Egress of light particles among filopodia on the surface of Varicella-Zoster virus-infected cells.

abstract：:Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampered the development of appropriate antiviral therapies. Here we show that the NoV NS3 protein, derived from murine NoV (MNV), is intimately associated with the MNV replication complex and the...

journal_title：Journal of virology

authors： Cotton BT,Hyde JL,Sarvestani ST,Sosnovtsev SV,Green KY,White PA,Mackenzie JM

更新日期：2017-01-18 00:00:00

abstract：:Development of a vaccine for the common cold has been thwarted by the fact that there are more than 100 serotypes of human rhinovirus (HRV). We previously demonstrated that the HRV14 capsid is dynamic and transiently displays the buried N termini of viral protein 1 (VP1) and VP4. Here, further evidence for this "breat...

journal_title：Journal of virology

authors： Katpally U,Fu TM,Freed DC,Casimiro DR,Smith TJ

更新日期：2009-07-01 00:00:00

abstract：:While a diversity of immunogens that elicit qualitatively different cellular immune responses are being assessed in clinical human immunodeficiency virus vaccine trials, the consequences of those varied responses for viral control remain poorly understood. In the present study, we evaluated the induction of virus-spec...

journal_title：Journal of virology

authors： Sun Y,Santra S,Schmitz JE,Roederer M,Letvin NL

更新日期：2008-09-01 00:00:00

abstract：:The herpesvirus saimiri (HVS) immediate-early gene product encoded by open reading frame (ORF) 57 shares limited amino acid homology with HSV-1 ICP27 and Epstein-Barr virus BMLF1, both regulatory proteins. The ORF 57 gene has been proposed to be spliced based on the genome sequence, and here we confirm the intron-exon...

journal_title：Journal of virology

authors： Whitehouse A,Cooper M,Meredith DM

更新日期：1998-01-01 00:00:00

abstract：:Nevirapine forms the mainstay of our efforts to curtail the pediatric AIDS epidemic through prevention of mother-to-child transmission of HIV-1. A key limitation, however, is the rapid selection of HIV-1 strains resistant to nevirapine following the administration of a single dose. This rapid selection of resistance s...

journal_title：Journal of virology

authors： Gadhamsetty S,Dixit NM

更新日期：2010-10-01 00:00:00

abstract：:The RNA elements that are required for replication of defective interfering (DI) RNA of the JHM strain of mouse hepatitis virus (MHV) consist of three discontinuous genomic regions: about 0.46 to 0.47 kb from both terminal sequences and an internal 58-nucleotide (nt)-long sequence (58-nt region) present at about 0.9 k...

journal_title：Journal of virology

authors： Repass JF,Makino S

更新日期：1998-10-01 00:00:00

abstract：:Protocols have been established for the preparation of large amounts of pure measles virus intracellular nucleocapsids. As a result, it has been possible to routinely achieve nucleocapsid RNA yields of approximately 200 micrograms (from approximately 5 X 10(8) infected cells). Electrophoretic analysis of this RNA unde...

journal_title：Journal of virology

authors： Udem SA,Cook KA

更新日期：1984-01-01 00:00:00

abstract：UNLABELLED:Human metapneumovirus (HMPV), a recently discovered paramyxovirus, infects nearly 100% of the world population and causes severe respiratory disease in infants, the elderly, and immunocompromised patients. We previously showed that HMPV binds heparan sulfate proteoglycans (HSPGs) and that HMPV binding requir...

journal_title：Journal of virology

authors： Klimyte EM,Smith SE,Oreste P,Lembo D,Dutch RE

更新日期：2016-09-29 00:00:00

abstract：:Recent studies suggest the existence of cancer stem cells (CSC) and cancer progenitor cells (CPC), although strict definitions of neither CSC nor CPC have been developed. We have produced evidence that the principal oncoprotein of Epstein-Barr virus (EBV), latent membrane protein 1 (LMP1), which is associated with hum...

journal_title：Journal of virology

authors： Kondo S,Wakisaka N,Muramatsu M,Zen Y,Endo K,Murono S,Sugimoto H,Yamaoka S,Pagano JS,Yoshizaki T

更新日期：2011-11-01 00:00:00

abstract：UNLABELLED:The possibility that vaccination with adenovirus (AdV) vectors increased mucosal T cell activation remains a central hypothesis to explain the potential enhancement of HIV acquisition within the Step trial. Modeling this within rhesus macaques is complicated because human adenoviruses, including human adenov...

journal_title：Journal of virology

authors： Bukh I,Calcedo R,Roy S,Carnathan DG,Grant R,Qin Q,Boyd S,Ratcliffe SJ,Veeder CL,Bellamy SL,Betts MR,Wilson JM

