Processing of the encephalomyocarditis virus capsid precursor protein studied in rabbit reticulocyte lysates incubated with N-formyl-[35S]methionine-tRNAfMet.

abstract：:Previous results have indicated that Rous sarcoma virus env gene expression is specifically inhibited by antisense RNA (L.-J. Chang and C. M. Stoltzfus, Mol. Cell. Biol. 5:2341-2348, 1985). In this study, we compare the extents of inhibition by antisense RNA derived from different parts of the Rous sarcoma virus genom...

journal_title：Journal of virology

authors： Chang LJ,Stoltzfus CM

更新日期：1987-03-01 00:00:00

abstract：:Biological and genetic variability is a prominent feature of human immunodeficiency virus (HIV) strains, especially in tropism, syncytium formation, and replicative capacity. To determine whether there were variable host cell effects on HIV replication in monocytes, three different strains of low-passage-number monocy...

journal_title：Journal of virology

authors： Chang J,Naif HM,Li S,Sullivan JS,Randle CM,Cunningham AL

更新日期：1996-11-01 00:00:00

abstract：:In response to viral infection, host cells elicit a number of responses, including the expression of alpha/beta interferon (IFN-alpha/beta). In these cells, IFN regulatory factor-3 (IRF-3) undergoes a sequence of posttranslational modifications that allow it to act as a potent transcriptional coactivator of specific I...

journal_title：Journal of virology

authors： Melroe GT,DeLuca NA,Knipe DM

更新日期：2004-08-01 00:00:00

abstract：:The DA strain of Theiler's murine encephalomyelitis virus persists in the white matter of the spinal cords of susceptible mice. Previous results showed that the difference in susceptibility to viral persistence between the susceptible SJL/J strain and the resistant B10.S strain was due to multiple non-H-2 loci. The re...

journal_title：Journal of virology

authors： Aubagnac S,Brahic M,Bureau JF

更新日期：2002-06-01 00:00:00

abstract：:Cells that express glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) resist infection by HSV-1 and HSV-2 because of interference with viral penetration. The results presented here show that both HSV-1 and HSV-2 gD can mediate interference and that various HSV-1 and HSV-2 strains differ in sensitivity to this ...

journal_title：Journal of virology

authors： Dean HJ,Warner MS,Terhune SS,Johnson RM,Spear PG

更新日期：1995-08-01 00:00:00

abstract：:Poliovirus inactivation by ammonia causes a slight reduction in the sedimentation coefficients of viral particles, but has no detectable effect on either the electrophoretic pattern of viral capsid proteins or the isoelectric points of inactivated particles. These virions still attach to cells, but are unable to repre...

journal_title：Journal of virology

authors： Ward RL

更新日期：1978-05-01 00:00:00

abstract：:As part of the continuing effort to develop an effective HIV vaccine, we generated a poxviral vaccine vector (previously described) designed to improve on the results of the RV144 phase III clinical trial. The construct, NYVAC-KC, is a replication-competent, attenuated recombinant of the vaccinia virus strain NYVAC. N...

journal_title：Journal of virology

authors： Kibler KV,Asbach B,Perdiguero B,García-Arriaza J,Yates NL,Parks R,Stanfield-Oakley S,Ferrari G,Montefiori DC,Tomaras GD,Roederer M,Foulds KE,Forthal DN,Seaman MS,Self S,Gottardo R,Phogat S,Tartaglia J,Barnett S,Cris

更新日期：2019-01-17 00:00:00

abstract：:Cytomegalovirus (CMV) is a betaherpesvirus that latently infects most adult humans worldwide and is a major cause of morbidity and mortality in immunocompromised hosts. Latent human CMV (HCMV) is believed to reside in precursors of myeloid-lineage leukocytes and monocytes, which give rise to macrophages and dendritic ...

journal_title：Journal of virology

authors： Kasmapour B,Kubsch T,Rand U,Eiz-Vesper B,Messerle M,Vondran FWR,Wiegmann B,Haverich A,Cicin-Sain L

更新日期：2017-12-14 00:00:00

abstract：:Phenol-extracted, infectious deoxyribonucleic acid (DNA) species from phi105 phage particles, from phi105 lysogenic bacteria, and from induced phi105 lysogenic bacteria were sedimented in sucrose gradients. Infectious DNA from phi105 particles sedimented like the bulk of mature phage DNA in neutral sucrose. Infectivit...

journal_title：Journal of virology

authors： Rutberg L,Rutberg B

更新日期：1970-05-01 00:00:00

abstract：:We investigated the use of infectious cDNA for the production of poliovirus type 1-type 3 recombinants. One such recombinant virus was produced, but a second construct involving the transfer of part of the capsid protein region was not infectious. Our results suggest that the approach may prove valuable but that not a...

