Multiple functions of immunoglobulin A in mucosal defense against viruses: an in vitro measles virus model.

abstract：:Newborn mice suckled on dams immunized either orally or parenterally with primate rotavirus SA-11 were protected against diarrhea induced by SA-11 virus challenge. Experimental oral administration of milk from orally immunized dams protected suckling mice against challenge; protective activity was detected both in the...

journal_title：Journal of virology

authors： Offit PA,Clark HF

更新日期：1985-04-01 00:00:00

abstract：:The multiplicity of attachment (MOA) of a virion in any particular time interval is the average number of cellular attachment opportunities that must be blocked to keep the virion in suspension. MOA is usually proportional to incubation time and cell concentration. Low MOA (like low multiplicity of infection) is requi...

journal_title：Journal of virology

authors： Spouge JL

更新日期：1994-03-01 00:00:00

abstract：:Two strains of minute virus of mice (MVM) show different host cell specificities. The prototype strain MVM(p) grows in fibroblasts, whereas the immunosuppressive variant MVM(i) grows in T lymphocytes. In this study, we have mapped on the viral genome a cell type-specific determinant: it is located between 69 and 85 ma...

journal_title：Journal of virology

authors： Antonietti JP,Sahli R,Beard P,Hirt B

更新日期：1988-02-01 00:00:00

abstract：:Infection by viruses depends on a balance between capsid stability and dynamics. This study investigated biologically and biotechnologically relevant aspects of the relationship in foot-and-mouth disease virus (FMDV) between capsid structure and thermostability and between thermostability and infectivity. In the FMDV ...

journal_title：Journal of virology

authors： López-Argüello S,Rincón V,Rodríguez-Huete A,Martínez-Salas E,Belsham GJ,Valbuena A,Mateu MG

更新日期：2019-05-01 00:00:00

abstract：:Two serologically distinguishable primate herpesviruses, Herpesvirus aotus type 1 and type 3, were examined with regard to their genomes and structural polypeptides. The duplex DNA genomes of these two viruses were found to be essentially identical in molecular weight (Mr approximately equal to 145 X 10(6)) and guanin...

journal_title：Journal of virology

authors： Ebeling A,Keil G,Nowak B,Fleckenstein B,Berthelot N,Sheldrick P

更新日期：1983-02-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) protein is a transcriptional regulator of viral and cellular genes that is essential for EBV-mediated immortalization of B lymphocytes in vitro. EBNA-3C can inhibit transcription through an association with the cellular DNA-binding protein Jkappa, a function sh...

journal_title：Journal of virology

authors： Zhao B,Sample CE

更新日期：2000-06-01 00:00:00

abstract：:The structural polypeptides of purified Plodia interpunctella granulosis virus were analyzed by three different two-dimensional gel systems. Isoelectric focusing followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis allowed resolution of 53 acidic polypeptides in the enveloped nucleocapsid of the virus...

journal_title：Journal of virology

authors： Russell DL,Consigli RA

更新日期：1986-10-01 00:00:00

abstract：:The ascomycete Botrytis porri causes clove rot and leaf blight of garlic worldwide. We report here the biological and molecular features of a novel bipartite double-stranded RNA (dsRNA) mycovirus named Botrytis porri RNA virus 1 (BpRV1) from the hypovirulent strain GarlicBc-72 of B. porri. The BpRV1 genome comprises t...

journal_title：Journal of virology

authors： Wu M,Jin F,Zhang J,Yang L,Jiang D,Li G

更新日期：2012-06-01 00:00:00

abstract：:On the basis of the conservation of neuraminidase (N) active-site residues in influenza virus N and paramyxovirus hemagglutinin-neuraminidase (HN), it has been suggested that the three-dimensional (3D) structures of the globular heads of the two proteins are broadly similar. In this study, details of this structural s...

journal_title：Journal of virology

authors： Langedijk JP,Daus FJ,van Oirschot JT

更新日期：1997-08-01 00:00:00

abstract：:The mechanism by which simian virus 40 converts the abortive adenovirus type 7 infection of monkey cells into an efficient lytic infection has been investigated. Analysis of ribonucleic acid (RNA) synthesis during unenhanced and enhanced infection of monkey cells has shown that adenovirus RNA synthesized in the aborti...

journal_title：Journal of virology

authors： Fox RI,Baum SG

更新日期：1972-08-01 00:00:00

abstract：:A recombinant adenovirus was constructed by inserting the human immunodeficiency virus type 1 (HIV-1) envelope gene downstream from the early region 3 (E3) promoter of adenovirus type 5 (Ad5), replacing the coding sequences of E3. The recombinant virus replicated as efficiently as the parent virus in all cell lines te...

