The zinc finger antiviral protein directly binds to specific viral mRNAs through the CCCH zinc finger motifs.

abstract：:We have reinvestigated the subcellular distribution of the duck hepatitis B virus (DHBV) core protein in infected duck hepatocytes and in transfected cells. By using indirect immunofluorescence, the protein was found to be localized not only in the cytoplasm, as described previously, but also within the cell nucleus, ...

journal_title：Journal of virology

authors： Mabit H,Knaust A,Breiner KM,Schaller H

更新日期：2003-02-01 00:00:00

abstract：:Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a gammaherpesvirus of mice, is transmitted sexually. We show that this depends on the major virion envelope glycoprotein gp150. gp...

journal_title：Journal of virology

authors： Zeippen C,Javaux J,Xiao X,Ledecq M,Mast J,Farnir F,Vanderplasschen A,Stevenson P,Gillet L

更新日期：2017-06-09 00:00:00

abstract：:Nine pre-early polypeptides have been detected after infection with bacteriophage T5 and 10 pre-early polypeptides have been detected after infection with bacteriophage BF23. Only about one-half of the coding capacity of the redundant ends of the phage DNA, which code for pre-early proteins, is needed for these 9 to 1...

journal_title：Journal of virology

authors： McCorquodale DJ,Shaw AR,Shaw PK,Chinnadurai G

更新日期：1977-05-01 00:00:00

abstract：:The prevailing hypothesis is that the intracellular site of budding of coronaviruses is determined by the localization of its membrane protein M (previously called E1). We tested this by analyzing the site of budding of four different coronaviruses in relation to the intracellular localization of their M proteins. Mou...

journal_title：Journal of virology

authors： Klumperman J,Locker JK,Meijer A,Horzinek MC,Geuze HJ,Rottier PJ

更新日期：1994-10-01 00:00:00

abstract：:Grasshoppers, Melanoplus sanguinipes (F.), infected with the grasshopper inclusion body virus (GIBV) showed a general torpor, took longer to develop, and had abnormally high rates of mortality. Infection was found only in the fat body, and developing viruses and inclusion bodies were observed in the nuclei and cytopla...

journal_title：Journal of virology

authors： Henry JE,Nelson BP,Jutila JW

更新日期：1969-06-01 00:00:00

abstract：:In intact Madin-Darby canine kidney (MDCK) cell monolayers, vesicular stomatitis virus (VSV) matures only at basolateral membranes beneath tight junctions, whereas influenza virus buds from apical cell surfaces. Early in the growth cycle, the viral glycoproteins are restricted to the membrane domain from which each vi...

journal_title：Journal of virology

authors： Roth MG,Compans RW

更新日期：1981-12-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a ubiquitously distributed pathogen that causes severe disease in immunosuppressed patients and newborn infants infected in utero. The viral envelope glycoprotein B (gB) is an attractive molecule for active vaccination and passive immunoprophylaxis and therapy. Using human monoclonal an...

journal_title：Journal of virology

authors： Spindler N,Rücker P,Pötzsch S,Diestel U,Sticht H,Martin-Parras L,Winkler TH,Mach M

更新日期：2013-08-01 00:00:00

abstract：:Pancreatic islets from DBA/2 mice infected with the D variant of encephalomyocarditis (EMC-D) virus revealed lymphocytic infiltration with moderate to severe destruction of pancreatic beta cells. Our previous studies showed that the major population of infiltrating cells at the early stages of infection is macrophages...

journal_title：Journal of virology

authors： Hirasawa K,Jun HS,Maeda K,Kawaguchi Y,Itagaki S,Mikami T,Baek HS,Doi K,Yoon JW

更新日期：1997-05-01 00:00:00

abstract：:Hypoviruses Cryphonectria hypovirus 1 (CHV-1)/EP713, CHV-1/Euro7, and CHV-1/EP721, which infect the chestnut blight fungus Cryphonectria parasitica, differ in their degrees of virulence attenuation (hypovirulence), symptom expression, and viral RNA accumulation, even though they share between 90% and 99% amino acid se...

journal_title：Journal of virology

authors： Zhang X,Shi D,Nuss DL

更新日期：2012-12-01 00:00:00

abstract：:Inhibition of hepatitis B virus (HBV) replication and viral clearance from an infected host requires both the innate and adaptive immune responses. Expression of interferon (IFN)-inducible proteasome catalytic and regulatory subunits correlates with the IFN-alpha/beta- and IFN-gamma-mediated noncytopathic inhibition o...

