Herpes simplex virus ICP27 activation of stress kinases JNK and p38.

abstract：:Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after infection. Our goal was to identify molecular changes in blood that are related to disease progression. Rhesus macaques (Macaca mulatta) infected intravenously with...

journal_title：Journal of virology

authors： Djavani MM,Crasta OR,Zapata JC,Fei Z,Folkerts O,Sobral B,Swindells M,Bryant J,Davis H,Pauza CD,Lukashevich IS,Hammamieh R,Jett M,Salvato MS

更新日期：2007-08-01 00:00:00

abstract：:CD8+ T cells were previously shown to be important in preventing lymphoproliferation and immunodeficiency following infection of murine AIDS (MAIDS)-resistant mice with the LP-BM5 mixture of murine leukemia viruses. To further evaluate the mechanisms contributing to MAIDS resistance, we studied mice lacking CD8+ T cel...

journal_title：Journal of virology

authors： Tang Y,Hügin AW,Giese NA,Gabriele L,Chattopadhyay SK,Fredrickson TN,Kägi D,Hartley JW,Morse HC 3rd

更新日期：1997-03-01 00:00:00

abstract：:The murine monoclonal antibody (MAb) 5A8, which is reactive with domain 2 of CD4, blocks human immunodeficiency virus type 1 (HIV-1) infection and syncytium formation of CD4+ cells (L. C. Burkly, D. Olson, R. Shapiro, G. Winkler, J. J. Rosa, D. W. Thomas, C. Williams, and P. Chisholm, J. Immunol., in press). Here we s...

journal_title：Journal of virology

authors： Moore JP,Sattentau QJ,Klasse PJ,Burkly LC

更新日期：1992-08-01 00:00:00

abstract：:The steady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decreased in cells that express high-risk human papillomavirus (HPV) E7 proteins. Here we show that pRB degradation is a direct activity of E7 and does not reflect a property of cell lines acquired during the selection pr...

journal_title：Journal of virology

authors： Gonzalez SL,Stremlau M,He X,Basile JR,Münger K

更新日期：2001-08-01 00:00:00

abstract：:The development of a reproducible model system for the study of hepatitis C virus (HCV) infection has the potential to significantly enhance the study of virus-host interactions and provide future direction for modeling the pathogenesis of HCV. While there are studies describing global gene expression changes associat...

journal_title：Journal of virology

authors： Jacobs JM,Diamond DL,Chan EY,Gritsenko MA,Qian W,Stastna M,Baas T,Camp DG 2nd,Carithers RL Jr,Smith RD,Katze MG

更新日期：2005-06-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) play an important role in the immune response against respiratory syncytial virus (RSV) infection. The cell surface molecule lymphocyte function-associated antigen 1 (LFA-1) is an important contributor to CTL activation, CTL-mediated direct cell lysis, and lymphocyte migration. In an att...

journal_title：Journal of virology

authors： Rutigliano JA,Johnson TR,Hollinger TN,Fischer JE,Aung S,Graham BS

更新日期：2004-03-01 00:00:00

abstract：:Polyomavirus large T antigen has an N-terminal domain of approximately 260 amino acids which can immortalize primary cells but lacks sequences known to be required for DNA binding and replication. Treatment of full-length large T with either V8 protease or chymotrypsin yields an N-terminal fragment of 36 to 40 kDa and...

journal_title：Journal of virology

authors： Holman PS,Gjoerup OV,Davin T,Schaffhausen BS

更新日期：1994-02-01 00:00:00

abstract：:Prestimulation of the TLR4 pathway with lipopolysaccharide (LPS) protects mice from lethal infection with H5N1 influenza virus. Here, we reveal that the TLR4-TRIF pathway is required for this protective effect by using mice whose TLR4-related molecules were knocked out. Microarray analysis of primary mouse lung cultur...

journal_title：Journal of virology

authors： Shinya K,Ito M,Makino A,Tanaka M,Miyake K,Eisfeld AJ,Kawaoka Y

更新日期：2012-01-01 00:00:00

abstract：UNLABELLED:To investigate the molecular mechanism(s) by which herpes simplex virus 1 (HSV-1) tegument protein UL51 promotes viral replication, we screened for viral proteins that interact with UL51 in infected cells. Affinity purification of tagged UL51 in HSV-1-infected Vero cells was coupled with immunoblotting of th...

journal_title：Journal of virology

authors： Oda S,Arii J,Koyanagi N,Kato A,Kawaguchi Y

更新日期：2016-09-12 00:00:00

abstract：:Although recombinant human adenovirus (HAV)-based vectors offer several advantages for somatic gene therapy and vaccination over other viral vectors, it would be desirable to develop alternative vectors with prolonged expression and decreased toxicity. Toward this objective, a replication-defective bovine adenovirus t...

