Protection against rotavirus-induced gastroenteritis in a murine model by passively acquired gastrointestinal but not circulating antibodies.

abstract：:Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with the major viral proteins, p40 and p23. Although p40 and p23 are unrelated in amino acid sequence structure, cross-reactive antibodies are described. Protein fragments and synthetic peptides were analyzed to characterize the sp...

journal_title：Journal of virology

authors： Kliche S,Stitz L,Mangalam H,Shi L,Binz T,Niemann H,Briese T,Lipkin WI

更新日期：1996-11-01 00:00:00

abstract：:Adenovirus type 2 (Ad2)-transformed hamster and rat cells are susceptible to lysis by natural killer (NK) cells from the host of origin and are nontumorigenic in immunocompetent hamsters and rats, respectively. These NK-cell-susceptible, virus-transformed cells are, however, highly tumorigenic in athymic (nude) mice--...

journal_title：Journal of virology

authors： Cook JL,Lewis AM Jr

更新日期：1987-07-01 00:00:00

abstract：:The 86-kDa IE2 protein (IE86) of human cytomegalovirus (HCMV) can act as both an activator and a repressor of gene expression. The mechanisms for both of these functions are not well defined. It has recently been demonstrated that this protein has sequence-specific DNA binding properties: it interacts directly with a ...

journal_title：Journal of virology

authors： Arlt H,Lang D,Gebert S,Stamminger T

更新日期：1994-07-01 00:00:00

abstract：:The oncolytic herpes simplex virus (HSV) that has been approved for clinical practice and those HSVs in clinical trials are attenuated viruses, often with the neurovirulence gene γ134.5 and additional genes deleted. One strategy to engineer nonattenuated oncolytic HSVs consists of retargeting the viral tropism to a ca...

journal_title：Journal of virology

authors： Leoni V,Gatta V,Casiraghi C,Nicosia A,Petrovic B,Campadelli-Fiume G

更新日期：2017-04-28 00:00:00

abstract：:Virus entry into host cells is a complex process that is largely regulated by access to specific cellular receptors. Human adenoviruses (HAdVs) and many other viruses use cell adhesion molecules such as the coxsackievirus and adenovirus receptor (CAR) for attachment to and entry into target cells. These molecules are ...

journal_title：Journal of virology

authors： Persson BD,Lenman A,Frängsmyr L,Schmid M,Ahlm C,Plückthun A,Jenssen H,Arnberg N

更新日期：2020-07-01 00:00:00

abstract：:The vaccinia virus (VV) A10L gene codes for a major core protein, P4a. This polypeptide is synthesized at late times during viral infection and is proteolytically cleaved during virion assembly. To investigate the role of P4a in the virus life cycle and morphogenesis, we have generated an inducer-dependent conditional...

journal_title：Journal of virology

authors： Heljasvaara R,Rodríguez D,Risco C,Carrascosa JL,Esteban M,Rodríguez JR

更新日期：2001-07-01 00:00:00

abstract：:We report here the complete genomic sequence of the duck Tembusu virus (DTMUV) WJ-1 strain, isolated from Muscovy ducks. This is the first complete genome sequence of DTMUV reported in southern China. Compared with the other strains (TA, GH-2, YY5, and ZJ-407) that were previously found in eastern China, WJ-1 bears a ...

journal_title：Journal of virology

authors： Zhu W,Chen J,Wei C,Wang H,Huang Z,Zhang M,Tang F,Xie J,Liang H,Zhang G,Su S

更新日期：2012-12-01 00:00:00

abstract：:Virus-specific proteins were examined in cultured cells infected with bovine viral diarrhea virus. By using antisera obtained from virus-infected animals, three major virus-specific polypeptides with molecular weights of 115,000 (115K), 80K, and 55K were observed. Minor proteins of 45,000 and 38,000 daltons were also ...

journal_title：Journal of virology

authors： Purchio AF,Larson R,Collett MS

更新日期：1984-05-01 00:00:00

abstract：:We have reinvestigated the subcellular distribution of the duck hepatitis B virus (DHBV) core protein in infected duck hepatocytes and in transfected cells. By using indirect immunofluorescence, the protein was found to be localized not only in the cytoplasm, as described previously, but also within the cell nucleus, ...

journal_title：Journal of virology

authors： Mabit H,Knaust A,Breiner KM,Schaller H

更新日期：2003-02-01 00:00:00

abstract：:The cellular immune response contributes to viral clearance as well as to liver injury in acute and chronic hepatitis C virus (HCV) infection. An immunodominant determinant frequently recognized by liver-infiltrating and circulating CD8(+) T cells of HCV-infected patients is the HCV(NS3-1073) peptide CVNGVCWTV. Using ...

