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Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice.

Abstract：

:Following intranasal administration, the severe acute respiratory syndrome (SARS) coronavirus replicated to high titers in the respiratory tracts of BALB/c mice. Peak replication was seen in the absence of disease on day 1 or 2, depending on the dose administered, and the virus was cleared within a week. Viral antigen and nucleic acid were detected in bronchiolar epithelial cells during peak viral replication. Mice developed a neutralizing antibody response and were protected from reinfection 28 days following primary infection. Passive transfer of immune serum to naïve mice prevented virus replication in the lower respiratory tract following intranasal challenge. Thus, antibodies, acting alone, can prevent replication of the SARS coronavirus in the lung, a promising observation for the development of vaccines, immunotherapy, and immunoprophylaxis regimens.

journal_name

J Virol

journal_title

Journal of virology

authors

Subbarao K,McAuliffe J,Vogel L,Fahle G,Fischer S,Tatti K,Packard M,Shieh WJ,Zaki S,Murphy B

doi

10.1128/jvi.78.7.3572-3577.2004

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

3572-7

issue

7

eissn

0022-538X

issn

1098-5514

journal_volume

78

pub_type

杂志文章

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