Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus.

abstract：:Human hepatitis B virus (HBV) HBx protein is a multifunctional protein that activates cellular signaling pathways and is thought to be essential for viral infection. Woodchuck HBV mutants that lack HBx are unable to replicate in vivo or are severely impaired. HBV replication in HepG2 cells, a human hepatoblastoma cell...

journal_title：Journal of virology

authors： Bouchard MJ,Puro RJ,Wang L,Schneider RJ

更新日期：2003-07-01 00:00:00

abstract：:The capsid (CA) domain of the Moloney murine leukemia virus (Mo-MuLV) Gag protein has a unique carboxy terminus with a highly charged arginine-rich sequence. Mutant viruses harboring arginine-to-alanine mutations affecting this region of CA displayed significant defects in virion release, and the few viral particles p...

journal_title：Journal of virology

authors： Wang MQ,Goff SP

更新日期：2003-03-01 00:00:00

abstract：:Aphid transmission of poleroviruses is highly specific, but the viral determinants governing this specificity are unknown. We used a gene exchange strategy between two poleroviruses with different vectors, Beet western yellows virus (BWYV) and Cucurbit aphid-borne yellows virus (CABYV), to analyze the role of the majo...

journal_title：Journal of virology

authors： Brault V,Périgon S,Reinbold C,Erdinger M,Scheidecker D,Herrbach E,Richards K,Ziegler-Graff V

更新日期：2005-08-01 00:00:00

abstract：:The activity and epithelial tropism of the human papillomavirus type 18 P105 early promoter, which directs the synthesis of the E6 and E7 transforming genes, are controlled by cis elements included in the viral long control region. To identify potential cellular regulators of this promoter, we mutagenized one or both ...

journal_title：Journal of virology

authors： Thierry F,Spyrou G,Yaniv M,Howley P

更新日期：1992-06-01 00:00:00

abstract：:Protein kinase activity is associated with both the extracellular and the occluded forms of Autographa californica nuclear polyhedrosis virus, a baculovirus. Serine and threonine are the predominant amino acids phosphorylated by the kinase activity associated with both viral forms; no phosphotyrosine was detected. The...

journal_title：Journal of virology

authors： Miller LK,Adang MJ,Browne D

更新日期：1983-04-01 00:00:00

abstract：:Picornavirus genomes encode unique 5' noncoding regions (5' NCRs) which are approximately 600 to 1,300 nucleotides in length, contain multiple upstream AUG codons, and display the ability to form extensive secondary structures. A number of recent reports have shown that picornavirus 5' NCRs are able to facilitate cap-...

journal_title：Journal of virology

authors： Dildine SL,Semler BL

更新日期：1992-07-01 00:00:00

abstract：:Mutations critical for the central nervous system (CNS) attenuation of the Sabin vaccine strains of poliovirus (PV) are located within the viral internal ribosome entry site (IRES). We examined the interaction of the IRESs of PV type 3 (PV3) and Sabin type 3 (Sabin3) with polypyrimidine tract-binding protein (PTB) and...

journal_title：Journal of virology

authors： Guest S,Pilipenko E,Sharma K,Chumakov K,Roos RP

更新日期：2004-10-01 00:00:00

abstract：:The Epstein-Barr virus latent membrane protein (LMP) is an integral membrane protein that is expressed in cells latently infected with the virus. LMP is believed to play an important role in Epstein-Barr virus transformation and has been shown to induce expression of several cellular proteins. We performed a series of...

journal_title：Journal of virology

authors： Hammarskjöld ML,Simurda MC

更新日期：1992-11-01 00:00:00

abstract：:The involvement of mouse mammary tumor virus (MTV) in the development of mammary tumors of nonviral etiology in BALB/c mice was studied by measuring the levels of MTV RNA, MTV DNA, and MTV proteins in spontaneously arising and hormonally, chemically, and/or physically induced mammary tumors of BALB/c females. The foll...

journal_title：Journal of virology

authors： Michalides R,van Deemter L,Nusse R,Hageman P

更新日期：1979-07-01 00:00:00

abstract：:The monoclonal antibody PAb280 binds to small t antigen but not to large T antigen. Its binding site within the unique region of small t antigen was localized by studying its reaction with simian virus 40 mutants, other papovaviruses, and bacterial expression vectors coding for fragments of small t antigen. The antibo...

