Abstract:
:The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is a potent activator of viral transcription. Tax also activates the expression of specific cellular genes involved in the control of T-lymphocyte growth via effects on cellular transcription factors, including members of the NF-kappaB/cRel family. Immunocytochemistry and electron microscopy were used to characterize the intracellular localization of Tax and identify cellular factors which are the potential targets for its transcriptional activity. These studies indicated that Tax localizes in discrete nuclear foci in T lymphocytes transformed by HTLV-1 and in cells transduced with Tax expression vectors. The Tax-containing foci are complex nuclear structures comprising a central core in which Tax colocalizes with splicing factor Sm. In addition to splicing factors Sm and SC-35, the Tax-containing nuclear structures also contain transcriptional components, including the largest subunit of RNA polymerase II and cyclin-dependent kinase CDK8. The inclusion of the two subunits of NF-kappaB, p50 and RelA, and the presence of the mRNA from a gene specifically activated by Tax through NF-kappaB binding sites suggest that these unique nuclear structures participate in Tax-mediated activation of gene expression via the NF-kappaB pathway.
journal_name
J Viroljournal_title
Journal of virologyauthors
Bex F,McDowall A,Burny A,Gaynor Rdoi
10.1128/JVI.71.5.3484-3497.1997subject
Has Abstractpub_date
1997-05-01 00:00:00pages
3484-97issue
5eissn
0022-538Xissn
1098-5514journal_volume
71pub_type
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pub_type: 杂志文章
doi:10.1128/JVI.70.4.2420-2430.1996
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2015-12-09 00:00:00
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pub_type: 杂志文章
doi:10.1128/jvi.76.24.12940-12950.2002
更新日期:2002-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.67.5.2716-2722.1993
更新日期:1993-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.51.3.776-787.1984
更新日期:1984-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01044-08
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.68.9.5365-5374.1994
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1996-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.12.9803-9807.1997
更新日期:1997-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
abstract::The tsB5 mutant of herpes simplex virus type 1 (HSV-1) strain HFEM was shown previously to be temperature sensitive for accumulation of the mature form of glycoprotein gB, for production or activity of a factor required in virus-induced cell fusion, and for production of virions with normal levels of infectivity. In a...
journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1980-07-01 00:00:00