Dynamics of persistent TT virus infection, as determined in patients treated with alpha interferon for concomitant hepatitis C virus infection.

abstract：:The phosphoprotein (P protein) of respiratory syncytial virus (RSV) is a key component of the viral RNA-dependent RNA polymerase complex. The protein is constitutively phosphorylated at the two clusters of serine residues (116, 117, and 119 [116/117/119] and 232 and 237 [232/237]). To examine the role of phosphorylati...

journal_title：Journal of virology

authors： Lu B,Ma CH,Brazas R,Jin H

更新日期：2002-11-01 00:00:00

abstract：:After herpes simplex virus infection of hamster kidney cells there is an induction of nucleoside phosphotransferase activity which can utilize AMP as phosphate donor. The activity is immunologically specific for the infected cell and is induced concomitantly with the virus-coded pyrimidine deoxynucleoside kinase activ...

journal_title：Journal of virology

authors： Jamieson AT,Hay J,Subak-Sharpe JH

更新日期：1976-03-01 00:00:00

abstract：:H5N1 highly pathogenic avian influenza virus (HPAIV) has continued to spread and poses a significant threat to both animal and human health. Current influenza vaccine strategies have limitations that prevent their effective use for widespread inoculation of animals in the field. Vaccine strains of Newcastle disease vi...

journal_title：Journal of virology

authors： Ge J,Deng G,Wen Z,Tian G,Wang Y,Shi J,Wang X,Li Y,Hu S,Jiang Y,Yang C,Yu K,Bu Z,Chen H

更新日期：2007-01-01 00:00:00

abstract：:In vitro studies have suggested an important role for the minor capsid protein (VP1) unique region and the junction between VP1 and the major capsid protein (VP2) in the neutralizing immune response to B19 parvovirus. We investigated the role of the NH2-terminal region of the major structural protein in capsid structu...

journal_title：Journal of virology

authors： Kawase M,Momoeda M,Young NS,Kajigaya S

更新日期：1995-10-01 00:00:00

abstract：:The lack of a mouse model has hampered an understanding of the pathogenesis and immunity of Marburg hemorrhagic fever (MHF), the disease caused by marburgvirus (MARV), and has created a bottleneck in the development of antiviral therapeutics. Primary isolates of the filoviruses, i.e., ebolavirus (EBOV) and MARV, are n...

journal_title：Journal of virology

authors： Warfield KL,Bradfute SB,Wells J,Lofts L,Cooper MT,Alves DA,Reed DK,VanTongeren SA,Mech CA,Bavari S

更新日期：2009-07-01 00:00:00

abstract：:We have identified a trans-dominant mutant form of the herpes simplex virus (HSV) DNA-binding protein ICP8 which inhibits viral replication. When expressed by the V2.6 cell line, the mutant gene product inhibited wild-type HSV production by 50- to 150-fold when the multiplicity of infection was less than 5. Production...

journal_title：Journal of virology

authors： Gao M,Knipe DM

更新日期：1991-05-01 00:00:00

abstract：:Expression of the human T-cell leukemia virus type 1 (HTLV-1) oncoprotein Tax is correlated with cellular transformation contributing to the development of adult T-cell leukemia. Tax has been shown to modulate the activities of several cellular promoters. Existing evidence suggests that Tax need not directly bind to D...

journal_title：Journal of virology

authors： Kibler KV,Jeang KT

更新日期：2001-03-01 00:00:00

abstract：:After rabies virus glycoprotein was treated with CNBr, the peptide mixture was fractionated by preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis. CNBr-cleaved peptide fragments were resolved into seven peptide bands under reducing conditions and six peptide bands under nonreducing conditions. The i...

journal_title：Journal of virology

authors： Dietzschold B,Wiktor TJ,Macfarlan R,Varrichio A

更新日期：1982-11-01 00:00:00

abstract：:Infection of newborn Lewis rats with Borna disease virus (neonatal Borna disease [NBD]) results in cerebellar damage without the cellular inflammation associated with infections in later life. Purkinje cell (PC) damage has been reported for several models of early-life viral infection, including NBD; however, the time...

journal_title：Journal of virology

authors： Williams BL,Yaddanapudi K,Hornig M,Lipkin WI

更新日期：2007-03-01 00:00:00

abstract：:The E6 oncoprotein of high-risk human papillomavirus type 16 (HPV16) interacts with several nuclear transcription factors and coactivators in addition to cytoplasmic proteins, suggesting that nuclear import of HPV16 E6 plays a role in the cellular transformation process. In this study we have investigated the nuclear ...

