Reduced leukemogenicity caused by mutations in the membrane glycoprotein gene of Rauscher spleen focus-forming virus.

abstract：:Reciprocal three-factor crosses and the use of a partial revertant of a putative ribonucleotide reductase mutant of Escherichia coli B/5 as indicator have made it possible to map denA (deficient in endonuclease II) between nrd-11 (ribonucleotide reductase gene B) and amM69 (gene 63) on the bacteriophage T4 chromosome....

journal_title：Journal of virology

authors： Ray P,Sinha NK,Warner HR,Snustad DP

更新日期：1972-01-01 00:00:00

abstract：UNLABELLED:Paramyxoviruses and other negative-strand RNA viruses encode matrix proteins that coordinate the virus assembly process. The matrix proteins link the viral glycoproteins and the viral ribonucleoproteins at virus assembly sites and often recruit host machinery that facilitates the budding process. Using a co-...

journal_title：Journal of virology

authors： Sun W,McCrory TS,Khaw WY,Petzing S,Myers T,Schmitt AP

更新日期：2014-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a lymphotrophic herpesvirus infecting most of the world's population. It is associated with a number of human lymphoid and epithelial tumors and lymphoproliferative diseases in immunocompromised patients. Recent studies have shown an in vitro and in vivo interaction between the EBV nuclear ...

journal_title：Journal of virology

authors： Subramanian C,Robertson ES

更新日期：2002-09-01 00:00:00

abstract：:The antigenic binding sites of two monoclonal antibodies are located in the COOH-terminal region (clone 412) and probably in an internal region (clone 7) of simian virus 40 large T antigen. A third monoclonal antibody (clone 122), which has been shown to bind nonviral T antigen, does not react with HeLa cells infected...

journal_title：Journal of virology

authors： Deppert W,Gurney EG,Harrison RO

更新日期：1981-01-01 00:00:00

abstract：:A widespread porcine epidemic diarrhea virus (PEDV) occurred in southern China during 2010 to 2012. A virulent field PEDV strain, GD-B, was isolated from a sucking piglet suffering from severe diarrhea in Guangdong, China. We sequenced and analyzed the complete genome of strain GD-B, which will promote a better unders...

journal_title：Journal of virology

authors： Luo Y,Zhang J,Deng X,Ye Y,Liao M,Fan H

更新日期：2012-09-01 00:00:00

abstract：:Purified Semliki Forest virus (SFV) contains three structural proteins while its core (nucleocapsid) contains two of these proteins. To identify all of the proteins synthesized under virus direction, cells were infected with SFV in the presence of actinomycin D and guanidine. Cell protein synthesis was markedly and ir...

journal_title：Journal of virology

authors： Friedman RM

更新日期：1968-10-01 00:00:00

abstract：:The phenotypic properties of ICP27 temperature-sensitive and deletion mutants and the results of transient expression assays have demonstrated that ICP27 has a modulatory effect on viral gene expression induced by ICPs 0 and 4. In order to identify the regions of the ICP27 molecule that are responsible for its enhanci...

journal_title：Journal of virology

authors： McMahan L,Schaffer PA

更新日期：1990-07-01 00:00:00

abstract：:RNA from adenovirus 2-infected KB cells was annealed in liquid with RNA in vast excess to viral heavy (l) and light (r) 32P-labeled DNA strands. Hybridization kinetics were analyzed by computer to estimate the number of viral RNA abundance classes, their relative concentrations, and the fraction of each DNA strand fro...

journal_title：Journal of virology

authors： Wold WS,Green M,Brackmann KH,Cartas MA,Devine C

更新日期：1976-11-01 00:00:00

abstract：:Current knowledge of human immunodeficiency virus type 1 envelope (Env) glycoprotein structure and function is based on studies of clade B viruses. We present evidence of sequence and structural differences in viral glycoprotein gp120 between clades B and C. In clade C, the C3 region alpha2-helix exhibits high sequenc...

journal_title：Journal of virology

authors： Gnanakaran S,Lang D,Daniels M,Bhattacharya T,Derdeyn CA,Korber B

更新日期：2007-05-01 00:00:00

abstract：:Xenotropic murine leukemia virus-related virus (XMRV) is a novel human gammaretrovirus discovered in association with human prostate tumors. XMRV was first identified in prostate stromal cells surrounding the tumors of patients carrying a mutation in the HPC1 gene locus. To determine the tropism of XMRV in cell cultur...

journal_title：Journal of virology

authors： Rodriguez JJ,Goff SP

更新日期：2010-03-01 00:00:00

abstract：:Latent cytomegalovirus (CMV) is frequently transmitted by organ transplantation, and its reactivation under conditions of immunosuppressive prophylaxis against graft rejection by host-versus-graft disease bears a risk of graft failure due to viral pathogenesis. CMV is the most common cause of infection following liver...

