Abstract:
:Stress signaling from mitochondria and the endoplasmic reticulum (ER) leads to the induction of the proapoptotic transcription factor CHOP/GADD153. Many viruses use the ER as a site of replication and/or envelopment, and this activity can lead to the activation of ER stress and apoptosis. African swine fever virus (ASFV) is assembled on the cytoplasmic face of the ER and ultimately enveloped by ER membrane cisternae. The virus also recruits mitochondria to sites of viral replication and induces the mitochondrial stress protein hsp60. Here we studied the effects of ASFV on the induction of CHOP/GADD153 in infected cells. Interestingly, unlike other ER-tropic viruses, ASFV did not activate CHOP and was able to inhibit the induction of CHOP/GADD153 by a number of exogenous stimuli.
journal_name
J Viroljournal_title
Journal of virologyauthors
Netherton CL,Parsley JC,Wileman Tdoi
10.1128/JVI.78.19.10825-10828.2004subject
Has Abstractpub_date
2004-10-01 00:00:00pages
10825-8issue
19eissn
0022-538Xissn
1098-5514pii
78/19/10825journal_volume
78pub_type
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