The 86-kilodalton IE-2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE-1/2 enhancer-promoter.

abstract：:The effectiveness of attenuated poliovirus vaccines when given orally to induce both systemic and mucosal immune responses against poliovirus has resulted in an effort to develop poliovirus-based vectors to express foreign proteins. We have previously described the construction of poliovirus genomes (referred to as re...

journal_title：Journal of virology

authors： Porter DC,Melsen LR,Compans RW,Morrow CD

更新日期：1996-04-01 00:00:00

abstract：:Caprine arthritis encephalitis virus (CAEV) is a lentivirus closely related to visna virus and more distantly to other lentiviruses, such as human immunodeficiency virus. The genomes of visna virus and CAEV contain a tat gene encoding a protein able to weakly transactivate its own long terminal repeat, suggesting that...

journal_title：Journal of virology

authors： Harmache A,Vitu C,Russo P,Bouyac M,Hieblot C,Peveri P,Vigne R,Suzan M

更新日期：1995-09-01 00:00:00

abstract：:Phosphorylation of the βC1 protein encoded by the betasatellite of tomato yellow leaf curl China virus (TYLCCNB-βC1) by SNF1-related protein kinase 1 (SnRK1) plays a critical role in defense of host plants against geminivirus infection in Nicotiana benthamiana However, how phosphorylation of TYLCCNB-βC1 impacts its pa...

journal_title：Journal of virology

authors： Zhong X,Wang ZQ,Xiao R,Cao L,Wang Y,Xie Y,Zhou X

更新日期：2017-07-27 00:00:00

abstract：:Following the initial detection of viral infection, innate immune responses trigger the induction of numerous interferon-stimulated genes (ISGs) to inhibit virus replication and dissemination. One such ISG encodes cholesterol-25-hydroxylase (CH25H), an enzyme that catalyzes the oxidation of cholesterol to form a solub...

journal_title：Journal of virology

authors： Doms A,Sanabria T,Hansen JN,Altan-Bonnet N,Holm GH

更新日期：2018-08-29 00:00:00

abstract：:The hepatitis B virus (HBV) capsid or core protein (Cp) can self-assemble to form an icosahedral capsid. It is now being pursued as a target for small-molecule antivirals that enhance the rate and extent of its assembly to yield empty and/or aberrant capsids. These small molecules are thus called core protein alloster...

journal_title：Journal of virology

authors： Ruan L,Hadden JA,Zlotnick A

更新日期：2018-09-26 00:00:00

abstract：:Varicella-zoster virus (VZV) causes varicella and establishes latency in sensory nerve ganglia, but the characteristics of VZV latency are not well defined. Immunohistochemical detection of the VZV immediate-early 63 (IE63) protein in ganglion neurons has been described, but there are significant discrepancies in esti...

journal_title：Journal of virology

authors： Zerboni L,Sobel RA,Ramachandran V,Rajamani J,Ruyechan W,Abendroth A,Arvin A

更新日期：2010-04-01 00:00:00

abstract：:The two canine adenoviruses, infectious canine hepatitis (ICH) virus and infectious canine laryngotracheitis (ICL) virus (also designated as Toronto A26/61 virus), were studied with respect to their morphology and the biological properties of their soluble components. The two viruses were found to be composed of solub...

journal_title：Journal of virology

authors： Marusyk RG,Norrby E,Lundqvist U

更新日期：1970-04-01 00:00:00

abstract：:Phosphorylation of viral proteins plays important roles in the influenza A virus (IAV) life cycle. By using mass spectrometry, we identified tyrosine 132 (Y132) as a phosphorylation site of the matrix protein (M1) of the influenza virus A/WSN/1933(H1N1). Phosphorylation at this site is essential to the process of viru...

journal_title：Journal of virology

authors： Wang S,Zhao Z,Bi Y,Sun L,Liu X,Liu W

更新日期：2013-06-01 00:00:00

abstract：:Vaccine-induced memory is necessary for protective immunity to pathogens, but many viruses induce a state of transient immune suppression that might contribute to the inability of a vaccine to elicit immunity. We evaluated here the fate of bystander T cells activated by third party cognate antigens during acute viral ...

journal_title：Journal of virology

authors： Marshall HD,Urban SL,Welsh RM

更新日期：2011-06-01 00:00:00

abstract：:The region of the human cytomegalovirus (CMV) genome between the UL127 open reading frame and the major immediate-early (MIE) enhancer is referred to as the unique region. DNase I protection analysis with human cell nuclear extracts demonstrated multiple protein binding sites in this region of the viral genome (P. Gha...

