Nucleotide sequence analysis of two simian virus 40 mutants with deletions in the region coding for the carboxyl terminus of the T antigen.

abstract：UNLABELLED:Viral myocarditis, which is most prevalently caused by coxsackievirus B3 (CVB3), is a serious clinical condition characterized by excessive myocardial inflammation. Recent studies suggest that regulation of protein acetylation levels by inhibiting histone deacetylase (HDAC) activity modulates inflammatory re...

journal_title：Journal of virology

authors： Zhou L,He X,Gao B,Xiong S

更新日期：2015-10-01 00:00:00

abstract：:Human papillomaviruses (HPVs) infect keratinocytes of skin and mucosa. Homeostasis of these constantly renewing, stratified epithelia is maintained by balanced keratinocyte proliferation and terminal differentiation. Instructions from the extracellular matrix engaging integrins strongly regulate these keratinocyte fun...

journal_title：Journal of virology

authors： Oldak M,Smola H,Aumailley M,Rivero F,Pfister H,Smola-Hess S

更新日期：2004-10-01 00:00:00

abstract：:The evolution of human immunodeficiency virus (HIV) type 1 nef quasispecies in a patient clonally infected with a contaminated batch of blood clotting factor IX was monitored. nef sequences were derived at 11, 25, and 41 months postinfection from infected peripheral blood mononuclear cells after molecular cloning of P...

journal_title：Journal of virology

authors： Plikat U,Nieselt-Struwe K,Meyerhans A

更新日期：1997-06-01 00:00:00

abstract：:Paramyxoviruses initiate entry through the concerted action of the tetrameric attachment glycoprotein (HN, H, or G) and the trimeric fusion glycoprotein (F). The ectodomains of HN/H/G contain a stalk region important for oligomeric stability and for the F triggering resulting in membrane fusion. Paramyxovirus HN, H, a...

journal_title：Journal of virology

authors： Maar D,Harmon B,Chu D,Schulz B,Aguilar HC,Lee B,Negrete OA

更新日期：2012-06-01 00:00:00

abstract：:Enviroxime is an antienterovirus compound that targets viral protein 3A and/or 3AB and suppresses a step in enterovirus replication by unknown mechanism. To date, four antienterovirus compounds, i.e., GW5074, Flt3 inhibitor II, TTP-8307, and AN-12-H5, are known to have similar mutations in the 3A protein-encoding regi...

journal_title：Journal of virology

authors： Arita M,Kojima H,Nagano T,Okabe T,Wakita T,Shimizu H

更新日期：2011-03-01 00:00:00

abstract：UNLABELLED:A balance between the functions of the influenza virus surface proteins hemagglutinin (HA) and neuraminidase (NA) is thought to be important for the transmission of viruses between humans. Here we describe two pandemic H1N1 viruses, A/swine/Virginia/1814-1/2012 and A/swine/Virginia/1814-2/2012 (pH1N1low-1 an...

journal_title：Journal of virology

authors： Zanin M,Marathe B,Wong SS,Yoon SW,Collin E,Oshansky C,Jones J,Hause B,Webby R

更新日期：2015-06-01 00:00:00

abstract：:The phosphoprotein, P, of vesicular stomatitis virus (VSV) is a key subunit of the viral RNA-dependent RNA polymerase complex. The protein is phosphorylated at multiple sites in two different domains. We recently showed that specific serine and threonine residues within the amino-terminal acidic domain I of P protein ...

journal_title：Journal of virology

authors： Hwang LN,Englund N,Das T,Banerjee AK,Pattnaik AK

更新日期：1999-07-01 00:00:00

abstract：UNLABELLED:Many coxsackievirus B (CVB) isolates bind to human decay-accelerating factor (DAF) as well as to the coxsackievirus and adenovirus receptor (CAR). However, the virus does not interact with murine DAF. To understand why CVB3 binds specifically to human DAF, we constructed a series of chimeric molecules in whi...

journal_title：Journal of virology

authors： Pan J,Zhang L,Organtini LJ,Hafenstein S,Bergelson JM

更新日期：2015-01-15 00:00:00

abstract：:Tegument is a unique structure of herpesvirus, which surrounds the capsid and interacts with the envelope. Morphogenesis of gammaherpesvirus is poorly understood due to lack of efficient lytic replication for Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, which are etiologically as...

journal_title：Journal of virology

authors： Guo H,Wang L,Peng L,Zhou ZH,Deng H

更新日期：2009-10-01 00:00:00

abstract：:Natural Killer (NK) cells are important in the immune response to a number of viruses; however, the mechanisms used by NK cells to discriminate between healthy and virus-infected cells are only beginning to be understood. Infection with vaccinia virus provokes a marked increase in the susceptibility of target cells to...