journal_title：Journal of virology

authors： Seckert CK,Renzaho A,Tervo HM,Krause C,Deegen P,Kühnapfel B,Reddehase MJ,Grzimek NK

更新日期：2009-09-01 00:00:00

abstract：:When mouse L cells are infected for 22 hr with vesicular stomatitis virus (VSV), a ribonucleic acid-containing enveloped virus, greater than 70% of the major histocompatibility antigen (H-2), is no longer detectable by the method of inhibition of immune cytolysis. Infected cells prelabeled with (14)C-glucosamine also ...

journal_title：Journal of virology

authors： Hecht TT,Summers DF

更新日期：1972-10-01 00:00:00

abstract：:The entry of animal viruses into cells is associated with permeabilization of the infected cells to protein toxins such as alpha-sarcin (C. Fernández-Puentes and L. Carrasco, Cell 20:769-775, 1980). This phenomenon has been referred to as "the early permeabilization by animal viruses" (L. Carrasco, Virology 113:623-62...

journal_title：Journal of virology

authors： Almela MJ,González ME,Carrasco L

更新日期：1991-05-01 00:00:00

abstract：:The spikes of alphaviruses are composed of three copies of an E2-E1 heterodimer. The E1 protein possesses membrane fusion activity, and the E2 protein, or its precursor form, p62 (sometimes called PE2), controls this function. Both proteins are, together with the viral capsid protein, translated from a common C-p62-E1...

journal_title：Journal of virology

authors： Andersson H,Barth BU,Ekström M,Garoff H

更新日期：1997-12-01 00:00:00

abstract：:Murine cytomegalovirus encodes three regulators of antigen presentation to antiviral CD8 T cells. According to current paradigms, all three regulators are committed to the inhibition of the presentation of antigenic peptides. Whereas m152/gp40 catalyzes the retention of peptide-loaded major histocompatibility complex ...

journal_title：Journal of virology

authors： Holtappels R,Gillert-Marien D,Thomas D,Podlech J,Deegen P,Herter S,Oehrlein-Karpi SA,Strand D,Wagner M,Reddehase MJ

更新日期：2006-08-01 00:00:00

abstract：:Following intranasal administration, the severe acute respiratory syndrome (SARS) coronavirus replicated to high titers in the respiratory tracts of BALB/c mice. Peak replication was seen in the absence of disease on day 1 or 2, depending on the dose administered, and the virus was cleared within a week. Viral antigen...

journal_title：Journal of virology

authors： Subbarao K,McAuliffe J,Vogel L,Fahle G,Fischer S,Tatti K,Packard M,Shieh WJ,Zaki S,Murphy B

更新日期：2004-04-01 00:00:00

abstract：UNLABELLED:Generalized immune activation during HIV infection is associated with an increased risk of cardiovascular disease, neurocognitive disease, osteoporosis, metabolic disorders, and physical frailty. The mechanisms driving this immune activation are poorly understood, particularly for individuals effectively tre...

journal_title：Journal of virology

authors： Liang EC,Sceats L,Bayless NL,Strauss-Albee DM,Kubo J,Grant PM,Furman D,Desai M,Katzenstein DA,Davis MM,Zolopa AR,Blish CA

更新日期：2014-08-01 00:00:00

abstract：:The largest tegument protein of herpes simplex virus 1 (HSV-1), UL36, contains a novel deubiquitinating activity embedded in it. All members of the Herpesviridae contain a homologue of HSV-1 UL36, the N-terminal segments of which show perfect conservation of those residues implicated in catalysis. For murine cytomegal...

journal_title：Journal of virology

authors： Schlieker C,Korbel GA,Kattenhorn LM,Ploegh HL

更新日期：2005-12-01 00:00:00

abstract：:The inclusion of Mimiviridae members in the putative monophyletic nucleocytoplasmic large DNA virus (NCLDV) group is based on genomic and phylogenomic patterns. This shows that, along with other viral families, they share a set of genes known as core or "hallmark genes," including the gene for the major capsid protein...

journal_title：Journal of virology

authors： Boratto PVM,Dornas FP,da Silva LCF,Rodrigues RAL,Oliveira GP,Cortines JR,Drumond BP,Abrahão JS

更新日期：2018-01-02 00:00:00

abstract：:The vif gene of human immunodeficiency virus type 1 is absolutely required for productive infection of primary cells derived from human blood and certain immortalized T lymphoid cells, for example, H9. Cells with this restrictive phenotype are termed nonpermissive, whereas cell lines in which vif-deficient virus can r...