journal_title：Journal of virology

authors： Robek MD,Garcia ML,Boyd BS,Chisari FV

更新日期：2007-01-01 00:00:00

abstract：:Adeno-associated virus (AAV) integrates very efficiently into a specific site (AAVS1) of human chromosome 19. Two elements of the AAV genome are sufficient: the inverted terminal repeats (ITRs) and the Rep78 or Rep68 protein. The incorporation of the AAV integration machinery in nonviral delivery systems is of great i...

journal_title：Journal of virology

authors： Lamartina S,Roscilli G,Rinaudo D,Delmastro P,Toniatti C

更新日期：1998-09-01 00:00:00

abstract：:The fate of polyomavirus genomes in stable transformants was examined in experiments in which rat or hamster cells were infected with mixed viral populations containing either two distinguishable wild types or a wild type plus a transformation-deficient mutant. The results demonstrate that in 90% of the cases in eithe...

journal_title：Journal of virology

authors： Oh SY,Amalfitano A,Friderici K,Chen MC,Fluck MM

更新日期：1990-03-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Nef interferes with the endocytic machinery to modulate the cell surface expression of CD4. However, the basal trafficking of CD4 is governed by different rules in the target cells of HIV-1: whereas CD4 is rapidly internalized from the cell surface in myeloid cells, CD4 is s...

journal_title：Journal of virology

authors： Laguette N,Brégnard C,Bouchet J,Benmerah A,Benichou S,Basmaciogullari S

更新日期：2009-07-01 00:00:00

abstract：:"L-cell virion," obtained from chronically infected 929 L-cell lines, was purified on 70% sucrose pads and its ribonucleic acid (RNA) was extracted and analyzed on sucrose gradients. Two RNA components were isolated from the virion, a rapidly sedimenting species (82S) and a more slowly sedimenting species (6S). When t...

journal_title：Journal of virology

authors： Faras AJ,Erikson RL

更新日期：1969-07-01 00:00:00

abstract：:Receptors (FcgammaRs) for the constant region of immunoglobulin G (IgG) are an important link between humoral immunity and cellular immunity. To help define the role of FcgammaRs in determining the fate of human immunodeficiency virus type 1 (HIV-1) immune complexes, cDNAs for the four major human Fcgamma receptors (F...

journal_title：Journal of virology

authors： Perez LG,Costa MR,Todd CA,Haynes BF,Montefiori DC

更新日期：2009-08-01 00:00:00

abstract：:CD4+ T-cell depletion in AIDS patients involves induction of apoptosis in human immunodeficiency virus (HIV)-infected and noninfected T cells. The HIV type 1 (HIV-1)-transactivating protein Tat enhances apoptosis and activation-induced cell death (AICD) of human T cells. This effect is mediated by the CD95 (APO-1/Fas)...

journal_title：Journal of virology

authors： Ehret A,Westendorp MO,Herr I,Debatin KM,Heeney JL,Frank R,Krammer PH

更新日期：1996-09-01 00:00:00

abstract：:Parvovirus capsids are small but complex molecular machines responsible for undertaking many of the steps of cell infection, genome packing, and cell-to-cell as well as host-to-host transfer. The details of parvovirus infection of cells are still not fully understood, but the processes must involve small changes in th...

journal_title：Journal of virology

authors： Callaway HM,Feng KH,Lee DW,Allison AB,Pinard M,McKenna R,Agbandje-McKenna M,Hafenstein S,Parrish CR

更新日期：2017-01-03 00:00:00

abstract：:RNA silencing is a conserved eukaryotic gene regulatory system in which sequence specificity is determined by small RNAs. Plant RNA silencing also acts as an antiviral mechanism; therefore, viral infection requires expression of a silencing suppressor. The mechanism and the evolution of silencing suppression are still...

journal_title：Journal of virology

authors： Mérai Z,Kerényi Z,Molnár A,Barta E,Válóczi A,Bisztray G,Havelda Z,Burgyán J,Silhavy D

更新日期：2005-06-01 00:00:00

abstract：:New zonal centrifuges can conveniently process as much as five orders of magnitude (10(5)) greater sample volumes than conventional swinging-bucket rotors. The continuous-sample-flow-with-banding versions may be used in series with ancillary purification procedures. Here we have studied the combined process: absorptio...

journal_title：Journal of virology

authors： Reimer CB,Baker RS,Van Frank RM,Newlin TE,Cline GB,Anderson NG

更新日期：1967-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) can infect nondividing cells productively because the nuclear import of viral nucleic acids occurs in the absence of cell division. A number of viral factors that are present in HIV-1 preintegration complexes (PICs) have been assigned functions in nuclear import, including a...

