Abstract:
:The N-terminal alpha-helix domain of the human immunodeficiency virus type 1 (HIV-1) Nef protein plays important roles in enhancement of viral infectivity, virion incorporation of Nef, and the down-regulation of major histocompatibility complex class I (MHC-I) expression on cell surfaces. In this study, we demonstrated that Met 20 in the alpha-helix domain was indispensable for the ability of Nef to modulate MHC-I expression but not for other events. We also showed that Met 20 was unnecessary for the down-regulation of CD4. These findings indicate that the region governing MHC-I down-regulation is proximate in the alpha-helix domain but is dissociated functionally from that determining enhancement of viral infectivity, virion incorporation of Nef, and CD4 down-regulation.
journal_name
J Viroljournal_title
Journal of virologyauthors
Akari H,Arold S,Fukumori T,Okazaki T,Strebel K,Adachi Adoi
10.1128/jvi.74.6.2907-2912.2000subject
Has Abstractpub_date
2000-03-01 00:00:00pages
2907-12issue
6eissn
0022-538Xissn
1098-5514journal_volume
74pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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更新日期:2011-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/jvi.78.4.1858-1864.2004
更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
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pub_type: 杂志文章
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