journal_title：Journal of virology

authors： Lundquist CA,Meier JL,Stinski MF

更新日期：1999-11-01 00:00:00

abstract：UNLABELLED:The novel H7N9 avian influenza virus (AIV) was demonstrated to cause severe human respiratory infections in China. Here, we examined poultry specimens from live bird markets linked to human H7N9 infection in Hangzhou, China. Metagenomic sequencing revealed mixed subtypes (H5, H7, H9, N1, N2, and N9). Subsequ...

journal_title：Journal of virology

authors： Yu Y,Wang X,Jin T,Wang H,Si W,Yang H,Wu J,Yan Y,Liu G,Sang X,Wu X,Gao Y,Xia X,Yu X,Pan J,Gao GF,Zhou J

更新日期：2015-09-01 00:00:00

abstract：:Influenza A virus (IAV) is a highly transmissible respiratory pathogen and a major cause of morbidity and mortality around the world. Nucleoprotein (NP) is an abundant IAV protein essential for multiple steps of the viral life cycle. Our recent proteomic study of the IAV-host interaction network found that TRIM41 (tri...

journal_title：Journal of virology

authors： Patil G,Zhao M,Song K,Hao W,Bouchereau D,Wang L,Li S

更新日期：2018-07-31 00:00:00

abstract：:The feline homolog of the alpha-chemokine receptor CXCR4 has recently been shown to support cell-cell fusion mediated by CXCR4-dependent strains of human immunodeficiency virus (HIV) and strains of feline immunodeficiency virus (FIV) that have been selected for growth in the Crandell feline kidney (CrFK) cell line. In...

journal_title：Journal of virology

authors： Willett BJ,Adema K,Heveker N,Brelot A,Picard L,Alizon M,Turner JD,Hoxie JA,Peiper S,Neil JC,Hosie MJ

更新日期：1998-08-01 00:00:00

abstract：:The transcription map of the Aedes albopictus densovirus (AalDNV) brevidensovirus was identified by Northern blotting, rapid amplification of cDNA ends (RACE) analysis, and RNase protection assays. AalDNV produced mRNAs of 3,359 (NS1), 3,345 (NS2), and 1,246 (VP) nucleotides. The two overlapping P7/7.4 NS promoters em...

journal_title：Journal of virology

authors： Pham HT,Jousset FX,Perreault J,Shike H,Szelei J,Bergoin M,Tijssen P

更新日期：2013-09-01 00:00:00

abstract：:An immunochemical analysis of the hemagglutinin (VP4) of the simian rotavirus SA11 was performed to better understand the structure and function of this molecule. Following immunization of mice with double-shelled virus particles and VP4-enriched fractions from CsCl gradients, a battery of anti-SA11 hybridomas was gen...

journal_title：Journal of virology

authors： Burns JW,Greenberg HB,Shaw RD,Estes MK

更新日期：1988-06-01 00:00:00

abstract：:Viral fusogenic membrane proteins have been proposed as tools to increase the potency of oncolytic viruses, but there is a need for mechanisms to control the spread of fusogenic viruses in normal versus tumor cells. We have previously shown that a mutant of the paramyxovirus simian virus 5 (SV5) that harbors mutations...

journal_title：Journal of virology

authors： Gainey MD,Manuse MJ,Parks GD

更新日期：2008-10-01 00:00:00

abstract：:Influenza A virus encodes M2, a proton channel that has been shown to be important during virus entry and assembly. In order to systematically investigate the role of the membrane-proximal residues in the M2 cytoplasmic tail in virus replication, we utilized scanning and directed alanine mutagenesis in combination wit...

journal_title：Journal of virology

authors： Stewart SM,Pekosz A

更新日期：2011-12-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) capsid is a T=16 icosahedral shell that forms in the nuclei of infected cells. Capsid assembly also occurs in vitro in reaction mixtures created from insect cell extracts containing recombinant baculovirus-expressed HSV-1 capsid proteins. During capsid formation, the major capsi...

journal_title：Journal of virology

authors： Spencer JV,Newcomb WW,Thomsen DR,Homa FL,Brown JC

更新日期：1998-05-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is renowned for its very low titer when grown in cultured cells. There remains no single explanation for the low infectivity. In this study, viral particles on the surfaces of infected cells were examined by several imaging technologies. Few surface particles were detected at 48 h postinfe...

journal_title：Journal of virology

authors： Carpenter JE,Hutchinson JA,Jackson W,Grose C

更新日期：2008-03-01 00:00:00

abstract：:The genome structure of a newly isolated sarcoma virus, Y73, was studied. Y73 is a defective, potent sarcomagenic virus and contains 4.8-kilobase (kb) RNA as its genome; in contrast, helper virus associated with Y73 had 8.5-kb RNA, similar to other avian leukemia viruses. Fingerprinting analysis these RNAs demonstrate...

