Contributions to transcriptional activity and to viral leukemogenicity made by sequences within and downstream of the MCF13 murine leukemia virus enhancer.

abstract：:Treatment of influenza virus and its purified hemagglutining with glycosidases from Diplococcus pneumoniae, which included beta-galactosidase, beta-N-acetylglucosminidase, and endoglycosidase D, released amino and neutral sugars from the virus and these as well as large oligosaccharides from the purified hemagglutinin...

journal_title：Journal of virology

authors： Collins JK,Knight CA

更新日期：1978-07-01 00:00:00

abstract：:Persistent hepatitis B virus (HBV) infection is characterized by a weak and narrowly focused CD8+ T-cell response to HBV that is thought to reflect the induction of central and/or peripheral tolerance to HBV proteins in neonatal and adult onset infections, respectively. Immunotherapeutic strategies that overcome toler...

journal_title：Journal of virology

authors： Kakimi K,Isogawa M,Chung J,Sette A,Chisari FV

更新日期：2002-09-01 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV) is a human gammaherpesvirus with latent and lytic reactivation cycles. The mechanism by which KSHV evades the innate immune system to establish latency has not yet been precisely elucidated. Toll-like receptors (TLRs) are the first line of defense against viral ...

journal_title：Journal of virology

authors： Zhao Q,Liang D,Sun R,Jia B,Xia T,Xiao H,Lan K

更新日期：2015-01-01 00:00:00

abstract：:We have previously shown that alpha/beta interferon (IFN-alpha/beta) and IFN-gamma inhibit hepatitis B virus (HBV) replication noncytopathically in the livers of HBV transgenic mice and in hepatocyte cell lines derived from these mice. The present study was designed to identify transcriptionally controlled hepatocellu...

journal_title：Journal of virology

authors： Wieland SF,Vega RG,Müller R,Evans CF,Hilbush B,Guidotti LG,Sutcliffe JG,Schultz PG,Chisari FV

更新日期：2003-01-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (gammaHV68; also known as MHV-68) can establish a latent infection in both inbred and outbred strains of mice and, as such, provides a tractable small-animal model to address mechanisms and cell types involved in the establishment and maintenance of chronic gammaherpesvirus infection. Latenc...

journal_title：Journal of virology

authors： Willer DO,Speck SH

更新日期：2003-08-01 00:00:00

abstract：:Long-acting antiretrovirals could provide a useful alternative to daily oral therapy for HIV-1-infected individuals. Building on a bi-specific molecule with adnectins targeting CD4 and gp41, a potential long-acting biologic, GSK3732394, was developed with three independent and synergistic modes of HIV entry inhibition...

journal_title：Journal of virology

authors： Wensel D,Sun Y,Davis J,Li Z,Zhang S,McDonagh T,Langley D,Mitchell T,Tabruyn S,Nef P,Cockett M,Krystal M

更新日期：2019-09-30 00:00:00

abstract：:F111 rat cells transformed by simian virus 40 mutant tsA1499 are cold sensitive for the expression of transformation. Yet, unlike F111 cells transformed by tsA58, they do not lose the ability to stabilize the transformation-associated host cell protein p53 at the temperature at which transformation is extinguished. ...

journal_title：Journal of virology

authors： Bouck N,Fikes J,Rundell MK

更新日期：1984-03-01 00:00:00

abstract：:The Epstein-Barr virus oriP, when examined with the use of in vitro nucleosome reconstitution, was found to exhibit a partial sparing of nucleosome assembly within the 3' dyad. Analysis of the homologous region containing the origin of replication of herpesvirus papio disclosed that sparing of nucleosome assembly was ...

journal_title：Journal of virology

authors： Sexton CJ,Pagano JS

更新日期：1989-12-01 00:00:00

abstract：:Proteins located in the tegument layer of herpesvirus particles play important roles in the replicative cycle at both early and late times after infection. As major constituents of the virion, they execute important functions in particular during formation of progeny virions. These functions have mostly been elucidate...

journal_title：Journal of virology

authors： Michael K,Klupp BG,Mettenleiter TC,Karger A

更新日期：2006-02-01 00:00:00

abstract：:The Hsp70 chaperone plays a central role in multiple processes within cells, including protein translation, folding, intracellular trafficking, and degradation. This protein is implicated in the replication of numerous viruses. We have shown that rabies virus infection induced the cellular expression of Hsp70, which a...

journal_title：Journal of virology

authors： Lahaye X,Vidy A,Fouquet B,Blondel D

更新日期：2012-05-01 00:00:00

abstract：:HLA-B*57 is strongly associated with immune control of HIV and delayed AIDS progression. The closely related, but less protective, HLA-B*58:01 presents similar epitopes, but HLA-B*58:01(+) individuals do not generate CD8(+) T cells targeting the KF11-Gag epitope, which has been linked to low viremia. Here we show that...