journal_title：Journal of virology

authors： Chisholm SE,Reyburn HT

更新日期：2006-03-01 00:00:00

abstract：:Understanding the role of host factors during lethal influenza virus infection is critical to deciphering the events that determine the fate of the host. One such factor is encoded by the Mx1 gene, which confers resistance to influenza virus infection. Here, we compared pathology and global gene expression profiles in...

journal_title：Journal of virology

authors： Cilloniz C,Pantin-Jackwood MJ,Ni C,Carter VS,Korth MJ,Swayne DE,Tumpey TM,Katze MG

更新日期：2012-03-01 00:00:00

abstract：:Primary telencephalic cultures derived from neonatal Wistar Furth rats were able to support the growth of coronavirus JHM if a viable neuronal population was maintained. This occurred under serum-free defined, but not serum-supplemented, growth conditions. The importance of neurons in establishing infections in mixed ...

journal_title：Journal of virology

authors： Pasick JM,Dales S

更新日期：1991-09-01 00:00:00

abstract：:DNA of the avian hepadnavirus, duck hepatitis B virus, was found to be integrated at low abundance into the cellular DNA extracted from the livers of infected ducklings. The frequency of integration was estimated to be at least one viral genome per 10(3) to 10(4) cells by 6 days postinfection. The structures of virus-...

journal_title：Journal of virology

authors： Yang W,Summers J

更新日期：1999-12-01 00:00:00

abstract：:The fusion (F) protein of simian virus 5 (strain W3A) induced extensive cell fusion in BHK cells when expressed alone, while that of strain WR did not. Mutational analysis demonstrated that the fusing activity can be transferred to the WR F protein by a proline residue at position 22 of subunit W3A F2. ...

journal_title：Journal of virology

authors： Ito M,Nishio M,Kawano M,Kusagawa S,Komada H,Ito Y,Tsurudome M

更新日期：1997-12-01 00:00:00

abstract：:Recombinant strains of replication-competent rhesus monkey rhadinovirus (RRV) were constructed in which strong promoter/enhancer elements were used to drive expression of simian immunodeficiency virus (SIV) Env or Gag or a Rev-Tat-Nef fusion protein. Cultured rhesus monkey fibroblasts infected with each recombinant st...

journal_title：Journal of virology

authors： Bilello JP,Manrique JM,Shin YC,Lauer W,Li W,Lifson JD,Mansfield KG,Johnson RP,Desrosiers RC

更新日期：2011-12-01 00:00:00

abstract：:In less than 3 months after the first cases of swine origin 2009 influenza A (H1N1) virus infections were reported from Mexico, WHO declared a pandemic. The pandemic virus is antigenically distinct from seasonal influenza viruses, and the majority of human population lacks immunity against this virus. We have studied ...

journal_title：Journal of virology

authors： Osterlund P,Pirhonen J,Ikonen N,Rönkkö E,Strengell M,Mäkelä SM,Broman M,Hamming OJ,Hartmann R,Ziegler T,Julkunen I

更新日期：2010-02-01 00:00:00

abstract：:Members of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC3 [A3]) family of DNA cytidine deaminases are intrinsic restriction factors against retroviruses. In felids such as the domestic cat (Felis catus), the A3 genes encode the A3Z2, A3Z3, and A3Z2Z3 antiviral cytidine deaminases. Only A3...

journal_title：Journal of virology

authors： Gu Q,Zhang Z,Gertzen CGW,Häussinger D,Gohlke H,Münk C

更新日期：2018-02-26 00:00:00

abstract：:H9N2 influenza viruses are panzootic in domestic poultry in Eurasia and since 1999 have caused transient infections in humans and pigs. To investigate the zoonotic potential of H9N2 viruses, we studied the evolution of the viruses in live-poultry markets in Hong Kong in 2003. H9N2 was the most prevalent influenza viru...

journal_title：Journal of virology

authors： Choi YK,Ozaki H,Webby RJ,Webster RG,Peiris JS,Poon L,Butt C,Leung YH,Guan Y

更新日期：2004-08-01 00:00:00

abstract：:The sequences of several hundred nucleotides around the junctions between the L and S components in concatemeric DNA and in mature virion DNA were ascertained. The two ends of the mature genome (which are joined in concatemeric DNA) show no sequence homology. Several directly repeated elements are present near both en...

journal_title：Journal of virology

authors： DeMarchi JM,Lu ZQ,Rall G,Kupershmidt S,Ben-Porat T

更新日期：1990-10-01 00:00:00

abstract：:The role of the T4 bacteriophage regA gene in stabilizing early mRNA was investigated by assaying the level of functional mRNA from eight prereplicative genes (56 [dCMP hydroxymethylase], cd [dCMP deaminase], 1 [deoxynucleotide kinase], rIIA, rIIB, 46 [DNA arrest], and 45) during extended infection of Escherichia coli...

