Unfolding of the host genome after infection of Escherichia coli with bacteriophage T4.

abstract：:The 3'-untranslated region (3'-UTR) of mouse hepatitis virus (MHV) RNA regulates the replication of and transcription from the viral RNA. Several host cell proteins have previously been shown to interact with this regulatory region. By immunoprecipitation of UV-cross-linked cellular proteins and in vitro binding of th...

journal_title：Journal of virology

authors： Huang P,Lai MM

更新日期：2001-06-01 00:00:00

abstract：:In HIV-1 vaccine research, native-like, soluble envelope glycoprotein SOSIP trimers are widely used for immunizing animals. The epitopes of autologous neutralizing antibodies (NAbs) induced by the BG505 and B41 SOSIP trimers in rabbits and macaques have been mapped to a few holes in the glycan shields that cover most ...

journal_title：Journal of virology

authors： Ringe RP,Pugach P,Cottrell CA,LaBranche CC,Seabright GE,Ketas TJ,Ozorowski G,Kumar S,Schorcht A,van Gils MJ,Crispin M,Montefiori DC,Wilson IA,Ward AB,Sanders RW,Klasse PJ,Moore JP

更新日期：2019-02-05 00:00:00

abstract：:SERINC3 (serine incorporator 3) and SERINC5 are recently identified host cell inhibitors of HIV-1 particle infectivity that are counteracted by the viral pathogenesis factor Nef. Here we confirm that HIV-1 Nef, but not HIV-1 Vpu, antagonizes the particle infectivity restriction of SERINC5. SERINC5 antagonism occurred ...

journal_title：Journal of virology

authors： Trautz B,Pierini V,Wombacher R,Stolp B,Chase AJ,Pizzato M,Fackler OT

更新日期：2016-11-14 00:00:00

abstract：:Identification of cellular receptors used by coronavirus (CoV) entry into the host cells is critical to an understanding of pathogenesis and to development of intervention strategies. The fourth CoV genus, Deltacoronavirus, evolutionarily related to the Gammacoronavirus, has just been defined recently. In the current ...

journal_title：Journal of virology

authors： Wang B,Liu Y,Ji CM,Yang YL,Liang QZ,Zhao P,Xu LD,Lei XM,Luo WT,Qin P,Zhou J,Huang YW

更新日期：2018-05-29 00:00:00

abstract：:Reactivations of persistent viral infections pose a significant medical problem in immunocompromised cancer, transplant, and AIDS patients, yet little is known about how persistent viral infections are immunologically controlled. Here we describe a mouse model for investigating the role of the immune response in contr...

journal_title：Journal of virology

authors： Hasenkrug KJ,Brooks DM,Dittmer U

更新日期：1998-08-01 00:00:00

abstract：:Many complex viruses use an assembly pathway in which their genome is packaged into an empty procapsid which subsequently matures into its final expanded form. We utilized Pseudomonas phage 6, a well-established virus assembly model, to probe the plasticity of the procapsid maturation pathway. The 6 packaging nucleosi...

journal_title：Journal of virology

authors： Sun X,Pirttimaa MJ,Bamford DH,Poranen MM

更新日期：2013-12-01 00:00:00

abstract：:Western equine encephalitis virus (WEEV; Togaviridae, Alphavirus) is an enveloped RNA virus that is typically transmitted to vertebrate hosts by infected mosquitoes. WEEV is an important cause of viral encephalitis in humans and horses in the Americas, and infection results in a range of disease, from mild flu-like il...

journal_title：Journal of virology

authors： Sherman MB,Weaver SC

更新日期：2010-10-01 00:00:00

abstract：:Phosphorylation of viral proteins plays important roles in the influenza A virus (IAV) life cycle. By using mass spectrometry, we identified tyrosine 132 (Y132) as a phosphorylation site of the matrix protein (M1) of the influenza virus A/WSN/1933(H1N1). Phosphorylation at this site is essential to the process of viru...

journal_title：Journal of virology

authors： Wang S,Zhao Z,Bi Y,Sun L,Liu X,Liu W

更新日期：2013-06-01 00:00:00

abstract：:The nucleoprotein (NP) of influenza B virus is 50 amino acids longer at the N-terminus than influenza A virus NP and lacks homology to the A virus protein over the first 69 residues. We have deleted the N-terminal 51 and 69 residues of the influenza B/Ann Arbor/1/66 virus NP and show that nuclear accumulation of the p...