journal_title：Journal of virology

authors： Stanway G,Hughes PJ,Westrop GD,Evans DM,Dunn G,Minor PD,Schild GC,Almond JW

更新日期：1986-03-01 00:00:00

abstract：:Recombinant rotavirus (RV) with cDNA-derived chimeric VP4 was generated using recently developed reverse genetics for RV. The rescued virus, KU//rVP4(SA11)-II(DS-1), contains SA11 (simian RV strain, G3P[2])-based VP4, in which a cross-reactive neutralization epitope (amino acids 381 to 401) on VP5* is replaced by the ...

journal_title：Journal of virology

authors： Komoto S,Kugita M,Sasaki J,Taniguchi K

更新日期：2008-07-01 00:00:00

abstract：:The replication and packaging of the rotavirus genome, comprising 11 segments of double-stranded RNA, take place in specialized compartments called viroplasms, which are formed during infection and involve a coordinated interplay of multiple components. Two rotavirus nonstructural proteins, NSP2 (with nucleoside triph...

journal_title：Journal of virology

authors： Jiang X,Jayaram H,Kumar M,Ludtke SJ,Estes MK,Prasad BV

更新日期：2006-11-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) is transmitted through a viral synapse and enters target cells via interaction with the glucose transporter GLUT1. Here, we show that Neuropilin-1 (NRP1), the receptor for semaphorin-3A and VEGF-A165 and a member of the immune synapse, is also a physical and functional p...

journal_title：Journal of virology

authors： Ghez D,Lepelletier Y,Lambert S,Fourneau JM,Blot V,Janvier S,Arnulf B,van Endert PM,Heveker N,Pique C,Hermine O

更新日期：2006-07-01 00:00:00

abstract：:A polymorphism in the gene encoding CCR2 is associated with a delay in progression to AIDS in human immunodeficiency virus (HIV)-infected individuals. The polymorphism, CCR2-64I, changes valine 64 of CCR2 to isoleucine. However, it is not clear whether the effect on AIDS progression results from the amino acid change ...

journal_title：Journal of virology

authors： Mariani R,Wong S,Mulder LC,Wilkinson DA,Reinhart AL,LaRosa G,Nibbs R,O'Brien TR,Michael NL,Connor RI,Macdonald M,Busch M,Koup RA,Landau NR

更新日期：1999-03-01 00:00:00

abstract：:Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for ...

journal_title：Journal of virology

authors： Rinaldo C,Huang XL,Fan ZF,Ding M,Beltz L,Logar A,Panicali D,Mazzara G,Liebmann J,Cottrill M

更新日期：1995-09-01 00:00:00

abstract：:HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study th...

journal_title：Journal of virology

authors： Behrens RT,Aligeti M,Pocock GM,Higgins CA,Sherer NM

更新日期：2017-01-18 00:00:00

abstract：:Our study was designed to investigate the nature of an antigen-specific suppressor factor generated by antigen-stimulated herpes simplex virus (HSV)-immune splenocytes. Factor SF-200, a 90,000- to 100,000-dalton fraction obtained after Sephacryl gel filtration, suppressed the generation of HSV-specific cytotoxic T-lym...

journal_title：Journal of virology

authors： Horohov DW,Wyckoff JH 3rd,Moore RN,Rouse BT

更新日期：1986-05-01 00:00:00

abstract：:Viral recombination has been postulated to play two roles in the development of human immunodeficiency virus (HIV) resistance to antiretroviral drugs. First, recombination has the capacity to associate resistance mutations expressed by distinct viruses, thereby contributing to the development of viruses with improved ...

journal_title：Journal of virology

authors： Nora T,Charpentier C,Tenaillon O,Hoede C,Clavel F,Hance AJ

更新日期：2007-07-01 00:00:00

abstract：:Synthesis of cytoplasmic viral RNA was studied during infection of cultured human (KB) cells with adenovirus 2. At 6 h, before viral DNA synthesis began 5% of the poly(A)-containing RNA hybridized to viral DNA; by 12 h and at later times more than 80% was virus specified. At 18 h after infection, four major size class...

journal_title：Journal of virology

authors： Tal J,Craig EA,Raskas HJ

更新日期：1975-01-01 00:00:00

abstract：:Nucleotide sequencing and phylogenetic analysis of 10 recognized prototype strains of the porcine enterovirus (PEV) cytopathic effect (CPE) group I reveals a close relationship of the viral genomes to the previously sequenced strain F65, supporting the concept of a reclassification of this virus group into a new picor...

journal_title：Journal of virology

authors： Zell R,Dauber M,Krumbholz A,Henke A,Birch-Hirschfeld E,Stelzner A,Prager D,Wurm R

