Three size-classes of intracellular adenovirus deoxyribonucleic acid.

abstract：:A protamine-like protein named P6.9 is thought to play a role in the condensation of genomes of the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) during an infection. Previous studies have shown that P6.9 is phosphorylated immediately upon synthesis and dephosphorylated upon the entry of th...

journal_title：Journal of virology

authors： Liu X,Zhao H,Fang Z,Yuan M,Yang K,Pang Y

更新日期：2012-11-01 00:00:00

abstract：:Substitution of a methionine residue at position 79 in poliovirus protein 3A with valine or threonine caused defective viral RNA synthesis, manifested as delayed onset and reduced yield of viral RNA, in HeLa cells transfected with a luciferase-containing replicon. Viruses containing these same mutations produced small...

journal_title：Journal of virology

authors： Teterina NL,Rinaudo MS,Ehrenfeld E

更新日期：2003-12-01 00:00:00

abstract：:Immune responses to vector-corrected cells have limited the application of gene therapy for treatment of chronic disorders such as inherited deficiency states. We have found that recombinant adeno-associated virus (AAV) efficiently transduces muscle fibers in vivo without activation of cellular and humoral immunity to...

journal_title：Journal of virology

authors： Jooss K,Yang Y,Fisher KJ,Wilson JM

更新日期：1998-05-01 00:00:00

abstract：:We previously demonstrated that the adeno-associated virus (AAV) Rep68 and Rep78 proteins are able to nick the AAV origin of DNA replication at the terminal resolution site (trs) in an ATP-dependent manner. Using four types of modified or mutant substrates, we now have investigated the substrate requirements of Rep68 ...

journal_title：Journal of virology

authors： Snyder RO,Im DS,Ni T,Xiao X,Samulski RJ,Muzyczka N

更新日期：1993-10-01 00:00:00

abstract：:Partial deletion of the second hypervariable region from the envelope of the primary-like SF162 virus increases the exposure of certain neutralization epitopes and renders the virus, SF162DeltaV2, highly susceptible to neutralization by clade B and non-clade B human immunodeficiency virus (HIV-positive) sera (L. Stama...

journal_title：Journal of virology

authors： Barnett SW,Lu S,Srivastava I,Cherpelis S,Gettie A,Blanchard J,Wang S,Mboudjeka I,Leung L,Lian Y,Fong A,Buckner C,Ly A,Hilt S,Ulmer J,Wild CT,Mascola JR,Stamatatos L

更新日期：2001-06-01 00:00:00

abstract：:Purified retrovirus Gag proteins can assemble in vitro into virus-like particles (VLPs) in the presence of RNA. It was shown previously that a Rous sarcoma virus Gag protein missing only the protease domain forms spherical particles resembling immature virions lacking a membrane but that a similar protein missing the ...

journal_title：Journal of virology

authors： Joshi SM,Vogt VM

更新日期：2000-11-01 00:00:00

abstract：:Hepatitis delta virus (HDV) contains a circular RNA genome of 1.7 kb. HDV RNA replication is thought to proceed via a rolling-circle mechanism that is dependent on autocatalytic cleavage and ligation reactions. However, it has never been established that these ribozyme activities are indeed involved in HDV RNA replica...

journal_title：Journal of virology

authors： Macnaughton TB,Wang YJ,Lai MM

更新日期：1993-04-01 00:00:00

abstract：:The pneumopathogenicity of a trypsin-sensitive revertant of Sendai virus, TSrev-58, which was derived from a trypsin-resistant mutant, TR-5, was examined in mice. In comparison with TR-5, the revertant had a single amino acid substitution at residue 116 (Ile----Arg) on F protein, which was the cleavage site, and had t...

journal_title：Journal of virology

authors： Mochizuki Y,Tashiro M,Homma M

更新日期：1988-08-01 00:00:00

abstract：:Although the genetic organization of tobacco mosaic virus (TMV) differs considerably from that of the tripartite viruses (alfalfa mosaic virus [AlMV] and brome mosaic virus [BMV]), all of these RNA plant viruses share three domains of homology among their nonstructural proteins. One such domain, common to the AlMV and...

journal_title：Journal of virology

authors： Ahlquist P,Strauss EG,Rice CM,Strauss JH,Haseloff J,Zimmern D

更新日期：1985-02-01 00:00:00

abstract：:Incubation of highly purified adeno-associated virus (AAV) capsids in vitro at pH 5.5 induced significant autocleavage of capsid proteins at several amino acid positions. No autocleavage was seen at pH 7.5. Examination of other AAV serotypes showed at least two different pH-induced cleavage patterns, suggesting that d...

