Abstract:
:CD4+ T-cell depletion in AIDS patients involves induction of apoptosis in human immunodeficiency virus (HIV)-infected and noninfected T cells. The HIV type 1 (HIV-1)-transactivating protein Tat enhances apoptosis and activation-induced cell death (AICD) of human T cells. This effect is mediated by the CD95 (APO-1/Fas) receptor-CD95 ligand (CD95L) system and may be linked to the induction of oxidative stress by Tat. Here we show that HIV-1 Tat-induced oxidative stress is necessary for sensitized AICD in T cells caused by CD95L expression. Tat-enhanced apoptosis and CD95L expression in T cells are inhibited by neutralizing anti-Tat antibodies, antioxidants, and the Tat inhibitor Ro24-7429. Chimpanzees infected with HIV-1 show viral replication resembling early infection in humans but do not show T-cell depletion or progression towards AIDS. The cause for this discrepancy is unknown. Here we show that unlike Tat-treated T cells in humans, Tat-treated chimpanzee T cells do not show downregulation of manganese superoxide dismutase or signs of oxidative stress. Chimpanzee T cells are also resistant to Tat-enhanced apoptosis, AICD, and CD95L upregulation.
journal_name
J Viroljournal_title
Journal of virologyauthors
Ehret A,Westendorp MO,Herr I,Debatin KM,Heeney JL,Frank R,Krammer PHdoi
10.1128/JVI.70.9.6502-6507.1996subject
Has Abstractpub_date
1996-09-01 00:00:00pages
6502-7issue
9eissn
0022-538Xissn
1098-5514journal_volume
70pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.10.8112-8119.1999
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.11.6616-6625.1992
更新日期:1992-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.79.4.2493-2505.2005
更新日期:2005-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.4.2602-2604.1995
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.4.2051-2058.1994
更新日期:1994-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1976-08-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00