更新日期：2001-02-01 00:00:00

abstract：:Under natural conditions and in some experimental models, rabies virus infection of the central nervous system causes relatively mild histopathological changes, without prominent evidence of neuronal death despite its lethality. In this study, the effects of rabies virus infection on the structure of neurons were inve...

journal_title：Journal of virology

authors： Scott CA,Rossiter JP,Andrew RD,Jackson AC

更新日期：2008-01-01 00:00:00

abstract：:Infection by viruses depends on a balance between capsid stability and dynamics. This study investigated biologically and biotechnologically relevant aspects of the relationship in foot-and-mouth disease virus (FMDV) between capsid structure and thermostability and between thermostability and infectivity. In the FMDV ...

journal_title：Journal of virology

authors： López-Argüello S,Rincón V,Rodríguez-Huete A,Martínez-Salas E,Belsham GJ,Valbuena A,Mateu MG

更新日期：2019-05-01 00:00:00

abstract：:The combinatorial nature of genetic recombination can potentially provide organisms with immediate access to many more positions in sequence space than can be reached by mutation alone. Recombination features particularly prominently in the evolution of a diverse range of viruses. Despite rapid progress having been ma...

journal_title：Journal of virology

authors： Lefeuvre P,Lett JM,Varsani A,Martin DP

更新日期：2009-03-01 00:00:00

abstract：UNLABELLED:Type I IFN signaling, which is initiated through activation of the alpha interferon receptor (IFNAR), regulates the expression of proteins that are crucial contributors to immune responses. Paramyxoviruses, including human metapneumovirus (HMPV), have evolved mechanisms to inhibit IFNAR signaling, but the sp...

journal_title：Journal of virology

authors： Hastings AK,Erickson JJ,Schuster JE,Boyd KL,Tollefson SJ,Johnson M,Gilchuk P,Joyce S,Williams JV

更新日期：2015-04-01 00:00:00

abstract：:The presence of cycloheximide, an inhibitor of protein synthesis, during the period 30 to 60 min after vaccinia infection produced an irreversible block in virus replication. In contrast (i) cycloheximide given at earlier or later times, even for prolonged periods, did not prevent continuation of the infectious cycle ...

journal_title：Journal of virology

authors： Mss B,Filler R

更新日期：1970-02-01 00:00:00

abstract：:The Cp promoter of Epstein-Barr virus (EBV) directs most transcription of the EBNA genes in lymphoblastoid cell lines. The functions of two control regions in the Cp promoter have been studied by construction of recombinant EBV strains containing specific mutations in these elements. Mutation of the RBP-Jk (CBF1) bind...

journal_title：Journal of virology

authors： Evans TJ,Farrell PJ,Swaminathan S

更新日期：1996-03-01 00:00:00

abstract：:Open reading frame 24 (ORF24) of murine gammaherpesvirus 68 (MHV-68) is conserved among beta- and gammaherpesviruses; however, its function in viral replication has not been defined. Using MHV-68 as a model, we have identified ORF24 as being essential for viral replication. An ORF24-null virus was generated and shown ...

journal_title：Journal of virology

authors： Wong E,Wu TT,Reyes N,Deng H,Sun R

更新日期：2007-06-01 00:00:00

abstract：UNLABELLED:An understanding of the antigen-specific B-cell response to the influenza virus hemagglutinin (HA) is critical to the development of universal influenza vaccines, but it has not been possible to examine these cells directly because HA binds to sialic acid (SA) on most cell types. Here, we use structure-based...

journal_title：Journal of virology

authors： Whittle JR,Wheatley AK,Wu L,Lingwood D,Kanekiyo M,Ma SS,Narpala SR,Yassine HM,Frank GM,Yewdell JW,Ledgerwood JE,Wei CJ,McDermott AB,Graham BS,Koup RA,Nabel GJ

更新日期：2014-04-01 00:00:00

abstract：:Borna disease virus (BDV) is a nonsegmented negative-strand (NNS) RNA virus that is unusual because it replicates in the nucleus. The most abundant viral protein in infected cells is a 38/39-kDa doublet that is presumed to represent the nucleocapsid. Infectious particles also contain high levels of this protein, accou...

journal_title：Journal of virology

authors： Pyper JM,Gartner AE

更新日期：1997-07-01 00:00:00

abstract：:The glycosylated Gag protein (gPr80) of murine leukemia viruses (MLVs) has been shown to exhibit multiple roles in facilitating retrovirus release, infection, and resistance to host-encoded retroviral restriction factors, such as APOBEC3, SERINC3, and SERINC5. One way in which gPr80 helps MLVs to escape host innate im...

journal_title：Journal of virology

authors： Renner TM,Bélanger K,Lam C,Gerpe MCR,McBane JE,Langlois MA

更新日期：2018-02-26 00:00:00