Activation of cytomegalovirus in pig-to-primate organ xenotransplantation.

abstract：:A gene encoding a polypeptide with homology to mammalian vascular endothelial growth factors (VEGFs) has been discovered in the genome of orf virus (OV), a parapoxvirus that affects sheep and goats and, occasionally, humans. The gene is transcribed abundantly early in infection and is found immediately outside the inv...

journal_title：Journal of virology

authors： Lyttle DJ,Fraser KM,Fleming SB,Mercer AA,Robinson AJ

更新日期：1994-01-01 00:00:00

abstract：:The C-terminal domain of human immunodeficiency virus type 1 (HIV-1) integrase (IN) is a dimer that binds to DNA in a nonspecific manner. The structure of the minimal region required for DNA binding (IN220-270) has been solved by nuclear magnetic resonance spectroscopy. The overall fold of the C-terminal domain of HIV...

journal_title：Journal of virology

authors： Lutzke RA,Plasterk RH

更新日期：1998-06-01 00:00:00

abstract：:Therapeutic suppression of human immunodeficiency virus type 1 (HIV-1) replication may help elucidate interactions between the host cellular immune responses and HIV-1 infection. We performed a detailed longitudinal evaluation of two subjects before and after the start of highly active antiretroviral therapy (HAART). ...

journal_title：Journal of virology

authors： Kalams SA,Goulder PJ,Shea AK,Jones NG,Trocha AK,Ogg GS,Walker BD

更新日期：1999-08-01 00:00:00

abstract：:Sindbis virus (SINV) is an alphavirus that causes infection of neurons and encephalomyelitis in adult immunocompetent mice. Recovery can occur without apparent neurological damage. To better define the factors facilitating noncytolytic clearance of SINV in different regions of the central nervous system (CNS) and the ...

journal_title：Journal of virology

authors： Burdeinick-Kerr R,Wind J,Griffin DE

更新日期：2007-06-01 00:00:00

abstract：:V3-glycan-targeting broadly neutralizing antibodies (bNAbs) are a focus of HIV-1 vaccine development. Understanding the viral dynamics that stimulate the development of these antibodies can provide insights for immunogen design. We used a deep-sequencing approach, together with neutralization phenotyping, to investiga...

journal_title：Journal of virology

authors： Anthony C,York T,Bekker V,Matten D,Selhorst P,Ferreria RC,Garrett NJ,Karim SSA,Morris L,Wood NT,Moore PL,Williamson C

更新日期：2017-08-24 00:00:00

abstract：:Infectious bursal disease virus (IBDV), a double-stranded RNA (dsRNA) virus belonging to the Birnaviridae family, is an economically important avian pathogen. The IBDV capsid is based on a single-shelled T=13 lattice, and the only structural subunits are VP2 trimers. During capsid assembly, VP2 is synthesized as a pro...

journal_title：Journal of virology

authors： Luque D,Saugar I,Rodríguez JF,Verdaguer N,Garriga D,Martín CS,Velázquez-Muriel JA,Trus BL,Carrascosa JL,Castón JR

更新日期：2007-07-01 00:00:00

abstract：:Mammalian reoviruses are internalized into cells by receptor-mediated endocytosis. Within the endocytic compartment, the viral outer capsid undergoes acid-dependent proteolysis resulting in removal of the sigma3 protein and proteolytic cleavage of the mu1/mu1C protein. Ammonium chloride (AC) is a weak base that blocks...

journal_title：Journal of virology

authors： Clark KM,Wetzel JD,Gu Y,Ebert DH,McAbee SA,Stoneman EK,Baer GS,Zhu Y,Wilson GJ,Prasad BV,Dermody TS

更新日期：2006-01-01 00:00:00

abstract：:We propose that a nucleotide template-based mechanism facilitates the acquisition of the K65R mutation in subtype C human immunodeficiency virus type 1 (HIV-1). Different patterns of DNA synthesis were observed using DNA templates from viruses of subtype B or C origin. When subtype C reverse transcriptase (RT) was emp...

journal_title：Journal of virology

authors： Coutsinos D,Invernizzi CF,Xu H,Moisi D,Oliveira M,Brenner BG,Wainberg MA

更新日期：2009-02-01 00:00:00

abstract：:Mutations in several subgenomic regions of hepatitis C virus (HCV) have been implicated in influencing the response to interferon (IFN) therapy. Sequences within HCV NS5A (PKR binding domain [PKRBD], IFN sensitivity-determining region [ISDR], and variable region 3 [V3]) were analyzed for the pretreatment serum samples...

journal_title：Journal of virology

authors： Muñoz de Rueda P,Casado J,Patón R,Quintero D,Palacios A,Gila A,Quiles R,León J,Ruiz-Extremera A,Salmerón J

更新日期：2008-07-01 00:00:00

abstract：:Friend virus induces an erythroleukemia in susceptible mice that is initiated by the interaction of the Friend virus-encoded glycoprotein gp55 with the erythropoietin (Epo) receptor and the product of the host Fv2 gene, a naturally occurring truncated form of the Stk receptor tyrosine kinase (Sf-Stk). We have previous...

