Abstract:
:The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We used electron cryomicroscopy and antibody labeling to show that the 8-kDa SCP of human cytomegalovirus is attached only to major capsid protein subunits of the hexons, not the pentons. Thus, the SCPs of different herpesviruses illustrate that a protein can evolve significantly in sequence, structure, and function, while preserving its role in the architecture of the virus by binding to a specific partner in a specific oligomeric state.
journal_name
J Viroljournal_title
Journal of virologyauthors
Yu X,Shah S,Atanasov I,Lo P,Liu F,Britt WJ,Zhou ZHdoi
10.1128/JVI.79.2.1327-1332.2005subject
Has Abstractpub_date
2005-01-01 00:00:00pages
1327-32issue
2eissn
0022-538Xissn
1098-5514pii
79/2/1327journal_volume
79pub_type
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