Abstract:
:A number of retrovirus-like sequences have been cloned from chimpanzee DNA which constitute the chimpanzee homologs of the endogenous colobus type C virus CPC-1. One of the clones contains a nearly complete viral genome, but others have sustained deletions of 1 to 2 kilobases in the polymerase gene. The pattern of related sequences detected in other primate species is consistent with the genetic transmission of these sequences for millions of years. However, the appropriately related sequences have not been detected in human, gibbon, or orangutan DNAs. These results suggest either that this family of sequences has been deleted from humans, gibbons, and orangutans, or that the genes were recently acquired in the chimpanzee and gorilla lineages.
journal_name
J Viroljournal_title
Journal of virologyauthors
Bonner TI,Birkenmeier EH,Gonda MA,Mark GE,Searfoss GH,Todaro GJdoi
10.1128/JVI.43.3.914-924.1982subject
Has Abstractpub_date
1982-09-01 00:00:00pages
914-24issue
3eissn
0022-538Xissn
1098-5514journal_volume
43pub_type
杂志文章abstract::Purified rabies virions, unlabeled or labeled with radioactive amino acids or d-glucosamine, were dissociated into their polypeptides by treatment with sodium dodecyl sulfate in a reducing environment and fractionated by electroiphoresis in sodium dodecyl sulfate-containing polyacrylamide gel. The molecular weights of...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.7.2.241-249.1971
更新日期:1971-02-01 00:00:00
abstract::We have examined the influence of the V1/V2 region of the human immunodeficiency virus type 1 (HIV-1) gp120 on certain biologic properties of the virus. We observed that on the genomic background of the T-cell-line-tropic strain, HIV-1SF2mc, both the V1 and V2 domains of the macrophage-tropic strain, HIV-1SF162mc, in ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.4.2253-2259.1994
更新日期:1994-04-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) clade C causes >50% of all HIV infections worldwide, and an estimated 90% of all transmissions occur mucosally with R5 strains. A pathogenic R5 simian-human immunodeficiency virus (SHIV) encoding HIV clade C env is highly desirable to evaluate candidate AIDS vaccines in nonh...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00558-06
更新日期:2006-09-01 00:00:00
abstract::Precore and core proteins are two related co-carboxy-terminal proteins of hepatitis B virus. Precore protein contains the entire sequence of core protein plus an amino-terminal extension of 29 amino acid residues. Both proteins can display a common antigenic determinant known as core antigen (HBcAg). Clinically, HBcAg...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.12.6141-6147.1990
更新日期:1990-12-01 00:00:00
abstract::An extensive genetic map of coliphage P1 has been constructed for 113 amber mutants, using primarily a modification of the conventional complementation spot test. These spot tests failed to classify the mutants into cistrons, but when they were quantitated they permitted assignment of the mutants into 10 linkage clust...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.20.1.177-187.1976
更新日期:1976-10-01 00:00:00
abstract::Partial E1 envelope glycoprotein gene sequences and complete structural polyprotein sequences were used to compare divergence and construct phylogenetic trees for the genus Alphavirus. Tree topologies indicated that the mosquito-borne alphaviruses could have arisen in either the Old or the New World, with at least two...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.21.10118-10131.2001
更新日期:2001-11-01 00:00:00
abstract::Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of PRRS, which has important impacts on the pig industry. PRRSV infection results in disruption of the swine leukocyte antigen class I (SLA-I) antigen presentation pathway. In this study, highly pathogenic PRRSV (HP-PRRSV) infection inh...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01755-16
更新日期:2017-02-14 00:00:00
abstract::Herpes simplex virus 1 (HSV-1) causes significant morbidity and mortality in humans worldwide. HSV-1 enters epithelial cells via an endocytosis mechanism that is low-pH dependent. However, the precise intracellular pathway has not been identified, including the compartment where fusion occurs. In this study, we utiliz...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01910-20
更新日期:2020-11-23 00:00:00
