DNA repair enzyme uracil DNA glycosylase is specifically incorporated into human immunodeficiency virus type 1 viral particles through a Vpr-independent mechanism.

abstract：:Recombinant poxvirus vectors are undergoing intensive evaluation as vaccine candidates for a variety of infectious pathogens. Avipoxviruses, such as canarypox virus, are replication deficient in mammalian cells by virtue of a poorly understood species-specific restriction. Highly attenuated vaccinia virus strains such...

journal_title：Journal of virology

authors： Zhang X,Cassis-Ghavami F,Eller M,Currier J,Slike BM,Chen X,Tartaglia J,Marovich M,Spearman P

更新日期：2007-07-01 00:00:00

abstract：:Vaccinia virus genes are expressed in a sequential fashion, suggesting a role for negative as well as positive regulatory mechanisms. A potential down regulator of gene expression was mapped by transfection assays to vaccinia virus open reading frame D10, which encodes a protein with no previously known function. Inhi...

journal_title：Journal of virology

authors： Shors T,Keck JG,Moss B

更新日期：1999-01-01 00:00:00

abstract：:Purified Kunjin virus was disrupted with sodium dodecyl sulfate, urea, and mercaptoethanol or acetic acid. Electrophoresis on 7.5% polyacrylamide gel separated four proteins of high (120,000), intermediate (65,000) and low (18,000 and 13,000) molecular weights. A "core" particle was obtained by degradation of the viri...

journal_title：Journal of virology

authors： Westaway EG,Reedman BM

更新日期：1969-11-01 00:00:00

abstract：:Hepatitis B virus (HBV) is an enveloped DNA virus that presumably buds at intracellular membranes of infected cells. HBV budding involves two endocytic host proteins, the ubiquitin-interacting adaptor gamma 2-adaptin and the Nedd4 ubiquitin ligase. Here, we demonstrate that HBV release also requires the cellular machi...

journal_title：Journal of virology

authors： Lambert C,Döring T,Prange R

更新日期：2007-09-01 00:00:00

abstract：:Broadly neutralizing antibodies have been isolated that bind the glycan shield of the HIV-1 envelope spike. One such antibody, PGT135, contacts the intrinsic mannose patch of gp120 at the Asn332, Asn392, and Asn386 glycosylation sites. Here, site-specific glycosylation analysis of recombinant gp120 revealed glycan mic...

journal_title：Journal of virology

authors： Pritchard LK,Spencer DI,Royle L,Vasiljevic S,Krumm SA,Doores KJ,Crispin M

更新日期：2015-07-01 00:00:00

abstract：:Alphavirus infection of fibroblastic cell types in vitro inhibits host cell translation and transcription, leading to suppression of interferon alpha/beta (IFN-α/β) production. However, the effect of infection upon myeloid cells, which are often the first cells encountered by alphaviruses in vivo, is unclear. Previous...

journal_title：Journal of virology

authors： Bhalla N,Gardner CL,Downs SN,Dunn M,Sun C,Klimstra WB

更新日期：2019-11-26 00:00:00

abstract：:The monoclonal antibody PAb280 binds to small t antigen but not to large T antigen. Its binding site within the unique region of small t antigen was localized by studying its reaction with simian virus 40 mutants, other papovaviruses, and bacterial expression vectors coding for fragments of small t antigen. The antibo...

journal_title：Journal of virology

authors： Montano X,Lane DP

更新日期：1989-07-01 00:00:00

abstract：:Coronaviruses generally have a narrow host range, infecting one or just a few species. Using targeted RNA recombination, we constructed a mutant of the coronavirus mouse hepatitis virus (MHV) in which the ectodomain of the spike glycoprotein (S) was replaced with the highly divergent ectodomain of the S protein of fel...

journal_title：Journal of virology

authors： Kuo L,Godeke GJ,Raamsman MJ,Masters PS,Rottier PJ

更新日期：2000-02-01 00:00:00

abstract：:Equine infectious anemia virus (EIAV) is an equine lentivirus similar to HIV-1, targets host immune cells, and causes a life-long infection in horses. The Chinese live EIAV vaccine is attenuated from long-term passaging of a highly virulent strain in vitro The parent pathogenic strain (EIAVDLV34) induces a host inflam...

journal_title：Journal of virology

authors： Du C,Duan Y,Wang XF,Lin Y,Na L,Wang X,Chen K,Wang X

更新日期：2019-10-15 00:00:00

abstract：:Retroviruses are believed to induce tumors by acting as insertional mutagens that activate expression of cellular protooncogenes. Indeed, almost 90% of mouse mammary tumor virus (MMTV)-induced mammary tumors in C3H/He mice show upregulation of Int protooncogenes. We have analyzed three different MMTV variants [MMTV(C3...