journal_title：Journal of virology

authors： Trimble RB,Maley

更新日期：1976-02-01 00:00:00

abstract：:There is an incomplete understanding of the differences between neonatal immune responses that contribute to the increased susceptibility of neonates to some viral infections. We tested the hypothesis that neonates are more susceptible than adults to mouse adenovirus type 1 (MAV-1) respiratory infection and are impair...

journal_title：Journal of virology

authors： Procario MC,Levine RE,McCarthy MK,Kim E,Zhu L,Chang CH,Hershenson MB,Weinberg JB

更新日期：2012-04-01 00:00:00

abstract：:Using resistance to the base analog 8-azaguanine as a genetic marker, we showed that adenovirus type 2, but not adenovirus type 12, is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned diploid rat liver epithelial cells. Adenovirus type 2 increased the frequency of 8-azaguanine-resistant colonies...

journal_title：Journal of virology

authors： Paraskeva C,Roberts C,Biggs P,Gallimore PH

更新日期：1983-04-01 00:00:00

abstract：:The genome of infectious hematopoietic necrosis virus (IHNV), a salmonid novirhabdovirus, has been engineered to modify the gene order and to evaluate the impact on a possible attenuation of the virus in vitro and in vivo By reverse genetics, eight recombinant IHNVs (rIHNVs), termed NxGy according to the respective po...

journal_title：Journal of virology

authors： Rouxel RN,Tafalla C,Mérour E,Leal E,Biacchesi S,Brémont M

更新日期：2016-11-14 00:00:00

abstract：:The nr allele at the mouse Fv1 restriction locus governs resistance to B-tropic and some N-tropic murine leukemia viruses (MLVs). Sequence analysis and site-specific mutagenesis of N-tropic MLVs identified a single amino acid difference responsible for this restriction that is distinct from the site that governs N or ...

journal_title：Journal of virology

authors： Jung YT,Kozak CA

更新日期：2000-06-01 00:00:00

abstract：:Infection of cells with herpes simplex virus type 1 (HSV-1) results in a rapid alteration of phosphorylation on the large subunit of cellular RNA polymerase II (RNAP II), most likely on its C-terminal domain (S. A. Rice, M. C. Long, V. Lam, C. A. Spencer, J. Virol. 68:988-1001, 1994). This phosphorylation modification...

journal_title：Journal of virology

authors： Rice SA,Long MC,Lam V,Schaffer PA,Spencer CA

更新日期：1995-09-01 00:00:00

abstract：:Treatment of human immunodeficiency virus type 1 (HIV-1)-infected CEM cell cultures with escalating concentrations of the quinoxaline S-2720 resulted in an ordered appearance of single and multiple mutant virus strains that gradually became resistant to the quinoxaline and other nonnucleoside reverse transcriptase (RT...

journal_title：Journal of virology

authors： Pelemans H,Esnouf R,Dunkler A,Parniak MA,Vandamme AM,Karlsson A,De Clercq E,Kleim JP,Balzarini J

更新日期：1997-11-01 00:00:00

abstract：:Research in the last 2 decades has demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB) or nuclear domain 10 (ND10), is frequently modified during viral infection. This correlates with antagonization of a direct repressive function of individual PML-NB components, such as the PM...

journal_title：Journal of virology

authors： Scherer M,Stamminger T

更新日期：2016-06-10 00:00:00

abstract：:Avian leukosis virus subgroup J (ALV-J), an exogenous avian retrovirus, is thought to have evolved by recombination with the highly identical env gene of the endogenous avian retrovirus EAV-HP. Embryonic expression of EAV-HP env has been suggested to be associated with the induction of immunological tolerance, a featu...

journal_title：Journal of virology

authors： Sacco MA,Venugopal K

更新日期：2001-12-01 00:00:00

abstract：:An immunodominant envelope glycoprotein is encoded by the human herpesvirus 8 (HHV-8) (also termed Kaposi's sarcoma-associated herpesvirus) K8.1 gene. The functional role of glycoprotein K8.1 is unknown, and recognizable sequence homology to K8.1 is not detectable in the genomes of most other closely related gammaherp...

journal_title：Journal of virology

authors： Birkmann A,Mahr K,Ensser A,Yağuboğlu S,Titgemeyer F,Fleckenstein B,Neipel F

更新日期：2001-12-01 00:00:00

abstract：:Infection of HeLa cells with adenovirus serotype 2 causes rearrangements in nuclear matrix morphology which can best be seen by gentle cell extraction and embedment-free section electron microscopy. We used these techniques to examine the nuclear matrices and cytoskeletons of cells at 6, 13, 28, and 44 h after infecti...

journal_title：Journal of virology

authors： Zhai ZH,Nickerson JA,Krochmalnic G,Penman S

更新日期：1987-04-01 00:00:00