RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection.

Abstract:

:During lytic infection, herpes simplex virus subverts the host cell RNA polymerase II transcription machinery to efficiently express its own genome while repressing the expression of most cellular genes. The mechanism by which RNA polymerase II is directed to the viral delayed-early and late genes is still unresolved. We report here that RNA polymerase II is preferentially localized to viral replication compartments early after infection with herpes simplex virus type 1. Concurrent with recruitment of RNA polymerase II into viral compartments is a rapid and aberrant phosphorylation of the large subunit carboxy-terminal domain (CTD). Aberrant phosphorylation of the CTD requires early viral gene expression but is not dependent on viral DNA replication or on the formation of viral replication compartments. Localization of RNA polymerase II and modifications to the CTD may be instrumental in favoring transcription of viral genes and repressing specific transcription of cellular genes.

journal_name

J Virol

journal_title

Journal of virology

authors

Rice SA,Long MC,Lam V,Spencer CA

doi

10.1128/JVI.68.2.988-1001.1994

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

988-1001

issue

2

eissn

0022-538X

issn

1098-5514

journal_volume

68

pub_type

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