Generation of recombinant rotavirus with an antigenic mosaic of cross-reactive neutralization epitopes on VP4.

abstract：:The initial host response to viral infection occurs after Toll-like receptors (TLRs) on dendritic cells (DC) are stimulated by viral nucleic acids (double-stranded RNA, single-stranded RNA) and alpha interferon (IFN-alpha) and IFN-beta are produced. We hypothesized that pharmacologic induction of innate antiviral resp...

journal_title：Journal of virology

authors： Wang Y,Abel K,Lantz K,Krieg AM,McChesney MB,Miller CJ

更新日期：2005-11-01 00:00:00

abstract：:The synthesis of viral RNA by wild-type vesicular stomatitis virus (L(1)VSV) and a small, plaque-size mutant (S(2)VSV) was studied in vitro and in chicken embryo (CE) and mouse L-cell cultures. Virus-specific RNA synthesized in CE or L cells infected with either L(1) or S(2)VSV at low multiplicity was of the same size...

journal_title：Journal of virology

authors： Wertz GW,Levine M

更新日期：1973-08-01 00:00:00

abstract：:Recombinant strains of replication-competent rhesus monkey rhadinovirus (RRV) were constructed in which strong promoter/enhancer elements were used to drive expression of simian immunodeficiency virus (SIV) Env or Gag or a Rev-Tat-Nef fusion protein. Cultured rhesus monkey fibroblasts infected with each recombinant st...

journal_title：Journal of virology

authors： Bilello JP,Manrique JM,Shin YC,Lauer W,Li W,Lifson JD,Mansfield KG,Johnson RP,Desrosiers RC

更新日期：2011-12-01 00:00:00

abstract：:We previously reported the establishment of several lymphoid cell lines from X-ray-induced thymomas of C57BL/Ka mice, and all, except one, produce retroviruses (P. Sankar-Mistry and P. Jolicoeur, J. Virol.35:270-275, 1980). Biological characterization of five of these new primary radiation leukemia viruses (RadLVs) in...

journal_title：Journal of virology

authors： Rassart E,Sankar-Mistry P,Lemay G,DesGroseillers L,Jolicoeur P

更新日期：1983-02-01 00:00:00

abstract：:We previously demonstrated that polyhedron formation (PF) mutants arise at a high frequency during serial passage of the Lymantria dispar nucleopolyhedrovirus (LdMNPV) in the L. dispar 652Y cell line (J. M. Slavicek, N. Hayes-Plazolles, and M. E. Kelly, Biol. Control 5:251-261, 1995). Most of these PF mutants exhibite...

journal_title：Journal of virology

authors： Bischoff DS,Slavicek JM

更新日期：1997-02-01 00:00:00

abstract：:Small amounts of infectious simian virus 40 (SV40) were recovered from parental cultures of SV40-transformed human embryonic lung (WI38 Va13A) cells, from 12 primary clones, from 17 secondary clones, and from 18 tertiary clones. The cloning experiments demonstrated that the capacity for spontaneous virus production is...

journal_title：Journal of virology

authors： Dubbs DR,Kit S

更新日期：1971-10-01 00:00:00

abstract：:Equine infectious anemia virus (EIAV) provides a natural model system by which immunological control of lentivirus infections may be studied. To date, no detailed study addressing in parallel both the humoral and cellular immune responses induced in horses upon infection by EIAV has been conducted. Therefore, we initi...

journal_title：Journal of virology

authors： Hammond SA,Cook SJ,Lichtenstein DL,Issel CJ,Montelaro RC

更新日期：1997-05-01 00:00:00

abstract：:We have begun to characterize the genomic structure and replication of the baboon papovavirus simian agent 12 (SA12). We have defined a wild-type clone of SA12 (SA12 wt100) by plaque purification from a heterogeneous stock. The functional map of SA12 wt100 can be aligned with those of the other primate papovaviruses b...

journal_title：Journal of virology

authors： Cunningham TP,Pipas JM

更新日期：1985-05-01 00:00:00

abstract：:Borna disease virus (BDV) is an enveloped virus with a genome organization characteristic of Mononegavirales. However, based on its unique features, BDV is considered the prototypic member of a new virus family, Bornaviridae, within the order Mononegavirales. We have described the establishment of a reverse genetics s...

journal_title：Journal of virology

authors： Rosario D,Perez M,de la Torre JC

更新日期：2005-05-01 00:00:00

abstract：:Type I interferons (IFNs), as major components of the innate immune system, play a vital role in host resistance to a variety of pathogens. Canonical signaling mediated by type I IFNs activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway through binding to the IFN-α/β receptor ...