journal_title：Journal of virology

authors： Hook LM,Agafonova Y,Ross SR,Turner SJ,Golovkina TV

更新日期：2000-10-01 00:00:00

abstract：UNLABELLED:PML is the organizer of cellular structures termed nuclear domain 10 (ND10) or PML-nuclear bodies (PML-NBs) that act as key mediators of intrinsic immunity against human cytomegalovirus (HCMV) and other viruses. The antiviral function of ND10 is antagonized by viral regulatory proteins such as the immediate ...

journal_title：Journal of virology

authors： Scherer M,Otto V,Stump JD,Klingl S,Müller R,Reuter N,Muller YA,Sticht H,Stamminger T

更新日期：2015-11-11 00:00:00

abstract：:The membrane-proximal region of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein (TM) is critical for envelope (Env)-mediated membrane fusion and contains the target for broadly reactive neutralizing antibody 2F5. It has been proposed that 2F5 neutralization might involve interaction of its long, ...

journal_title：Journal of virology

authors： Ou W,Lu N,Yu SS,Silver J

更新日期：2006-03-01 00:00:00

abstract：:ABT-378, a new human immunodeficiency virus type 1 (HIV-1) protease inhibitor which is significantly more active than ritonavir in cell culture, is currently under investigation for the treatment of AIDS. Development of viral resistance to ABT-378 in vitro was studied by serial passage of HIV-1 (pNL4-3) in MT-4 cells....

journal_title：Journal of virology

authors： Carrillo A,Stewart KD,Sham HL,Norbeck DW,Kohlbrenner WE,Leonard JM,Kempf DJ,Molla A

更新日期：1998-09-01 00:00:00

abstract：:Upon inoculation into AKR mice, mink cell focus-forming murine leukemia virus (MCF MLV) accelerates thymic lymphoma formation. During the preleukemic phase of disease, we observed the induction of apoptosis in thymic lymphocytes. A similar induction of apoptosis was observed for cultured mink epithelial cells after MC...

journal_title：Journal of virology

authors： Nanua S,Yoshimura FK

更新日期：2004-05-01 00:00:00

abstract：:The multiplicity of attachment (MOA) of a virion in any particular time interval is the average number of cellular attachment opportunities that must be blocked to keep the virion in suspension. MOA is usually proportional to incubation time and cell concentration. Low MOA (like low multiplicity of infection) is requi...

journal_title：Journal of virology

authors： Spouge JL

更新日期：1994-03-01 00:00:00

abstract：:The mammalian tripartite motif protein, TRIM5α, recognizes retroviral capsids entering the cytoplasm and blocks virus infection. Depending on the particular TRIM5α protein and retrovirus, complete disruption of the TRIM5α RING domain decreases virus-restricting activity to various degrees. TRIM5α exhibits RING domain-...

journal_title：Journal of virology

authors： Kim J,Tipper C,Sodroski J

更新日期：2011-08-01 00:00:00

abstract：:A large number of polyoma virus-transformed cells of rat, mouse, and hamster origin were examined for presence of T-antigen species. The results showed that all lines of cells contained middle and small T antigens, but not all contained a full-sized large T antigen, in some cell lines large T antigen was absent, where...

journal_title：Journal of virology

authors： Ito Y,Spurr N,Griffin BE

更新日期：1980-07-01 00:00:00

abstract：:The full repertoire of hepatitis B virus (HBV) peptides that bind to the common HLA class I molecules found in areas with a high prevalence of chronic HBV infection has not been determined. This information may be useful for designing immunotherapies for chronic hepatitis B. We identified amino acid residues under pos...

journal_title：Journal of virology

authors： Abbott WG,Tsai P,Leung E,Trevarton A,Ofanoa M,Hornell J,Gane EJ,Munn SR,Rodrigo AG

更新日期：2010-01-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) entry inhibitor eCD4-Ig is a fusion of CD4-Ig and a coreceptor-mimetic peptide. eCD4-Ig is markedly more potent than CD4-Ig, with neutralization efficiencies approaching those of HIV-1 broadly neutralizing antibodies (bNAbs). However, unlike bNAbs, eCD4-Ig neutralized al...

journal_title：Journal of virology

authors： Fetzer I,Gardner MR,Davis-Gardner ME,Prasad NR,Alfant B,Weber JA,Farzan M

更新日期：2018-05-29 00:00:00

abstract：:Human cytomegalovirus (HCMV) major immediate-early protein IE1 is an abundant 72-kDa nuclear phosphoprotein that is thought to play an important role in efficient triggering of the lytic cycle, especially at low multiplicity of infection. The best-known properties of IE1 at present are its transient targeting to punct...