journal_title：Journal of virology

authors： Kløverpris HN,Stryhn A,Harndahl M,Payne R,Towers GJ,Chen F,Riddell L,Walker BD,Ndung'u T,Leslie A,Buus S,Goulder P

更新日期：2013-10-01 00:00:00

abstract：:Herpesviruses encode a set of core proteins essential for lytic replication of their genomes. Three of these proteins form a tripartite helix-primase complex that, in the case of Epstein-Barr virus (EBV), consists of the helicase BBLF4, the primase BSLF1, and the linker protein BBLF2/3. BBLF2/3 and its homologs in the...

journal_title：Journal of virology

authors： Liao G,Huang J,Fixman ED,Hayward SD

更新日期：2005-01-01 00:00:00

abstract：:Human norovirus (HuNoV) is a major causative agent of food-borne gastroenteritis worldwide. Currently, there are no vaccines or effective therapeutic interventions for this virus. Development of an attenuated vaccine for HuNoV has been hampered by the inability to grow the virus in cell culture. Thus, a vector-based v...

journal_title：Journal of virology

authors： Ma Y,Li J

更新日期：2011-03-01 00:00:00

abstract：:We have developed a high-throughput sequencing (HTS) workflow for investigating paramyxovirus transcription and replication. We show that sequencing of oligo(dT)-selected polyadenylated mRNAs, without considering the orientation of the RNAs from which they had been generated, cannot accurately be used to analyze the a...

journal_title：Journal of virology

authors： Wignall-Fleming EB,Hughes DJ,Vattipally S,Modha S,Goodbourn S,Davison AJ,Randall RE

更新日期：2019-08-13 00:00:00

abstract：:Chikungunya virus (CHIKV), a mosquito-borne alphavirus, has traditionally circulated in Africa and Asia, causing human febrile illness accompanied by severe, chronic joint pain. In Africa, epidemic emergence of CHIKV involves the transition from an enzootic, sylvatic cycle involving arboreal mosquito vectors and nonhu...

journal_title：Journal of virology

authors： Volk SM,Chen R,Tsetsarkin KA,Adams AP,Garcia TI,Sall AA,Nasar F,Schuh AJ,Holmes EC,Higgs S,Maharaj PD,Brault AC,Weaver SC

更新日期：2010-07-01 00:00:00

abstract：:We propose that a nucleotide template-based mechanism facilitates the acquisition of the K65R mutation in subtype C human immunodeficiency virus type 1 (HIV-1). Different patterns of DNA synthesis were observed using DNA templates from viruses of subtype B or C origin. When subtype C reverse transcriptase (RT) was emp...

journal_title：Journal of virology

authors： Coutsinos D,Invernizzi CF,Xu H,Moisi D,Oliveira M,Brenner BG,Wainberg MA

更新日期：2009-02-01 00:00:00

abstract：:Retroviruses have been isolated from the tissues of human leukemia patients. Previous studies have shown that these isolates share some antigenic determinants with the family of viruses isolated from the woolly monkey and gibbon ape and that they exhibit partial nuclei acid homology with this same group of viruses. We...

journal_title：Journal of virology

authors： Sahagan BG,Haseltine WA

更新日期：1980-05-01 00:00:00

abstract：:The mammalian APOBEC3 family of cytidine deaminases includes members that can act as potent inhibitors of retroviral infectivity and retrotransposon mobility. Here, we have examined whether the alpharetrovirus Rous sarcoma virus (RSV) is susceptible to inhibition by a range of human APOBEC3 proteins. We report that RS...

journal_title：Journal of virology

authors： Wiegand HL,Cullen BR

更新日期：2007-12-01 00:00:00

abstract：:The protein product of the v-myb oncogene of avian myeloblastosis virus, p48v-myb, differs structurally in several ways from its normal cellular homolog, p75c-myb. We demonstrated that the 11 specific amino acid substitutions found in two independent molecular clones of this virus were not required for the transformat...

journal_title：Journal of virology

authors： Stober-Grässer U,Lipsick JS

更新日期：1988-03-01 00:00:00

abstract：:Transcription of herpesviral late genes is stimulated after the onset of viral DNA replication but otherwise restricted. Late gene expression in gammaherpesviruses requires the coordination of six early viral proteins, termed viral transactivation factors (vTFs). Here, we mapped the organization of this protein comple...

journal_title：Journal of virology

authors： Davis ZH,Hesser CR,Park J,Glaunsinger BA

更新日期：2015-10-14 00:00:00

abstract：:Partial deletion of the second hypervariable region from the envelope of the primary-like SF162 virus increases the exposure of certain neutralization epitopes and renders the virus, SF162DeltaV2, highly susceptible to neutralization by clade B and non-clade B human immunodeficiency virus (HIV-positive) sera (L. Stama...

