Abstract:
:Integrins mediate cell adhesion and motility on the extracellular matrix, yet they also promote viral attachment and/or entry. Evidence is presented that adenovirus internalization by alpha(v) integrins requires activation of phosphoinositide-3-OH kinase (PI3K), whereas alpha(v) integrin-mediated cell motility depends on the ERK1/ERK2 mitogen-activated protein kinase pathway. Interaction of adenovirus with alpha(v), integrins induced activation of PI3K. Pharmacologic or genetic disruption of endogenous PI3K activity blocked adenovirus internalization and virus-mediated gene delivery yet had no effect on integrin-mediated cell adhesion or motility. Therefore, integrin ligation engages distinct signaling pathways that promote viral endocytosis or cell movement.
journal_name
J Viroljournal_title
Journal of virologyauthors
Li E,Stupack D,Klemke R,Cheresh DA,Nemerow GRdoi
10.1128/JVI.72.3.2055-2061.1998subject
Has Abstractpub_date
1998-03-01 00:00:00pages
2055-61issue
3eissn
0022-538Xissn
1098-5514journal_volume
72pub_type
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