Repair and evolution of nef in vivo modulates simian immunodeficiency virus virulence.

abstract：:Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing antibodies. "Hijacked" leukocytes, previously identified as monocytic cells and T lymphocytes, transmit EHV1 to endothelial cells of t...

journal_title：Journal of virology

authors： Poelaert KCK,Van Cleemput J,Laval K,Favoreel HW,Couck L,Van den Broeck W,Azab W,Nauwynck HJ

更新日期：2019-03-21 00:00:00

abstract：:After rabies virus glycoprotein was treated with CNBr, the peptide mixture was fractionated by preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis. CNBr-cleaved peptide fragments were resolved into seven peptide bands under reducing conditions and six peptide bands under nonreducing conditions. The i...

journal_title：Journal of virology

authors： Dietzschold B,Wiktor TJ,Macfarlan R,Varrichio A

更新日期：1982-11-01 00:00:00

abstract：:Treatment of polyoma virions with ethyleneglycol-bil-N,N'-tetraacetic acid (EGTA) and dithiothreitol (DTT) at pH 8.5 resulted in the dissociation of the virions into a DNA-protein complex and individual structural capsomere subunits. The sedimentation value of the DNA-protein complex in sucrose gradients was approxima...

journal_title：Journal of virology

authors： Brady JN,Winston VD,Consigli RA

更新日期：1978-07-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) accessory protein Vpu enhances virus particle release by counteracting a host factor that retains virions at the surfaces of infected cells. It was recently demonstrated that cellular protein BST-2/CD317/Tetherin restricts HIV-1 release in a Vpu-dependent manner. Calcium...

journal_title：Journal of virology

authors： Bego MG,Dubé M,Mercier J,Cohen EA

更新日期：2009-12-01 00:00:00

abstract：:Adenine residues of 70S avian myeloblastosis virus (AMV) RNA are modified when reacted with chloroacetaldehyde. This modification introduces characteristic fluorescent epsilon-adenosine (epsilonA) probes which were used to monitor the reaction. Under suitable conditions, modified 70S(epsilonA) RNA was maintained intac...

journal_title：Journal of virology

authors： Papas TS,Chirikjian JG,Pry TW,Massicot JG,Irwin RD,Chirigos MA

更新日期：1974-11-01 00:00:00

abstract：:The N terminus of the capsid protein (CA) undergoes a considerable conformational change when the human immunodeficiency virus (HIV) protease cleaves it free from the Pr55(Gag) polyprotein. This rearrangement is thought to facilitate the establishment of specific CA-CA interactions that are required for the formation ...

journal_title：Journal of virology

authors： Rue SM,Roos JW,Amzel LM,Clements JE,Barber SA

更新日期：2003-07-01 00:00:00

abstract：:ETnII elements are mobile members of the repetitive early transposon family of mouse long terminal repeat (LTR) retroelements and have caused a number of mutations by inserting into genes. ETnII sequences lack retroviral genes, but the recent discovery of related MusD retroviral elements with regions similar to gag, p...

journal_title：Journal of virology

authors： Baust C,Gagnier L,Baillie GJ,Harris MJ,Juriloff DM,Mager DL

更新日期：2003-11-01 00:00:00

abstract：:The first 86 residues of the Rous sarcoma virus (RSV) Gag protein form a membrane-binding (M) domain that directs Gag to the plasma membrane during budding. Unlike other retroviral Gag proteins, RSV Gag is not myristylated; however, the RSV M domain does contain 11 basic residues that could potentially interact with a...

journal_title：Journal of virology

authors： Callahan EM,Wills JW

更新日期：2000-12-01 00:00:00

abstract：:JC virus (JCV), along with other members of the polyomavirus family, encodes a class of highly conserved proteins, T antigens, that are capable of inducing aneuploidy in cultured cells. We have previously isolated T-antigen DNA variants of JCV from both colon cancer tissues and the corresponding nonneoplastic gastroin...

journal_title：Journal of virology

authors： Ricciardiello L,Chang DK,Laghi L,Goel A,Chang CL,Boland CR

更新日期：2001-02-01 00:00:00

abstract：:The assembly of hepatitis C virus (HCV) is poorly understood, largely due to the lack of mammalian cell culture systems that are easily manipulated and produce high titers of virus. This problem is highlighted by the inability of the recently established HCV replicon systems to support HCV capsid assembly despite high...

journal_title：Journal of virology

authors： Klein KC,Polyak SJ,Lingappa JR

更新日期：2004-09-01 00:00:00

abstract：:We previously reported that nucleolin, a representative nucleolar marker, interacts with nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) through two independent regions of NS5B, amino acids 208 to 214 and 500 to 506. We also showed that truncated nucleolin that harbors the NS5B-binding region inhibited the ...

