Low probability of double integration in transformation of nonpermissive cells by polyomavirus.

abstract：:The tetrameric paramyxovirus hemagglutinin-neuraminidase (HN) protein mediates attachment to sialic acid-containing receptors as well as cleavage of the same moiety via its neuraminidase (NA) activity. The X-ray crystallographic structure of an HN dimer from Newcastle disease virus (NDV) suggests that a single site in...

journal_title：Journal of virology

authors： Corey EA,Mirza AM,Levandowsky E,Iorio RM

更新日期：2003-06-01 00:00:00

abstract：:The E1A gene of highly oncogenic type 12 adenovirus (Ad12) possesses a segment unique to this serotype and comprising 60 base pairs contiguous with and separating conserved regions 2 and 3 in the gene. A similar but slightly longer segment is also present in the E1A gene of highly oncogenic simian adenovirus type 7 (D...

journal_title：Journal of virology

authors： Telling GC,Williams J

更新日期：1994-02-01 00:00:00

abstract：:A new group of nucleocytoplasmic shuttling proteins has recently been identified in the structural proteins encoded by several alphaherpesvirus UL47 genes. Nuclear import and export signals for the bovine herpesvirus type 1 UL47 protein (VP8 or bUL47) have been described previously. Here, we study the trafficking of b...

journal_title：Journal of virology

authors： Verhagen J,Donnelly M,Elliott G

更新日期：2006-10-01 00:00:00

abstract：:The hemagglutinin of fowl plague virus has been expressed in Spodoptera frugiperda (Sf9) cells and in Estigmene acrea cells by using a baculovirus vector. Structural analysis revealed that the endo-H-resistant N-glycans of HA from Sf9 cells were predominantly trimannosyl core oligosaccharides, whereas in E. acrea cell...

journal_title：Journal of virology

authors： Wagner R,Geyer H,Geyer R,Klenk HD

更新日期：1996-06-01 00:00:00

abstract：:Measles virus (MV) interacts with cellular receptors on the surface of peripheral blood lymphocytes (PBL) which mediate virus binding and uptake. Simultaneously, the direct contact of the viral glycoproteins with the cell surface induces a negative signal blocking progression to the S phase of the cell cycle, resultin...

journal_title：Journal of virology

authors： Erlenhoefer C,Wurzer WJ,Löffler S,Schneider-Schaulies S,ter Meulen V,Schneider-Schaulies J

更新日期：2001-05-01 00:00:00

abstract：:West Nile virus (WNV) is a human pathogen that can cause neurological disorders, including meningoencephalitis. Experiments with mice and mammalian cell cultures revealed that WNV exhibited resistance to the innate immune program induced by alpha interferon (IFN-alpha). We have investigated the nature of this inhibiti...

journal_title：Journal of virology

authors： Guo JT,Hayashi J,Seeger C

更新日期：2005-02-01 00:00:00

abstract：:Endogenous retroviruses, records of past retroviral infections, are ubiquitous in vertebrate genomes. On occasion, vertebrate hosts have co-opted retroviral genes for their own biological functions. Here, we perform a phylogenomic survey of retroviral gag gene homologs within vertebrate genomes and identify two ancien...

journal_title：Journal of virology

authors： Wang J,Gong Z,Han GZ

更新日期：2019-06-28 00:00:00

abstract：:Herpes simplex virus (HSV) glycoprotein B (gB) is an integral part of the multicomponent fusion system required for virus entry and cell-cell fusion. Here we investigated the mechanism of viral neutralization by the monoclonal antibody (MAb) 2c, which specifically recognizes the gB of HSV type 1 (HSV-1) and HSV-2. Bin...

journal_title：Journal of virology

authors： Krawczyk A,Krauss J,Eis-Hübinger AM,Däumer MP,Schwarzenbacher R,Dittmer U,Schneweis KE,Jäger D,Roggendorf M,Arndt MA

更新日期：2011-02-01 00:00:00

abstract：:The E2 gene products of papillomavirus play key roles in viral replication, both as regulators of viral transcription and as auxiliary factors that act with E1 in viral DNA replication. We have carried out a detailed structure-function analysis of conserved amino acids within the N-terminal domain of the human papillo...

journal_title：Journal of virology

authors： Sakai H,Yasugi T,Benson JD,Dowhanick JJ,Howley PM

更新日期：1996-03-01 00:00:00

abstract：:Bovine papilloma virus (BPV) appears to be the etiological agent of common equine connective tissue tumors. We investigated the physical state of the viral DNA within such tumors and found no indication for integration into the host genome. The BPV genomes were present as free circular episomes. Two equine sarcoids we...