journal_title：Journal of virology

authors： Stevens MP,Barclay WS

更新日期：1998-06-01 00:00:00

abstract：:A system has been developed for generating chimeric yellow fever/Japanese encephalitis (YF/JE) viruses from cDNA templates encoding the structural proteins prM and E of JE virus within the backbone of a molecular clone of the YF17D strain. Chimeric viruses incorporating the proteins of two JE strains, SA14-14-2 (human...

journal_title：Journal of virology

authors： Chambers TJ,Nestorowicz A,Mason PW,Rice CM

更新日期：1999-04-01 00:00:00

abstract：:HIV CRF01_AE accounted for 84% of the recent infections among men who have sex with men (MSM) in Liaoning Province of northeastern China. CRF01_AE strains were grouped into two distinct clusters (designated clusters 1 and 2) that were also detected in other regions in China. Phylodynamics study revealed that these two...

journal_title：Journal of virology

authors： An M,Han X,Xu J,Chu Z,Jia M,Wu H,Lu L,Takebe Y,Shang H

更新日期：2012-11-01 00:00:00

abstract：:Although recombinant human adenovirus (HAV)-based vectors offer several advantages for somatic gene therapy and vaccination over other viral vectors, it would be desirable to develop alternative vectors with prolonged expression and decreased toxicity. Toward this objective, a replication-defective bovine adenovirus t...

journal_title：Journal of virology

authors： Reddy PS,Idamakanti N,Chen Y,Whale T,Babiuk LA,Mehtali M,Tikoo SK

更新日期：1999-11-01 00:00:00

abstract：:The simian virus 40 (SV40) core origin of replication consists of three functional domains. The sequence 5'-CACTACTTCTGGAATAG-3' with an imperfect inverted repeat (underlined), a palindrome with four 5'-GAGGC-3' pentanucleotide repeats, and a 17-base-pair A + T-rich segment. We have been able to assign primary functio...

journal_title：Journal of virology

authors： Parsons R,Anderson ME,Tegtmeyer P

更新日期：1990-02-01 00:00:00

abstract：:During Epstein-Barr virus (EBV) latent infection of B lymphocytes in vitro, six EBV nuclear antigens (EBNAs) are expressed from one of two promoters, Cp and Wp, whose activities are mutually exclusive. Upon infection, Wp is initially active, followed by a switch to Cp for the duration of latency. In this study, the im...

journal_title：Journal of virology

authors： Puglielli MT,Desai N,Speck SH

更新日期：1997-01-01 00:00:00

abstract：:The immunosuppressant drug rapamycin blocks progression of the cell cycle at G1 in mammalian cells and yeast. We recently showed that rapamycin inhibits both in vitro and in vivo cap-dependent, but not cap-independent, translation. This inhibition is causally related to reduced phosphorylation and consequent activatio...

journal_title：Journal of virology

authors： Beretta L,Svitkin YV,Sonenberg N

更新日期：1996-12-01 00:00:00

abstract：:Dendritic cells (DC) are believed to play an important role in the initiation of innate and adaptive immune responses to infection, including respiratory tract infections, where respiratory DC (RDC) perform this role. In this report, we examined the susceptibilities of isolated murine RDC to influenza virus infection ...

journal_title：Journal of virology

authors： Hao X,Kim TS,Braciale TJ

更新日期：2008-05-01 00:00:00

abstract：:Strains of Theiler's murine encephalomyelitis virus (TMEV) are divided into two subgroups, TO and GDVII. TMEV strains show subgroup-specific virus growth and cell tropism and induce subgroup-specific diseases. Using site-directed mutagenesis, we demonstrated that the amino acid at position 57 of the leader protein (L(...

journal_title：Journal of virology

authors： Takano-Maruyama M,Ohara Y,Asakura K,Okuwa T

更新日期：2006-12-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) play an important role in recovery from a number of viral infections. They are also implicated in virus-induced immunopathology as best demonstrated in lymphocytic choriomeningitis virus (LCMV) infection of adult immunocompetent mice. In the present study, the structure of the T-cell rece...

journal_title：Journal of virology

authors： Yanagi Y,Maekawa R,Cook T,Kanagawa O,Oldstone MB

更新日期：1990-12-01 00:00:00

abstract：:Inbred LSH hamster brain cells were transformed in vitro by the GS strain of BK virus (BKV), and transplantable tumors classified as undifferentiated glioblastomas were induced in the syngeneic host. The viral status in the transformed cells, designated LSH-BR-BK, was established. About 46 genome equivalents per cell ...