journal_title：Journal of virology

authors： Reddy PS,Idamakanti N,Chen Y,Whale T,Babiuk LA,Mehtali M,Tikoo SK

更新日期：1999-11-01 00:00:00

abstract：:Infection and transformation of chondrocytes by Rous sarcoma viruses (RSVs) (Schmidt-Ruppin, Prague) stimulated the rate of cell growth. In contrast, several transformation-defective (td) mutants (tdPRA, tdNY105, tdNY106, tdNY107, and tdNY108) retaining various sizes of the src gene did not stimulate cell growth, indi...

journal_title：Journal of virology

authors： Tanaka A,Parker C,Kaji A

更新日期：1980-08-01 00:00:00

abstract：:Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for ...

journal_title：Journal of virology

authors： Rinaldo C,Huang XL,Fan ZF,Ding M,Beltz L,Logar A,Panicali D,Mazzara G,Liebmann J,Cottrill M

更新日期：1995-09-01 00:00:00

abstract：:The mechanism of heparan sulfate (HS)-mediated human immunodeficiency virus type 1 (HIV-1) binding to and infection of T cells was investigated with a clone (H9h) of the T-cell line H9 selected on the basis of its high level of cell surface CD4 expression. Semiquantitative PCR analysis revealed that enzymatic removal ...

journal_title：Journal of virology

authors： Roderiquez G,Oravecz T,Yanagishita M,Bou-Habib DC,Mostowski H,Norcross MA

更新日期：1995-04-01 00:00:00

abstract：:Our previous study has shown that recombinant adeno-associated virus (rAAV) vector integrates preferentially in genes, near transcription start sites and CpG islands in mouse liver (H. Nakai, X. Wu, S. Fuess, T. A. Storm, D. Munroe, E. Montini, S. M. Burgess, M. Grompe, and M. A. Kay, J. Virol. 79:3606-3614, 2005). Ho...

journal_title：Journal of virology

authors： Inagaki K,Lewis SM,Wu X,Ma C,Munroe DJ,Fuess S,Storm TA,Kay MA,Nakai H

更新日期：2007-10-01 00:00:00

abstract：:Hypervariable region 5 (HVR5) is a hydrophilic, serotypically nonconserved loop of the hexon monomer which extrudes from the adenovirus (Ad) capsid. We have replaced the HVR5 sequence of Ad5 with that of heterologous peptides and studied their effects on virus viability and peptide accessibility. A poliovirus model ep...

journal_title：Journal of virology

authors： Vigne E,Mahfouz I,Dedieu JF,Brie A,Perricaudet M,Yeh P

更新日期：1999-06-01 00:00:00

abstract：:Genetic and biochemical studies have suggested the existence of a bacteriophage-like, DNA-packaging/ejecting portal complex in herpesviruses capsids, but its arrangement remained unknown. Here, we report the first visualization of a unique vertex in the Kaposi's sarcoma-associated herpesvirus (KSHV) capsid by cryoelec...

journal_title：Journal of virology

authors： Deng B,O'Connor CM,Kedes DH,Zhou ZH

更新日期：2007-04-01 00:00:00

abstract：:We have studied the unintegrated infectious DNA of Harvey sarcoma virus (Ha-SV) and Moloney leukemia virus (Mo-MuLV). The source of infectious viral DNA was the Hirt supernatant fraction from cells acutely infected with Ha-SV and Mo-MuLV. To obtain a direct quantitative assay for infectious viral DNA, recipient mouse ...

journal_title：Journal of virology

authors： Lowy DR,Rands E,Scolnick EM

更新日期：1978-05-01 00:00:00

abstract：:An immunological hierarchy among three H-2Db-restricted cytotoxic T lymphocyte (CTL) determinants in simian virus 40 (SV40) large T antigen (Tag) was described previously: determinants I and II/III are immunodominant, whereas determinant V is immunorecessive. To assess the immunogenicity of each determinant individual...

journal_title：Journal of virology

authors： Fu TM,Mylin LM,Schell TD,Bacik I,Russ G,Yewdell JW,Bennink JR,Tevethia SS

更新日期：1998-02-01 00:00:00

abstract：:The relatively small package capacity (less than 5 kb) of adeno-associated virus (AAV) vectors has been effectively doubled with the development of dual-vector heterodimerization approaches. However, the efficiency of such dual-vector systems is limited not only by the extent to which intermolecular recombination occu...

journal_title：Journal of virology

authors： Yan Z,Zak R,Zhang Y,Engelhardt JF

更新日期：2005-01-01 00:00:00

abstract：:Most current diagnostic tests for transmissible spongiform encephalopathies (TSE) rely on the presence of proteinase K (PK)-resistant PrP(Sc) (PrP-res) in postmortem tissues as an indication of TSE disease. However, a number of studies have highlighted a discrepancy between TSE infectivity and PrP-res levels in both n...

