Human T-cell leukemia virus type 2 Rex protein increases stability and promotes nuclear to cytoplasmic transport of gag/pol and env RNAs.

abstract：:Hepatitis B virus (HBV) is an enveloped DNA virus that presumably buds at intracellular membranes of infected cells. HBV budding involves two endocytic host proteins, the ubiquitin-interacting adaptor gamma 2-adaptin and the Nedd4 ubiquitin ligase. Here, we demonstrate that HBV release also requires the cellular machi...

journal_title：Journal of virology

authors： Lambert C,Döring T,Prange R

更新日期：2007-09-01 00:00:00

abstract：:Among the five serine incorporator (SERINC) family members, SERINC5 (Ser5) was reported to strongly inhibit HIV-1 replication, which is counteracted by Nef. Ser5 produces 5 alternatively spliced isoforms: Ser5-001 has 10 putative transmembrane domains, whereas Ser5-004, -005, -008a, and -008b do not have the last one....

journal_title：Journal of virology

authors： Zhang X,Zhou T,Yang J,Lin Y,Shi J,Zhang X,Frabutt DA,Zeng X,Li S,Venta PJ,Zheng YH

更新日期：2017-04-28 00:00:00

abstract：:Human rhinoviruses (HRVs) were discovered as common cold pathogens over 50 years ago. Recent advances in molecular viral diagnostics have led to an appreciation of their role in more-significant respiratory illnesses, including bronchiolitis in infancy, childhood pneumonia, and acute exacerbations of chronic respirato...

journal_title：Journal of virology

authors： Gern JE

更新日期：2010-08-01 00:00:00

abstract：:Despite reports of viral genetic defects in persons who control human immunodeficiency virus type 1 (HIV-1) in the absence of antiviral therapy, the extent to which such defects contribute to the long-term containment of viremia is not known. Most previous studies examining for such defects have involved small numbers...

journal_title：Journal of virology

authors： Miura T,Brockman MA,Brumme CJ,Brumme ZL,Carlson JM,Pereyra F,Trocha A,Addo MM,Block BL,Rothchild AC,Baker BM,Flynn T,Schneidewind A,Li B,Wang YE,Heckerman D,Allen TM,Walker BD

更新日期：2008-09-01 00:00:00

abstract：:The double-stranded-DNA bacteriophages employ powerful molecular motors to translocate genomic DNA into preformed capsids during the packaging step in phage assembly. Bacillus subtilis bacteriophage 29 has an oligomeric prohead RNA (pRNA) that is an essential component of its packaging motor. The crystal structure of ...

journal_title：Journal of virology

authors： Zhao W,Saha M,Ke A,Morais MC,Jardine PJ,Grimes S

更新日期：2012-11-01 00:00:00

abstract：:Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are highly susceptible to ...

journal_title：Journal of virology

authors： Yun NE,Seregin AV,Walker DH,Popov VL,Walker AG,Smith JN,Miller M,de la Torre JC,Smith JK,Borisevich V,Fair JN,Wauquier N,Grant DS,Bockarie B,Bente D,Paessler S

更新日期：2013-10-01 00:00:00

abstract：:Activated Notch1 (AcN1) alleles cooperate with oncogenes from DNA tumor viruses in transformation of epithelial cells. AcN1 signaling has pleiotropic effects, and suggested oncogenic roles include driving proliferation through cyclin D1 or the generation of resistance to apoptosis on matrix withdrawal through a phosph...

journal_title：Journal of virology

authors： Nair P,Somasundaram K,Krishna S

更新日期：2003-06-01 00:00:00

abstract：:A polypeptide (p40) of approximately 40,000 molecular weight was isolated from herpes simplex virus type 1 and 2 nucleocapsids by gel filtration and ion exchange chromatography. This protein appears to be the same as protein 22a described previously (Gibson and Roizman, J. Virol. 10:1044--1052, 1972). Competition immu...

journal_title：Journal of virology

authors： Heilman CJ Jr,Zweig M,Stephenson JR,Hampar B

更新日期：1979-01-01 00:00:00

abstract：:Transfection has been found and characterized in pneumococcus. For replicating omega3 phage DNA extracted from infected cells, transfection was relatively efficient and rose linearly with DNA concentration and quadratically with time, according to T(T - 3.5) min(2). For mature DNA extracted from phage particles, trans...

journal_title：Journal of virology

authors： Porter RD,Guild WR

更新日期：1978-01-01 00:00:00

abstract：:Since most human immunodeficiency virus (HIV) infections are initiated following mucosal exposure to the virus, the anatomic containment or abortion of an HIV infection is likely to require vaccine-elicited cellular immune responses in those mucosal sites. Studying vaccine-elicited mucosal immune responses has been pr...