journal_title：Journal of virology

authors： Amtmann E,Müller H,Sauer G

更新日期：1980-09-01 00:00:00

abstract：:We observed two patterns of chemokine expression in the lungs of mice infected with murine gammaherpesvirus 68: peaks of chemokine expression correlated with or occurred after the peak of viral gene expression. Chemokine expression remained elevated through 29 days postinfection. ...

journal_title：Journal of virology

authors： Weinberg JB,Lutzke ML,Efstathiou S,Kunkel SL,Rochford R

更新日期：2002-10-01 00:00:00

abstract：UNLABELLED:Human metapneumovirus (HMPV), a recently discovered paramyxovirus, infects nearly 100% of the world population and causes severe respiratory disease in infants, the elderly, and immunocompromised patients. We previously showed that HMPV binds heparan sulfate proteoglycans (HSPGs) and that HMPV binding requir...

journal_title：Journal of virology

authors： Klimyte EM,Smith SE,Oreste P,Lembo D,Dutch RE

更新日期：2016-09-29 00:00:00

abstract：:Herpes simplex virus (HSV)-infected cells can activate the human complement system without interference of specific anti-HSV antibodies. Analysis by flow cytometry showed that C3-like molecules were deposited on the membrane of the infected cell when incubated with human serum without specific antibodies. Depletion of...

journal_title：Journal of virology

authors： van Strijp JA,van Kessel KP,Miltenburg LA,Fluit AC,Verhoef J

更新日期：1988-03-01 00:00:00

abstract：:The human cyclin T1 (hCycT1) protein from the positive transcription elongation factor b (P-TEFb) binds the transactivator Tat and the transactivation response (TAR) RNA stem loop from human immunodeficiency virus type 1 (HIV). This complex activates the elongation of viral transcription. To create effective inhibitor...

journal_title：Journal of virology

authors： Fujinaga K,Irwin D,Geyer M,Peterlin BM

更新日期：2002-11-01 00:00:00

abstract：:Using a yeast two-hybrid screen of a T-cell cDNA library to identify cellular proteins that bind to the human immunodeficiency virus type 2 (HIV-2) Gag polyprotein, we identified PRP4, a serine-threonine protein kinase. Specific interaction of PRP4 and HIV-2 Gag was confirmed in in vitro and in vivo assays. The intera...

journal_title：Journal of virology

authors： Bennett EM,Lever AM,Allen JF

更新日期：2004-10-01 00:00:00

abstract：:The E7 proteins of human papillomaviruses (HPVs) promote S-phase reentry in differentiated keratinocytes of the squamous epithelia to support viral DNA amplification. In this study, we showed that nuclear p130 was present in the differentiated strata of several native squamous epithelia susceptible to HPV infection. I...

journal_title：Journal of virology

authors： Genovese NJ,Banerjee NS,Broker TR,Chow LT

更新日期：2008-05-01 00:00:00

abstract：:Arenaviruses can cause lethal hemorrhagic fevers in humans with few preventative and therapeutic measures. The arenaviral glycoprotein stable signal peptide (SSP) is unique among signal peptides in that it is an integral component of the mature glycoprotein complex (GPC) and plays important roles not only in GPC expre...

journal_title：Journal of virology

authors： Shao J,Liu X,Ly H,Liang Y

更新日期：2016-10-28 00:00:00

abstract：:The development of neoplasia frequently involves inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways and disruption of cell cycle checkpoints that monitor the integrity of replication and cell division. The human papillomavirus type 16 (HPV-16) oncoproteins, E6 and E7, have been shown to bind p53...

journal_title：Journal of virology

authors： Martin LG,Demers GW,Galloway DA

更新日期：1998-02-01 00:00:00

abstract：:Infection of cells with herpes simplex virus type 1 (HSV-1) induces high levels of deoxypyrimidine triphosphatase. The majority of the enzyme activity is found in infected cell nuclei. A similar activity is induced by HSV type 2 (HSV-2) which, in contrast to the HSV-1 enzyme, fractionates to more than 99% in the solub...

journal_title：Journal of virology

authors： Wohlrab F,Garrett BK,Francke B

更新日期：1982-09-01 00:00:00

abstract：:The degree of genetic variability in the hypervariable region 1 of hepatitis C virus (HCV) was analyzed by cloning and sequencing HCV genomes obtained in paired samples of serum, liver tissue, and peripheral blood mononuclear cells (PBMC) from four chronic hepatitis C patients. Genetic variability in serum was higher ...

journal_title：Journal of virology

authors： Navas S,Martín J,Quiroga JA,Castillo I,Carreño V

更新日期：1998-02-01 00:00:00

abstract：:A general theme that has emerged from studies of DNA tumor viruses is that otherwise unrelated oncoproteins encoded by these viruses often target the same important cellular factors. Major oncogenic determinants for human adenovirus type 9 (Ad9) and high-risk human papillomaviruses (HPV) are the E4-ORF1 and E6 oncopro...

