Coronavirus M proteins accumulate in the Golgi complex beyond the site of virion budding.

abstract：:Recent evidence supports a role for vitamin K-dependent coagulation zymogens in adenovirus serotype 5 (Ad5, subgroup C) infection of hepatocytes. Here, we assessed the effect of virus-zymogen interaction on cellular transduction using a panel of fiber (f)-pseudotyped viruses derived from subgroup D (f47, f33, f24, f45...

journal_title：Journal of virology

authors： Parker AL,McVey JH,Doctor JH,Lopez-Franco O,Waddington SN,Havenga MJ,Nicklin SA,Baker AH

更新日期：2007-04-01 00:00:00

abstract：:Two forms of herpes simplex virus glycoprotein gD were recombined into Autographa californica nuclear polyhedrosis virus (baculovirus) and expressed in infected Spodoptera frugiperda (Sf9) cells. Each protein was truncated at residue 306 of mature gD. One form, gD-1(306t), contains the coding sequence of Patton strain...

journal_title：Journal of virology

authors： Sisk WP,Bradley JD,Leipold RJ,Stoltzfus AM,Ponce de Leon M,Hilf M,Peng C,Cohen GH,Eisenberg RJ

更新日期：1994-02-01 00:00:00

abstract：:Retroviral Gag proteins have the ability to induce budding and particle release from the plasma membrane when expressed in the absence of all of the other virus-encoded components; however, the locations of the functional domains within the Gag protein that are important for this process are poorly understood. It was ...

journal_title：Journal of virology

authors： Weldon RA Jr,Wills JW

更新日期：1993-09-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of the aggressive and fatal disease adult T-cell leukemia. Previous studies have demonstrated that the HTLV-1-encoded Tax protein inhibits the function of tumor suppressor p53 through a Tax-induced NF-kappaB pathway. Given these attributes, we were int...

journal_title：Journal of virology

authors： Jung KJ,Dasgupta A,Huang K,Jeong SJ,Pise-Masison C,Gurova KV,Brady JN

更新日期：2008-09-01 00:00:00

abstract：:Nucleic acids from an unidentified virus from ringed seals (Phoca hispida) were amplified using sequence-independent PCR, subcloned, and then sequenced. The full genome of a novel RNA virus was derived, identifying the first sequence-confirmed picornavirus in a marine mammal. The phylogenetic position of the tentative...

journal_title：Journal of virology

authors： Kapoor A,Victoria J,Simmonds P,Wang C,Shafer RW,Nims R,Nielsen O,Delwart E

更新日期：2008-01-01 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus type 1 (HIV-1) infection in the central nervous system (CNS) is characterized by replication in macrophages or brain microglia that express low levels of the CD4 receptor and is the cause of HIV-associated dementia and related cognitive and motor disorders that affect 20 to 30% o...

journal_title：Journal of virology

authors： Zhuang K,Leda AR,Tsai L,Knight H,Harbison C,Gettie A,Blanchard J,Westmoreland S,Cheng-Mayer C

更新日期：2014-08-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) infection results in the disruption of ND10 (also called nuclear bodies, PODs, or PML-associated bodies), which are nuclear matrix domains of unknown function present in mammalian cells. After ND10 disruption, viral transcription and DNA replication occur in globular nuclear domains...

journal_title：Journal of virology

authors： Burkham J,Coen DM,Weller SK

更新日期：1998-12-01 00:00:00

abstract：:The pathogenesis of Epstein-Barr virus (EBV) infection, including development of lymphomas and carcinomas, is dependent on the ability of the virus to transit from latency to the lytic phase. This conversion, and ultimately disease development, depends on the molecular switch protein, ZEBRA, a viral bZIP transcription...

journal_title：Journal of virology

authors： Weber E,Buzovetsky O,Heston L,Yu KP,Knecht KM,El-Guindy A,Miller G,Xiong Y

更新日期：2019-06-28 00:00:00

abstract：:During lytic infection, herpes simplex virus subverts the host cell RNA polymerase II transcription machinery to efficiently express its own genome while repressing the expression of most cellular genes. The mechanism by which RNA polymerase II is directed to the viral delayed-early and late genes is still unresolved....

journal_title：Journal of virology

authors： Rice SA,Long MC,Lam V,Spencer CA

更新日期：1994-02-01 00:00:00

abstract：:Epstein-Barr virus (EBV), a member of human gammaherpesvirus, infects mainly B cells. EBV has two alternative life cycles, latent and lytic, and is reactivated occasionally from the latent stage to the lytic cycle. To combat EBV-associated disorders, understanding the molecular mechanisms of the EBV lytic replication ...