journal_title：Journal of virology

authors： Le Roux LG,Moroianu J

更新日期：2003-02-01 00:00:00

abstract：:In this study, we investigated the expression levels of host restriction factors in six untreated HIV-1-positive patients over the course of infection. We found that the host restriction factor gene expression profile consistently increased over time and was significantly associated with CD4+ T cell activation and vir...

journal_title：Journal of virology

authors： Raposo RA,Abdel-Mohsen M,Deng X,Hecht FM,Pilcher CD,Pillai SK,Nixon DF

更新日期：2014-10-01 00:00:00

abstract：:Two poliovirus mutants were isolated that contain an oligonucleotide linker insertion in the 2C-coding region of the viral genome. One, 2C-31, has a strongly temperature-sensitive phenotype and the other, 2C-32, forms small plaques on HeLa cell monolayers at all temperatures. Both mutants have a severe temperature-sen...

journal_title：Journal of virology

authors： Li JP,Baltimore D

更新日期：1988-11-01 00:00:00

abstract：:Viral myocarditis is an important human disease, and reovirus-induced murine myocarditis provides an excellent model system for study. Cardiac myocytes, like neurons in the central nervous system, are not replenished, yet there is no cardiac protective equivalent to the blood-brain barrier. Thus, cardiac myocytes may ...

journal_title：Journal of virology

authors： Zurney J,Howard KE,Sherry B

更新日期：2007-12-01 00:00:00

abstract：:The efficient attachment of pseudorabies virus to cultured cells is dependent on an electrostatic interaction between negatively charged cell surface heparan sulfate and the viral envelope glycoprotein gC. Deletion of the first one-third of gC severely impairs virus attachment, but the mutant virions are still capable...

journal_title：Journal of virology

authors： Flynn SJ,Ryan P

更新日期：1995-02-01 00:00:00

abstract：:Major histocompatibility complex class I (MHC I)-restricted CD8(+) T-cell responses play a pivotal role in anti-human immunodeficiency virus (HIV) immunity and the control of viremia. The rhesus macaque is an important animal model for HIV-related research. Among the MHC I alleles of the rhesus macaque, Mamu-A 02 is p...

journal_title：Journal of virology

authors： Liu J,Dai L,Qi J,Gao F,Feng Y,Liu W,Yan J,Gao GF

更新日期：2011-07-01 00:00:00

abstract：:Vaccinia virus (VACV) stimulates long-term immunity against highly pathogenic orthopoxvirus infection of humans (smallpox) and mice (mousepox [ectromelia virus {ECTV}]) despite the lack of a natural host-pathogen relationship with either of these species. Previous research revealed that VACV is able to induce polyfunc...

journal_title：Journal of virology

authors： Hersperger AR,Siciliano NA,Eisenlohr LC

更新日期：2012-07-01 00:00:00

abstract：:Diminished in vitro proliferation of human immunodeficiency virus type 1 (HIV-1)-specific CD4+T cells has been associated with HIV-1 viremia and declining CD4+ T-cell counts during chronic infection. To better understand this phenomenon, we examined whether HIV-1 Gag p24 antigen-induced CD4+ T-cell proliferation might...

journal_title：Journal of virology

authors： Boritz E,Palmer BE,Wilson CC

更新日期：2004-11-01 00:00:00

abstract：:A thorough understanding of the diversity of viruses in wildlife provides epidemiological baseline information about potential pathogens. Metagenomic analysis of the enteric viral flora revealed a new anellovirus and bocavirus species in pine martens and a new circovirus-like virus and geminivirus-related DNA virus in...

journal_title：Journal of virology

authors： van den Brand JM,van Leeuwen M,Schapendonk CM,Simon JH,Haagmans BL,Osterhaus AD,Smits SL

更新日期：2012-02-01 00:00:00

abstract：:Recently developed antiviral strategies based upon RNA interference (RNAi), which harnesses an innate cellular system for the targeted down-regulation of gene expression, appear highly promising and offer alternative approaches to conventional highly active antiretroviral therapy or efforts to develop an AIDS vaccine....

journal_title：Journal of virology

authors： Leonard JN,Schaffer DV

更新日期：2005-02-01 00:00:00

abstract：:Reoviruses isolated from persistently infected cultures (PI viruses) can grow in the presence of ammonium chloride, a weak base that blocks acid-dependent proteolysis of viral outer-capsid proteins during viral entry into cells. We used reassortant viruses isolated from crosses of wild-type (wt) reovirus strain, type ...