journal_title：Journal of virology

authors： Shimakami T,Honda M,Kusakawa T,Murata T,Shimotohno K,Kaneko S,Murakami S

更新日期：2006-04-01 00:00:00

abstract：:The coronavirus, mouse hepatitis virus strain JHM, causes acute and chronic neurological diseases in rodents. Here we demonstrate that two closely related virus variants, both of which cause acute encephalitis in susceptible strains of mice, cause markedly different diseases if mice are protected with a suboptimal amo...

journal_title：Journal of virology

authors： Ontiveros E,Kim TS,Gallagher TM,Perlman S

更新日期：2003-10-01 00:00:00

abstract：:Friend murine leukemia virus (F-MuLV) is a replication-competent, ecotropic, NB-tropic retrovirus which produces a rapidly fatal erythroleukemia in susceptible strains of mice. We previously molecularly cloned the entire F-MuLV genome. Transfection of this cloned DNA into NIH 3T3 mouse fibroblasts produces a virus wit...

journal_title：Journal of virology

authors： Oliff A,Ruscetti S

更新日期：1983-06-01 00:00:00

abstract：:The herpes simplex virus type 1 genome contains three origins of DNA replication: two copies of oriS and one copy of oriL. Although oriS has been characterized extensively, characterization of oriL has been severely limited by the inability to amplify oriL sequences in an undeleted form in Escherichia coli. We report ...

journal_title：Journal of virology

authors： Hardwicke MA,Schaffer PA

更新日期：1995-03-01 00:00:00

abstract：:Ovine herpesvirus 2 (OvHV-2) is a gammaherpesvirus in the genus Macavirus that is carried asymptomatically by sheep. Infection of poorly adapted animals with OvHV-2 results in sheep-associated malignant catarrhal fever, a fatal disease characterized by lymphoproliferation and vasculitis. There is no treatment or vacci...

journal_title：Journal of virology

authors： AlHajri SM,Cunha CW,Nicola AV,Aguilar HC,Li H,Taus NS

更新日期：2017-02-28 00:00:00

abstract：UNLABELLED:Recent evidence suggests that even in treated infections, human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication may continue in lymph nodes (LN), serving as a potential virus reservoir. Here we investigated the effects of lentivirus infection on natural killer (NK) cell frequ...

journal_title：Journal of virology

authors： Schafer JL,Li H,Evans TI,Estes JD,Reeves RK

更新日期：2015-07-01 00:00:00

abstract：:Herpes simplex virus (HSV) entry requires the interaction between the envelope glycoprotein D (gD) and a cellular receptor such as nectin-1 (also named herpesvirus entry mediator C [HveC]) or HveA/HVEM. Nectin-1 is a cell adhesion molecule found at adherens junctions associated with the cytoplasmic actin-binding prote...

journal_title：Journal of virology

authors： Krummenacher C,Baribaud I,Sanzo JF,Cohen GH,Eisenberg RJ

更新日期：2002-03-01 00:00:00

abstract：:The number, chromosomal distribution, and insertional polymorphisms of endogenous feline leukemia viruses (enFeLVs) were determined in four domestic cats (Burmese, Egyptian Mau, Persian, and nonbreed) using fluorescent in situ hybridization and radiation hybrid mapping. Twenty-nine distinct enFeLV loci were detected a...

journal_title：Journal of virology

authors： Roca AL,Nash WG,Menninger JC,Murphy WJ,O'Brien SJ

更新日期：2005-04-01 00:00:00

abstract：:Influenza A viruses (IAVs) cause seasonal epidemics and occasional pandemics, representing a serious public health concern. It has been described that one mechanism used by some IAV strains to escape the host innate immune responses and modulate virus pathogenicity involves the ability of the PA-X and NS1 proteins to ...

journal_title：Journal of virology

authors： Nogales A,Rodriguez L,DeDiego ML,Topham DJ,Martínez-Sobrido L

更新日期：2017-08-10 00:00:00

abstract：UNLABELLED:Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and characterized by a high rate of abortion in ruminants and hemorrhagic fever, encephalitis, or blindness in humans. RVF is caused by Rift Valley fever virus (RVFV; family Bunyaviridae, genus Phlebovirus), which has a tripartite...

journal_title：Journal of virology

authors： Ikegami T,Hill TE,Smith JK,Zhang L,Juelich TL,Gong B,Slack OA,Ly HJ,Lokugamage N,Freiberg AN

更新日期：2015-07-01 00:00:00

abstract：:The emergence in 1997 and continuance today of a highly lethal H5N1 avian influenza virus (AIV) causing human disease has raised concern about an impending pandemic and the need for a vaccine to prepare for such an occurrence. We previously generated an efficacious vesicular stomatitis virus (VSV)-based AIV vaccine ex...