journal_title：Journal of virology

authors： Dobie K,Barron R

更新日期：2013-05-01 00:00:00

abstract：:The hemagglutinin of fowl plague virus has been expressed in Spodoptera frugiperda (Sf9) cells and in Estigmene acrea cells by using a baculovirus vector. Structural analysis revealed that the endo-H-resistant N-glycans of HA from Sf9 cells were predominantly trimannosyl core oligosaccharides, whereas in E. acrea cell...

journal_title：Journal of virology

authors： Wagner R,Geyer H,Geyer R,Klenk HD

更新日期：1996-06-01 00:00:00

abstract：:The genomes of influenza A viruses consist of eight negative-strand RNA segments. Recent studies suggest that influenza viruses are able to specifically package their segmented genomes into the progeny virions. Segment-specific packaging signals of influenza virus RNAs (vRNAs) are located in the 5' and 3' noncoding re...

journal_title：Journal of virology

authors： Gao Q,Chou YY,Doğanay S,Vafabakhsh R,Ha T,Palese P

更新日期：2012-07-01 00:00:00

abstract：:Gammaherpesvirus 68 (gammaHV68, or MHV68) is a naturally occurring rodent pathogen that replicates to high titer in cell culture and is amenable to in vivo experimental evaluation of viral and host determinants of gammaherpesvirus disease. However, the inability of MHV68 to transform primary murine B cells in culture,...

journal_title：Journal of virology

authors： Forrest JC,Speck SH

更新日期：2008-08-01 00:00:00

abstract：:The immune response to a synthetic peptide, H3 HA1(305-328), representing the C'-terminal 24 amino acid residues of the HA1 chain of the hemagglutinin of the H3 subtype of influenza virus is controlled by genes in the I region of the major histocompatibility complex. Mice of the H-2d haplotype are high responders and ...

journal_title：Journal of virology

authors： Brown LE,Murray JM,Anders EM,Tang XL,White DO,Tregear GW,Jackson DC

更新日期：1988-05-01 00:00:00

abstract：:Analysis of the pronase-derived glycopeptides of isolated mumps virus glycoproteins revealed the presence of both complex and high-mannose-type oligosaccharides on the HN and F1 glycoproteins, whereas only high-mannose-type glycopeptides were detected on F2. Endoglycosidase F, a newly described glycosidase that cleave...

journal_title：Journal of virology

authors： Herrler G,Compans RW

更新日期：1983-08-01 00:00:00

abstract：:Affinity-purified medium T antigen encoded by NG59, a nontransforming mutant of polyomavirus, is specifically associated with a protein of 72,000 daltons (72K protein). Medium T antigens of wild-type polyomavirus and the transformation-competent mutant dl8 are not associated with the 72K protein. Instead, they form a ...

journal_title：Journal of virology

authors： Walter G,Carbone A,Welch WJ

更新日期：1987-02-01 00:00:00

abstract：:To examine the prerequisites for cleavage activation of the hemagglutinin of human influenza viruses, a cDNA clone obtained from strain A/Port Chalmers/1/73 (serotype H3) was subjected to site-directed mutagenesis and expressed in CV-1 cells by using a simian virus 40 vector. The number of basic residues at the cleava...

journal_title：Journal of virology

authors： Ohuchi R,Ohuchi M,Garten W,Klenk HD

更新日期：1991-07-01 00:00:00

abstract：:Human papillomavirus (HPV) type 16 E6 (16E6) is an oncogenic, multifunctional nuclear protein that induces p53 degradation and perturbs normal cell cycle control, leading to immortalization and transformation of infected keratinocytes and epithelial cells. Although it is unclear how 16E6 disrupts the epigenetic profil...

journal_title：Journal of virology

authors： Tao M,Kruhlak M,Xia S,Androphy E,Zheng ZM

更新日期：2003-12-01 00:00:00

abstract：:The expression of reporter genes driven by the same human elongation factor 1alpha (EF1alpha) promoter in murine leukemia virus (MLV)- and human immunodeficiency virus type 1 (HIV-1)-based vectors was studied in either transfected or virally transduced cells. The HIV-1 vectors consistently expressed 3 to 10 times high...

journal_title：Journal of virology

authors： Zaiss AK,Son S,Chang LJ

更新日期：2002-07-01 00:00:00

abstract：:The Rev protein of human immunodeficiency virus type 1 (HIV-1) is essential for the expression of the structural genes of HIV-1. To determine whether a functional threshold level of Rev is required to allow efficient HIV-1 replication, CD4-positive HeLa cells, constitutively expressing a Rev-deficient provirus, were t...

journal_title：Journal of virology

authors： Pomerantz RJ,Seshamma T,Trono D

更新日期：1992-03-01 00:00:00