abstract::The folded genome of Escherichia coli is converted to a slower-sedimenting form within 5 min after infection with bacteriophage T4 or T4nd28(den A)-amN82(44). Chloramphenicol sensitivity and response to UV-irradiation of the phage suggest participation of viral-induced functions. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.13.2.548-550.1974
更新日期:1974-02-01 00:00:00
abstract::Sequences from the 5' end of type 1 human immunodeficiency virus RNA dimerize spontaneously in vitro in a reaction thought to mimic the initial step of genomic dimerization in vivo. Dimer initiation has been proposed to occur through a "kissing-loop" interaction involving a specific RNA stem-loop element designated SL...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.9.5902-5908.1996
更新日期:1996-09-01 00:00:00
abstract::African green monkeys can maintain long-term persistent infection with simian immunodeficiency viruses (SIVagm) without developing AIDS and thus provide an important model for understanding mechanisms of natural host resistance to disease. This study assessed the levels and anatomic distribution of SIVagm in healthy, ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.5.2262-2275.2001
更新日期:2001-03-01 00:00:00
abstract::Mitochondria are important for the viral life cycle, mainly by providing the energy required for viral replication and assembly. A highly complex interaction with mitochondria is exerted by rubella virus (RV), which includes an increase in the mitochondrial membrane potential as a general marker for mitochondrial acti...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00533-13
更新日期:2013-08-01 00:00:00
abstract::To study fundamental aspects of RNA recombination, an in vivo RNA recombination system was established. This system allowed the efficient generation of recombinant cytopathogenic pestiviruses after transfection of synthetic, nonreplicatable, subgenomic transcripts in cells infected with a replicating noncytopathogenic...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.12.6271-6281.2004
更新日期:2004-06-01 00:00:00
abstract::Research in the last 2 decades has demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB) or nuclear domain 10 (ND10), is frequently modified during viral infection. This correlates with antagonization of a direct repressive function of individual PML-NB components, such as the PM...
journal_title:Journal of virology
pub_type: 杂志文章,评审
doi:10.1128/JVI.01979-15
更新日期:2016-06-10 00:00:00
abstract::Our study was designed to investigate the nature of an antigen-specific suppressor factor generated by antigen-stimulated herpes simplex virus (HSV)-immune splenocytes. Factor SF-200, a 90,000- to 100,000-dalton fraction obtained after Sephacryl gel filtration, suppressed the generation of HSV-specific cytotoxic T-lym...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.58.2.331-338.1986
更新日期:1986-05-01 00:00:00
abstract::Viruses of the family Coronaviridae have recently emerged through zoonotic transmission to become serious human pathogens. The pathogenic agent responsible for severe acute respiratory syndrome (SARS), the SARS coronavirus (SARS-CoV), is a member of this large family of positive-strand RNA viruses that cause a spectru...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02322-09
更新日期:2010-03-01 00:00:00
abstract::The DNA sequence of 3,240 nucleotides of the XbaI G fragment located in the unique long (UL) region of the equine herpesvirus 1 genome revealed two major open reading frames (ORFs) designated UL3 and UL4. The UL3 ORF of 470 amino acids (aa) maps at nucleotides (nt) 4450 to 3038 from the long terminus, and its predicte...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.9.5363-5372.1992
更新日期:1992-09-01 00:00:00
abstract::The hemagglutinin of fowl plague virus has been expressed in Spodoptera frugiperda (Sf9) cells and in Estigmene acrea cells by using a baculovirus vector. Structural analysis revealed that the endo-H-resistant N-glycans of HA from Sf9 cells were predominantly trimannosyl core oligosaccharides, whereas in E. acrea cell...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.6.4103-4109.1996
更新日期:1996-06-01 00:00:00
abstract::Retroviral vectors offer major advantages for gene transfer studies but have not been useful for producing proteins in large quantities. This deficiency has resulted in part from interference to superinfection, which limits the numbers of active proviruses in cells. Recently, we found that these vectors amplify when t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.7.3500-3508.1990
更新日期:1990-07-01 00:00:00
