Purification and chemistry of bacteriophage chi.

abstract：:Some of the properties of a new human papovavirus, BK, have been examined. Host range studies of BK virus (BKV) showed human cells to be more sensitive to infection than monkey cells; human fetal brain cells appear to be highly sensitive to BKV, with the production of extensive cytopathology characterized by cytoplasm...

journal_title：Journal of virology

authors： Takemoto KK,Mullarkey MF

更新日期：1973-09-01 00:00:00

abstract：:A bacteriophage with a contractile tail which shows very similar features to R-type pyocins was isolated and characterized. This phage, named PS17,was purified by DEAE-cellulose chromatography and CsCl density gradient centrifugation. It was a DNA-containing phage, and the density of the purified particles in CsCl was...

journal_title：Journal of virology

authors： Kageyama M,Shinomiya T,Aihara Y,Kobayashi M

更新日期：1979-12-01 00:00:00

abstract：:It has been suggested that vaccination prior to infection may direct the mutational evolution of human immunodeficiency virus type 1 (HIV-1) to a less fit virus, resulting in an attenuated course of disease. The present study was initiated to explore whether prior immunization might prevent the reversion of the virus ...

journal_title：Journal of virology

authors： Manuel ER,Yeh WW,Balachandran H,Clarke RH,Lifton MA,Letvin NL

更新日期：2010-12-01 00:00:00

abstract：:The DNA sequence of 3,240 nucleotides of the XbaI G fragment located in the unique long (UL) region of the equine herpesvirus 1 genome revealed two major open reading frames (ORFs) designated UL3 and UL4. The UL3 ORF of 470 amino acids (aa) maps at nucleotides (nt) 4450 to 3038 from the long terminus, and its predicte...

journal_title：Journal of virology

authors： Zhao Y,Holden VR,Harty RN,O'Callaghan DJ

更新日期：1992-09-01 00:00:00

abstract：:Identification of cellular receptors used by coronavirus (CoV) entry into the host cells is critical to an understanding of pathogenesis and to development of intervention strategies. The fourth CoV genus, Deltacoronavirus, evolutionarily related to the Gammacoronavirus, has just been defined recently. In the current ...

journal_title：Journal of virology

authors： Wang B,Liu Y,Ji CM,Yang YL,Liang QZ,Zhao P,Xu LD,Lei XM,Luo WT,Qin P,Zhou J,Huang YW

更新日期：2018-05-29 00:00:00

abstract：:Viral transcription and replication of Ebola virus (EBOV) is balanced by transcription factor VP30, an RNA binding protein. An RNA hairpin at the transcription start site (TSS) of the first gene (NP hairpin) in the 3'-leader promoter is thought to mediate the VP30 dependency of transcription. Here, we investigated the...

journal_title：Journal of virology

authors： Bach S,Demper JC,Grünweller A,Becker S,Biedenkopf N,Hartmann RK

更新日期：2020-12-02 00:00:00

abstract：UNLABELLED:The HIV-1 envelope glycoprotein (Env) is a trimer of gp120-gp41 heterodimers and is essential for viral entry. The gp41 subunit in native, prefusion trimeric Env exists in a metastable conformation and attains a stable six-helix bundle (6-HB) conformation comprised of a trimer of N-heptad repeat (NHR) and C-...

journal_title：Journal of virology

authors： Kesavardhana S,Varadarajan R

更新日期：2014-09-01 00:00:00

abstract：:Infection of the central nervous system (CNS) by several viruses can lead to upregulation of proinflammatory cytokines and chemokines. In immunocompetent adults, these molecules induce prominent inflammatory infiltrates. However, with immunosuppressive retroviruses, such as human immunodeficiency virus (HIV), little C...

journal_title：Journal of virology

authors： Peterson KE,Robertson SJ,Portis JL,Chesebro B

更新日期：2001-03-01 00:00:00

abstract：:Structural proteins of temperature-sensitive (ts) mutants of vesicular stomatitis virus, Indiana serotype, were compared with those of wild-type and revertant virions by electrophoresis on polyacrylamide gels of partial digests with Staphylococcus aureus V8 protease. Mutants of complementation groups III (tsG31 and ts...

journal_title：Journal of virology

authors： Metzel PS,Reichmann ME

更新日期：1981-01-01 00:00:00

abstract：:Recruitment and extravasation of T cells through the blood-brain barrier are favored by adhesion molecule-mediated interactions of circulating T cells with endothelial cells. Since a common pathological finding in human T-cell leukemia virus type 1 (HTLV-1)-associated diseases is the infiltration of HTLV-1-infected T ...