更新日期：2014-08-01 00:00:00

abstract：:The sole immediate-early (IE) gene of equine herpesvirus 1 encodes a 1,487-amino-acid (aa) regulatory phosphoprotein that independently activates expression of early viral genes. Coimmunoprecipitation assays demonstrated that the IE protein physically interacts with the general transcription factor TFIIB. Using a vari...

journal_title：Journal of virology

authors： Jang HK,Albrecht RA,Buczynski KA,Kim SK,Derbigny WA,O'Callaghan DJ

更新日期：2001-11-01 00:00:00

abstract：:To study the function of the varicella-zoster virus (VZV) gB cytoplasmic domain during viral infection, we produced a VZV recombinant virus that expresses a truncated form of gB lacking the C-terminal 36 amino acids of its cytoplasmic domain (VZV gB-36). VZV gB-36 replicates in noncomplementing cells and grows at a ra...

journal_title：Journal of virology

authors： Heineman TC,Hall SL

更新日期：2002-01-01 00:00:00

abstract：UNLABELLED:Cell culture (cc)-derived hepatitis B virus (HBV) can infect differentiated HepaRG cells, but efficient infection requires addition of polyethylene glycol (PEG) during inoculation. Identification of sodium taurocholate cotransporting polypeptide (NTCP) as an HBV receptor enabled ccHBV infection of NTCP recon...

journal_title：Journal of virology

authors： Li J,Zong L,Sureau C,Barker L,Wands JR,Tong S

更新日期：2016-08-26 00:00:00

abstract：:Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) causes acute lung injury (ALI) that often leads to severe lung disease. A mouse model of acute SARS-CoV infection has been helpful in understanding the host response to infection; however, there are still unanswered questions concerning SARS-CoV p...

journal_title：Journal of virology

authors： Page C,Goicochea L,Matthews K,Zhang Y,Klover P,Holtzman MJ,Hennighausen L,Frieman M

更新日期：2012-12-01 00:00:00

abstract：:Mixed infection of a cell by vesicular stomatitis virus (VSV) and retroviruses results in the production of progeny virions bearing the genome of one virus encapsidated by the envelope proteins of the other. The mechanism for the phenomenon of pseudotype formation is not clear, although specific recognition of a viral...

journal_title：Journal of virology

authors： Emi N,Friedmann T,Yee JK

更新日期：1991-03-01 00:00:00

abstract：:Measles virus (MeV) infection is characterized by the formation of multinuclear giant cells (MGC). We report that beta interferon (IFN-beta) production is amplified in vitro by the formation of virus-induced MGC derived from human epithelial cells or mature conventional dendritic cells. Both fusion and IFN-beta respon...

journal_title：Journal of virology

authors： Herschke F,Plumet S,Duhen T,Azocar O,Druelle J,Laine D,Wild TF,Rabourdin-Combe C,Gerlier D,Valentin H

更新日期：2007-12-01 00:00:00

abstract：:Rotavirus is the major cause of diarrhea among young infants in both humans and animals. Immune protection of newborns by vaccination is difficult to achieve since there is not enough time to mount an immune response before exposure to the virus. We have designed a vaccination strategy mediating transfer of neutralizi...

journal_title：Journal of virology

authors： Coste A,Sirard JC,Johansen K,Cohen J,Kraehenbuhl JP

更新日期：2000-10-01 00:00:00

abstract：UNLABELLED:Next-generation sequence analysis of virus-like particles (VLPs) produced during agroinfiltration of cucumber necrosis virus (CNV) coat protein (CP) and of authentic CNV virions was conducted to assess if host RNAs can be encapsidated by CNV CP. VLPs containing host RNAs were found to be produced during agro...

journal_title：Journal of virology

authors： Ghoshal K,Theilmann J,Reade R,Maghodia A,Rochon D

更新日期：2015-11-01 00:00:00

abstract：:Koala retrovirus (KoRV) is of an interest to virologists due to its currently active endogenization into the koala (Phascolarctos cinereus) genome. Although KoRV has frequently been isolated in wild and captive koala populations, its pathogenesis and transmission remain to be fully characterized, and most previous res...

journal_title：Journal of virology

authors： Hashem MA,Maetani F,Kayesh MEH,Eiei T,Mochizuki K,Ito A,Sakurai H,Asai T,Tsukiyama-Kohara K

更新日期：2020-05-18 00:00:00

abstract：:Proliferation responses of naïve CD4(+) T cells to T-cell receptor and interleukin-7 (IL-7) stimulation were evaluated by using cells from human immunodeficiency virus-positive (HIV(+)) donors. IL-7 enhanced responses to T-cell receptor stimulation, and the magnitude of this enhancement was similar in cells from healt...

