatitis, which often develops into malignant chronic diseases, including liver cirrhosis and hepatocellular carcinoma. We have cloned from human carriers overlapping cDNAs (9,416 bp) covering the entire coding region of the HCV genome...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.3.1105-1113.1991
更新日期:1991-03-01 00:00:00
abstract:UNLABELLED:The encephalitic response to viral infection requires local chemokine production and the ensuing recruitment of immune and inflammatory leukocytes. Accordingly, chemokine receptors present themselves as plausible therapeutic targets for drugs aimed at limiting encephalitic responses. However, it remains uncl...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03421-13
更新日期:2014-09-01 00:00:00
abstract::The sequences of several hundred nucleotides around the junctions between the L and S components in concatemeric DNA and in mature virion DNA were ascertained. The two ends of the mature genome (which are joined in concatemeric DNA) show no sequence homology. Several directly repeated elements are present near both en...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.10.4968-4977.1990
更新日期:1990-10-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) can infect nondividing cells productively because the nuclear import of viral nucleic acids occurs in the absence of cell division. A number of viral factors that are present in HIV-1 preintegration complexes (PICs) have been assigned functions in nuclear import, including a...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.23.12087-12096.2002
更新日期:2002-12-01 00:00:00
abstract::The yeast retrotransposon Ty1 resembles retroviruses in a number of important respects but also shows several fundamental differences from them. We now report that, as in retroviruses, the genomic RNA in Ty1 virus-like particles is dimeric. The Ty1 dimers also resemble retroviral dimers in that they are stabilized dur...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.22.10819-10821.2000
更新日期:2000-11-01 00:00:00
abstract::Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of alpha/beta interferons (IFN-alpha/beta). However, recombinant HRSV lacking the NS1 and NS2 genes (Delta NS1/2) induced high levels of IFN-alpha and -beta in human pulmonary epithelial cells (A549) as well as in macrophages derived from primary hum...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.8.4363-4369.2004
更新日期:2004-04-01 00:00:00
abstract::Neurons of the sensory ganglia are the major site of varicella-zoster virus (VZV) latency and may undergo productive infection during reactivation. Although the VZV glycoprotein E/glycoprotein I (gE/gI) complex is known to be critical for neurovirulence, few studies have assessed the roles of these proteins during inf...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02293-13
更新日期:2013-12-01 00:00:00
abstract::The herpes simplex virus glycoprotein designated VP7(B2) is extracted from virions by nonionic detergent in the form of an oligomer, whereas the other detergent-soluble envelope proteins appear to be extracted as monomers. The subunits of the VP7(B2) oligomer cannot be dissociated by 2-mercaptoethanol and are also res...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.29.3.1159-1167.1979
更新日期:1979-03-01 00:00:00
abstract::The binding of cyclophilin A (CypA) to the human immunodeficiency virus type 1 (HIV-1) capsid protein (CA protein) is required soon after virus entry into natural target cells. In Jurkat T lymphocytes, disrupting CypA-CA interaction either by cyclosporine (Cs) treatment or by alteration (e.g., P90A) of the CA inhibits...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00682-09
更新日期:2009-11-01 00:00:00
abstract::A vaccinia-directed deoxyribonucleic acid (DNA) polymerase has been partially purified from the cytoplasmic fractions of virus-infected HeLa cells. The utilization of natural and synthetic templates by this enzyme resembles that of the host cell DNA-dependent DNA polymerases. The vaccinia DNA polymerase cannot copy ri...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.10.4.721-729.1972
更新日期:1972-10-01 00:00:00
abstract::The nef genes of the human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) and the related simian immunodeficiency viruses (SIVs) encode a protein (Nef) whose role in virus replication and cytopathicity remains uncertain. As an attempt to elucidate the function of nef, we characterized the nucleotide and corre...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.8.4639-4650.1993
更新日期:1993-08-01 00:00:00
abstract::The human immunodeficiency virus type 1 (HIV-1) epidemic in Southeast Asia has been largely due to the emergence of clade E (HIV-1E). It has been suggested that HIV-1E is derived from a recombinant lineage of subtype A (HIV-1A) and subtype E, with multiple breakpoints along the E genome. We obtained complete genome se...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.22.10752-10765.2000
更新日期:2000-11-01 00:00:00
abstract::Animals that naturally acquire the prion diseases have a well-developed olfactory sense that they utilize for a variety of basic behaviors. To assess the potential for the nasal cavity to serve as a point of entry for prion diseases, a small amount of prion-infected brain homogenate was placed inferior to the nostrils...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02649-06
更新日期:2007-05-01 00:00:00
abstract::Vilyuisk human encephalitis virus (VHEV) is a picornavirus related to Theiler's murine encephalomyelitis virus (TMEV). VHEV was isolated from human material passaged in mice. Whether this VHEV is of human or mouse origin is therefore unclear. We took advantage of the species-specific activity of the nonstructural L* p...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00573-17