journal_title：Journal of virology

authors： Valentin H,Lemasson I,Hamaia S,Cassé H,König S,Devaux C,Gazzolo L

更新日期：1997-11-01 00:00:00

abstract：:Strong determinants of the host range of influenza A viruses have been identified on the polymerase complex formed by the PB1, PB2, and PA subunits and on the nucleoprotein (NP). In the present study, molecular mechanisms that may involve these four core proteins and contribute to the restriction of avian influenza vi...

journal_title：Journal of virology

authors： Rameix-Welti MA,Tomoiu A,Dos Santos Afonso E,van der Werf S,Naffakh N

更新日期：2009-02-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) is a common human pathogen that causes lifelong latent infection of sensory neurons. Non-nucleoside inhibitors that can limit HSV-1 recurrence are particularly useful in treating immunocompromised individuals or cases of emerging acyclovir-resistant strains of herpesvirus. We report that...

journal_title：Journal of virology

authors： Lin LT,Chen TY,Chung CY,Noyce RS,Grindley TB,McCormick C,Lin TC,Wang GH,Lin CC,Richardson CD

更新日期：2011-05-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) isolates derived directly from clinical samples are usually unable to grow in cytokine-independent continuous cell lines, thus hindering the study of their biological features and their sensitivity to humoral and cellular protective immunity. To overcome these limitations, w...

journal_title：Journal of virology

authors： Lusso P,Cocchi F,Balotta C,Markham PD,Louie A,Farci P,Pal R,Gallo RC,Reitz MS Jr

更新日期：1995-06-01 00:00:00

abstract：:Among the numerous immunological abnormalities observed in chronically human immunodeficiency virus (HIV)-infected individuals, perturbations in memory CD4 T cells are thought to contribute specifically to disease pathogenesis. Among these, functional imbalances in the frequencies of T regulatory cells (Tregs) and int...

journal_title：Journal of virology

authors： Lai SH,Starke CE,Flynn JK,Vinton CL,Ortiz AM,Mudd JC,Brenchley JM

更新日期：2019-04-17 00:00:00

abstract：:The herpes simplex virus type 1 UL6 protein forms a 12-subunit ring structure at a unique capsid vertex which functions as a conduit for encapsidation of the viral genome. To characterize UL6 protein domains that are involved in intersubunit interactions and interactions with other capsid proteins, we engineered a set...

journal_title：Journal of virology

authors： Nellissery JK,Szczepaniak R,Lamberti C,Weller SK

更新日期：2007-09-01 00:00:00

abstract：:It has previously been shown that: (i) during infection of its host, the DNA bacteriophage T7 assembles a DNA-free procapsid (capsid I), a capsid with an envelope differing physically and chemically from the capsid of the mature bacteriophage, and (ii) capsid I converts to a capsid (capsid II) with a bacteriophage-lik...

journal_title：Journal of virology

authors： Serwer P,Watson RH,Hayes SJ

更新日期：1982-05-01 00:00:00

abstract：:In this study, we document that efficient interaction between arenavirus nucleoprotein (NP) and RNA-dependent RNA polymerase (L protein), the two trans-acting viral factors required for both virus RNA replication and gene transcription, requires the presence of virus-specific RNA sequences located within the untransla...

journal_title：Journal of virology

authors： Iwasaki M,Ngo N,Cubitt B,de la Torre JC

更新日期：2015-05-01 00:00:00

abstract：:Closed circular unintegrated DNA of the SEATO strain of gibbon ape leukemia virus (GaLV-S) was isolated from canine thymus fibroblasts after cocultivation with chronically infected bat lung fibroblasts. Restriction endonuclease HindIII cleaves GaLV-S DNA once, thus allowing isolation and cloning of HindIII-digested un...

journal_title：Journal of virology

authors： Gelmann EP,Trainor CD,Wong-Staal F,Reitz MS

更新日期：1982-10-01 00:00:00

abstract：:To explore the roles played by specific human immunodeficiency virus type 1 (HIV-1) genes in determining the in vivo replicative capacity of AIDS viruses, we have examined the replication kinetics and virus-specific immune responses in rhesus monkeys following infection with two chimeric simian/human immunodeficiency ...

journal_title：Journal of virology

authors： Reimann KA,Li JT,Voss G,Lekutis C,Tenner-Racz K,Racz P,Lin W,Montefiori DC,Lee-Parritz DE,Lu Y,Collman RG,Sodroski J,Letvin NL

更新日期：1996-05-01 00:00:00

abstract：:The distantly related lentiviruses human immunodeficiency virus type 1 (HIV-1) and visna virus each encode a posttranscriptional regulatory protein, termed Rev, that is critical for expression of the viral structural proteins. We genetically mapped the cis-acting target sequence for visna virus Rev, the visna virus Re...