journal_title：Journal of virology

authors： Montano X,Lane DP

更新日期：1989-07-01 00:00:00

abstract：:The major phosphoprotein common to woolly monkey sarcoma virus, gibbon ape lymphosarcoma virus, and type C viruses of the lower mammalian species (mouse, rat, cat), with the exception of the endogenous cat virus (RD-114), is the polypeptide of about 12,000 molecular weight. The protein-phosphate bond in this polypepti...

journal_title：Journal of virology

authors： Pal BK,McAllister RM,Gardner MB,Roy-Burman P

更新日期：1975-07-01 00:00:00

abstract：:Expression of the immediate-early (IE) genes of herpes simplex virus (HSV) is specifically stimulated by a 65-kilodalton virion transcription factor (VF65 or VP16) that is introduced as a component of infecting virions. In both the IE175(ICP4) and IE110(ICP0) promoters, this activation requires an upstream cis-acting ...

journal_title：Journal of virology

authors： apRhys CM,Ciufo DM,O'Neill EA,Kelly TJ,Hayward GS

更新日期：1989-06-01 00:00:00

abstract：:Reovirus encephalitis in mice was used as a model system to investigate astrocyte activation (astrogliosis) following viral infection of the brain. Reovirus infection resulted in astrogliosis, as evidenced by increased expression of glial fibrillary acidic protein (GFAP), and the upregulation of genes that have been p...

journal_title：Journal of virology

authors： Clarke P,Zhuang Y,Berens HM,Leser JS,Tyler KL

更新日期：2019-05-01 00:00:00

abstract：:Toscana virus (TOSV) is a phlebovirus, of the Bunyaviridae family, that is responsible for central nervous system (CNS) injury in humans. Previous data have shown that the TOSV NSs protein is a gamma interferon (IFN-β) antagonist when transiently overexpressed in mammalian cells, inhibiting IRF-3 induction (G. Gori Sa...

journal_title：Journal of virology

authors： Gori-Savellini G,Valentini M,Cusi MG

更新日期：2013-06-01 00:00:00

abstract：:Hepatitis A virus (HAV), an atypical member of the Picornaviridae, grows poorly in cell culture. To define determinants of HAV growth, we introduced a blasticidin (Bsd) resistance gene into the virus genome and selected variants that grew at high concentrations of Bsd. The mutants grew fast and had increased rates of ...

journal_title：Journal of virology

authors： Konduru K,Kaplan GG

更新日期：2010-08-01 00:00:00

abstract：:To analyze the proposed growth-inhibitory function of wild-type p53, we compared simian virus 40 (SV40) DNA replication in primary rhesus monkey kidney (PRK) cells, which express wild-type p53, and in the established rhesus monkey kidney cell line LLC-MK2, which expresses a mutated p53 that does not complex with large...

journal_title：Journal of virology

authors： von der Weth A,Deppert W

更新日期：1993-02-01 00:00:00

abstract：:Hepatitis A virus (HAV) 3C proteinase expressed in Escherichia coli was purified to homogeneity, and its cleavage specificity towards various parts of the viral polyprotein was analyzed. Intermolecular cleavage of the P2-P3 domain of the HAV polyprotein gave rise to proteins 2A, 2B, 2C, 3ABC, and 3D, suggesting that i...

journal_title：Journal of virology

authors： Schultheiss T,Sommergruber W,Kusov Y,Gauss-Müller V

更新日期：1995-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a global challenge to public health. Several factors have been proven to be critical for HCV entry, including the newly identified claudin-1 (CLDN1). However, the mechanism of HCV entry is still obscure. Presently, among the 20 members of the claudin family identified in humans so far, CLDN1...

journal_title：Journal of virology

authors： Zheng A,Yuan F,Li Y,Zhu F,Hou P,Li J,Song X,Ding M,Deng H

更新日期：2007-11-01 00:00:00

abstract：:3-O-(3',3'-Dimethysuccinyl) betulinic acid (PA-457) has been shown to potently inhibit human immunodeficiency virus (HIV) replication in culture. In contrast to inhibitors that act upon the viral proteinase, PA-457 appears to block only the final maturational cleavage of p25CA-p2 to p24CA. However, attempts to replica...

journal_title：Journal of virology

authors： Sakalian M,McMurtrey CP,Deeg FJ,Maloy CW,Li F,Wild CT,Salzwedel K

更新日期：2006-06-01 00:00:00

abstract：:Enzymatic markers and electron microscopy were utilized to determine the cellular origin of the membrane types isolated from type 2 dengue virus-infected BHK cells by discontinuous sucrose gradient centrifugation. The results showed an apparent separation of plasma membrane, smooth and rough endoplasmic reticulum with...