journal_title：Journal of virology

authors： Dvorin JD,Bell P,Maul GG,Yamashita M,Emerman M,Malim MH

更新日期：2002-12-01 00:00:00

abstract：:Gene transfer to differentiated airway epithelia with existing viral vectors is very inefficient when they are applied to the apical surface. This largely reflects the polarized distribution of receptors on the basolateral surface. To identify new receptor-ligand interactions that might be used to redirect vectors to ...

journal_title：Journal of virology

authors： Wang G,Deering C,Macke M,Shao J,Burns R,Blau DM,Holmes KV,Davidson BL,Perlman S,McCray PB Jr

更新日期：2000-10-01 00:00:00

abstract：:A mutation that disrupts the interaction between the NS2 protein of minute virus of mice and the nuclear export factor Crm1 results in a block to egress of mutant-generated full virions from the nucleus of infected murine cells. These mutants produce wild-type levels of monomer and dimer replicative DNA forms but are ...

journal_title：Journal of virology

authors： Miller CL,Pintel DJ

更新日期：2002-04-01 00:00:00

abstract：:Reovirus encephalitis in mice was used as a model system to investigate astrocyte activation (astrogliosis) following viral infection of the brain. Reovirus infection resulted in astrogliosis, as evidenced by increased expression of glial fibrillary acidic protein (GFAP), and the upregulation of genes that have been p...

journal_title：Journal of virology

authors： Clarke P,Zhuang Y,Berens HM,Leser JS,Tyler KL

更新日期：2019-05-01 00:00:00

abstract：:The v-src coding region was deleted from cloned Rous sarcoma virus DNA, and the deleted clones were tested for infectivity by transfection. All of the coding region, as well as most of the sequences lying between v-src and the unique 3' region (U3), could be deleted without affecting viability. However, at least 9 and...

journal_title：Journal of virology

authors： Sorge J,Hughes SH

更新日期：1982-08-01 00:00:00

abstract：:Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of nanobodies (Nbs) to target lentiv...

journal_title：Journal of virology

authors： Goyvaerts C,Dingemans J,De Groeve K,Heirman C,Van Gulck E,Vanham G,De Baetselier P,Thielemans K,Raes G,Breckpot K

更新日期：2013-10-01 00:00:00

abstract：:To assess the heterogeneity of cytotoxic T lymphocytes (CTLs) directed against viral epitopes, we studied six class I major histocompatibility complex-restricted (H-2Db) CTL clones that recognize the same 9-amino-acid immunodominant epitope, amino acids 278 to 286 from envelope glycoprotein 2 (GP2) of lymphocytic chor...

journal_title：Journal of virology

authors： Joly E,Salvato M,Whitton JL,Oldstone MB

更新日期：1989-05-01 00:00:00

abstract：:In order to analyze the function of VPg amplification in aphthoviruses, we have undertaken the first mutational analysis of the repetitive VPg-coding region using an improved foot-and-mouth disease virus (FMDV) cDNA clone from which infective viral RNA was synthesized. A set of VPg mutants was constructed by site-dire...

journal_title：Journal of virology

authors： Falk MM,Sobrino F,Beck E

更新日期：1992-04-01 00:00:00

abstract：:Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. In this study, we have analyzed nucleotide sequences encompassing 629 bp at the carboxy terminus of the G glycoprotein gene for HRSV subgr...

journal_title：Journal of virology

authors： Zlateva KT,Lemey P,Vandamme AM,Van Ranst M

更新日期：2004-05-01 00:00:00

abstract：:In order to clarify the effect of an accumulation of amino acid substitutions on the hemadsorption character of the influenza AH3 virus hemagglutinin (HA) protein, we introduced single-point amino acid changes into the HA1 domain of the HA proteins of influenza viruses isolated in 1968 (A/Aichi/2/68) and 1997 (A/Sydne...

journal_title：Journal of virology

authors： Nakajima K,Nobusawa E,Nagy A,Nakajima S

更新日期：2005-05-01 00:00:00

abstract：:Vaccinia virus J1R protein is required for virion morphogenesis (W. L. Chiu and W. Chang, J. Virol. 76:9575-9587, 2002). In this work, we further characterized the J1R protein of wild-type vaccinia virus and compared it with the protein encoded by the temperature-sensitive mutant virus Cts45. The mutant Cts45 was foun...

journal_title：Journal of virology

authors： Chiu WL,Szajner P,Moss B,Chang W

更新日期：2005-07-01 00:00:00