Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7.

abstract：UNLABELLED:Giardia lamblia virus (GLV) is a small, nonenveloped, nonsegmented double-stranded RNA (dsRNA) virus infecting Giardia lamblia, the most common protozoan pathogen of the human intestine and a major agent of waterborne diarrheal disease worldwide. GLV (genus Giardiavirus) is a member of family Totiviridae, al...

journal_title：Journal of virology

authors： Janssen ME,Takagi Y,Parent KN,Cardone G,Nibert ML,Baker TS

更新日期：2015-01-15 00:00:00

abstract：UNLABELLED:To date, the response of teleost B cells to specific pathogens has been only scarcely addressed. In this work, we have demonstrated that viral hemorrhagic septicemia virus (VHSV), a fish rhabdovirus, has the capacity to infect rainbow trout spleen IgM-positive (IgM(+)) cells, although the infection is not pr...

journal_title：Journal of virology

authors： Abós B,Castro R,González Granja A,Havixbeck JJ,Barreda DR,Tafalla C

更新日期：2015-02-01 00:00:00

abstract：:Repeated passages of vaccinia virus in increasing concentrations of hydroxyurea followed by plaque purification resulted in the isolation of variants capable of growth in 5 mM hydroxyurea, a drug concentration which inhibited the reproduction of wild-type vaccinia virus 1,000-fold. Analyses of viral protein synthesis ...

journal_title：Journal of virology

authors： Slabaugh MB,Mathews CK

更新日期：1986-11-01 00:00:00

abstract：:The phosphoprotein pp65 (ppUL83) of human cytomegalovirus (HCMV) is abundantly synthesized during lytic infection in cultured fibroblasts. As a major constituent of extracellular particles, it gains entry to infected cells immediately after adsorption and subsequently translocates to the cell nucleus. This efficient t...

journal_title：Journal of virology

authors： Schmolke S,Kern HF,Drescher P,Jahn G,Plachter B

更新日期：1995-10-01 00:00:00

abstract：:It is generally accepted that the fitness cost of resistance mutations plays a role in the persistence of transmitted drug-resistant human immunodeficiency virus type 1 and that mutations that confer a high fitness cost are less able to persist in the absence of drug pressure. Here, we show that the fitness cost of re...

journal_title：Journal of virology

authors： Cong ME,Heneine W,García-Lerma JG

更新日期：2007-03-01 00:00:00

abstract：:The cottontail rabbit papillomavirus (CRPV) a and b subtypes display a conserved E8 open reading frame encoding a 50-amino-acid hydrophobic protein, with structural similarities to the E5 transmembrane oncoprotein of genital human PVs (HPVs). CRPV E8 has been reported to play a role in papilloma growth but not to be e...

journal_title：Journal of virology

authors： Nonnenmacher M,Salmon J,Jacob Y,Orth G,Breitburd F

更新日期：2006-05-01 00:00:00

abstract：:The inhibition of protein synthesis by cycloheximide markedly stimulated adenovirus 2 early transcription (assayed in vivo and in vitro in nuclei) when the drug was added 3 h after infection of HeLa cells. The stimulation was not uniform but ranged from three- to eightfold for region 1A to 10- to 30-fold for region 2 ...

journal_title：Journal of virology

authors： Cross FR,Darnell JE Jr

更新日期：1983-02-01 00:00:00

abstract：UNLABELLED:Human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 encode auxiliary proteins that play important roles in viral replication, viral latency, and immune escape. The presence of auxiliary protein-encoding open reading frames (ORFs) in HTLV-3, the latest HTLV to be discovered, is unknown. Simian T-cell l...

journal_title：Journal of virology

authors： Turpin J,Journo C,Ko NL,Sinet F,Carpentier A,Galioot A,Edwards D,Vandamme AM,Gazzolo L,Duc Dodon M,Gessain A,Kashanchi F,Balansard I,Lacoste R,Mahieux R

更新日期：2015-01-15 00:00:00

abstract：:We reported previously that an N-terminally truncated insulinlike growth factor I receptor (IGFR) fused to avian sarcoma virus UR2 gag p19 had a greater transforming potential than did the native IGFR, but it failed to cause tumors in vivo. To investigate whether the 36 amino acids (aa) of the IGFR extracellular (EC) ...

journal_title：Journal of virology

authors： Liu D,Rutter WJ,Wang LH

更新日期：1993-01-01 00:00:00

abstract：:The N-terminal alpha-helix domain of the human immunodeficiency virus type 1 (HIV-1) Nef protein plays important roles in enhancement of viral infectivity, virion incorporation of Nef, and the down-regulation of major histocompatibility complex class I (MHC-I) expression on cell surfaces. In this study, we demonstrate...

