Chimeric porcine circoviruses (PCV) containing amino acid epitope tags in the C terminus of the capsid gene are infectious and elicit both anti-epitope tag antibodies and anti-PCV type 2 neutralizing antibodies in pigs.

abstract：:Herpes simplex virus 2 (HSV-2) infection is still one of the common causes of sexually transmitted diseases worldwide. The prevalence of HSV strains resistant to traditional nucleoside antiviral agents has led to the development of novel antiviral drugs. Human alpha-defensin 5 (HD5), a kind of endogenous antimicrobial...

journal_title：Journal of virology

authors： Wang A,Chen F,Wang Y,Shen M,Xu Y,Hu J,Wang S,Geng F,Wang C,Ran X,Su Y,Cheng T,Wang J

更新日期：2013-03-01 00:00:00

abstract：:Herpes simplex virus (HSV) entry requires the interaction between the envelope glycoprotein D (gD) and a cellular receptor such as nectin-1 (also named herpesvirus entry mediator C [HveC]) or HveA/HVEM. Nectin-1 is a cell adhesion molecule found at adherens junctions associated with the cytoplasmic actin-binding prote...

journal_title：Journal of virology

authors： Krummenacher C,Baribaud I,Sanzo JF,Cohen GH,Eisenberg RJ

更新日期：2002-03-01 00:00:00

abstract：:Information was sought on the temporal distribution of transmissible mink encephalopathy virus in royal pastel mink inoculated subcutaneously with 10(3.0) 50% intracerebral lethal doses of the Idaho strain. As determined by intracerebral assay in mink, extremely little replication of the virus occurred during the prec...

journal_title：Journal of virology

authors： Hadlow WJ,Race RE,Kennedy RC

更新日期：1987-10-01 00:00:00

abstract：:Human herpesvirus 8 (HHV8) downregulates major histocompatibility complex (MHC) class I complexes from the plasma membrane via two of its genes, K3 and K5. The N termini of K3 and K5 contain a plant homeodomain (PHD) predicted to be structurally similar to RING domains found in E3 ubiquitin ligases. In view of the imp...

journal_title：Journal of virology

authors： Lorenzo ME,Jung JU,Ploegh HL

更新日期：2002-06-01 00:00:00

abstract：:The spindles of Anomala cuprea entomopoxvirus (AncuEPV), which are composed of glycoprotein fusolin, are known to enhance the peroral infectivity of AncuEPV itself and of nucleopolyhedroviruses. This has been demonstrated to involve the disruption of intestinal peritrophic membrane (PM), composed of chitin matrix, gly...

journal_title：Journal of virology

authors： Takemoto Y,Mitsuhashi W,Murakami R,Konishi H,Miyamoto K

更新日期：2008-12-01 00:00:00

abstract：:JC virus (JCV) is a DNA virus causing progressive multifocal leukoencephalopathy (PML) in immunodeficient patients. In the present study, 22 genetic quasispecies with more than 1.5% variant frequency were detected in JCV genomes from six clinical samples of PML by next-generation sequencing. A mutation from A to C at ...

journal_title：Journal of virology

authors： Takahashi K,Sekizuka T,Fukumoto H,Nakamichi K,Suzuki T,Sato Y,Hasegawa H,Kuroda M,Katano H

更新日期：2016-12-16 00:00:00

abstract：:Herpesviruses encode a set of core proteins essential for lytic replication of their genomes. Three of these proteins form a tripartite helix-primase complex that, in the case of Epstein-Barr virus (EBV), consists of the helicase BBLF4, the primase BSLF1, and the linker protein BBLF2/3. BBLF2/3 and its homologs in the...

journal_title：Journal of virology

authors： Liao G,Huang J,Fixman ED,Hayward SD

更新日期：2005-01-01 00:00:00

abstract：:We have previously characterized five proteins induced by the presence of the E2 open reading frame (ORF) region of bovine papillomavirus type 1 (BPV-1) in C127 mouse fibroblasts (R. M. Levenson, U. G. Brinckmann, M. K. O'Banion, E. J. Androphy, J. T. Schiller, F. Tabatabai, L. P. Turek, K. Neary, M. T. Chin, T. R. Br...

journal_title：Journal of virology

authors： O'Banion MK,Young DA

更新日期：1991-07-01 00:00:00

abstract：:Identification of cell surface viral binding proteins is important for understanding viral attachment and internalization. We have fused the pre-S domain of the duck hepatitis B virus (DHBV) large envelope protein to glutathione S-transferase and demonstrated a 170-kDa binding protein (p170) in [35S]methionine-labeled...

journal_title：Journal of virology

authors： Tong S,Li J,Wands JR

更新日期：1995-11-01 00:00:00

abstract：:Recently, novel arenaviruses were found in snakes with boid inclusion body disease (BIBD); these form the new genus Reptarenavirus within the family Arenaviridae. We used next-generation sequencing and de novo sequence assembly to investigate reptarenavirus isolates from our previous study. Four of the six isolates an...