journal_title：Journal of virology

authors： Stohlman SA,Wisseman CL Jr,Eylar OR,Silverman DJ

更新日期：1975-10-01 00:00:00

abstract：:Type I interferons (IFNs), as major components of the innate immune system, play a vital role in host resistance to a variety of pathogens. Canonical signaling mediated by type I IFNs activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway through binding to the IFN-α/β receptor ...

journal_title：Journal of virology

authors： Yuan H,You J,You H,Zheng C

更新日期：2018-09-12 00:00:00

abstract：:Infectious vaccinia virus can be purified from whole cells by experimentally induced lysis (intracellular virus) or from supernatant growth medium (extracellular virus). Extracellular virus and intracellular virus differed by buoyant density (1.237 versus 1.272 g/cm3), phospholipid content and composition, and polypep...

journal_title：Journal of virology

authors： Hiller G,Eibl H,Weber K

更新日期：1981-09-01 00:00:00

abstract：:Borna disease virus (BDV) uses a unique strategy of replication and transcription which takes place in the nucleus, unlike other known, nonsegmented, negative-stranded RNA viruses of animal origin. In this process, viral constituents necessary for replication must be transported to the nucleus from the cytoplasm. We r...

journal_title：Journal of virology

authors： Shoya Y,Kobayashi T,Koda T,Ikuta K,Kakinuma M,Kishi M

更新日期：1998-12-01 00:00:00

abstract：:The goose parvovirus (GPV) Rep 1 and Rep 2 proteins are encoded by P9-generated mRNAs that are either unspliced or spliced within the rep gene region, respectively. These mRNAs are present in an approximately equal ratio. The translation of Rep 1 was initiated from the first AUG in unspliced P9-generated mRNA; however...

journal_title：Journal of virology

authors： Li L,Qiu J,Pintel DJ

更新日期：2009-10-01 00:00:00

abstract：:Host cell interactions of human adenovirus serotypes belonging to subgroups B (adenovirus type 3 [Ad3] and Ad7) and C (Ad2 and Ad5) were comparatively analyzed at three levels: (i) binding of virus particles with host cell receptors; (ii) cointernalization of macromolecules with adenovirions; and (iii) adenovirus-indu...

journal_title：Journal of virology

authors： Defer C,Belin MT,Caillet-Boudin ML,Boulanger P

更新日期：1990-08-01 00:00:00

abstract：:Higher-order RNA structures in the 3' untranslated region (3'UTR) of enteroviruses are thought to play a pivotal role in viral negative-strand RNA synthesis. The structure of the 3'UTR was predicted by thermodynamic calculations using the STAR (structural analysis of RNA) computer program and experimentally verified u...

journal_title：Journal of virology

authors： Melchers WJ,Hoenderop JG,Bruins Slot HJ,Pleij CW,Pilipenko EV,Agol VI,Galama JM

更新日期：1997-01-01 00:00:00

abstract：:The lymphoid cell line #1670 has been derived from the infiltrated spleen of a tumor-bearing marmoset monkey infected with Herpesvirus saimiri. The cells contain both types of H. saimiri DNA, unique light (L-) DNA (36% cytosine plus guanine) and repetitive heavy (H-) DNA (71% cytosine plus guanine), without producing ...

journal_title：Journal of virology

authors： Werner FJ,Bornkamm GW,Fleckenstein B

更新日期：1977-06-01 00:00:00

abstract：:Grasshoppers, Melanoplus sanguinipes (F.), infected with the grasshopper inclusion body virus (GIBV) showed a general torpor, took longer to develop, and had abnormally high rates of mortality. Infection was found only in the fat body, and developing viruses and inclusion bodies were observed in the nuclei and cytopla...

journal_title：Journal of virology

authors： Henry JE,Nelson BP,Jutila JW

更新日期：1969-06-01 00:00:00

abstract：:HB-3, a temperate bacteriophage of Streptococcus pneumoniae, synthesizes its own murein hydrolase activity when multiplying on cultures of pneumococcus. The enzyme (HBL) was purified and biochemically characterized as an N-acetylmuramoyl-L-alanine amidase of 36,000 daltons, and a 2.1-kilobase DraI fragment containing ...

journal_title：Journal of virology

authors： Romero A,Lopez R,Garcia P

更新日期：1990-01-01 00:00:00

abstract：:The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease. To find genes that protect cells from apoptosis, we used an expression cloning strategy and identifi...

journal_title：Journal of virology

authors： Foghsgaard L,Jäättelä M

更新日期：1997-10-01 00:00:00