journal_title：Journal of virology

authors： Akari H,Arold S,Fukumori T,Okazaki T,Strebel K,Adachi A

更新日期：2000-03-01 00:00:00

abstract：:To determine whether the tripartite leader is required for efficient translation in adenovirus-infected cells at late times of infection, we constructed recombinant adenoviruses containing the influenza virus nucleocapsid protein (NP) gene expressed under the control of the adenovirus major late promoter (MLP). We cho...

journal_title：Journal of virology

authors： Alonso-Caplen FV,Katze MG,Krug RM

更新日期：1988-05-01 00:00:00

abstract：:Using real-time fluorescence PCR, we quantitated the numbers of copies of latent varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) genomes in 15 human trigeminal ganglia. Eight (53%) and 1 (7%) of 15 ganglia were PCR positive for HSV-1 or -2 glycoprotein G genes, with means of 2,9...

journal_title：Journal of virology

authors： Pevenstein SR,Williams RK,McChesney D,Mont EK,Smialek JE,Straus SE

更新日期：1999-12-01 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV), a member of the Picornaviridae, is a pathogen of cloven-hoofed animals and causes a disease of major economic importance. Picornavirus-infected cells show changes in cell morphology and rearrangement of cytoplasmic membranes, which are a consequence of virus replication. We show he...

journal_title：Journal of virology

authors： Armer H,Moffat K,Wileman T,Belsham GJ,Jackson T,Duprex WP,Ryan M,Monaghan P

更新日期：2008-11-01 00:00:00

abstract：:Enteroviral persistence has been implicated in the pathogenesis of several chronic human diseases, including dilated cardiomyopathy, insulin-dependent diabetes mellitus, and chronic inflammatory myopathy. However, these viruses are considered highly cytolytic, and it is unclear what mechanisms might permit their long-...

journal_title：Journal of virology

authors： Feuer R,Mena I,Pagarigan R,Slifka MK,Whitton JL

更新日期：2002-05-01 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) protein of paramyxoviruses carries out three discrete activities that each affect the ability of HN to promote viral fusion and entry: receptor binding, receptor cleaving (neuraminidase), and triggering of the fusion protein. The interrelationship between the receptor binding and f...

journal_title：Journal of virology

authors： Porotto M,Fornabaio M,Kellogg GE,Moscona A

更新日期：2007-04-01 00:00:00

abstract：:This paper is concerned with the physiological role(s) of T4 phage-coded dihydrofolate reductase, which functions both in DNA precursor metabolism and as a virion protein. (i) We have detected enzyme activity in noninfectious particles produced under restrictive conditions by gene 11 mutants. This supports the conclus...

journal_title：Journal of virology

authors： Mosher RA,DiRenzo AB,Mathews CK

更新日期：1977-09-01 00:00:00

abstract：:Temperature-sensitive (ts) mutants were isolated from the baculovirus Autographa californica (alfalfa looper) MNPV, grown in Spodoptera frugiperda (fall armyworm) cells in the presence of N-methyl-N'-nitro-N-nitrosoguanidine. Of 567 plaque isolates screened, 27 were temperature sensitive (ts), representing a mutation ...

journal_title：Journal of virology

authors： Brown M,Crawford AM,Faulkner P

更新日期：1979-07-01 00:00:00

abstract：UNLABELLED:The emergence of Middle East respiratory syndrome-coronavirus (MERS-CoV) in the Middle East since 2012 has caused more than 900 human infections with ∼40% mortality to date. Animal models are needed for studying pathogenesis and for development of preventive and therapeutic agents against MERS-CoV infection....

journal_title：Journal of virology

authors： Agrawal AS,Garron T,Tao X,Peng BH,Wakamiya M,Chan TS,Couch RB,Tseng CT

更新日期：2015-04-01 00:00:00

abstract：:Long interspersed nuclear element 1 (LINE-1; L1) retrotransposons are the most common retroelements in mammalian genomes. Unlike individual families of endogenous retroviruses (ERVs), they have remained active throughout the mammalian radiation and are responsible for most of the retroelement movement and much genome ...

journal_title：Journal of virology

authors： Erickson IK,Cantrell MA,Scott L,Wichman HA

更新日期：2011-12-01 00:00:00

abstract：:Dendritic cells (DC) are believed to play an important role in the initiation of innate and adaptive immune responses to infection, including respiratory tract infections, where respiratory DC (RDC) perform this role. In this report, we examined the susceptibilities of isolated murine RDC to influenza virus infection ...

