Abstract:
:The C-type lectins DC-SIGN and DC-SIGNR [collectively referred to as DC-SIGN(R)] bind and transmit human immunodeficiency virus (HIV) and simian immunodeficiency virus to T cells via the viral envelope glycoprotein (Env). Other viruses containing heavily glycosylated glycoproteins (GPs) fail to interact with DC-SIGN(R), suggesting some degree of specificity in this interaction. We show here that DC-SIGN(R) selectively interact with HIV Env and Ebola virus GPs containing more high-mannose than complex carbohydrate structures. Modulation of N-glycans on Env or GP through production of viruses in different primary cells or in the presence of the mannosidase I inhibitor deoxymannojirimycin dramatically affected DC-SIGN(R) infectivity enhancement. Further, murine leukemia virus, which typically does not interact efficiently with DC-SIGN(R), could do so when produced in the presence of deoxymannojirimycin. We predict that other viruses containing GPs with a large proportion of high-mannose N-glycans will efficiently interact with DC-SIGN(R), whereas those with solely complex N-glycans will not. Thus, the virus-producing cell type is an important factor in dictating both N-glycan status and virus interactions with DC-SIGN(R), which may impact virus tropism and transmissibility in vivo.
journal_name
J Viroljournal_title
Journal of virologyauthors
Lin G,Simmons G,Pöhlmann S,Baribaud F,Ni H,Leslie GJ,Haggarty BS,Bates P,Weissman D,Hoxie JA,Doms RWdoi
10.1128/jvi.77.2.1337-1346.2003subject
Has Abstractpub_date
2003-01-01 00:00:00pages
1337-46issue
2eissn
0022-538Xissn
1098-5514journal_volume
77pub_type
杂志文章abstract::Adeno-associated virus (AAV) integrates site specifically into the AAVS1 locus on human chromosome 19. Although recruitment of the AAV nonstructural protein Rep78/68 to the Rep binding site (RBS) on AAVS1 is thought to be an essential step, the mechanism of the site-specific integration, particularly, how the site of ...
journal_title:Journal of virology
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doi:10.1128/JVI.02014-06
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doi:10.1128/JVI.00462-13
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01397-13
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.1.323-331.1993
更新日期:1993-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.5.4239-4250.1999
更新日期:1999-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.75.15.7097-7106.2001
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.5.2393-2405.2000
更新日期:2000-03-01 00:00:00
abstract:UNLABELLED:Human metapneumovirus (HMPV), a recently discovered paramyxovirus, infects nearly 100% of the world population and causes severe respiratory disease in infants, the elderly, and immunocompromised patients. We previously showed that HMPV binds heparan sulfate proteoglycans (HSPGs) and that HMPV binding requir...
journal_title:Journal of virology
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journal_title:Journal of virology
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doi:10.1128/JVI.05869-11
更新日期:2011-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.9.7598-7602.1998
更新日期:1998-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1976-04-01 00:00:00
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更新日期:2008-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.00780-07
更新日期:2007-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.53.1.40-43.1985
更新日期:1985-01-01 00:00:00
abstract::White spot syndrome virus (WSSV) is a crustacean-infecting, double-stranded DNA virus and is the most serious viral pathogen in the global shrimp industry. WSSV is the sole recognized member of the family Nimaviridae, and the lack of genomic data on other nimaviruses has obscured the evolutionary history of WSSV. Here...
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.8.3726-3733.1990
更新日期:1990-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.6.3470-3480.1993
更新日期:1993-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.4.1859-1860.1990
更新日期:1990-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.23.12300-12311.2002
更新日期:2002-12-01 00:00:00
abstract::The complete DNA sequence of bovine adenovirus type 3 is reported here. The size of the genome is 34,446 bp in length with a G+C content of 54%. All the genes of the early and late regions are present in the expected locations of the genome. However, the late-region genes are organized into seven families, instead of ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.2.1394-1402.1998
更新日期:1998-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-07-01 00:00:00