journal_title：Journal of virology

authors： Tiley LS,Cullen BR

更新日期：1992-06-01 00:00:00

abstract：:A DNA vaccine plasmid containing the Japanese encephalitis (JE) virus premembrane (prM) and envelope (E) genes (designated pcDNA3JEME) was evaluated for immunogenicity and protective efficacy in mice. Two immunizations of 4-week-old female ICR mice with pcDNA3JEME by intramuscular or intradermal injections at a dose o...

journal_title：Journal of virology

authors： Konishi E,Yamaoka M,Khin-Sane-Win,Kurane I,Mason PW

更新日期：1998-06-01 00:00:00

abstract：:Domains required late in the virus budding process (L domains) have been identified in the Gag proteins of a number of retroviruses. Here we show that the human T-cell leukemia virus type 1 candidate L domain motif PPPY is indeed required for virus production. Strikingly, however, mutation of this motif arrested virus...

journal_title：Journal of virology

authors： Le Blanc I,Prévost MC,Dokhélar MC,Rosenberg AR

更新日期：2002-10-01 00:00:00

abstract：:Recently, it was demonstrated that the coxsackievirus B3 variant PD (CVB3 PD) is able to infect coxsackievirus-adenovirus receptor (CAR)-lacking cells by using heparan sulfates (HS) as additional receptors (A. E. Zautner, U. Korner, A. Henke, C. Badorff, and M. Schmidtke, J. Virol. 77:10071-10077, 2003). For this stud...

journal_title：Journal of virology

authors： Zautner AE,Jahn B,Hammerschmidt E,Wutzler P,Schmidtke M

更新日期：2006-07-01 00:00:00

abstract：:Severe complications of Zika virus (ZIKV) infection might be caused by inflammation, but how ZIKV induces proinflammatory cytokines is not understood. In this study, we show opposite regulatory effects of the ZIKV NS5 protein on interferon (IFN) signaling. Whereas ZIKV and its NS5 protein were potent suppressors of ty...

journal_title：Journal of virology

authors： Chaudhary V,Yuen KS,Chan JF,Chan CP,Wang PH,Cai JP,Zhang S,Liang M,Kok KH,Chan CP,Yuen KY,Jin DY

更新日期：2017-06-26 00:00:00

abstract：:Simian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV) infections lead to rapid depletion of CD4(+) T cells from gut-associated lymphoid tissue (GALT). Although the administration of antiretroviral therapy (ART) has been shown to increase CD4(+) T-cell levels in the peripheral blood in both SIV and...

journal_title：Journal of virology

authors： George MD,Reay E,Sankaran S,Dandekar S

更新日期：2005-03-01 00:00:00

abstract：:Adenovirus types 5 and 3 (Ad5 and Ad3), two human adenovirus serotypes of evolutionarily divergent subgroups, show very different levels of E1A gene expression early after infection of permissive cells. Since adenovirus E1A gene expression is known to be transcriptionally autoregulated, we have investigated the differ...

journal_title：Journal of virology

authors： Jones SN,Tibbetts C

更新日期：1989-04-01 00:00:00

abstract：:The enhancer within the long terminal repeats (LTRs) of acquired somatic mouse mammary tumor viruses (MMTV) can activate juxtaposed genes and induce mammary tumors. In contrast, germ line proviral MMTV genomes are integrated in the host genome and considered to be genetically confined transcription units. Here we demo...

journal_title：Journal of virology

authors： Stegalkina SS,Guerrero A,Walton KD,Liu X,Robinson GW,Hennighausen L

更新日期：1999-10-01 00:00:00

abstract：:Dactylosporangiophage A1 has a polygonal head (75 nm) with spherical capsomeres (3 nm) and a noncontractile tail (200 by 10 nm) with cross-striations which is terminated with at least three prongs which are used for attachment. It contains double-stranded deoxyribonucleic acid and produces very little lysis. Intracell...

journal_title：Journal of virology

authors： Higgins ML,Lechevalier MP

更新日期：1969-02-01 00:00:00

abstract：:The interaction of the human immunodeficiency virus (HIV) Gag protein with the plasma membrane of a cell is a critical event in the assembly of HIV particles. The matrix protein region (MA) of HIV type 1 (HIV-1) Pr55Gag has previously been demonstrated to confer membrane-binding properties on the precursor polyprotein...

journal_title：Journal of virology

authors： Spearman P,Horton R,Ratner L,Kuli-Zade I

更新日期：1997-09-01 00:00:00

abstract：:Antibodies against CCR5, the major coreceptor for human immunodeficiency virus type 1 (HIV-1), may have antiviral potential as viral fusion inhibitors. In this study, we generated a virus-like particle (VLP)-based vaccine that effectively breaks B-cell tolerance and elicits autoantibodies against CCR5 in pig-tailed ma...

journal_title：Journal of virology

authors： Chackerian B,Briglio L,Albert PS,Lowy DR,Schiller JT

更新日期：2004-04-01 00:00:00