journal_title：Journal of virology

authors： Salganik M,Venkatakrishnan B,Bennett A,Lins B,Yarbrough J,Muzyczka N,Agbandje-McKenna M,McKenna R

更新日期：2012-11-01 00:00:00

abstract：:The activity and epithelial tropism of the human papillomavirus type 18 P105 early promoter, which directs the synthesis of the E6 and E7 transforming genes, are controlled by cis elements included in the viral long control region. To identify potential cellular regulators of this promoter, we mutagenized one or both ...

journal_title：Journal of virology

authors： Thierry F,Spyrou G,Yaniv M,Howley P

更新日期：1992-06-01 00:00:00

abstract：:Mitogenic activities of simian virus 40 large T and small t antigens were studied in serum-deprived human diploid fibroblasts. Wild-type large T and small t cooperated in stimulating DNA synthesis and in inducing hyperphosphorylation of the Rb gene product (pRb). In contrast, a T antigen mutant defective for pRb bindi...

journal_title：Journal of virology

authors： Ogryzko VV,Hirai TH,Shih CE,Howard BH

更新日期：1994-06-01 00:00:00

abstract：:Enhancement of cell death is a distinguishing feature of H1N1 influenza virus A/Puerto Rico/8/34 protein PB1-F2. Comparing the sequences (amino acids [aa] 61 to 87 using PB1-F2 amino acid numbering) of the PB1-F2-derived C-terminal peptides from influenza A viruses inducing high or low levels of cell death, we identif...

journal_title：Journal of virology

authors： Alymova IV,Samarasinghe A,Vogel P,Green AM,Weinlich R,McCullers JA

更新日期：2014-01-01 00:00:00

abstract：UNLABELLED:Marek's disease virus (MDV), an alphaherpesvirus, is the causative agent of a lethal disease in chickens characterized by generalized nerve inflammation and rapid lymphoma development. The extensive colinearity of the MDV genome with those of related herpesviruses has eased functional characterization of man...

journal_title：Journal of virology

authors： Schippers T,Jarosinski K,Osterrieder N

更新日期：2015-01-15 00:00:00

abstract：:Human herpesvirus 8 (HHV8) open reading frame (ORF) 21 is predicted to encode a protein similar to the thymidine kinase (TK) enzyme of other herpesviruses. Expressed in mammalian cells, ORF 21 was found to have low TK activity, based on poor growth in media containing hypoxanthine-aminopterin-thymidine (HAT) and low i...

journal_title：Journal of virology

authors： Gustafson EA,Schinazi RF,Fingeroth JD

更新日期：2000-01-01 00:00:00

abstract：:Cycloheximide and 6-azauridine were employed to study the time course of measles virus protein and nucleic acid syntheses in AV3 cells. Synthesis of ribonucleic acid (RNA) essential for infectivity was first detected at 6 hr and increased concurrently with the formation of essential protein. Maximum levels of virus-sp...

journal_title：Journal of virology

authors： Portner A,Bussell RH

更新日期：1973-01-01 00:00:00

abstract：:A major difference between vaccine and wild-type strains of measles virus (MV) in vitro is the wider cell specificity of vaccine strains, resulting from the receptor usage of the hemagglutinin (H) protein. Wild-type H proteins recognize the signaling lymphocyte activation molecule (SLAM) (CD150), which is expressed on...

journal_title：Journal of virology

authors： Takeuchi K,Nagata N,Kato SI,Ami Y,Suzaki Y,Suzuki T,Sato Y,Tsunetsugu-Yokota Y,Mori K,Van Nguyen N,Kimura H,Nagata K

更新日期：2012-03-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) has a tropism for T lymphocytes and monocytes/macrophages, suggesting that HHV-6 infection affects the immunosurveillance system. In the present study, we investigated the HHV-6-induced phenotypic and functional alterations of dendritic cells (DCs), which are professional antigen-presenting...

journal_title：Journal of virology

authors： Kakimoto M,Hasegawa A,Fujita S,Yasukawa M

更新日期：2002-10-01 00:00:00

abstract：:Recombinant retroviruses containing the trans activator genes of human T-cell leukemia virus (HTLV) type II and human T-cell lymphotropic virus type III were constructed. The trans activator genes tat II and tat III were inserted into the murine retroviral vector pZIPNEOSV(X)1. Recombinant plasmids were transfected in...

journal_title：Journal of virology

authors： Rosen CA,Sodroski JG,Campbell K,Haseltine WA

更新日期：1986-01-01 00:00:00

abstract：:Human parainfluenza type 2 virus (hPIV-2)-infected HeLa (HeLa-CA) cells and hPIV-2 V-expressing HeLa (HeLa-V) cells show high resistance to alpha/beta interferons (IFN-alpha/beta) irrespective of whether vesicular stomatitis virus or Sindbis virus is used as a challenge virus. When Sindbis virus is used, these cells s...

