The sequence of human immunodeficiency virus type 2 circle junction suggests that integration protein cleaves the ends of linear DNA asymmetrically.

abstract：:The positive-strand RNA bromoviruses encode two nonstructural proteins, 1a and 2a, involved in RNA-dependent RNA replication. These proteins have extensive sequence similarities with methyltransferase, helicase, and polymerase proteins of other plant and animal viruses. 1a and 2a can also form a complex in vitro. To e...

journal_title：Journal of virology

authors： Dinant S,Janda M,Kroner PA,Ahlquist P

更新日期：1993-12-01 00:00:00

abstract：:Barley stripe mosaic virus (BSMV) encodes three movement proteins in an overlapping triple gene block (TGB), but little is known about the physical interactions of these proteins. We have characterized a ribonucleoprotein (RNP) complex consisting of the TGB1 protein and plus-sense BSMV RNAs from infected barley plants...

journal_title：Journal of virology

authors： Lim HS,Bragg JN,Ganesan U,Lawrence DM,Yu J,Isogai M,Hammond J,Jackson AO

更新日期：2008-05-01 00:00:00

abstract：:Human cytomegalovirus encodes four unique short (US) region proteins, each of which is independently sufficient for causing the down-regulation of major histocompatibility complex (MHC) class I molecules on the cell surface. This down-regulation enables infected cells to evade recognition by cytotoxic T lymphocytes (C...

journal_title：Journal of virology

authors： Shin J,Park B,Lee S,Kim Y,Biegalke BJ,Kang S,Ahn K

更新日期：2006-06-01 00:00:00

abstract：:Herpes simplex virus establishes latent infections in the nuclei of sensory neurons. These infections are characterized by the abundant expression of a series of 5' coterminal transcripts termed the latency-associated transcripts (LATs). Available evidence indicates that LAT expression is specifically regulated in lat...

journal_title：Journal of virology

authors： Frazier DP,Cox D,Godshalk EM,Schaffer PA

更新日期：1996-11-01 00:00:00

abstract：:The major phosphoprotein common to woolly monkey sarcoma virus, gibbon ape lymphosarcoma virus, and type C viruses of the lower mammalian species (mouse, rat, cat), with the exception of the endogenous cat virus (RD-114), is the polypeptide of about 12,000 molecular weight. The protein-phosphate bond in this polypepti...

journal_title：Journal of virology

authors： Pal BK,McAllister RM,Gardner MB,Roy-Burman P

更新日期：1975-07-01 00:00:00

abstract：:Experimental evidence from the simian immunodeficiency virus (SIV) model of AIDS has shown that the nef gene is critical in the pathogenesis of AIDS. Consequently, nef is of considerable interest in both antiviral drug and vaccine development. Preliminary findings in two rhesus macaques indicated that a deletion of on...

journal_title：Journal of virology

authors： Whatmore AM,Cook N,Hall GA,Sharpe S,Rud EW,Cranage MP

更新日期：1995-08-01 00:00:00

abstract：:We have used deletion and recombinant long terminal repeat (LTR) mutants to examine enhancer activity differences between LTRs of the nonpathogenic Akv and the thymus lymphomagenic MCF13 murine retroviruses. Deletion mutant analysis revealed that major control regions for MCF13 and Akv LTR enhancer activity were simil...

journal_title：Journal of virology

authors： Hollon T,Yoshimura FK

更新日期：1989-08-01 00:00:00

abstract：:The proteins of purified avian oncoviruses were analyzed by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis and isoelectric focusing. Certain members of the avian leukosis-sarcoma viruses (ALSV) had group-specific antigens with altered electrophoretic properties. (i) The p27 protein of Rous-associated ...

journal_title：Journal of virology

authors： Rettenmier CW,Hanafusa H

更新日期：1977-12-01 00:00:00

abstract：:The CC-chemokines RANTES, macrophage inflammatory protein 1alpha (MIP-1alpha), and MIP-1beta are natural ligands for the CC-chemokine receptor CCR5. MIP-1alpha, also known as LD78alpha, has an isoform, LD78beta, which was identified as the product of a nonallelic gene. The two isoforms differ in only 3 amino acids. LD...

journal_title：Journal of virology

authors： Aquaro S,Menten P,Struyf S,Proost P,Van Damme J,De Clercq E,Schols D

更新日期：2001-05-01 00:00:00

abstract：:Kilham rat virus (KRV) was grown in a rat nephroma cell line and was purified by two isopycnic centrifugations in cesium chloride. The virus contains single-stranded deoxyribonucleic acid (DNA) with a molecular weight of approximately 1.6 x 10(6). The DNA was extracted from the virion by both phenol extraction and by ...