journal_title：Journal of virology

authors： He S,Ni S,Hegde S,Wang X,Sharda DR,August A,Paulson RF,Hankey PA

更新日期：2010-03-01 00:00:00

abstract：:The DNA molecules from T7 bacteriophage and a recently obtained mutant form of T4D were studied. The DNA of this T4 mutant contains cytosine in place of all of the glucosylated hydroxymethylcytosines normally present in T4. Molecular weights were measured with an electron microscope technique, and sedimentation coeffi...

journal_title：Journal of virology

authors： Clark RW,Wever GH,Wiberg JS

更新日期：1980-01-01 00:00:00

abstract：:Bacteriophage with linear, double-stranded DNA genomes package DNA into preassembled protein shells called procapsids. Located at one vertex in the procapsid is a portal complex composed of a ring of 12 subunits of portal protein. The portal complex serves as a docking site for the DNA packaging enzymes, a conduit for...

journal_title：Journal of virology

authors： Moore SD,Prevelige PE Jr

更新日期：2002-10-01 00:00:00

abstract：:Rotavirus replication and virulence are strongly influenced by virus strain and host species. The rotavirus proteins VP3, VP4, VP7, NSP1, and NSP4 have all been implicated in strain and species restriction of replication; however, the mechanisms have not been fully determined. Simian (RRV) and bovine (UK) rotaviruses ...

journal_title：Journal of virology

authors： Feng N,Sen A,Wolf M,Vo P,Hoshino Y,Greenberg HB

更新日期：2011-03-01 00:00:00

abstract：:Ebola virus (EBOV) continues to pose a significant threat to human health, as evidenced by the 2013-2016 epidemic in West Africa and the ongoing outbreak in the Democratic Republic of the Congo. EBOV causes hemorrhagic fever, organ damage, and shock culminating in death, with case fatality rates as high as 90%. This h...

journal_title：Journal of virology

authors： Jankeel A,Menicucci AR,Woolsey C,Fenton KA,Mendoza N,Versteeg K,Cross RW,Geisbert TW,Messaoudi I

更新日期：2020-05-18 00:00:00

abstract：:Glycoprotein C (gC) of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) binds complement component C3b and protects virus from complement-mediated neutralization. Differences in complement interacting domains exist between gC of HSV-1 (gC1) and HSV-2 (gC2), since the amino terminus of gC1 blocks complement C5 fr...

journal_title：Journal of virology

authors： Hook LM,Lubinski JM,Jiang M,Pangburn MK,Friedman HM

更新日期：2006-04-01 00:00:00

abstract：:Phage XP-12, which has complete substitution of the cytosine residues in its DNA with 5-methylcytosine residues, was shown to inhibit incorporation of uracil into host DNA and RNA during the latent period. This apparent inhibition of host macromolecular synthesis was not accompanied by extensive degradation of the hos...

journal_title：Journal of virology

authors： Ehrlich M,Lin FH,Ehrlich K,Brown SL,Mayo JA

更新日期：1977-09-01 00:00:00

abstract：:Herpesviruses are important pathogens of humans and other animals. Herpesvirus infectious clones that can reconstitute phenotypically wild-type (wt) virus are extremely valuable tools for elucidating the roles of specific genes in virus pathophysiology as well as for making vaccines. Ictalurid herpesvirus 1 (channel c...

journal_title：Journal of virology

authors： Kunec D,Hanson LA,van Haren S,Nieuwenhuizen IF,Burgess SC

更新日期：2008-04-01 00:00:00

abstract：:More than 200 open reading frames (ORFs) from the human cytomegalovirus genome have been reported as potentially coding for proteins. We have used two pattern-based in silico approaches to analyze this set of putative viral genes. With the help of an objective annotation method that is based on the Bio-Dictionary, a c...

journal_title：Journal of virology

authors： Rigoutsos I,Novotny J,Huynh T,Chin-Bow ST,Parida L,Platt D,Coleman D,Shenk T

更新日期：2003-04-01 00:00:00

abstract：:HIV-1 circulates within an infected host as a genetically heterogeneous viral population. Viral intrahost diversity is shaped by substitutional evolution and recombination. Although many studies have speculated that recombination could have a significant impact on viral phenotype, this has never been definitively demo...

journal_title：Journal of virology

authors： Brown RJ,Peters PJ,Caron C,Gonzalez-Perez MP,Stones L,Ankghuambom C,Pondei K,McClure CP,Alemnji G,Taylor S,Sharp PM,Clapham PR,Ball JK

更新日期：2011-06-01 00:00:00

abstract：:Apoptin, a viral death protein derived from chicken anemia virus, displays a number of tumor-specific behaviors. In particular, apoptin is phosphorylated, translocates to the nucleus, and induces apoptosis specifically in tumor or transformed cells, whereas it is nonphosphorylated and remains primarily inactive in the...