journal_title：Journal of virology

authors： Baig J,Levy DB,McKay PF,Schmitz JE,Santra S,Subbramanian RA,Kuroda MJ,Lifton MA,Gorgone DA,Wyatt LS,Moss B,Huang Y,Chakrabarti BK,Xu L,Kong WP,Yang ZY,Mascola JR,Nabel GJ,Carville A,Lackner AA,Veazey RS,Letvin N

更新日期：2002-11-01 00:00:00

abstract：:The L5R gene of vaccinia virus is conserved among all sequenced members of the Poxviridae but has no predicted function or recognized nonpoxvirus homolog. Here we provide the initial characterization of the L5 protein. L5 is expressed following DNA replication with kinetics typical of a viral late protein, contains a ...

journal_title：Journal of virology

authors： Townsley AC,Senkevich TG,Moss B

更新日期：2005-09-01 00:00:00

abstract：:In bacterial strains containing the deoxyribonuclease endonuclease I (endonuclease I(+) strains), 70 to 80% of the injected superinfecting T-even phage deoxyribonucleic acid (DNA) is rapidly degraded to oligonucleotides having an average chain length of 8, the same value as that obtained by endonuclease I digestion of...

journal_title：Journal of virology

authors： Anderson CW,Eigner J

更新日期：1971-12-01 00:00:00

abstract：:Penetration of the nervous systems of suckling mice by prototype strains of the three mammalian reovirus serotypes was studied after footpad inoculation of a dose (10(7) PFU) representing 3.5 x 10(3) 50% lethal doses (LD50) for reovirus type 3 Dearing and less than 1 LD50 for reoviruses type 1 Lang and type 2 Jones. T...

journal_title：Journal of virology

authors： Flamand A,Gagner JP,Morrison LA,Fields BN

更新日期：1991-01-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) has been shown to progress through a number of changes that lead to the emergence of pathogenic viral variants in macaques initially infected with a mildly cytopathic variant, SIVMneCL8. One of these late-stage isolates, SIVMne170, replicates to high levels in vivo and causes a rapi...

journal_title：Journal of virology

authors： Voronin Y,Overbaugh J,Emerman M

更新日期：2005-12-01 00:00:00

abstract：UNLABELLED:Pandemic influenza is a major public health concern, but conventional strain-matched vaccines are unavailable early in a pandemic. Candidate "universal" vaccines targeting the viral antigens nucleoprotein (NP) and matrix 2 (M2), which are conserved among all influenza A virus strains and subtypes, could be m...

journal_title：Journal of virology

authors： Price GE,Lo CY,Misplon JA,Epstein SL

更新日期：2014-06-01 00:00:00

abstract：:HIV-1 infectivity is strongly restricted by TRIM5α from certain primate species but has been described as being only marginally susceptible to human TRIM5α. In this study, we evaluated the effects of the modulation of human TRIM5α activity (pretreatment of target cells with alpha interferon, expression of a pre-miRNA ...

journal_title：Journal of virology

authors： Battivelli E,Lecossier D,Matsuoka S,Migraine J,Clavel F,Hance AJ

更新日期：2010-11-01 00:00:00

abstract：:A coxsackievirus B3 (CB3) isolate adapted to growth in RD cells shows an alteration in cell tropism as a result of its capacity to bind a 70-kDa cell surface molecule expressed on these cells. We now show that this molecule is the complement regulatory protein, decay-accelerating factor (DAF) (CD55). Anti-DAF antibodi...

journal_title：Journal of virology

authors： Bergelson JM,Mohanty JG,Crowell RL,St John NF,Lublin DM,Finberg RW

更新日期：1995-03-01 00:00:00

abstract：:Influenza viruses unable to express NS1 protein (delNS1) replicate poorly and induce large amounts of interferon (IFN). They are therefore considered candidate viruses for live-attenuated influenza vaccines. Their attenuated replication is generally assumed to result from the inability to counter the antiviral host re...

journal_title：Journal of virology

authors： van Wielink R,Harmsen MM,Martens DE,Peeters BP,Wijffels RH,Moormann RJ

更新日期：2012-11-01 00:00:00

abstract：:The adenovirus type 4 origins of replication are located at each end of the linear, protein-linked viral DNA molecule and consist of the terminal 18 bp of the viral genome. The sequence of the first 8 bp of the viral genome varies among different adenovirus serotypes, but the sequence from bp 9 to 18 is conserved in a...

journal_title：Journal of virology

authors： Temperley SM,Burrow CR,Kelly TJ,Hay RT

更新日期：1991-09-01 00:00:00

abstract：:The biologically relevant form of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein is oligomeric, with the major points of contact between oligomeric partners located in the ectodomain of gp41. To identify and map conserved epitopes and regions in gp41 where structure is influenced by quater...