journal_title：Journal of virology

authors： Masud HMAA,Watanabe T,Yoshida M,Sato Y,Goshima F,Kimura H,Murata T

更新日期：2017-11-14 00:00:00

abstract：:Crucial steps in high-risk human papillomavirus (HR-HPV)-related carcinogenesis are the integration of HR-HPV into the host genome and loss of viral episomes. The mechanisms that promote cervical neoplastic progression are, however, not clearly understood. During HR-HPV infection, the HPV E5 protein is expressed in pr...

journal_title：Journal of virology

authors： Muto V,Stellacci E,Lamberti AG,Perrotti E,Carrabba A,Matera G,Sgarbanti M,Battistini A,Liberto MC,Focà A

更新日期：2011-05-01 00:00:00

abstract：:Strong determinants of the host range of influenza A viruses have been identified on the polymerase complex formed by the PB1, PB2, and PA subunits and on the nucleoprotein (NP). In the present study, molecular mechanisms that may involve these four core proteins and contribute to the restriction of avian influenza vi...

journal_title：Journal of virology

authors： Rameix-Welti MA,Tomoiu A,Dos Santos Afonso E,van der Werf S,Naffakh N

更新日期：2009-02-01 00:00:00

abstract：:Genetic conflicts between retroviruses and their receptors result in the evolution of novel host entry restrictions and novel virus envelopes, and such variants can influence trans-species transmission. We screened rodents and other mammals for sequence variation in the Xpr1 receptor for the mouse xenotropic or polytr...

journal_title：Journal of virology

authors： Yan Y,Liu Q,Wollenberg K,Martin C,Buckler-White A,Kozak CA

更新日期：2010-11-01 00:00:00

abstract：:Polyacrylamide gel electrophoresis and tryptic peptide fingerprint analysis of the proteins made in a cell-free system derived from L-cells and immunoprecipitated with simian virus 40 (SV40) anti-T serum demonstrated that both SV40 large-T and small-T antigens are synthesized in vitro in response to mRNA isolated from...

journal_title：Journal of virology

authors： Paucha E,Harvey R,Smith AE

更新日期：1978-10-01 00:00:00

abstract：:Characterization of endogenous ecotropic Akv proviruses in DNA of low and high leukemic mouse strains revealed the presence of one to six copies of the Akv genome per haploid genome equivalent integrated in the germ line. Low leukemic strains analyzed so far contained only one complete copy of the Akv proviral DNA. Th...

journal_title：Journal of virology

authors： Quint W,van der Putten H,Janssen F,Berns A

更新日期：1982-03-01 00:00:00

abstract：:The adenovirus (Ad) E4 ORF3 protein is both necessary and sufficient to reorganize a nuclear subdomain, the PML nuclear body (PML-NB), from punctate structures into elongated nuclear tracks. PML-NB disruption is recapitulated by a variety of DNA viruses that encode proteins responsible for compromising PML-NB integrit...

journal_title：Journal of virology

authors： Ullman AJ,Hearing P

更新日期：2008-08-01 00:00:00

abstract：:The fraction of the adenovirus type 5 genome expressed as mRNA in a rat cell line, 5RK, transformed by the HsuI-G restriction fragment was analyzed by saturation hybridization using separated strands of 32P-labeled HindIII-G fragment. It was found that 45 to 50% of G fragment (about 8 X 10(5) daltons) is expressed as ...

journal_title：Journal of virology

authors： Chinnadural G,Fujinaga K,Rho MH,van der Eb AJ,Green M

更新日期：1978-12-01 00:00:00

abstract：:Papillomavirus disease poses a special challenge to people with compromised immune systems. Appropriate models to study infections in these individuals are lacking. We report here the development of a model that will help to address these deficiencies. The MmuPV1 genome was synthesized and used successfully to produce...

journal_title：Journal of virology

authors： Cladel NM,Budgeon LR,Cooper TK,Balogh KK,Hu J,Christensen ND

更新日期：2013-08-01 00:00:00

abstract：:Immune precipitation with monospecific antiserum was employed to study the intracellular synthesis of viral glycoproteins gp85 and gp37. Labeled gp85 and gp37 were detected from lysates of cells transformed with Rous sacroma virus, strain B77, after long-term labeling with radioactive glucosamine or phenylalanine. Imm...

journal_title：Journal of virology

authors： Moelling K,Hayami M

更新日期：1977-06-01 00:00:00

abstract：:The relationship between immunosenescence and the host response to virus infection is poorly understood at the molecular level. Two different patterns of pulmonary host responses to virus were observed when gene expression profiles from severe acute respiratory syndrome coronavirus (SARS-CoV)-infected young mice that ...