journal_title：Journal of virology

authors： Barnett SW,Lu S,Srivastava I,Cherpelis S,Gettie A,Blanchard J,Wang S,Mboudjeka I,Leung L,Lian Y,Fong A,Buckner C,Ly A,Hilt S,Ulmer J,Wild CT,Mascola JR,Stamatatos L

更新日期：2001-06-01 00:00:00

abstract：:Molluscum contagiosum virus (MCV), the only member of the Molluscipoxvirus genus, causes benign papules in healthy people but disfiguring lesions in immunocompromised patients. The sequence of MCV has been completed, revealing that MCV encodes a probable type I topoisomerase enzyme. All poxviruses sequenced to date al...

journal_title：Journal of virology

authors： Hwang Y,Wang B,Bushman FD

更新日期：1998-04-01 00:00:00

abstract：:Rio Bravo virus (RBV) is a member of the family Flaviviridae, genus Flavivirus. It belongs to a group of viruses in the genus with no known vector. In this report, we analyze the complete genome of the prototype RBV, strain M64. ...

journal_title：Journal of virology

authors： Volkova E,Tesh RB,Monath TP,Vasilakis N

更新日期：2012-04-01 00:00:00

abstract：:We characterized human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) isolated from two HIV-1-infected CCR5delta32 homozygotes. Envs from both subjects used CCR5 and CXCR4 for entry into transfected cells. Most R5X4 Envs were lymphocyte-tropic and used CXCR4 exclusively for entry into peripheral bl...

journal_title：Journal of virology

authors： Gray L,Churchill MJ,Keane N,Sterjovski J,Ellett AM,Purcell DF,Poumbourios P,Kol C,Wang B,Saksena NK,Wesselingh SL,Price P,French M,Gabuzda D,Gorry PR

更新日期：2006-04-01 00:00:00

abstract：UNLABELLED:Recent evidence suggests that even in treated infections, human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication may continue in lymph nodes (LN), serving as a potential virus reservoir. Here we investigated the effects of lentivirus infection on natural killer (NK) cell frequ...

journal_title：Journal of virology

authors： Schafer JL,Li H,Evans TI,Estes JD,Reeves RK

更新日期：2015-07-01 00:00:00

abstract：:Nucleic acids from an unidentified virus from ringed seals (Phoca hispida) were amplified using sequence-independent PCR, subcloned, and then sequenced. The full genome of a novel RNA virus was derived, identifying the first sequence-confirmed picornavirus in a marine mammal. The phylogenetic position of the tentative...

journal_title：Journal of virology

authors： Kapoor A,Victoria J,Simmonds P,Wang C,Shafer RW,Nims R,Nielsen O,Delwart E

更新日期：2008-01-01 00:00:00

abstract：:Several transgenic mouse models have been developed which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain discrimination. The present study was designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536(+/-), to bovine spongiform encephalopathy (BS...

journal_title：Journal of virology

authors： Vickery CM,Lockey R,Holder TM,Thorne L,Beck KE,Wilson C,Denyer M,Sheehan J,Marsh S,Webb PR,Dexter I,Norman A,Popescu E,Schneider A,Holden P,Griffiths PC,Plater JM,Dagleish MP,Martin S,Telling GC,Simmons MM,Spiro

更新日期：2014-02-01 00:00:00

abstract：:Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) disease is associated with an increased viral burden in the peripheral blood and a loss of circulating CD4+ T cells. HIV-1 isolates obtained prior to this stage of disease often have a "slow-low," non-syncytium-inducing (NSI) phenotype, whereas thos...

journal_title：Journal of virology

authors： Kaneshima H,Su L,Bonyhadi ML,Connor RI,Ho DD,McCune JM

更新日期：1994-12-01 00:00:00

abstract：:Treatment of [3H]glucosamine-labeled Friend mink cell focus-forming virus (FrMCF) gp70 with excess peptide:N-glycanase F (PNGase F) resulted in removal of the expected seven N-linked oligosaccharide chains; however, approximately 10% of the glucosamine label was retained in the resulting 49,000-Mr (49K) product. For [...

journal_title：Journal of virology

authors： Pinter A,Honnen WJ

更新日期：1988-03-01 00:00:00

abstract：:Previous studies with a limited number of strains have indicated that there are two genotypes of yellow fever (YF) virus in Africa, one in west Africa and the other in east and central Africa. We have examined the prM/M and a portion of the E protein for a panel of 38 wild strains of YF virus from Africa representing ...

journal_title：Journal of virology

authors： Mutebi JP,Wang H,Li L,Bryant JE,Barrett AD

更新日期：2001-08-01 00:00:00