journal_title：Journal of virology

authors： Schwartz JA,Buonocore L,Suguitan AL Jr,Silaghi A,Kobasa D,Kobinger G,Feldmann H,Subbarao K,Rose JK

更新日期：2010-05-01 00:00:00

abstract：:A major difference between vaccine and wild-type strains of measles virus (MV) in vitro is the wider cell specificity of vaccine strains, resulting from the receptor usage of the hemagglutinin (H) protein. Wild-type H proteins recognize the signaling lymphocyte activation molecule (SLAM) (CD150), which is expressed on...

journal_title：Journal of virology

authors： Takeuchi K,Nagata N,Kato SI,Ami Y,Suzaki Y,Suzuki T,Sato Y,Tsunetsugu-Yokota Y,Mori K,Van Nguyen N,Kimura H,Nagata K

更新日期：2012-03-01 00:00:00

abstract：:The present study was designed to investigate the endocytic pathway involved in canine parvovirus (CPV) infection. Reduced temperature (18 degrees C) or the microtubule-depolymerizing drug nocodazole was found to inhibit productive infection of canine A72 cells by CPV and caused CPV to be retained in cytoplasmic vesic...

journal_title：Journal of virology

authors： Vihinen-Ranta M,Kalela A,Mäkinen P,Kakkola L,Marjomäki V,Vuento M

更新日期：1998-01-01 00:00:00

abstract：:The Rev protein of human immunodeficiency virus type 1 (HIV-1) is essential for the expression of the structural genes of HIV-1. To determine whether a functional threshold level of Rev is required to allow efficient HIV-1 replication, CD4-positive HeLa cells, constitutively expressing a Rev-deficient provirus, were t...

journal_title：Journal of virology

authors： Pomerantz RJ,Seshamma T,Trono D

更新日期：1992-03-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 Tax protein activates the expression of cellular immediate early genes controlled by the serum response element (SRE), which contains both the serum response factor (SRF) binding element (CArG box) and the ternary complex factor (TCF) binding element (Ets box). We show that TCF b...

journal_title：Journal of virology

authors： Shuh M,Derse D

更新日期：2000-12-01 00:00:00

abstract：:The 3'-end host-virus junction fragments from two bovine leukemia virus (BLV)-induced lymphoid tumors (tumors 15-4 and 1351), each containing a single provirus, were used as probes to detect large restriction fragments flanking these proviruses. The DNAs from 28 other independent BLV-induced tumors were checked by Sou...

journal_title：Journal of virology

authors： Kettmann R,Deschamps J,Couez D,Claustriaux JJ,Palm R,Burny A

更新日期：1983-07-01 00:00:00

abstract：:NS4B is one of the nonstructural proteins of classical swine fever virus (CSFV), the etiological agent of a severe, highly lethal disease of swine. Protein domain analysis of the predicted amino acid sequence of the NS4B protein of highly pathogenic CSFV strain Brescia (BICv) identified a putative Toll/interleukin-1 r...

journal_title：Journal of virology

authors： Fernandez-Sainz I,Gladue DP,Holinka LG,O'Donnell V,Gudmundsdottir I,Prarat MV,Patch JR,Golde WT,Lu Z,Zhu J,Carrillo C,Risatti GR,Borca MV

更新日期：2010-02-01 00:00:00

abstract：:We measured the quantity of plasma feline immunodeficiency virus (FIV) RNA using a real-time sequence detecting system. Plasma viral RNA load was shown to correlate with the clinical stage, survival time, and disease progression in naturally FIV-infected cats. The present study indicates that the plasma viral RNA load...

journal_title：Journal of virology

authors： Goto Y,Nishimura Y,Baba K,Mizuno T,Endo Y,Masuda K,Ohno K,Tsujimoto H

更新日期：2002-10-01 00:00:00

abstract：:The majority of T-cell clones derived from a donor who experienced dengue illness following receipt of a live experimental dengue virus type 3 (DEN3) vaccine cross-reacted with all four serotypes of dengue virus, but some were serotype specific or only partially cross-reactive. The nonstructural protein, NS3, was immu...

journal_title：Journal of virology

authors： Zeng L,Kurane I,Okamoto Y,Ennis FA,Brinton MA

更新日期：1996-05-01 00:00:00

abstract：:Poliovirus infectious RNA can be synthesized in vitro using phage DNA-dependent RNA-polymerases. These synthetic transcripts contain several extra nucleotides at the 5' end, which are deleted during replication to generate authentic viral genomes. We removed those 5'-end extra nucleotides utilizing a hammerhead ribozy...

journal_title：Journal of virology

authors： Herold J,Andino R

更新日期：2000-07-01 00:00:00