journal_title：Journal of virology

authors： Zhang YH,Kooistra K,Pietersen A,Rohn JL,Noteborn MH

更新日期：2004-09-01 00:00:00

abstract：:Using synthetic peptides, we characterized the B-lymphocyte (antibody) and T-lymphocyte (proliferation) responses to an immunodominant epitope of human immunodeficiency virus type 1 (HIV-1) located near the amino-terminal end of the transmembrane glycoprotein (env amino acids 598 to 609). Both immunoglobulin M (IgM) a...

journal_title：Journal of virology

authors： Schrier RD,Gnann JW Jr,Langlois AJ,Shriver K,Nelson JA,Oldstone MB

更新日期：1988-08-01 00:00:00

abstract：:It has become evident that naturally occurring CD25(+) regulatory T cells (T(reg) cells) not only influence self-antigen specific immune response but also dampen foreign antigen specific immunity. This report extends our previous findings by demonstrating that immunity to certain herpes simplex virus (HSV) vaccines is...

journal_title：Journal of virology

authors： Toka FN,Suvas S,Rouse BT

更新日期：2004-12-01 00:00:00

abstract：UNLABELLED:Foot-and-mouth disease virus (FMDV) causes a highly contagious, debilitating disease in cloven-hoofed animals with devastating economic consequences. To survive in the host, FMDV has evolved to antagonize the host type I interferon (IFN) response. Previous studies have reported that the leader proteinase (L(...

journal_title：Journal of virology

authors： Du Y,Bi J,Liu J,Liu X,Wu X,Jiang P,Yoo D,Zhang Y,Wu J,Wan R,Zhao X,Guo L,Sun W,Cong X,Chen L,Wang J

更新日期：2014-05-01 00:00:00

abstract：:Previous analyses using in situ hybridization alone or together with PCR have yielded conflicting results regarding the cell type in which latent varicella-zoster virus (VZV) resides. We separated human trigeminal ganglia (TG) into neuronal and nonneuronal fractions, followed by primary and nested PCR to quantitate VZ...

journal_title：Journal of virology

authors： LaGuardia JJ,Cohrs RJ,Gilden DH

更新日期：1999-10-01 00:00:00

abstract：:We constructed a DNA fragment map of low-passage Towne strain cytomegalovirus by analyzing cross-blot hybridization and hybridizations of isolated recombinant clones. The abundant late transcripts were located on this map by hybridization of labeled total RNA of virus-infected cells to blotted DNA fragments. The most ...

journal_title：Journal of virology

authors： Davis MG,Mar EC,Wu YM,Huang ES

更新日期：1984-10-01 00:00:00

abstract：:HBI is a recombinant avian retrovirus with novel pathogenic properties that was derived from the myc-containing virus MC29. In contrast to MC29, which causes endotheliomas in chickens, HBI induces lymphoid tumors. The results of molecular cloning and nucleotide sequencing of HBI reported here show that the virus conta...

journal_title：Journal of virology

authors： Smith DR,Vennstrom B,Hayman MJ,Enrietto PJ

更新日期：1985-12-01 00:00:00

abstract：:Numerous deaths of koi and common carp (Cyprinus carpio) were observed on many farms throughout Israel, resulting in severe financial losses. The lethal viral disease observed is highly contagious and extremely virulent, but morbidity and mortality are restricted to koi and common carp populations. Diseased fish exhib...

journal_title：Journal of virology

authors： Hutoran M,Ronen A,Perelberg A,Ilouze M,Dishon A,Bejerano I,Chen N,Kotler M

更新日期：2005-02-01 00:00:00

abstract：:To examine the prerequisites for cleavage activation of the hemagglutinin of human influenza viruses, a cDNA clone obtained from strain A/Port Chalmers/1/73 (serotype H3) was subjected to site-directed mutagenesis and expressed in CV-1 cells by using a simian virus 40 vector. The number of basic residues at the cleava...

journal_title：Journal of virology

authors： Ohuchi R,Ohuchi M,Garten W,Klenk HD

更新日期：1991-07-01 00:00:00

abstract：:Hepatitis C virus (HCV), a member of the family Flaviviridae, is a leading cause of chronic liver disease and cancer. Recent advances in HCV therapeutics have resulted in improved cure rates, but an HCV vaccine is not available and is urgently needed to control the global pandemic. Vaccine development has been hampere...

journal_title：Journal of virology

authors： Sabahi A,Uprichard SL,Wimley WC,Dash S,Garry RF

更新日期：2014-09-01 00:00:00

abstract：:Chronic hepatitis B affects over 300 million people who are at risk of developing liver cancer. The basis for the persistence of hepatitis B virus (HBV) in hepatocytes, even in the presence of available antiviral therapies, lies in the accumulation of covalently closed circular DNA (cccDNA) in nuclei of infected cells...

journal_title：Journal of virology

authors： Li M,Sohn JA,Seeger C

更新日期：2017-12-14 00:00:00