journal_title：Journal of virology

authors： Dewar RL,Natarajan V,Vasudevachari MB,Salzman NP

更新日期：1989-01-01 00:00:00

abstract：:Bacteriophages of the C3 morphotype, characterized by very long heads that exceed their width several times, are extremely rare among the Podoviridae family members and constitute only 0.5% of over 5,500 phages that have been examined by the electron microscope (H. W. Ackermann, Arch. Virol. 152:227-243, 2007; H. W. A...

journal_title：Journal of virology

authors： Li Y,Chen M,Tang F,Yao H,Lu C,Zhang W

更新日期：2012-12-01 00:00:00

abstract：:Adeno-associated virus type 2 (AAV2) preferentially integrates its genome into the AAVS1 locus on human chromosome 19. Preferential integration requires the AAV2 Rep68 or Rep78 protein (Rep68/78), a Rep68/78 binding site (RBS), and a nicking site within AAVS1 and may also require an RBS within the virus genome. To obt...

journal_title：Journal of virology

authors： McAlister VJ,Owens RA

更新日期：2007-09-01 00:00:00

abstract：:The membrane-proximal region of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein (TM) is critical for envelope (Env)-mediated membrane fusion and contains the target for broadly reactive neutralizing antibody 2F5. It has been proposed that 2F5 neutralization might involve interaction of its long, ...

journal_title：Journal of virology

authors： Ou W,Lu N,Yu SS,Silver J

更新日期：2006-03-01 00:00:00

abstract：:Adeno-associated viruses (AAVs) are small single-stranded DNA viruses that can package and deliver nongenomic DNA for therapeutic gene delivery. AAV8, a liver-tropic vector, has shown great promise for the treatment of hemophilia A and B. However, as with other AAV vectors, host anti-capsid immune responses are a dete...

journal_title：Journal of virology

authors： Gurda BL,Raupp C,Popa-Wagner R,Naumer M,Olson NH,Ng R,McKenna R,Baker TS,Kleinschmidt JA,Agbandje-McKenna M

更新日期：2012-08-01 00:00:00

abstract：:We previously reported that herpes simplex virus type 1 (HSV-1) can activate the stress-activated protein kinases (SAPKs) p38 and JNK. In the present study, we undertook a comprehensive and comparative analysis of the requirements for viral protein synthesis in the activation of JNK and p38. Infection with the UL36 mu...

journal_title：Journal of virology

authors： Hargett D,McLean T,Bachenheimer SL

更新日期：2005-07-01 00:00:00

abstract：:Several members of the APOBEC3 DNA cytosine deaminase family can potently inhibit Vif-deficient human immunodeficiency virus type 1 (HIV-1) by catalyzing cytosine deamination in viral cDNA and impeding reverse transcription. HIV-1 counteracts restriction with the virally encoded Vif protein, which targets relevant APO...

journal_title：Journal of virology

authors： Wang J,Shaban NM,Land AM,Brown WL,Harris RS

更新日期：2018-05-29 00:00:00

abstract：:Although the herpes simplex virus type 1 (HSV-1) tegument is comprised of a large number of viral and cellular proteins, how and where in the cell these proteins are recruited into the virus structure is poorly understood. We have shown previously that the immediate-early gene product ICP0 is packaged by a mechanism d...

journal_title：Journal of virology

authors： Maringer K,Elliott G

更新日期：2010-05-01 00:00:00

abstract：:The temperature-sensitive defects of virus mutants isolated from L cells persistently infected with Newcastle disease virus (NDV) were analyzed. Genetic grouping of the mutants by complementation tests was attempted by using several different methods, including yield analysis, RNA synthesis, and heterozygote formation...

journal_title：Journal of virology

authors： Preble OT,Youngner JS

更新日期：1973-09-01 00:00:00

abstract：:The tegument of herpesviruses is a highly complex structural layer between the nucleocapsid and the envelope of virions. Tegument proteins play both structural and regulatory functions during replication and spread, but the interactions and functions of many of these proteins are poorly understood. Here we focus on tw...

journal_title：Journal of virology

authors： Albecka A,Owen DJ,Ivanova L,Brun J,Liman R,Davies L,Ahmed MF,Colaco S,Hollinshead M,Graham SC,Crump CM

更新日期：2017-01-03 00:00:00

abstract：:Both CD4(+) and CD8(+) T cells are required for clearance of the murine coronavirus mouse hepatitis virus (MHV) during acute infection. We investigated the effects of an epitope-specific CD8(+) T-cell response on acute infection of MHV, strain A59, in the murine CNS. Mice with CD8(+) T cells specific for gp33-41 (an H...

