Abstract:
:In this study, we characterized the viral determinants of coreceptor usage in relation to susceptibility to antibody-mediated neutralization or enhancement of infectivity by using chimeras of three highly related human immunodeficiency virus type 1 (HIV-1) isolates of different phenotypes. We found that the V3 region was the main determinant of antibody-mediated enhancement and coreceptor specificity but that the overall structure of gp120 was also important for these properties. Constructs susceptible to antibody-mediated enhancement preferentially use CCR5 as a coreceptor, in contrast to constructs that were neutralized or not affected. Using monoclonal antibodies directed against CD4 or CCR5, we were able to show that antibody-mediated enhancement was CD4 dependent. Altogether, our results suggest that the modulation of the interaction of gp120 with CCR5 is the mechanism underlying antibody-mediated enhancement of HIV-1 infectivity.
journal_name
J Viroljournal_title
Journal of virologyauthors
Guillon C,Schutten M,Boers PH,Gruters RA,Osterhaus ADdoi
10.1128/jvi.76.6.2827-2834.2002subject
Has Abstractpub_date
2002-03-01 00:00:00pages
2827-34issue
6eissn
0022-538Xissn
1098-5514journal_volume
76pub_type
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doi:10.1128/jvi.74.21.10112-10121.2000
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pub_type: 杂志文章
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journal_title:Journal of virology
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.69.9.5362-5367.1995
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.53.2.430-439.1985
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pub_type: 杂志文章
doi:10.1128/JVI.73.5.4239-4250.1999
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.2.1250-1254.1994
更新日期:1994-02-01 00:00:00
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journal_title:Journal of virology
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doi:10.1128/JVI.42.1.131-134.1982
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doi:10.1128/JVI.50.2.666-669.1984
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.48.1.18-30.1983
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1968-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.6.4043-4048.1994
更新日期:1994-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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