journal_title：Journal of virology

authors： Hepojoki J,Salmenperä P,Sironen T,Hetzel U,Korzyukov Y,Kipar A,Vapalahti O

更新日期：2015-08-01 00:00:00

abstract：:Infectious cDNA corresponding to the entire genome of the attenuated Sabin strain of type 1 poliovirus has been inserted into EcoRI site of bacterial plasmid pBR325. Two consecutive PstI fragments (nucleotide positions 1814 to 3421) of the infectious cDNA of the Sabin 1 strain were replaced by the corresponding DNA fr...

journal_title：Journal of virology

authors： Kohara M,Omata T,Kameda A,Semler BL,Itoh H,Wimmer E,Nomoto A

更新日期：1985-03-01 00:00:00

abstract：:Previous studies showed that the amino-terminal domain of Rous sarcoma virus p60v-src involved in myristylation and membrane association of the protein is required for morphological transformation and anchorage independence. Analysis of src delection mutants revealed that the amino-terminal one-third of p60v-src, incl...

journal_title：Journal of virology

authors： Calothy G,Laugier D,Cross FR,Jove R,Hanafusa T,Hanafusa H

更新日期：1987-05-01 00:00:00

abstract：:The matrix (MA) protein of human immunodeficiency virus type 1 (HIV-1) forms the outer protein shell directly underneath the lipid envelope of the virion. The MA protein has a key role in different aspects of virus assembly, including the incorporation of the HIV-1 Env protein complex, which contains a transmembrane g...

journal_title：Journal of virology

authors： Mammano F,Kondo E,Sodroski J,Bukovsky A,Göttlinger HG

更新日期：1995-06-01 00:00:00

abstract：:The Zaire ebolavirus protein VP24 was previously demonstrated to inhibit alpha/beta interferon (IFN-alpha/beta)- and IFN-gamma-induced nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1) and to inhibit IFN-alpha/beta- and IFN-gamma-induced gene expression. These properties correlated with the ability of V...

journal_title：Journal of virology

authors： Reid SP,Valmas C,Martinez O,Sanchez FM,Basler CF

更新日期：2007-12-01 00:00:00

abstract：:A bacteriophage with a contractile tail which shows very similar features to R-type pyocins was isolated and characterized. This phage, named PS17,was purified by DEAE-cellulose chromatography and CsCl density gradient centrifugation. It was a DNA-containing phage, and the density of the purified particles in CsCl was...

journal_title：Journal of virology

authors： Kageyama M,Shinomiya T,Aihara Y,Kobayashi M

更新日期：1979-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an enveloped positive-stranded RNA hepatotropic virus. HCV pseudoparticles infect liver-derived cells, supporting a model in which liver-specific molecules define HCV internalization. Three host cell molecules have been reported to be important entry factors or receptors for HCV internalizat...

journal_title：Journal of virology

authors： Harris HJ,Farquhar MJ,Mee CJ,Davis C,Reynolds GM,Jennings A,Hu K,Yuan F,Deng H,Hubscher SG,Han JH,Balfe P,McKeating JA

更新日期：2008-05-01 00:00:00

abstract：:In the spherical capsid of hepatitis B virus (HBV), intermolecular disulfide bonds cross-link the approximately 180 p21.5 capsid protein subunits into a stable lattice. In this study, we used mutant capsid proteins to investigate the role that disulfide bonds and the four p21.5 Cys residues (positions 48, 61, 107, and...

journal_title：Journal of virology

authors： Zhou S,Standring DN

更新日期：1992-09-01 00:00:00

abstract：:Alphaherpesviruses are parasites of the peripheral nervous system in their natural hosts. After the initial infection of peripheral tissues such as mucosal cells, these neurotropic viruses will invade the peripheral nervous system that innervates the site of infection via long-distance axonal transport of the viral ge...

journal_title：Journal of virology

authors： Ch'ng TH,Enquist LW

更新日期：2005-09-01 00:00:00

abstract：:We have analyzed the structure of rubella virus proteins labeled metabolically with [35S]methionine, [3H]mannose, and [3H]glucosamine or externally with [3H]borohydride after galactose oxidase treatment. Four structural proteins, with MrS of about 58,000 (E1), 47,000 (E2a), 42,000 (E2b), and 33,000 (C), were resolved ...

journal_title：Journal of virology

authors： Oker-Blom C,Kalkkinen N,Kääriäinen L,Pettersson RF

更新日期：1983-06-01 00:00:00

abstract：:The phosphoprotein (P protein) of respiratory syncytial virus (RSV) is a key component of the viral RNA-dependent RNA polymerase complex. The protein is constitutively phosphorylated at the two clusters of serine residues (116, 117, and 119 [116/117/119] and 232 and 237 [232/237]). To examine the role of phosphorylati...