journal_title：Journal of virology

authors： Wedemeyer H,Mizukoshi E,Davis AR,Bennink JR,Rehermann B

更新日期：2001-12-01 00:00:00

abstract：:The Coccolithoviridae are a group of viruses which infect the marine coccolithophorid microalga Emiliania huxleyi. The Emiliania huxleyi viruses (known as EhVs) described herein have 160- to 180-nm diameter icosahedral structures, have genomes of approximately 400 kbp, and consist of more than 450 predicted coding seq...

journal_title：Journal of virology

authors： Nissimov JI,Worthy CA,Rooks P,Napier JA,Kimmance SA,Henn MR,Ogata H,Allen MJ

更新日期：2012-03-01 00:00:00

abstract：:We previously reported that exosomal transfer of hepatitis C virus (HCV) positive-strand RNA from human Huh-7 hepatoma cells to human plasmacytoid dendritic cells (pDCs) triggers pDC alpha/beta interferon (IFN-α/β) production in a Toll-like receptor 7 (TLR7)-dependent, virus-independent manner. Here we show that human...

journal_title：Journal of virology

authors： Wieland SF,Takahashi K,Boyd B,Whitten-Bauer C,Ngo N,de la Torre JC,Chisari FV

更新日期：2014-01-01 00:00:00

abstract：:Mixed infection of a cell by vesicular stomatitis virus (VSV) and retroviruses results in the production of progeny virions bearing the genome of one virus encapsidated by the envelope proteins of the other. The mechanism for the phenomenon of pseudotype formation is not clear, although specific recognition of a viral...

journal_title：Journal of virology

authors： Emi N,Friedmann T,Yee JK

更新日期：1991-03-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) BamHI-A rightward transcripts (BARTs) are expressed in all EBV-associated tumors as well as in latently infected B cells in vivo and cultured B-cell lines. One of the BART family transcripts contains an open reading frame, RPMS1, that encodes a nuclear protein termed RPMS. Reverse transcri...

journal_title：Journal of virology

authors： Zhang J,Chen H,Weinmaster G,Hayward SD

更新日期：2001-03-01 00:00:00

abstract：:Endogenous viral elements derived from nonretroviral RNA viruses have been described in various animal genomes. Whether they have a biological function, such as host immune protection against related viruses, is a field of intense study. Here, we investigated the repertoire of endogenous flaviviral elements (EFVEs) in...

journal_title：Journal of virology

authors： Suzuki Y,Frangeul L,Dickson LB,Blanc H,Verdier Y,Vinh J,Lambrechts L,Saleh MC

更新日期：2017-07-12 00:00:00

abstract：:Dengue virus (DENV) is a mosquito-borne virus that infects upward of 300 million people annually and has the potential to cause fatal hemorrhagic fever and shock. While the parameters contributing to dengue immunopathogenesis remain unclear, the collapse of redox homeostasis and the damage induced by oxidative stress ...

journal_title：Journal of virology

authors： Ferrari M,Zevini A,Palermo E,Muscolini M,Alexandridi M,Etna MP,Coccia EM,Fernandez-Sesma A,Coyne C,Zhang DD,Marques ETA,Olagnier D,Hiscott J

更新日期：2020-11-23 00:00:00

abstract：:The RNA produced in vivo from bacteriophage phiX174 DNA has been analyzed by polyacrylamide-agarose gel electrophoresis and sedimentation in dimethyl sulfoxide gradients, and the results of Hayashi and Hayashi (1970) have been confirmed and extended. An efficient procedure for recovery of RNA from gels, followed by a ...

journal_title：Journal of virology

authors： Clements JB,Sinsheimer RL

更新日期：1975-01-01 00:00:00

abstract：:Multiple steps of the life cycle of hepatitis B virus (HBV) are known to be coupled to hepatic metabolism. However, the details of involvement of the hepatic metabolic milieu in HBV infection remain incompletely understood. Hepatic lipid metabolism is controlled by a complicated transcription factor network centered o...

journal_title：Journal of virology

authors： Song M,Sun Y,Tian J,He W,Xu G,Jing Z,Li W

更新日期：2018-03-28 00:00:00

abstract：:The pandemic H1N1 virus of 2009 (2009 H1N1) continues to cause illness worldwide, primarily in younger age groups. To better understand the pathogenesis of these viruses in mammals, we used a mouse model to evaluate the relative virulence of selected 2009 H1N1 viruses and compared them to a representative human triple...

journal_title：Journal of virology

authors： Belser JA,Wadford DA,Pappas C,Gustin KM,Maines TR,Pearce MB,Zeng H,Swayne DE,Pantin-Jackwood M,Katz JM,Tumpey TM

更新日期：2010-05-01 00:00:00

abstract：:Despite successful antiretroviral therapy (ART), low-level viremia (LLV) may be intermittently detected in most HIV-infected patients. Longitudinal blood plasma and resting CD4(+) T cells were obtained from two patients on suppressive ART to investigate the source of LLV. Single-genome sequencing of HIV-1 env from LLV...