journal_title：Journal of virology

authors： Yoshida M,Kawai S,Toyoshima K

更新日期：1981-05-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6)-specific monoclonal antibody (Mab) 9A5D12 reacted with the nucleus of HHV-6 strain GS-infected cells and immunoprecipitated a phosphorylated polypeptide with an approximate size of 41 kDa, designated HHV-6 P41. A 110-kDa polypeptide was also immunoprecipitated by the MAb. These polypeptides...

journal_title：Journal of virology

authors： Chang CK,Balachandran N

更新日期：1991-06-01 00:00:00

abstract：:Trigeminal ganglia (TG) from rabbits latently infected with either wild-type herpes simplex virus type 1 (HSV-1) or the latency-associated transcript (LAT) promoter deletion mutant 17DeltaPst were assessed for their viral chromatin profile and transcript abundance. The wild-type 17syn+ genomes were more enriched in th...

journal_title：Journal of virology

authors： Giordani NV,Neumann DM,Kwiatkowski DL,Bhattacharjee PS,McAnany PK,Hill JM,Bloom DC

更新日期：2008-06-01 00:00:00

abstract：:Recent evidence supports a role for vitamin K-dependent coagulation zymogens in adenovirus serotype 5 (Ad5, subgroup C) infection of hepatocytes. Here, we assessed the effect of virus-zymogen interaction on cellular transduction using a panel of fiber (f)-pseudotyped viruses derived from subgroup D (f47, f33, f24, f45...

journal_title：Journal of virology

authors： Parker AL,McVey JH,Doctor JH,Lopez-Franco O,Waddington SN,Havenga MJ,Nicklin SA,Baker AH

更新日期：2007-04-01 00:00:00

abstract：:Monomers of the genomic strand of hepatitis delta virus RNA were transcribed in vitro and then delivered to NIH 3T3 fibroblasts by using a liposome fusion technique. After 7 days, genome replication was detected, but only in fibroblasts that stably expressed the delta antigen. Sequence analysis of the replicated produ...

journal_title：Journal of virology

authors： Glenn JS,Taylor JM,White JM

更新日期：1990-06-01 00:00:00

abstract：:Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either r...

journal_title：Journal of virology

authors： Netterwald JR,Jones TR,Britt WJ,Yang SJ,McCrone IP,Zhu H

更新日期：2004-06-01 00:00:00

abstract：:The EICP0 protein of equine herpesvirus 1 (EHV-1) is an early, viral regulatory protein that independently trans-activates EHV-1 immediate-early (IE), early, gamma1 late, and gamma2 late promoters. To assess whether this powerful trans-activator functions in conjunction with three other EHV-1 regulatory proteins to ac...

journal_title：Journal of virology

authors： Bowles DE,Kim SK,O'Callaghan DJ

更新日期：2000-02-01 00:00:00

abstract：:Vaccinia virus (VACV) stimulates long-term immunity against highly pathogenic orthopoxvirus infection of humans (smallpox) and mice (mousepox [ectromelia virus {ECTV}]) despite the lack of a natural host-pathogen relationship with either of these species. Previous research revealed that VACV is able to induce polyfunc...

journal_title：Journal of virology

authors： Hersperger AR,Siciliano NA,Eisenlohr LC

更新日期：2012-07-01 00:00:00

abstract：:Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines constitutively produce high levels of biologically active lymphotoxin (LT; tumor necrosis factor-beta) protein and LT mRNA. To understand the regulation of LT transcription by HTLV-I, we analyzed the ability of a series of deletions of the LT promoter t...

journal_title：Journal of virology

authors： Paul NL,Lenardo MJ,Novak KD,Sarr T,Tang WL,Ruddle NH

更新日期：1990-11-01 00:00:00

abstract：:In this study, we characterized the viral determinants of coreceptor usage in relation to susceptibility to antibody-mediated neutralization or enhancement of infectivity by using chimeras of three highly related human immunodeficiency virus type 1 (HIV-1) isolates of different phenotypes. We found that the V3 region ...

journal_title：Journal of virology

authors： Guillon C,Schutten M,Boers PH,Gruters RA,Osterhaus AD

更新日期：2002-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) contains two membrane-associated envelope glycoproteins, E1 and E2, which assemble as a heterodimer in the endoplasmic reticulum (ER). In this study, predictive algorithms and genetic analyses of deletion mutants and glycosylation site variants of the E1 glycoprotein were used to suggest that t...

journal_title：Journal of virology

authors： Nakai K,Okamoto T,Kimura-Someya T,Ishii K,Lim CK,Tani H,Matsuo E,Abe T,Mori Y,Suzuki T,Miyamura T,Nunberg JH,Moriishi K,Matsuura Y

更新日期：2006-11-01 00:00:00