更新日期:2017-06-26 00:00:00
abstract::A variant of human T-cell leukemia virus subgroup I (HTLV-I), designated HTLV-Ib, has been isolated from a transformed T-lymphocytic cell line established from a Zairian patient with adult T-cell lymphoma. A recombinant phage clone of the variant provirus, denoted lambda MC-1, hybridizes under high stringency to HTLV-...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.54.3.781-790.1985
更新日期:1985-06-01 00:00:00
abstract::A panel of murine monoclonal antibodies (MAbs) to the human immunodeficiency virus type 1 trans-activator tat protein were characterized. The anti-tat MAbs were mapped to the different domains of the tat protein by Western blot (immunoblot) and Pepscan analyses. One-half of the MAbs tested mapped to the amino-terminal...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.2.962-965.1990
更新日期:1990-02-01 00:00:00
abstract::Viruses encode proteins that disrupt chemokine responses. The murine gammaherpesvirus 68 gene M3 encodes a chemokine binding protein (vCKBP-3) which has no sequence similarity to chemokine receptors but inhibits chemokine receptor binding and activity. We have used a panel of CXCL8 analogs to identify the structural r...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.15.8588-8592.2003
更新日期:2003-08-01 00:00:00
abstract::Arginine methylation of human immunodeficiency virus type 1 (HIV-1) Tat protein downregulates its key function in viral-gene transactivation. The fate of methylated Tat is unknown, so it is unclear whether methylated Tat is degraded or persists in the cell for additional functions. Here we show that the arginine methy...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00499-09
更新日期:2009-11-01 00:00:00
abstract::Severe acute respiratory syndrome (SARS), caused by a novel coronavirus (CoV) known as SARS-CoV, is a contagious and life-threatening respiratory illness with pneumocytes as its main target. A full understanding of how SARS-CoV would interact with lung epithelial cells will be vital for advancing our knowledge of SARS...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.15.9470-9479.2005
更新日期:2005-08-01 00:00:00
abstract::Thirty-six monoclonal antibodies from mice and three from rats were raised against a peptide corresponding to the immunodominant domain of the transmembrane gp41 protein of human immunodeficiency virus (HIV) type 1 (LGLWGCSGKLIC; amino acid residues 598 to 609). Of these, three monoclonal antibodies from the mice and ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.4.1727-1734.1991
更新日期:1991-04-01 00:00:00
abstract::Immature retroviral particles are assembled by self-association of the structural polyprotein precursor Gag. During maturation the Gag polyprotein is proteolytically cleaved, yielding mature structural proteins, matrix (MA), capsid (CA), and nucleocapsid (NC), that reassemble into a mature viral particle. Proteolytic ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.05564-11
更新日期:2012-02-01 00:00:00
abstract::Massive infection of memory CD4 T cells is a hallmark of early simian immunodeficiency virus (SIV) infection, with viral infection peaking at day 10 postinfection (p.i.), when a majority of memory CD4 T cells in mucosal and peripheral tissues are infected. It is not clear if mononuclear cells from the monocyte and mac...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.06372-11
更新日期:2012-01-01 00:00:00
abstract:UNLABELLED:JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). The viral capsid of JCPyV is composed primarily of the major capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomers results...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00089-15
更新日期:2015-04-01 00:00:00
abstract::ZAM is an env-containing member of the gypsy family of retrotransposons that represents a possible retrovirus of invertebrates. In this paper, we traced ZAM mobilization to get information about a potential path a retroelement may take to reach the germ line of its host. In situ hybridization on whole-mount tissues an...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.22.10658-10669.2000
更新日期:2000-11-01 00:00:00
abstract::Signal transducers and activators of transcription (STATs) relay signals from activated cell surface receptors directly to the nucleus. Previously, a protein required for T-cell transformation by the DNA tumor virus herpesvirus saimiri (HVS) and designated tyrosine kinase interacting protein (Tip-484) was shown to int...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.9.6677-6682.1997
更新日期:1997-09-01 00:00:00
abstract::Recently, novel H7N9 influenza viruses have caused an unprecedented outbreak in humans. Pigs are an important intermediate host for influenza; thus, we assessed the replication ability of three human H7N9 viruses (A/Anhui/1/2013, A/Shanghai/1/2013, A/Shanghai/2/2013) in swine tissue explants. All viruses tested replic...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02499-13
更新日期:2013-11-01 00:00:00
abstract::Detailed phylogenetic analyses were performed to characterize an HIV-1 outbreak among injection drug users (IDUs) in Stockholm, Sweden, in 2006. This study investigated the source and dynamics of HIV-1 spread during the outbreak as well as associated demographic and clinical factors. Seventy Swedish IDUs diagnosed dur...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01413-10
更新日期:2011-01-01 00:00:00
abstract:UNLABELLED:Human immunodeficiency virus type 1 (HIV-1) infection in the central nervous system (CNS) is characterized by replication in macrophages or brain microglia that express low levels of the CD4 receptor and is the cause of HIV-associated dementia and related cognitive and motor disorders that affect 20 to 30% o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01237-14
更新日期:2014-08-01 00:00:00