journal_title：Journal of virology

authors： Anderson JA,Archin NM,Ince W,Parker D,Wiegand A,Coffin JM,Kuruc J,Eron J,Swanstrom R,Margolis DM

更新日期：2011-05-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is a cellular enzyme in the eicosanoid synthetic pathway that mediates the synthesis of prostaglandins from arachidonic acid. The eicosanoids function as critical regulators of a number of cellular processes, including the acute and chronic inflammatory response, hemostasis, and the innate imm...

journal_title：Journal of virology

authors： Rue CA,Jarvis MA,Knoche AJ,Meyers HL,DeFilippis VR,Hansen SG,Wagner M,Früh K,Anders DG,Wong SW,Barry PA,Nelson JA

更新日期：2004-11-01 00:00:00

abstract：:Influenza virus has a set of ribonucleoproteins (RNPs) consisting of viral RNAs, influenza virus polymerase subunits, and nucleoprotein. Intracellular reconstitution of the whole set of RNPs via plasmid transfection results in the generation of influenza virus. By the use of reverse genetics and dual promoters, we con...

journal_title：Journal of virology

authors： Zhang X,Kong W,Ashraf S,Curtiss R 3rd

更新日期：2009-09-01 00:00:00

abstract：:The vesicular stomatitis virus (VSV) RNA-dependent RNA polymerase consists of two viral proteins; the large (L) protein is the main catalytic subunit, and the phosphoprotein (P) is an essential cofactor for polymerase function. The P protein interacts with the L protein and the N-RNA template, thus connecting the poly...

journal_title：Journal of virology

authors： Mondal A,Victor KG,Pudupakam RS,Lyons CE,Wertz GW

更新日期：2014-02-01 00:00:00

abstract：:African green monkeys can maintain long-term persistent infection with simian immunodeficiency viruses (SIVagm) without developing AIDS and thus provide an important model for understanding mechanisms of natural host resistance to disease. This study assessed the levels and anatomic distribution of SIVagm in healthy, ...

journal_title：Journal of virology

authors： Broussard SR,Staprans SI,White R,Whitehead EM,Feinberg MB,Allan JS

更新日期：2001-03-01 00:00:00

abstract：:The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We used electron cryomicroscopy and antibody labeling to show that the 8-kDa SCP of human cytomegalovirus is attached only to ...

journal_title：Journal of virology

authors： Yu X,Shah S,Atanasov I,Lo P,Liu F,Britt WJ,Zhou ZH

更新日期：2005-01-01 00:00:00

abstract：:A chimeric porcine circovirus (PCV1-2) with the capsid gene of pathogenic PCV2 cloned into the genomic backbone of nonpathogenic PCV1 is attenuated in pigs but elicits protective immunity against PCV2. In this study, short epitope tags were inserted into the C terminus of the capsid protein of the chimeric PCV1-2 vacc...

journal_title：Journal of virology

authors： Beach NM,Smith SM,Ramamoorthy S,Meng XJ

更新日期：2011-05-01 00:00:00

abstract：:Several aspects of the terminal stages of T4 head maturation were investigated using ts and am mutants blocked at single steps of the assembly pathway. We had previously found that cells infected with mutants of gene 13, e.g., tsN38 and amE609, accumulated both stable (10 to 20%)- and fragile (80%)-filled head precurs...

journal_title：Journal of virology

authors： Hamilton DL,Luftig RB

更新日期：1976-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) encodes four putative G protein-coupled receptors, including pUL78, whose rodent orthologues are known to be important for replication and spread in their hosts. To investigate the mechanism by which pUL78 contributes to viral replication and pathogenesis, we generated a derivative of the ...

journal_title：Journal of virology

authors： O'Connor CM,Shenk T

更新日期：2012-11-01 00:00:00

abstract：:The relative contributions of interleukin-12 (IL-12) and IL-23 to viral pathogenesis have not been extensively studied. IL-12p40 mRNA rapidly increases after neurotropic coronavirus infection. Infection of mice defective in both IL-12 and IL-23 (p40(-/-)), in IL-12 alone (p35(-/-)), and in IL-23 alone (p19(-/-)) revea...

journal_title：Journal of virology

authors： Kapil P,Atkinson R,Ramakrishna C,Cua DJ,Bergmann CC,Stohlman SA

更新日期：2009-06-01 00:00:00

abstract：:The ability of the 3A protein of coxsackievirus B (CVB) to inhibit protein secretion was investigated for this study. Here we show that the ectopic expression of CVB 3A blocked the transport of both the glycoprotein of vesicular stomatitis virus, a membrane-bound secretory marker, and the alpha-1 protease inhibitor, a...

journal_title：Journal of virology

authors： Wessels E,Duijsings D,Notebaart RA,Melchers WJ,van Kuppeveld FJ

更新日期：2005-04-01 00:00:00