journal_title：Journal of virology

authors： Yuan H,You J,You H,Zheng C

更新日期：2018-09-12 00:00:00

abstract：:Type I interferons induce a complex transcriptional program that leads to a generalized antiviral response against a large panel of viruses, including human immunodeficiency virus type 1 (HIV-1). However, despite the fact that interferons negatively regulate HIV-1 ex vivo, a chronic interferon state is linked to the p...

journal_title：Journal of virology

authors： Cordeil S,Nguyen XN,Berger G,Durand S,Ainouze M,Cimarelli A

更新日期：2013-03-01 00:00:00

abstract：:Extracts made from human respiratory syncytial virus (RSV)-infected Hep-2 cells synthesized mRNAs encoded by all known viral genes. In contrast, RSV ribonucleoproteins purified from infected cells failed to transcribe in vitro; transcription was restored by addition of a cytoplasmic extract of uninfected Hep-2 cells, ...

journal_title：Journal of virology

authors： Barik S

更新日期：1992-11-01 00:00:00

abstract：:We have previously demonstrated that open reading frame (ORF) 50 and ORF 57 encode transcriptional regulating genes in herpesvirus saimiri. ORF 50, a homolog of Epstein-Barr virus R protein, is a sequence-specific transactivator, whereas ORF 57 acts posttranscriptionally. In this report, we demonstrate that the ORF 57...

journal_title：Journal of virology

authors： Whitehouse A,Cooper M,Hall KT,Meredith DM

更新日期：1998-03-01 00:00:00

abstract：UNLABELLED:Protease is essential for retroviral replication, and protease inhibitors (PI) are important for treating HIV infection. HIV-2 exhibits intrinsic resistance to most FDA-approved HIV-1 PI, retaining clinically useful susceptibility only to lopinavir, darunavir, and saquinavir. The mechanisms for this resistan...

journal_title：Journal of virology

authors： Raugi DN,Smith RA,Gottlieb GS,University of Washington-Dakar HIV-2 Study Group.

更新日期：2015-11-11 00:00:00

abstract：:Borna disease virus (BDV) is a nonsegmented negative-strand (NNS) RNA virus that is unusual because it replicates in the nucleus. The most abundant viral protein in infected cells is a 38/39-kDa doublet that is presumed to represent the nucleocapsid. Infectious particles also contain high levels of this protein, accou...

journal_title：Journal of virology

authors： Pyper JM,Gartner AE

更新日期：1997-07-01 00:00:00

abstract：UNLABELLED:Woodchuck hepatitis virus (WHV), a close relative of human hepatitis B virus (HBV), has been a key model for disease progression and clinical studies. Sequences of the assembly domain of WHV and HBV core proteins (wCp149 and hCp149, respectively) have 65% identity, suggesting similar assembly behaviors. We r...

journal_title：Journal of virology

authors： Kukreja AA,Wang JC,Pierson E,Keifer DZ,Selzer L,Tan Z,Dragnea B,Jarrold MF,Zlotnick A

更新日期：2014-12-01 00:00:00

abstract：:Bovine papilloma virus (BPV) appears to be the etiological agent of common equine connective tissue tumors. We investigated the physical state of the viral DNA within such tumors and found no indication for integration into the host genome. The BPV genomes were present as free circular episomes. Two equine sarcoids we...

journal_title：Journal of virology

authors： Amtmann E,Müller H,Sauer G

更新日期：1980-09-01 00:00:00

abstract：:Under natural conditions and in some experimental models, rabies virus infection of the central nervous system causes relatively mild histopathological changes, without prominent evidence of neuronal death despite its lethality. In this study, the effects of rabies virus infection on the structure of neurons were inve...

journal_title：Journal of virology

authors： Scott CA,Rossiter JP,Andrew RD,Jackson AC

更新日期：2008-01-01 00:00:00

abstract：:Live-attenuated vesicular stomatitis virus (VSV) vectors expressing foreign antigens induce potent immune responses and protect against viral diseases in animal models. Highly attenuated (VSV-CT1) or single-cycle VSV (VSVDeltaG) vectors induce immune responses lower than those generated by attenuated wild-type VSV vec...

journal_title：Journal of virology

authors： Simon ID,Publicover J,Rose JK

更新日期：2007-02-01 00:00:00

abstract：:Domains required late in the virus budding process (L domains) have been identified in the Gag proteins of a number of retroviruses. Here we show that the human T-cell leukemia virus type 1 candidate L domain motif PPPY is indeed required for virus production. Strikingly, however, mutation of this motif arrested virus...