journal_title：Journal of virology

authors： Baas T,Roberts A,Teal TH,Vogel L,Chen J,Tumpey TM,Katze MG,Subbarao K

更新日期：2008-10-01 00:00:00

abstract：:The genomic RNA of an alphavirus encodes four different nonstructural proteins, nsP1, nsP2, nsP3, and nsP4. The polyprotein P123 is produced when translation terminates at an opal termination codon between nsP3 and nsP4. The polyprotein P1234 is produced when translational readthrough occurs or when the opal terminati...

journal_title：Journal of virology

authors： Myles KM,Kelly CL,Ledermann JP,Powers AM

更新日期：2006-05-01 00:00:00

abstract：:Nuclear domains called ND10 (nuclear domain 10) are discrete nuclear protein aggregations characterized by a set of interferon-upregulated proteins including Sp100 and PML, where papova-, adeno-, and herpesviruses begin their transcription and DNA replication. Both the alpha- and betaherpesvirus subfamilies disrupt ND...

journal_title：Journal of virology

authors： Bell P,Lieberman PM,Maul GG

更新日期：2000-12-01 00:00:00

abstract：:Preferential integration into transcriptionally active regions of genomes has been observed for retroviral vectors based on gamma-retroviruses and lentiviruses. However, differences in the integration site preferences were detected, which might be explained by differences in viral components of the preintegration comp...

journal_title：Journal of virology

authors： Monse H,Laufs S,Kuate S,Zeller WJ,Fruehauf S,Uberla K

更新日期：2006-08-01 00:00:00

abstract：:Although many human immunodeficiency virus type 1 (HIV-1)-infected persons are treated with multiple protease inhibitors in combination or in succession, mutation patterns of protease isolates from these persons have not been characterized. We collected and analyzed 2,244 subtype B HIV-1 isolates from 1,919 persons wi...

journal_title：Journal of virology

authors： Wu TD,Schiffer CA,Gonzales MJ,Taylor J,Kantor R,Chou S,Israelski D,Zolopa AR,Fessel WJ,Shafer RW

更新日期：2003-04-01 00:00:00

abstract：:Translation of encephalomyocarditis virus RNA in rabbit reticulocyte lysates in the presence of N-formyl-[(35)S]methionine-tRNA(f) (Met) revealed that a small polypeptide is cleaved from the N-terminus of the capsid protein precursor, preA, by virus-coded protease activity. Therefore, this N-terminal segment comprisin...

journal_title：Journal of virology

authors： Campbell EA,Jackson RJ

更新日期：1983-01-01 00:00:00

abstract：:Replication by many positive-strand RNA viruses includes genomic RNA amplification and subgenomic mRNA (sgRNA) transcription. For brome mosaic virus (BMV), both processes occur in virus-induced, membrane-associated compartments, require BMV replication factors 1a and 2a, and use negative-strand RNA3 as a template for ...

journal_title：Journal of virology

authors： Grdzelishvili VZ,Garcia-Ruiz H,Watanabe T,Ahlquist P

更新日期：2005-02-01 00:00:00

abstract：:Experimental evidence from the simian immunodeficiency virus (SIV) model of AIDS has shown that the nef gene is critical in the pathogenesis of AIDS. Consequently, nef is of considerable interest in both antiviral drug and vaccine development. Preliminary findings in two rhesus macaques indicated that a deletion of on...

journal_title：Journal of virology

authors： Whatmore AM,Cook N,Hall GA,Sharpe S,Rud EW,Cranage MP

更新日期：1995-08-01 00:00:00

abstract：:Interspecies transmission of the transmissible spongiform encephalopathies (TSEs), or prion diseases, can result in the adaptation and selection of TSE strains with an expanded host range and increased virulence such as in the case of bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease. To investiga...

journal_title：Journal of virology

authors： Bartz JC,Bessen RA,McKenzie D,Marsh RF,Aiken JM

更新日期：2000-06-01 00:00:00

abstract：:Papillomaviruses normally replicate in stratified squamous epithelial tissues of their mammalian hosts, in which the viral genome is found as a nuclear plasmid. Two viral proteins, E1, a helicase, and E2, a transcriptional activator and plasmid maintenance factor, are known to contribute to the episomal replication of...

journal_title：Journal of virology

authors： Angeletti PC,Kim K,Fernandes FJ,Lambert PF

更新日期：2002-04-01 00:00:00

abstract：:A monoclonal antibody, MAb vpg15, inhibits feline immunodeficiency virus (FIV) infection in tissue culture. The antibody is directed to a determinant of the feline cell surface marker, CD9, implying that CD9 may serve as a viral receptor or coreceptor in this system. In cells expressing CD9, MAb vpg15 markedly delayed...

journal_title：Journal of virology

authors： de Parseval A,Lerner DL,Borrow P,Willett BJ,Elder JH

更新日期：1997-08-01 00:00:00