journal_title：Journal of virology

authors： Xu Y,Ahn JH,Cheng M,apRhys CM,Chiou CJ,Zong J,Matunis MJ,Hayward GS

更新日期：2001-11-01 00:00:00

abstract：:The V1V2 region of HIV-1 gp120 harbors a major vulnerable site targeted by a group of broadly neutralizing monoclonal antibodies (MAbs) such as PG9 through strand-strand recognition. However, this epitope region is structurally polymorphic as it can also form a helical conformation recognized by RV144 vaccine-induced ...

journal_title：Journal of virology

authors： Jiang X,Totrov M,Li W,Sampson JM,Williams C,Lu H,Wu X,Lu S,Wang S,Zolla-Pazner S,Kong XP

更新日期：2016-11-28 00:00:00

abstract：:Naked DNA vaccines expressing the prM and E genes of two tick-borne flaviviruses, Russian spring summer encephalitis (RSSE) virus and Central European encephalitis (CEE) virus were evaluated in mice. The vaccines were administered by particle bombardment of DNA-coated gold beads by Accell gene gun inoculation. Two imm...

journal_title：Journal of virology

authors： Schmaljohn C,Vanderzanden L,Bray M,Custer D,Meyer B,Li D,Rossi C,Fuller D,Fuller J,Haynes J,Huggins J

更新日期：1997-12-01 00:00:00

abstract：:We have characterized by T1 fingerprint analysis several defective interfering (DI) double-stranded RNAs of the simple yeast virus ScV. A common sequence of about 0.5 to 0.6 kilobase pairs, including both 3' termini of the parental RNA, was present in each DI RNA. Several DI RNAs had novel T1 oligonucleotides not pres...

journal_title：Journal of virology

authors： Kane WP,Pietras DF,Bruenn JA

更新日期：1979-11-01 00:00:00

abstract：:Strategies were developed to insert the neo resistance marker into the junction between L DNA and the right terminal repetitive H DNA of herpesvirus saimiri. Recombinant viruses were selectable in permissive epithelioid cultures. The human T-cell line Jurkat could be infected persistently with the Neor virus; the cell...

journal_title：Journal of virology

authors： Grassmann R,Fleckenstein B

更新日期：1989-04-01 00:00:00

abstract：:Hemagglutinin (HA) of influenza virus must be activated by proteolysis before the virus can become infectious. Previous studies indicated that HA cleavage is driven by membrane-bound or extracellular serine proteases in the respiratory tract. However, there is still uncertainty as to which proteases are critical for a...

journal_title：Journal of virology

authors： Magnen M,Gueugnon F,Guillon A,Baranek T,Thibault VC,Petit-Courty A,de Veer SJ,Harris J,Humbles AA,Si-Tahar M,Courty Y

更新日期：2017-07-27 00:00:00

abstract：:The molecular mechanisms responsible for random integration and gene targeting by recombinant adeno-associated virus (AAV) vectors are largely unknown, and whether vectors derived from autonomous parvoviruses transduce cells by similar pathways has not been investigated. In this report, we constructed vectors based on...

journal_title：Journal of virology

authors： Hendrie PC,Hirata RK,Russell DW

更新日期：2003-12-01 00:00:00

abstract：:RNA-dependent RNA polymerases were found to be associated with two salmonid rhabdoviruses: infectious hematopoietic necrosis (IHN) virus and the virus of hemorrhagic septicemia (VHS). The protein composition of these rhabdoviruses closely resembles that of rabies virus rather than that of vesicular stomatitis virus (M...

journal_title：Journal of virology

authors： McAllister PE,Wagner RR

更新日期：1977-06-01 00:00:00

abstract：:The presence or absence of the receptor CD4 and the coreceptors CCR5 and CXCR4 restrict the cell tropism of human immunodeficiency virus type 1 (HIV-1). Despite the importance of thymic infection by HIV-1, conflicting reports regarding the expression of HIV-1 coreceptors on human thymocytes have not been resolved. We ...

journal_title：Journal of virology

authors： Taylor JR Jr,Kimbrell KC,Scoggins R,Delaney M,Wu L,Camerini D

更新日期：2001-09-01 00:00:00

abstract：:At a low pH, the influenza virus hemagglutinin (HA) undergoes conformational changes that promote membrane fusion. While the critical role of fusion peptide release from the trimer interface has been demonstrated previously, the role of globular head dissociation in the overall fusion mechanism remains unclear. To inv...

journal_title：Journal of virology

authors： Kemble GW,Bodian DL,Rosé J,Wilson IA,White JM

更新日期：1992-08-01 00:00:00

abstract：:The vaccinia virus (VV) A10L gene codes for a major core protein, P4a. This polypeptide is synthesized at late times during viral infection and is proteolytically cleaved during virion assembly. To investigate the role of P4a in the virus life cycle and morphogenesis, we have generated an inducer-dependent conditional...

journal_title：Journal of virology

authors： Heljasvaara R,Rodríguez D,Risco C,Carrascosa JL,Esteban M,Rodríguez JR

更新日期：2001-07-01 00:00:00