journal_title：Journal of virology

authors： Simon JH,Malim MH

更新日期：1996-08-01 00:00:00

abstract：:The Zaire ebolavirus (EBOV) glycoprotein (GP) is cleaved into two subunits (GP1 and GP2) that are both required for virus attachment and entry into cells. Sequence changes in the GP have been proposed to increase pathogenesis and to alter virus growth properties. Mutations in GP acquired during EBOV tissue culture pas...

journal_title：Journal of virology

authors： Ruedas JB,Arnold CE,Palacios G,Connor JH

更新日期：2018-09-12 00:00:00

abstract：:Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus related to rhabdoviruses and paramyxoviruses. Unlike animal viruses of these two families, BDV transcribes RNAs in the nuclei of infected cells and produces high levels of transcripts containing multiple open reading frames. Previous Northern blot ...

journal_title：Journal of virology

authors： Schneider PA,Schneemann A,Lipkin WI

更新日期：1994-08-01 00:00:00

abstract：:Nucleotide sequence analysis of two simian virus 40 early mutants dl1263 and dl1265, which lack a DNA segment around map positions 0.21 and 0.18, respectively (C. Cole, T. Landers, S. Goff, S. MAnteuil-Brutlag, and P. Berg, J. Virol. 24:277--294, 1977), revealed in-phase deletions of 33 nucleotide pairs for dl1263 and...

journal_title：Journal of virology

authors： Van Heuverswyn H,Cole C,Berg P,Fiers W

更新日期：1979-06-01 00:00:00

abstract：:A well-characterized mechanism by which anti-HLA class I monoclonal antibodies (MAb) inhibit human immunodeficiency virus type 1 (HIV-1) propagation in in vitro cell cultures is the neutralization of the virus through interactions with HLA molecules associated with the virion envelope. Yet, the possibility that anothe...

journal_title：Journal of virology

authors： Briant L,Benkirane M,Girard M,Hirn M,Iosef C,Devaux C

更新日期：1996-08-01 00:00:00

abstract：:The herpes simplex virus type 1 UL6 protein forms a 12-subunit ring structure at a unique capsid vertex which functions as a conduit for encapsidation of the viral genome. To characterize UL6 protein domains that are involved in intersubunit interactions and interactions with other capsid proteins, we engineered a set...

journal_title：Journal of virology

authors： Nellissery JK,Szczepaniak R,Lamberti C,Weller SK

更新日期：2007-09-01 00:00:00

abstract：:The RNA genome of influenza virus is transcribed and replicated by the viral RNA polymerase complex in the cell nucleus. We have generated green fluorescent protein (GFP)-tagged polymerase subunits to study the assembly of the polymerase complex. Our results show that individually expressed polymerase basic protein 1 ...

journal_title：Journal of virology

authors： Fodor E,Smith M

更新日期：2004-09-01 00:00:00

abstract：:Genomic replication of the negative-strand RNA viruses is dependent upon protein synthesis. To examine the requirement for protein synthesis in replication, we developed an in vitro system that supports the genome replication of defective interfering particles of the negative-strand rhabdovirus vesicular stomatitis vi...

journal_title：Journal of virology

authors： Patton JT,Davis NL,Wertz GW

更新日期：1984-02-01 00:00:00

abstract：:Since most human immunodeficiency virus (HIV) infections are initiated following mucosal exposure to the virus, the anatomic containment or abortion of an HIV infection is likely to require vaccine-elicited cellular immune responses in those mucosal sites. Studying vaccine-elicited mucosal immune responses has been pr...

journal_title：Journal of virology

authors： Baig J,Levy DB,McKay PF,Schmitz JE,Santra S,Subbramanian RA,Kuroda MJ,Lifton MA,Gorgone DA,Wyatt LS,Moss B,Huang Y,Chakrabarti BK,Xu L,Kong WP,Yang ZY,Mascola JR,Nabel GJ,Carville A,Lackner AA,Veazey RS,Letvin N

更新日期：2002-11-01 00:00:00

abstract：:Two defective RNAs (designated D RNA 3 alpha and D RNA 3 beta) were found to be associated with the Fny strain of cucumber mosaic cucumovirus but not with the Sny strain after serial passages in a tobacco host. The D RNAs were derived from RNA 3 by single, in-frame deletions within the 3a open reading frame. A full-le...

journal_title：Journal of virology

authors： Graves MV,Roossinck MJ

更新日期：1995-08-01 00:00:00

abstract：:The cytomegalovirus (CMV) serine proteinase assemblin is synthesized as a precursor that undergoes three principal autoproteolytic cleavages. Two of these are common to the assemblin homologs of all herpes group viruses: one at the maturational site near the carboxyl end of the precursor and another at the release sit...

journal_title：Journal of virology

authors： Hall MR,Gibson W

更新日期：1996-08-01 00:00:00