journal_title：Journal of virology

authors： Wetzel JD,Wilson GJ,Baer GS,Dunnigan LR,Wright JP,Tang DS,Dermody TS

更新日期：1997-02-01 00:00:00

abstract：:Parvovirus capsids are assembled from multiple forms of a single protein and are quite stable structurally. However, in order to infect cells, conformational plasticity of the capsid is required and this likely involves the exposure of structures that are buried within the structural models. The presence of functional...

journal_title：Journal of virology

authors： Nelson CD,Minkkinen E,Bergkvist M,Hoelzer K,Fisher M,Bothner B,Parrish CR

更新日期：2008-11-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) (also called human herpesvirus 8) is consistently found in Kaposi's sarcoma lesions and in body-cavity-based lymphomas. A 17-kb KSHV lambda clone was obtained directly from a Kaposi's sarcoma lesion. DNA sequence analysis of this clone identified an open reading frame whi...

journal_title：Journal of virology

authors： Li M,Lee H,Yoon DW,Albrecht JC,Fleckenstein B,Neipel F,Jung JU

更新日期：1997-03-01 00:00:00

abstract：:The enhancer unit present in the retrovirus equine infectious anemia virus (EIAV) was previously shown to contain binding sites for proteins belonging to MDBP, PEA2, AP-1, and ets families. The EIAV ets motif matches the consensus sequence for both PEA3- and PU.1-binding sites. Here, we show by gel shift analysis that...

journal_title：Journal of virology

authors： Carvalho M,Derse D

更新日期：1993-07-01 00:00:00

abstract：:The molecular basis of the temperature-sensitive (ts) phenotype of P3/Sabin, the type 3 vaccine strain of poliovirus, was investigated in light of the known correlation between ts and attenuation phenotypes. A phenylalanine at residue 91 of the capsid protein VP3 was a major determinant of both phenotypes, and attenua...

journal_title：Journal of virology

authors： Macadam AJ,Ferguson G,Arnold C,Minor PD

更新日期：1991-10-01 00:00:00

abstract：:Previous studies using wild-type Encephalomyocarditis virus (EMCV) and Mengo virus, which have long poly(C) tracts (61 to 146 C's) at the 5' nontranslated region of the genome, and variants of these viruses genetically engineered to truncate or substitute the poly(C) tracts have produced conflicting data on the role o...

journal_title：Journal of virology

authors： LaRue R,Myers S,Brewer L,Shaw DP,Brown C,Seal BS,Njenga MK

更新日期：2003-09-01 00:00:00

abstract：:We recently found that a human T-cell leukemia virus type 1-infected cell line, MT-2, could support the replication of hepatitis C virus (HCV) (N. Kato, T. Nakazawa, T. Mizutani, and K. Shimotohno, Biochem. Biophys. Res. Commun. 206:863-869, 1995). In order to develop a culture system in which HCV replicates more effi...

journal_title：Journal of virology

authors： Mizutani T,Kato N,Saito S,Ikeda M,Sugiyama K,Shimotohno K

更新日期：1996-10-01 00:00:00

abstract：:Influenza A virus (IAV) replication relies on an intricate interaction between virus and host cells. How the cellular proteins are usurped for IAV replication remains largely obscure. The aim of this study was to search for novel and potential cellular factors that participate in IAV replication. ZBTB25, a transcripti...

journal_title：Journal of virology

authors： Chen SC,Jeng KS,Lai MMC

更新日期：2017-09-27 00:00:00

abstract：:In order to explore the potential of retrovirus vectors for efficiently transferring foreign genes into mouse embryos, a replication-competent recombinant Moloney murine leukemia virus (Mo-MLV) vector carrying a mutant dihydrofolate reductase (DHFR) cDNA insert in the U3 region of the viral long terminal repeat was us...

journal_title：Journal of virology

authors： Stuhlmann H,Jaenisch R,Mulligan RC

更新日期：1989-11-01 00:00:00

abstract：:Retrovirus particles each contain two copies of the viral genome in the form of a noncovalently linked RNA dimer. Earlier studies have mapped a cis-acting region near the 5' end of the human immunodeficiency virus type 1 (HIV-1) genome, termed the psi locus, which appears essential for initiation of genomic dimerizati...

journal_title：Journal of virology

authors： Clever JL,Parslow TG

更新日期：1997-05-01 00:00:00

abstract：:A large percentage of the repetitive elements in mammalian genomes are retroelements, which have been moved primarily by LINE-1 retrotransposons and endogenous retroviruses. Although LINE-1 elements have remained active throughout the mammalian radiation, specific groups of endogenous retroviruses generally remain act...

journal_title：Journal of virology

authors： Cantrell MA,Ederer MM,Erickson IK,Swier VJ,Baker RJ,Wichman HA

更新日期：2005-12-01 00:00:00