journal_title：Journal of virology

authors： Chua MM,MacNamara KC,San Mateo L,Shen H,Weiss SR

更新日期：2004-02-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a human herpesvirus capable of establishing a latent state in B lymphocytes. EBV's BZLF1 gene product plays a central role in regulating the switch from latency to productive infection. Here, we identify a sequence element, 5'-CAGGTA-3', called ZV, located at nucleotides -17 to -12 relative...

journal_title：Journal of virology

authors： Kraus RJ,Mirocha SJ,Stephany HM,Puchalski JR,Mertz JE

更新日期：2001-01-01 00:00:00

abstract：:Infectious poxvirus particles are unusual in that they are brick shaped and lack symmetry. Nevertheless, an external honeycomb lattice comprised of a capsid-like protein dictates the spherical shape and size of immature poxvirus particles. In the case of vaccinia virus, trimers of 63-kDa D13 polypeptides form the buil...

journal_title：Journal of virology

authors： Bisht H,Weisberg AS,Szajner P,Moss B

更新日期：2009-09-01 00:00:00

abstract：UNLABELLED:An understanding of the antigen-specific B-cell response to the influenza virus hemagglutinin (HA) is critical to the development of universal influenza vaccines, but it has not been possible to examine these cells directly because HA binds to sialic acid (SA) on most cell types. Here, we use structure-based...

journal_title：Journal of virology

authors： Whittle JR,Wheatley AK,Wu L,Lingwood D,Kanekiyo M,Ma SS,Narpala SR,Yassine HM,Frank GM,Yewdell JW,Ledgerwood JE,Wei CJ,McDermott AB,Graham BS,Koup RA,Nabel GJ

更新日期：2014-04-01 00:00:00

abstract：:Jurkat T-cell clones, stably expressing the human immunodeficiency virus type 1 (HIV-1) Vpr protein, exhibited an impaired susceptibility to HIV-1 infection. A marked down-modulation of surface CD4 receptors was detected in Vpr-expressing clones with respect to control cells. Likewise, a reduced CD4 expression was als...

journal_title：Journal of virology

authors： Conti L,Varano B,Gauzzi MC,Matarrese P,Federico M,Malorni W,Belardelli F,Gessani S

更新日期：2000-11-01 00:00:00

abstract：:The RNA-dependent RNA polymerase of influenza A virus is composed of three subunits that together synthesize all viral mRNAs and also replicate the viral genomic RNA segments (vRNAs) through intermediates known as cRNAs. Here we describe functional characterization of 16 site-directed mutants of one polymerase subunit...

journal_title：Journal of virology

authors： Regan JF,Liang Y,Parslow TG

更新日期：2006-01-01 00:00:00

abstract：:We have investigated the molecular basis of biological differences observed among cell line-adapted isolates of the human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and the simian immunodeficiency virus (SIV) in response to receptor binding by using a soluble form of CD4 (sCD4) as a receptor mimic. We find...

journal_title：Journal of virology

authors： Sattentau QJ,Moore JP,Vignaux F,Traincard F,Poignard P

更新日期：1993-12-01 00:00:00

abstract：:Candidate foot-and-mouth disease (FMD) DNA vaccines designed to produce viral capsids lacking infectious viral nucleic acid were evaluated. Plasmid DNAs containing a portion of the FMDV genome coding for the capsid precursor protein (P1-2A) and wild-type or mutant viral proteinase 3C (plasmids P12X3C or P12X3C-mut, re...

journal_title：Journal of virology

authors： Chinsangaram J,Beard C,Mason PW,Zellner MK,Ward G,Grubman MJ

更新日期：1998-05-01 00:00:00

abstract：:We have previously demonstrated that the human papillomavirus (HPV) genome replicates effectively in U2OS cells after transfection using electroporation. The transient extrachromosomal replication, stable maintenance, and late amplification of the viral genome could be studied for high- and low-risk mucosal and cutane...

journal_title：Journal of virology

authors： Reinson T,Toots M,Kadaja M,Pipitch R,Allik M,Ustav E,Ustav M

更新日期：2013-01-01 00:00:00

abstract：:The RNA genomes from the cardioviruses, hepatoviruses, and aphthoviruses encode two to five tandem pseudoknots within their 5' untranslated regions. These pseudoknots lie adjacent to a pyrimidine-rich sequence, which in cardio- and aphthoviruses takes the form of a homopolymeric poly(C) tract. Seven deletion mutations...

journal_title：Journal of virology

authors： Martin LR,Palmenberg AC

更新日期：1996-11-01 00:00:00