journal_title：Journal of virology

authors： Le Blanc I,Prévost MC,Dokhélar MC,Rosenberg AR

更新日期：2002-10-01 00:00:00

abstract：:The infection of cells which belong to the B-cell lineage is thought to be the primary event leading to the phenotypic and functional alterations seen in the murine AIDS (M. Huang, C. Simard, D. Kay, and P. Jolicoeur, J. Virol. 65:6562-6571, 1991). Using in situ hybridization, we studied the time course of the anatomi...

journal_title：Journal of virology

authors： Simard C,Huang M,Jolicoeur P

更新日期：1994-03-01 00:00:00

abstract：:Information was sought on the temporal distribution of transmissible mink encephalopathy virus in royal pastel mink inoculated subcutaneously with 10(3.0) 50% intracerebral lethal doses of the Idaho strain. As determined by intracerebral assay in mink, extremely little replication of the virus occurred during the prec...

journal_title：Journal of virology

authors： Hadlow WJ,Race RE,Kennedy RC

更新日期：1987-10-01 00:00:00

abstract：:Poorly cytopathic or noncytopathic viruses can escape immune surveillance and establish a chronic infection. Here we exploited the strategy of combining antiviral drug treatment with the induction of a neutralizing antibody response to avoid the appearance of neutralization-resistant virus variants. Despite the fact t...

journal_title：Journal of virology

authors： Seiler P,Senn BM,Klenerman P,Kalinke U,Hengartner H,Zinkernagel RM

更新日期：2000-07-01 00:00:00

abstract：:Purified preparations of human adenovirus type 12 showed two bands when subjected to isopycnic centrifugation in a density gradient of cesium chloride. Their density difference was about 0.003 g/ml, suggesting a small difference in their deoxyribonucleic acid to protein ratio. Virions with a lighter density can kill h...

journal_title：Journal of virology

authors： Mak S

更新日期：1971-04-01 00:00:00

abstract：:We isolated revertants of a polyomavirus whose origin of DNA replication contains a point mutation in the palindrome to which large T antigen binds. Four independent second-site revertants contain an Asp-286----Asn-286 substitution in large T antigen. This mutant large T antigen activates replication of DNAs containin...

journal_title：Journal of virology

authors： Tang WJ,Folk WR

更新日期：1989-01-01 00:00:00

abstract：:Defective interfering (DI) RNAs of Tomato bushy stunt virus (TBSV), a plus-sense RNA virus, comprise four conserved noncontiguous regions (I through IV) derived from the viral genome. Region III, a 70-nucleotide-long sequence corresponding to a genomic segment located 378 nucleotides upstream of the 3' terminus of the...

journal_title：Journal of virology

authors： Ray D,White KA

更新日期：2003-01-01 00:00:00

abstract：:The matrix domain of human immunodeficiency virus type 1 Gag polyprotein was studied for its role in virus assembly. Deletion and substitution mutations caused a dramatic reduction in virus production. Mutant Gag polyproteins were myristoylated and had a high affinity for membrane association. Immunofluorescence stain...

journal_title：Journal of virology

authors： Yuan X,Yu X,Lee TH,Essex M

更新日期：1993-11-01 00:00:00

abstract：:During dengue virus replication, an incomplete cleavage of the envelope glycoprotein prM, generates a mixture of mature (prM-less) and prM-containing, immature extracellular particles. In this study, sequential immunoprecipitation and cryoelectron microscopy revealed a third type of extracellular particles, the partia...

journal_title：Journal of virology

authors： Junjhon J,Edwards TJ,Utaipat U,Bowman VD,Holdaway HA,Zhang W,Keelapang P,Puttikhunt C,Perera R,Chipman PR,Kasinrerk W,Malasit P,Kuhn RJ,Sittisombut N

更新日期：2010-08-01 00:00:00

abstract：:The structural polypeptides of purified Plodia interpunctella granulosis virus were analyzed by three different two-dimensional gel systems. Isoelectric focusing followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis allowed resolution of 53 acidic polypeptides in the enveloped nucleocapsid of the virus...

journal_title：Journal of virology

authors： Russell DL,Consigli RA

更新日期：1986-10-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) has been shown to progress through a number of changes that lead to the emergence of pathogenic viral variants in macaques initially infected with a mildly cytopathic variant, SIVMneCL8. One of these late-stage isolates, SIVMne170, replicates to high levels in vivo and causes a rapi...

journal_title：Journal of virology

authors： Voronin Y,Overbaugh J,Emerman M

更新日期：2005-12-01 00:00:00