journal_title：Journal of virology

authors： Salzman LA,White WL,Kakefuda T

更新日期：1971-06-01 00:00:00

abstract：:T-cell epitopes on the E2 protein of rubella virus were studied by using 15 overlapping synthetic peptides covering the E2 protein sequence. The most frequently recognized epitopes on E2 were E2-4 (residues 54 to 74), with 5 of 10 tested T-cell lines responding to it. Two CD4+ cytotoxic T-cell cloned isolated from one...

journal_title：Journal of virology

authors： Ou D,Chong P,Choi Y,McVeigh P,Jefferies WA,Koloitis G,Tingle AJ,Gillam S

更新日期：1992-11-01 00:00:00

abstract：:Human cytomegalovirus UL25 codes for a structural phosphoprotein of 85 kDa (C. J. Baldick and T. Shenk, J. Virol. 70:6097-6105, 1996; M. C. Battista et al., J. Virol. 73:3800-3809, 1999). In this study we analyzed the intracellular and intraviral localization of pUL25 by confocal and immunoelectron microscopy and foun...

journal_title：Journal of virology

authors： Zini N,Battista MC,Santi S,Riccio M,Bergamini G,Landini MP,Maraldi NM

更新日期：1999-07-01 00:00:00

abstract：:We isolated and characterized two spontaneous, weakly leukemogenic mutants of Rauscher spleen focus-forming virus (R-SFFV) that contain mutations in nonoverlapping regions of the membrane envelope (env) glycoprotein gene. As reported previously (M. Ruta and D. Kabat, J. Virol. 35:844-853, 1980), the replication-defect...

journal_title：Journal of virology

authors： Machida CA,Bestwick RK,Kabat D

更新日期：1984-02-01 00:00:00

abstract：:A virus recovered from the saliva of a child with chronic active Epstein-Barr virus (EBV) infection for 8 years was shown to induce EBV early antigen (EBV-EA) in Raji cells and to be expressed into EBV-EA in fresh EBV-negative peripheral blood leukocytes. However, it did not replicate its DNA. Oropharyngeal epithelial...

journal_title：Journal of virology

authors： Alfieri C,Joncas JH

更新日期：1987-10-01 00:00:00

abstract：:The foot-and-mouth disease virus (FMDV) capsid protein precursor, P1-2A, is cleaved by 3C(pro) to generate VP0, VP3, VP1, and the peptide 2A. The capsid proteins self-assemble into empty capsid particles or viruses which do not contain 2A. In a cell culture-adapted strain of FMDV (O1 Manisa [Lindholm]), three differen...

journal_title：Journal of virology

authors： Gullberg M,Polacek C,Bøtner A,Belsham GJ

更新日期：2013-11-01 00:00:00

abstract：:The molecular mechanism by which retroviral Gag proteins are directed to the plasma membrane for the formation of particles (budding) is unknown, but it is widely believed that the MA domain, located at the amino terminus, plays a critical role. Consistent with this idea, we found that small deletions in this segment ...

journal_title：Journal of virology

authors： Wills JW,Craven RC,Weldon RA Jr,Nelle TD,Erdie CR

更新日期：1991-07-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) readily infects both humans and chimpanzees, but the pathologic outcomes of infection in these two species differ greatly. In attempts to identify virus-cell interactions that might account for this differential pathogenicity, chimpanzee peripheral blood lymphocytes and ...

journal_title：Journal of virology

authors： Watanabe M,Ringler DJ,Fultz PN,MacKey JJ,Boyson JE,Levine CG,Letvin NL

更新日期：1991-06-01 00:00:00

abstract：:Amphiphilic fatty acid derivatives having a 14- to 20-carbon cis-unsaturated alkyl chain were found to be potent inhibitors of the entry process of the lipid-containing bacteriophage PR4. ...

journal_title：Journal of virology

authors： Sands JA,Reinhardt A,Auperin D,Landin P

更新日期：1979-01-01 00:00:00

abstract：:The Group B Staphylococcus phage P11-M15 is shown to be 51% protein and 49% deoxyribonucleic acid (DNA). The intact virion has a molecular weight of 66.7 x 10(6) daltons. The purified viral DNA has a molecular weight of 32.7 x 10(6) daltons. The intact virion is shown to be composed of a polyhedral head which is attac...

journal_title：Journal of virology

authors： Brown DT,Brown NC,Burlingham BT

更新日期：1972-04-01 00:00:00

abstract：UNLABELLED:Mumps virus (MuV), a paramyxovirus containing a negative-sense nonsegmented RNA genome, is a human pathogen that causes an acute infection with symptoms ranging from parotitis to mild meningitis and severe encephalitis. Vaccination against mumps virus has been effective in reducing mumps cases. However, rece...

journal_title：Journal of virology

authors： Pickar A,Xu P,Elson A,Li Z,Zengel J,He B

更新日期：2014-04-01 00:00:00

abstract：:Rabies, caused by rabies virus (RABV), is a fatal encephalitis in humans and other mammals, which continues to present a public health threat in most parts of the world. Our previous study demonstrated that Toll-like receptor 7 (TLR7) is essential in the induction of anti-RABV antibodies via the facilitation of germin...