journal_title：Journal of virology

authors： Hao X,Kim TS,Braciale TJ

更新日期：2008-05-01 00:00:00

abstract：UNLABELLED:The disease mechanisms associated with onset and secondary effects of rotavirus (RV) diarrhea remain to be determined and may not be identical. In this study, we investigated whether onset of RV diarrhea is associated with increased intestinal permeability and/or motility. To study the transit time, fluoresc...

journal_title：Journal of virology

authors： Istrate C,Hagbom M,Vikström E,Magnusson KE,Svensson L

更新日期：2014-03-01 00:00:00

abstract：:Effectively recognizing invading viruses and subsequently inducing innate antiviral immunity are essential for host antiviral defense. Although these processes are closely regulated by the host to maintain immune balance, viruses have evolved the ability to downregulate or upregulate these processes for their survival...

journal_title：Journal of virology

authors： Xu T,Chu Q,Cui J,Bi D

更新日期：2018-01-02 00:00:00

abstract：:Noninfectious spikeless particles have been obtained from vesicular stomatitis virus (VSV, Indiana serotype) by bromelain or Pronase treatment. They lack the viral glycoprotein (G) but contain all the other viral components (RNA, lipid, and other structural proteins). Triton-solubilized VSV-Indiana glycoprotein prepar...

journal_title：Journal of virology

authors： Bishop DH,Repik P,Obijeski JF,Moore NF,Wagner RR

更新日期：1975-07-01 00:00:00

abstract：UNLABELLED:Pattern recognition receptors (PRR) sense certain molecular patterns uniquely expressed by pathogens. Retinoic-acid-inducible gene I (RIG-I) is a cytosolic PRR that senses viral nucleic acids and induces innate immune activation and secretion of type I interferons (IFNs). Here, using influenza vaccine antige...

journal_title：Journal of virology

authors： Kulkarni RR,Rasheed MA,Bhaumik SK,Ranjan P,Cao W,Davis C,Marisetti K,Thomas S,Gangappa S,Sambhara S,Murali-Krishna K

更新日期：2014-12-01 00:00:00

abstract：:A single phosphorylation event at T-antigen residue Thr124 regulates initiation of simian virus 40 DNA replication. To explore this regulatory process, a series of peptides were synthesized, centered on Thr124. These peptides contain a nuclear localization signal (NLS) and a recognition site for cyclin/Cdk kinases. Wh...

journal_title：Journal of virology

authors： Kim RJ,Moine S,Reese DK,Bullock PA

更新日期：2002-12-01 00:00:00

abstract：:Adeno-associated virus (AAV) is gaining momentum as a gene therapy vector for human applications. However, there remain impediments to the development of this virus as a vector. One of these is the incomplete understanding of the biology of the virus, including nuclear targeting of the incoming virion during initial i...

journal_title：Journal of virology

authors： Grieger JC,Snowdy S,Samulski RJ

更新日期：2006-06-01 00:00:00

abstract：:Lentivectors stimulate potent immune responses to antigen transgenes and are being developed as novel genetic vaccines. To improve safety while retaining efficacy, we constructed a lentivector in which transgene expression was restricted to antigen-presenting cells using the mouse dectin-2 gene promoter. This lentivec...

journal_title：Journal of virology

authors： Lopes L,Dewannieux M,Gileadi U,Bailey R,Ikeda Y,Whittaker C,Collin MP,Cerundolo V,Tomihari M,Ariizumi K,Collins MK

更新日期：2008-01-01 00:00:00

abstract：:Chromatography of RNA polymerase purified from vaccinia virions and from vaccinia virus-infected HeLa cells resulted in the separation of populations active for early and late transcription. An RNA polymerase population immunodepleted for the vaccinia virus H4 gene peptide could support late transcription. ...

journal_title：Journal of virology

authors： Wright CF,Coroneos AM

更新日期：1995-04-01 00:00:00

abstract：:Sequences which encode Epstein-Barr virus (EBV) RNA in nasopharyngeal carcinoma (NPC) tissue have been identified. We utilized human biopsy material directly as well as NPC grown in nude mice. Total RNA was extracted from the tumor material and separated into polyadenylated and nonpolyadenylated fractions by oligodeox...

journal_title：Journal of virology

authors： Raab-Traub N,Hood R,Yang CS,Henry B 2nd,Pagano JS

更新日期：1983-12-01 00:00:00

abstract：:The Epstein-Barr virus (EBV)-induced membrane antigen (MA) was successfully solubilized from the membranes of viable EBV-infected Raji cells by treatment with papain (5 to 6 U per 1 X 10(7) to 2 X 10(7) cells). The loss of MA from viable cells was monitored by membrane immunofluorescence and antibody-dependent cellula...

journal_title：Journal of virology

authors： Pearson GR,Qualtiere LF

更新日期：1978-10-01 00:00:00