journal_title：Journal of virology

authors： Lee SS,Glaunsinger B,Mantovani F,Banks L,Javier RT

更新日期：2000-10-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) genome contains three origins of DNA replication, one copy of oriL and two copies of oriS. Although oriL and oriS are structurally different, they have extensive nucleotide sequence similarity and can substitute for each other to initiate viral DNA replication. A fundamental que...

journal_title：Journal of virology

authors： Hardwicke MA,Schaffer PA

更新日期：1997-05-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) Tat protein has a critical role in viral transcription, but this study focuses on its additional role as an extracellular effector of lymphocyte cell death. It is well known that Tat induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in peripheral blood mononu...

journal_title：Journal of virology

authors： Yang Y,Tikhonov I,Ruckwardt TJ,Djavani M,Zapata JC,Pauza CD,Salvato MS

更新日期：2003-06-01 00:00:00

abstract：UNLABELLED:Several innate sensing pathways contribute to the control of early cytomegalovirus (CMV) infection, leading to a multiphasic type I interferon (IFN-I) response that limits viral replication and promotes host defenses. Toll-like receptor (TLR)-dependent pathways induce IFN-I production in CMV-infected plasmac...

journal_title：Journal of virology

authors： Lio CW,McDonald B,Takahashi M,Dhanwani R,Sharma N,Huang J,Pham E,Benedict CA,Sharma S

更新日期：2016-08-12 00:00:00

abstract：:The host structural maintenance of chromosomes 5/6 complex (Smc5/6) suppresses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing the X protein (HBx), which redirects the cellular DNA damage-binding protein 1 (DDB1)-containing E3 ubiquitin ligase to target Smc5/6 for degradation. Howeve...

journal_title：Journal of virology

authors： Ramakrishnan D,Xing W,Beran RK,Chemuru S,Rohrs H,Niedziela-Majka A,Marchand B,Mehra U,Zábranský A,Doležal M,Hubálek M,Pichová I,Gross ML,Kwon HJ,Fletcher SP

更新日期：2019-07-30 00:00:00

abstract：:Secondary cultures of chicken embryo fibroblasts were infected with the Schmidt Ruppin strain of Rous sarcoma virus (RSV). Five days after infection, the medium was replaced at 2-h intervals with phosphate-free Eagle medium containing 50 muCi of [32P]orthophosphate per ml. Virus was collected by centrifugation, and th...

journal_title：Journal of virology

authors： Jacobson AB,Bromley PA

更新日期：1975-01-01 00:00:00

abstract：:Varicella-zoster virus DNA was digested with 11 restriction endonucleases, and the resulting fragments were separated on agarose gels. Terminal fragments were identified by lambda exonuclease digestion. Physical maps were then constructed using a combination of double restriction enzyme digestion and hybridization to ...

journal_title：Journal of virology

authors： Mishra L,Dohner DE,Wellinghoff WJ,Gelb LD

更新日期：1984-05-01 00:00:00

abstract：:The complement pathway is involved in eliminating antigen immune complexes. However, the role of the C3 complement system remains largely unknown in influenza virus M2 extracellular (M2e) domain or hemagglutinin (HA) vaccine-mediated protection after vaccination. Using a C3 knockout (C3 KO) mouse model, we found that ...

journal_title：Journal of virology

authors： Kim YJ,Kim KH,Ko EJ,Kim MC,Lee YN,Jung YJ,Lee YT,Kwon YM,Song JM,Kang SM

更新日期：2018-09-26 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) gp41 plays a critical role in the viral fusion process, and its N- and C-terminal heptad repeat domains serve as important targets for developing anti-HIV-1 drugs, like T-20 (generic name, enfuvirtide; brand name, Fuzeon). Here, we conducted a yeast two-hybrid screening on a...

journal_title：Journal of virology

authors： Zhu Y,Lu L,Xu L,Yang H,Jiang S,Chen YH

更新日期：2010-09-01 00:00:00

abstract：:The ability of human immunodeficiency virus type 1 (HIV-1) to transduce nondividing cells is key to infecting terminally differentiated macrophages, which can serve as a long-term reservoir of HIV-1 infection. The mutation N57A in the viral CA protein renders HIV-1 cell cycle dependent, allowing examination of HIV-1 i...

journal_title：Journal of virology

authors： Fischer DK,Saito A,Kline C,Cohen R,Watkins SC,Yamashita M,Ambrose Z

更新日期：2019-04-17 00:00:00