journal_title：Journal of virology

authors： Luo Z,Lv L,Li Y,Sui B,Wu Q,Zhang Y,Pei J,Li M,Zhou M,Hooper DC,Fu ZF,Zhao L

更新日期：2020-04-16 00:00:00

abstract：:Infectious vaccinia virus can be purified from whole cells by experimentally induced lysis (intracellular virus) or from supernatant growth medium (extracellular virus). Extracellular virus and intracellular virus differed by buoyant density (1.237 versus 1.272 g/cm3), phospholipid content and composition, and polypep...

journal_title：Journal of virology

authors： Hiller G,Eibl H,Weber K

更新日期：1981-09-01 00:00:00

abstract：:We investigated properties of the rotavirus genome segment 11 protein. A rotavirus SA11 genome segment 11 cDNA which contains the entire coding region was sequenced and inserted into the baculovirus transfer vector pVL941. Recombinants containing gene 11 cDNA were selected, and the gene 11 product expressed in Spodopt...

journal_title：Journal of virology

authors： Welch SK,Crawford SE,Estes MK

更新日期：1989-09-01 00:00:00

abstract：UNLABELLED:Foreskin is the principal site of heterosexual HIV-1 infection in men. However, little is known about HIV-1-specific immune responses or inflammation in foreskin. To the best of our knowledge, no previous studies have assessed immune responses to candidate HIV-1 vaccines in foreskin. Using the rhesus monkey ...

journal_title：Journal of virology

authors： Balandya E,Miller AD,Beck M,Liu J,Li H,Borducchi E,Smith K,Cabral C,Stanley K,Maxfield LF,Barouch DH

更新日期：2014-04-01 00:00:00

abstract：:While RNA silencing is a potent antiviral defense in plants, well-adapted plant viruses are known to encode suppressors of RNA silencing (VSR) that can neutralize the effectiveness of RNA silencing. As a result, most plant genes involved in antiviral silencing were identified by using debilitated viruses lacking silen...

journal_title：Journal of virology

authors： Zhang X,Zhang X,Singh J,Li D,Qu F

更新日期：2012-06-01 00:00:00

abstract：:To examine the cell fusion activity of hepatitis C virus (HCV) envelope proteins (E1 and E2), we have established a sensitive cell fusion assay based on the activation of a reporter gene as described previously (O. Nussbaum, C. C. Broder, and E. A. Berger, J. Virol. 68:5411-5422, 1994). The chimeric HCV E1 and E2 prot...

journal_title：Journal of virology

authors： Takikawa S,Ishii K,Aizaki H,Suzuki T,Asakura H,Matsuura Y,Miyamura T

更新日期：2000-06-01 00:00:00

abstract：:The bovine papillomavirus E5 gene encodes a 44-amino-acid, homodimeric transmembrane protein that is the smallest known transforming protein. The E5 protein transforms cultured fibroblasts by forming a stable complex with the endogenous platelet-derived growth factor (PDGF) beta receptor through transmembrane and juxt...

journal_title：Journal of virology

authors： Klein O,Kegler-Ebo D,Su J,Smith S,DiMaio D

更新日期：1999-04-01 00:00:00

abstract：:Venezuelan equine encephalitis virus (VEE) is an important equine and human pathogen of the Americas. In the adult mouse model, cDNA-derived, virulent V3000 inoculated subcutaneously (s.c.) causes high-titer peripheral replication followed by neuroinvasion and lethal encephalitis. A single change (G to A) at nucleotid...

journal_title：Journal of virology

authors： White LJ,Wang JG,Davis NL,Johnston RE

更新日期：2001-04-01 00:00:00

abstract：:N-terminal modifications of the chemokine RANTES bind to C-C chemokine receptor 5 (CCR5) and block human immunodeficiency virus type 1 (HIV-1) infection with greater efficacy than native RANTES. Modified RANTES compounds induce rapid CCR5 internalization and much slower receptor reexpression than native RANTES, sugges...

journal_title：Journal of virology

authors： Sabbe R,Picchio GR,Pastore C,Chaloin O,Hartley O,Offord R,Mosier DE

更新日期：2001-01-01 00:00:00

abstract：:Viruses of the family Coronaviridae have recently emerged through zoonotic transmission to become serious human pathogens. The pathogenic agent responsible for severe acute respiratory syndrome (SARS), the SARS coronavirus (SARS-CoV), is a member of this large family of positive-strand RNA viruses that cause a spectru...

journal_title：Journal of virology

authors： O'Keefe BR,Giomarelli B,Barnard DL,Shenoy SR,Chan PK,McMahon JB,Palmer KE,Barnett BW,Meyerholz DK,Wohlford-Lenane CL,McCray PB Jr

更新日期：2010-03-01 00:00:00