journal_title：Journal of virology

authors： Lu B,Ma CH,Brazas R,Jin H

更新日期：2002-11-01 00:00:00

abstract：:The phenotypic defects of two mutants of vaccinia virus, the lesions of which map to gene G2R, were characterized in vivo, and the results suggest a role for the G2R protein in viral transcription elongation. Both a temperature-sensitive mutant, Cts56, and an isatin-beta-thiosemicarbazone-dependent deletion mutant, G2...

journal_title：Journal of virology

authors： Black EP,Condit RC

更新日期：1996-01-01 00:00:00

abstract：:Therapeutic suppression of human immunodeficiency virus type 1 (HIV-1) replication may help elucidate interactions between the host cellular immune responses and HIV-1 infection. We performed a detailed longitudinal evaluation of two subjects before and after the start of highly active antiretroviral therapy (HAART). ...

journal_title：Journal of virology

authors： Kalams SA,Goulder PJ,Shea AK,Jones NG,Trocha AK,Ogg GS,Walker BD

更新日期：1999-08-01 00:00:00

abstract：:Here, we report a novel porcine circovirus type 2a (PCV2a) strain with 11 nucleotides (nt) inserted in the origin of genome replication (Ori). This is the first report of a PCV2a strain with nucleotide insertion in Ori. Our study will help further epidemiological studies and extend our knowledge of evolutionary charac...

journal_title：Journal of virology

authors： Cai L,Han X,Hu D,Li X,Wang B,Ni J,Zhou Z,Yu X,Zhai X,Tian K

更新日期：2012-06-01 00:00:00

abstract：:Rhesus monkey rhadinovirus (RRV) is a close relative of Kaposi's sarcoma-associated herpesvirus (KSHV; human herpesvirus 8). RRV serves as an in vitro and an in vivo model for KSHV, and the mapping of its transcription program during lytic replication is significant since it represents de novo infection in the absence...

journal_title：Journal of virology

authors： DeWire SM,McVoy MA,Damania B

更新日期：2002-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a global challenge to public health. Several factors have been proven to be critical for HCV entry, including the newly identified claudin-1 (CLDN1). However, the mechanism of HCV entry is still obscure. Presently, among the 20 members of the claudin family identified in humans so far, CLDN1...

journal_title：Journal of virology

authors： Zheng A,Yuan F,Li Y,Zhu F,Hou P,Li J,Song X,Ding M,Deng H

更新日期：2007-11-01 00:00:00

abstract：:The human papillomavirus type 18 (HPV-18) upstream regulatory region (URR) controls viral gene transcription in a cell-type-specific manner. The HPV-18 URR is active in HeLa cells but inactive in HepG2 cells. The activating activity of YY1 in HeLa cells is dependent on its functional interactions with the switch regio...

journal_title：Journal of virology

authors： Bauknecht T,See RH,Shi Y

更新日期：1996-11-01 00:00:00

abstract：:We sequenced the genes coding for the two neutralization proteins, VP4 and VP7, of human rotavirus strains L26 and L27 with subgroup I specificity but the long RNA pattern. The deduced VP7 amino acid sequence of strains L26 and L27 showed a low homology (73.6 to 81.9%) to those of rotavirus strains of the established ...

journal_title：Journal of virology

authors： Taniguchi K,Urasawa T,Kobayashi N,Gorziglia M,Urasawa S

更新日期：1990-11-01 00:00:00

abstract：:In all retroviruses analyzed to date (except for the spumaretroviruses), the Zn(2+)-coordinating residues of nucleocapsid (NC) perform or assist in crucial reactions necessary to complete the retrovirus life cycle. Six replication-defective mutations have been engineered in the two NC Zn(2+) fingers (ZFs) of simian im...

journal_title：Journal of virology

authors： Yovandich JL,Chertova EN,Kane BP,Gagliardi TD,Bess JW Jr,Sowder RC 2nd,Henderson LE,Gorelick RJ

更新日期：2001-01-01 00:00:00

abstract：:The deployment of adenovirus serotype 5 (Ad5)-based vectors is hampered by preexisting immunity. When such vectors are delivered intravenously, hepatocyte transduction is mediated by the hexon-coagulation factor X (FX) interaction. Here, we demonstrate that human sera efficiently block FX-mediated cellular binding and...

journal_title：Journal of virology

authors： Parker AL,Waddington SN,Buckley SM,Custers J,Havenga MJ,van Rooijen N,Goudsmit J,McVey JH,Nicklin SA,Baker AH

更新日期：2009-01-01 00:00:00

abstract：:Rabies, as the oldest known infectious disease, remains a serious threat to public health worldwide. The eukaryotic cytosolic chaperonin TRiC/CCT complex facilitates the folding of proteins through ATP hydrolysis. Here, we investigated the expression, cellular localization, and function of neuronal CCTγ during neurotr...

journal_title：Journal of virology

authors： Zhang J,Wu X,Zan J,Wu Y,Ye C,Ruan X,Zhou J

更新日期：2013-07-01 00:00:00