abstract::All presently available replication-competent proviral clones of human immunodeficiency virus type 1 (HIV-1) are derived from cell culture-amplified virus. Since tissue culture is highly selective for viral strains with an in vitro growth advantage, such clones may not be representative of the biologically relevant vi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.8.3973-3985.1991
更新日期:1991-08-01 00:00:00
abstract::APOBEC3G (A3G) is a cytidine deaminase that restricts human immunodeficiency virus type 1 (HIV-1) and other lentiviruses. Most of these viruses encode a Vif protein that directly binds A3G and leads to its proteasomal degradation. Both Vif proteins of HIV-1 and African green monkey simian immunodeficiency virus (SIVag...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01944-13
更新日期:2013-11-01 00:00:00
abstract::Hypoxia-inducible factor 1 (HIF-1) is a ubiquitously expressed transcriptional regulator involved in induction of numerous genes associated with angiogenesis and tumor growth. Kaposi's sarcoma, associated with increased angiogenesis, is a highly vascularized, endothelial cell-derived tumor. Previously, we have shown t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00611-07
更新日期:2007-10-01 00:00:00
abstract::Influenza virus infection initiates transcription of a variety of genes for cytokines such as tumor necrosis factor alpha (TNF-alpha), TNF-beta, interleukin 1 alpha, (IL-1 alpha), IL-1 beta, IL-2, IL-4, IL-6, IL-10, granulocyte macrophage colony-stimulating factor, and gamma interferon. However, the mechanism by which...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.3.1480-1484.1995
更新日期:1995-03-01 00:00:00
abstract::Kaposi's sarcoma-associated herpesvirus (KSHV) LANA is an 1,162-amino-acid protein that tethers terminal repeat (TR) DNA to mitotic chromosomes to mediate episome persistence in dividing cells. C-terminal LANA self-associates to bind TR DNA. LANA contains independent N- and C-terminal chromosome binding regions. N-ter...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02395-08
更新日期:2009-05-01 00:00:00
abstract::Foot-and-mouth disease (FMD), which is caused by FMD virus (FMDV), remains a major plague among cloven-hoofed animals worldwide, and its outbreak often has disastrous socioeconomic consequences. A live-attenuated FMDV vaccine will greatly facilitate the global control and eradication of FMD, but a safe and effective a...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00990-20
更新日期:2020-07-30 00:00:00
abstract::We cloned and analyzed the integrated human papillomavirus type 16 (HPV-16) genomes that are present in the human cervical carcinoma cell lines SiHa and CaSki. The single HPV-16 genome in the SiHa line was cloned as a 10-kilobase (kb) HindIII fragment. Integration of the HPV-16 genome occurred at bases 3132 and 3384 w...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.4.962-971.1987
更新日期:1987-04-01 00:00:00
abstract::Callitrichid hepatitis is an infection of New World primates caused by an arenavirus, currently referred to as callitrichid hepatitis virus, that is closely related to lymphocytic choriomeningitis virus (LCMV). We have cloned and sequenced the GP-C gene of callitrichid hepatitis virus and found that the cDNA sequence ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.2.1349-1352.1995
更新日期:1995-02-01 00:00:00
abstract::Live attenuated human immunodeficiency virus type 1 (HIV-1) vaccines are considered unsafe because faster-replicating pathogenic virus variants may evolve after vaccination. We previously presented a conditional-live HIV-1 variant of which replication can be switched off as an alternative vaccination strategy. To impr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.6.3855-3858.2005
更新日期:2005-03-01 00:00:00
abstract::The major envelope glycoprotein of bovine leukemia virus was isolated by lectin-bound Sepharose and DEAE-cellulose column chromatography. This protein was shown to have a molecular weight of about 41,000 and to lack detectable immunological cross-reactivity with glycoproteins of other oncornaviruses. Sera obtained fro...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.23.2.443-447.1977
更新日期:1977-08-01 00:00:00
abstract::Parvoviruses infect humans and a broad range of animals, from mammals to crustaceans, and generally are associated with a variety of acute and chronic diseases. However, many others cause persistent infections and are not known to be associated with any disease. Viral persistence is likely related to the ability to in...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00828-11
更新日期:2011-10-01 00:00:00