journal_title：Journal of virology

authors： Bazdar DA,Sieg SF

更新日期：2007-11-01 00:00:00

abstract：:A host-mediated RNA-editing event allows hepatitis delta virus (HDV) to express two essential proteins, the small delta antigen (HDAg-S) and the large delta antigen (HDAg-L), from a single open reading frame. One or several members of the ADAR (adenosine deaminases that act on RNA) family are thought to convert the ad...

journal_title：Journal of virology

authors： Sato S,Wong SK,Lazinski DW

更新日期：2001-09-01 00:00:00

abstract：UNLABELLED:Recent experiments suggest that some glycoprotein (GP)-specific monoclonal antibodies (MAbs) can protect experimental animals against the filovirus Ebola virus (EBOV). There is a need for isolation of MAbs capable of neutralizing multiple filoviruses. Antibody neutralization assays for filoviruses frequently...

journal_title：Journal of virology

authors： Ilinykh PA,Shen X,Flyak AI,Kuzmina N,Ksiazek TG,Crowe JE Jr,Bukreyev A

更新日期：2016-03-28 00:00:00

abstract：UNLABELLED:Herpes simplex virus 1 (HSV-1) and HSV-2 are among the most prevalent human pathogens. Both viruses can recognize, via the surface envelope glycoprotein D (gD), human nectin-1 as a functional receptor. Previous studies have successfully elucidated the molecular basis of the binding between HSV-1 gD and necti...

journal_title：Journal of virology

authors： Lu G,Zhang N,Qi J,Li Y,Chen Z,Zheng C,Gao GF,Yan J

更新日期：2014-12-01 00:00:00

abstract：UNLABELLED:Virions vary in size by at least 4 orders of magnitude, yet the evolutionary forces responsible for this enormous diversity are unknown. We document a significant allometric relationship, with an exponent of approximately 1.5, between the genome length and virion volume of viruses and find that this relation...

journal_title：Journal of virology

authors： Cui J,Schlub TE,Holmes EC

更新日期：2014-06-01 00:00:00

abstract：:Vaccinia virus maturation into infectious particles appears to be dependent on the proteolytic processing of at least five viral proteins, each containing a conserved AG*X cleavage motif and each requiring proper association with the previrion particle. To identify the responsible proteinase, a transcriptionally contr...

journal_title：Journal of virology

authors： Whitehead SS,Hruby DE

更新日期：1994-11-01 00:00:00

abstract：UNLABELLED:Retargeting of gammaretroviral envelope proteins has shown promising results in the isolation of novel isolates with therapeutic potential. However, the optimal conditions required to obtain high-affinity retargeted envelope proteins with narrow tropism are not understood. This study highlights the advantage...

journal_title：Journal of virology

authors： Valdivieso-Torres L,Sarangi A,Whidby J,Marcotrigiano J,Roth MJ

更新日期：2015-12-30 00:00:00

abstract：:Since HIV-1 replication is modulated at multiple stages by host cell factors, identification and characterization of those host cell factors are expected to contribute to the development of novel anti-HIV therapeutics. Previous studies showed that a C-terminally truncated cytosolic form of cleavage and polyadenylation...

journal_title：Journal of virology

authors： Hori T,Takeuchi H,Saito H,Sakuma R,Inagaki Y,Yamaoka S

更新日期：2013-07-01 00:00:00

abstract：UNLABELLED:The HIV-1 envelope protein (Env) is heavily glycosylated, with approximately 50% of the Env molecular mass being contributed by N-glycans. HIV-1 Env N-glycans shield the protein backbone and have been shown to play key roles in determining Env structure, surface exposure, and, consequently, antigenicity, inf...

journal_title：Journal of virology

authors： Shen R,Raska M,Bimczok D,Novak J,Smith PD

更新日期：2014-12-01 00:00:00

abstract：UNLABELLED:Venezuelan equine encephalitis virus (VEEV) is an important human and animal pathogen, for which no safe and efficient vaccines or therapeutic means have been developed. Viral particle assembly and budding processes represent potential targets for therapeutic intervention. However, our understanding of the m...

journal_title：Journal of virology

authors： Reynaud JM,Lulla V,Kim DY,Frolova EI,Frolov I

更新日期：2015-12-09 00:00:00

abstract：:Primary RNA transcripts from the human immunodeficiency virus type 1 (HIV-1) are processed into mature mRNA by a complex series of splicing events. Viral structural proteins and reverse transcriptase are translated from unspliced or singly spliced transcripts. Proteins which control virus replication, including tat, r...

journal_title：Journal of virology

authors： Robert-Guroff M,Popovic M,Gartner S,Markham P,Gallo RC,Reitz MS

更新日期：1990-07-01 00:00:00