journal_title：Journal of virology

authors： Earl PL,Broder CC,Doms RW,Moss B

更新日期：1997-04-01 00:00:00

abstract：:The nucleotide sequence corresponding to the P3 region of the hepatitis A virus (HAV) polyprotein genome was determined from cloned cDNA and translated into an amino acid sequence. Comparison of the amino acid sequences of the genome-linked proteins (VPgs) of other picornaviruses with the predicted amino acid sequence...

journal_title：Journal of virology

authors： Weitz M,Baroudy BM,Maloy WL,Ticehurst JR,Purcell RH

更新日期：1986-10-01 00:00:00

abstract：:The activity of uracil-DNA glycosylase in Escherichia coli decreases dramatically to less than 10% of its original level after infection of the cells by phage T5. Phage-induced protein synthesis is required for this inhibition to occur, and the inhibition is induced by a mutant capable of injecting only the first 8% o...

journal_title：Journal of virology

authors： Warner HR,Johnson LK,Snustad DP

更新日期：1980-01-01 00:00:00

abstract：:The gene encoding glycoprotein B (gB) of murine cytomegalovirus (MCMV) strain Smith was identified, sequenced, and expressed by recombinant vaccinia virus. The gB gene was found adjacent to the polymerase gene, as it is in the genome of human cytomegalovirus (HCMV). The open reading frame consists of 2,784 nucleotides...

journal_title：Journal of virology

authors： Rapp M,Messerle M,Bühler B,Tannheimer M,Keil GM,Koszinowski UH

更新日期：1992-07-01 00:00:00

abstract：:The nonstructural 4B (NS4B) protein of hepatitis C virus (HCV) plays a central role in the formation of the HCV replication complex. To gain insight into the role of charged residues for NS4B function in HCV RNA replication, alanine substitutions were engineered in place of 28 charged residues residing in the N- and C...

journal_title：Journal of virology

authors： Blight KJ

更新日期：2011-08-01 00:00:00

abstract：:HeLa cells infected with human rhinovirus type 2 synthesize a mixture of single-and double-stranded ribonucleic acid (RNA). The RNA synthesized by the membrane-bound RNA polymerase complex in vitro is also a mixture of single- and double-stranded RNA, whereas the deoxycholate-treated RNA polymerase complex synthesized...

journal_title：Journal of virology

authors： Yin FH,Knight E Jr

更新日期：1972-07-01 00:00:00

abstract：:Analyses of prototype vesicular stomatitis (VSV, Indiana serotype) mRNA-32P-labeled viral RNA duplexes have established the assignments of 65 of the 72 large oligonucleotides that are recovered by two-dimensional electrophoresis of RNase T1 digests of the viral RNA. Fifty of the oligonucleotides are recovered in the L...

journal_title：Journal of virology

authors： Clewley JP,Bishop DH

更新日期：1979-04-01 00:00:00

abstract：:The NS3 protein of hepatitis C virus (HCV) possesses protease activity responsible for the proteolytic cleavage of the viral polyprotein at the junctions of nonstructural proteins downstream of NS3. The NS3 protein was also found to be internally cleaved. In this study, we demonstrated that internal cleavages occurred...

journal_title：Journal of virology

authors： Kou YH,Chang MF,Wang YM,Hung TM,Chang SC

更新日期：2007-08-01 00:00:00

abstract：:Nonstructural protein 1 (NS1) of yellow fever virus (YF) is a glycoprotein localized to extracytoplasmic compartments within infected cells. We have previously shown that NS1 can be supplied in trans and is required for viral RNA replication, a process thought to occur in membrane-bound cytoplasmic complexes. Here we ...

journal_title：Journal of virology

authors： Lindenbach BD,Rice CM

更新日期：1999-06-01 00:00:00

abstract：:We investigated the cis-acting sequences involved in termination of vesicular stomatis virus mRNA synthesis by using bicistronic genomic analogs. All of the cis-acting signals necessary for termination reside within the first 13 nucleotides of the 23-nucleotide conserved gene junction. This 13-nucleotide termination s...

journal_title：Journal of virology

authors： Barr JN,Whelan SP,Wertz GW

更新日期：1997-11-01 00:00:00

abstract：:Hepatitis C virus core protein forms the viral nucleocapsid and plays a critical role in the formation of infectious particles. In this study, we demonstrate that the highly conserved residue G33, located within domain 1 of the core protein, is important for the production of cell culture-infectious virus (HCVcc). Ala...

journal_title：Journal of virology

authors： Angus AG,Loquet A,Stack SJ,Dalrymple D,Gatherer D,Penin F,Patel AH

更新日期：2012-01-01 00:00:00