Abstract:
:Recently, novel H7N9 influenza viruses have caused an unprecedented outbreak in humans. Pigs are an important intermediate host for influenza; thus, we assessed the replication ability of three human H7N9 viruses (A/Anhui/1/2013, A/Shanghai/1/2013, A/Shanghai/2/2013) in swine tissue explants. All viruses tested replicated efficiently in explants from tracheas and bronchi, with limited replication in alveolar cells. Swine respiratory tissue explants can serve as an efficient model for screening replication potential of newly emerging H7N9 viruses.
journal_name
J Viroljournal_title
Journal of virologyauthors
Jones JC,Baranovich T,Zaraket H,Guan Y,Shu Y,Webby RJ,Webster RGdoi
10.1128/JVI.02499-13subject
Has Abstractpub_date
2013-11-01 00:00:00pages
12496-8issue
22eissn
0022-538Xissn
1098-5514pii
JVI.02499-13journal_volume
87pub_type
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