journal_title：Journal of virology

authors： Nishio M,Tsurudome M,Ito M,Kawano M,Komada H,Ito Y

更新日期：2001-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRp) that acts as a key player in the HCV replication complex. Understanding the interplay between the viral and cellular components of the HCV replication complex could provide new insight for prevention of the progression of...

journal_title：Journal of virology

authors： Huang JT,Tseng CP,Liao MH,Lu SC,Yeh WZ,Sakamoto N,Chen CM,Cheng JC

更新日期：2013-05-01 00:00:00

abstract：:The membrane-proximal region of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein (TM) is critical for envelope (Env)-mediated membrane fusion and contains the target for broadly reactive neutralizing antibody 2F5. It has been proposed that 2F5 neutralization might involve interaction of its long, ...

journal_title：Journal of virology

authors： Ou W,Lu N,Yu SS,Silver J

更新日期：2006-03-01 00:00:00

abstract：:We report here that sex hormones modulate susceptibility to a sexually transmitted viral agent, herpes simplex virus type 2 (HSV-2), in a mouse model. Ovariectomized mice were administered either saline (control), estradiol (E(2)), progesterone (P(4)), or a combination of both estradiol and progesterone (E+P) and infe...

journal_title：Journal of virology

authors： Gillgrass AE,Fernandez SA,Rosenthal KL,Kaushic C

更新日期：2005-03-01 00:00:00

abstract：:Herpes simplex virus (HSV) virion host shutoff protein (vhs) destabilizes cellular and viral mRNAs. Previous work from several laboratories has indicated that vhs accelerates the turnover of most host mRNAs and provided evidence that at least some of these are degraded via endonucleolytic cleavage near regions of tran...

journal_title：Journal of virology

authors： Hsu WL,Saffran HA,Smiley JR

更新日期：2005-04-01 00:00:00

abstract：:The Rep78 and Rep68 proteins of adeno-associated virus type 2 (AAV) are multifunctional proteins which are required for viral replication, regulation of AAV promoters, and preferential integration of the AAV genome into a region of human chromosome 19. These proteins bind the hairpin structures formed by the AAV inver...

journal_title：Journal of virology

authors： Davis MD,Wonderling RS,Walker SL,Owens RA

更新日期：1999-03-01 00:00:00

abstract：:In HIV-1 vaccine research, native-like, soluble envelope glycoprotein SOSIP trimers are widely used for immunizing animals. The epitopes of autologous neutralizing antibodies (NAbs) induced by the BG505 and B41 SOSIP trimers in rabbits and macaques have been mapped to a few holes in the glycan shields that cover most ...

journal_title：Journal of virology

authors： Ringe RP,Pugach P,Cottrell CA,LaBranche CC,Seabright GE,Ketas TJ,Ozorowski G,Kumar S,Schorcht A,van Gils MJ,Crispin M,Montefiori DC,Wilson IA,Ward AB,Sanders RW,Klasse PJ,Moore JP

更新日期：2019-02-05 00:00:00

abstract：UNLABELLED:The noncovalent interactions that mediate trimerization of the influenza hemagglutinin (HA) are important determinants of its biological activities. Recent studies have demonstrated that mutations in the HA trimer interface affect the thermal and pH sensitivities of HA, suggesting a possible impact on vaccin...

journal_title：Journal of virology

authors： Yang H,Chang JC,Guo Z,Carney PJ,Shore DA,Donis RO,Cox NJ,Villanueva JM,Klimov AI,Stevens J

更新日期：2014-05-01 00:00:00

abstract：:Most patients infected with hepatitis C virus (HCV) become chronic carriers. Viruses that efficiently establish persistent infections must have effective ways of evading host defenses. In the case of HCV, little is known about how chronic infections are established or maintained. Besides hepatocytes, several reports s...

journal_title：Journal of virology

authors： Bergqvist A,Rice CM

更新日期：2001-01-01 00:00:00

abstract：UNLABELLED:JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). The viral capsid of JCPyV is composed primarily of the major capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomers results...

journal_title：Journal of virology

authors： Nelson CD,Ströh LJ,Gee GV,O'Hara BA,Stehle T,Atwood WJ

更新日期：2015-04-01 00:00:00

abstract：:Foamy viruses (FVs) are the least known retroviruses commonly found in primates, cats, horses, and cattle. Although FVs are considered apathogenic, simian and feline FVs have been shown to be associated with some transient health abnormalities in animal models. Currently, data regarding the course of infection with bo...

journal_title：Journal of virology

authors： Materniak M,Hechler T,Löchelt M,Kuzmak J

更新日期：2013-03-01 00:00:00