journal_title：Journal of virology

authors： Beth E,Giraldo G,Schmidt-Ullrich R,Pater MM,Pater A,di Mayorca G

更新日期：1981-10-01 00:00:00

abstract：:The adenovirus fiber protein is used for attachment of the virus to a specific receptor on the cell surface. Structurally, the protein consists of a long, thin shaft that protrudes from the vertex of the virus capsid and terminates in a globular domain termed the knob. To verify that the knob is the domain which inter...

journal_title：Journal of virology

authors： Henry LJ,Xia D,Wilke ME,Deisenhofer J,Gerard RD

更新日期：1994-08-01 00:00:00

abstract：:To analyze the proposed growth-inhibitory function of wild-type p53, we compared simian virus 40 (SV40) DNA replication in primary rhesus monkey kidney (PRK) cells, which express wild-type p53, and in the established rhesus monkey kidney cell line LLC-MK2, which expresses a mutated p53 that does not complex with large...

journal_title：Journal of virology

authors： von der Weth A,Deppert W

更新日期：1993-02-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is an essential regulatory protein that localizes to the nuclei of infected cells. The strong nuclear localization signal (NLS) of ICP27 was identified recently and shown to reside in the amino-terminal portion of the polypeptide from residues 110 t...

journal_title：Journal of virology

authors： Hibbard MK,Sandri-Goldin RM

更新日期：1995-08-01 00:00:00

abstract：:The rarely identified influenza A viruses of the H15 hemagglutinin subtype have been isolated exclusively in Australia. Here we report the isolation of an H15N4 influenza A virus (A/teal/Chany/7119/2008) in Western Siberia, Russia. Phylogenetic analysis demonstrated that the internal genes of the A/teal/Chany/7119/200...

journal_title：Journal of virology

authors： Sivay MV,Baranovich T,Marchenko VY,Sharshov KA,Govorkova EA,Shestopalov AM,Webby RJ

更新日期：2013-03-01 00:00:00

abstract：:Mutants of polyomavirus with altered host specificities were isolated in undifferentiated C2 myoblast cells (L. Ricci, R. Maione, C. Passananti, A. Felsani, and P. Amati, J. Virol. 66:7153-7158, 1992). The mutations responsible for this phenotype belonged to either of the two classes: a large duplication of the enhanc...

journal_title：Journal of virology

authors： Mezes B,Amati P

更新日期：1994-02-01 00:00:00

abstract：:The Ad2+ND4 virus is an adenovirus type 2 (Ad2)-simian virus 40 (SV40) recombination. The Ad2 genome of this recombinant has a rearrangement within early region 3; Ad2 DNA sequences between map positions 81.3 and 85.5 have been deleted, and the SV40 DNA sequences between map positions 0.11 and 0.626 have been inserted...

journal_title：Journal of virology

authors： Lewis AM Jr,Westphal H

更新日期：1983-08-01 00:00:00

abstract：:Adenovirus (Ad) entry into cells is initiated by the binding of the fiber knob to a cell surface receptor. The coxsackie- and adenovirus receptor (CAR) functions as the attachment receptor for many, but not all, Ad serotypes. Ad type 37 (Ad37), a subgroup D virus that causes keratoconjunctivitis in humans, does not in...

journal_title：Journal of virology

authors： Chiu CY,Wu E,Brown SL,Von Seggern DJ,Nemerow GR,Stewart PL

更新日期：2001-06-01 00:00:00

abstract：:During HIV-1 assembly, Gag polypeptides multimerize to form an immature capsid and also package HIV-1 genomic RNA. Assembling Gag forms immature capsids by progressing through a stepwise pathway of assembly intermediates containing the cellular ATPase ABCE1, which facilitates capsid formation. The NC domain of Gag is ...

journal_title：Journal of virology

authors： Klein KC,Reed JC,Tanaka M,Nguyen VT,Giri S,Lingappa JR

更新日期：2011-07-01 00:00:00

abstract：:The innate immune response is crucial for defense against viral infections. Cells recognize virus infection through pattern recognition receptors and induce type I interferons as well as proinflammatory cytokines to orchestrate an innate immune response. Herpes simplex virus 1 (HSV-1) triggers both the cyclic GMP-AMP ...

journal_title：Journal of virology

authors： Latif MB,Raja R,Kessler PM,Sen GC

更新日期：2020-02-28 00:00:00

abstract：:The virion proteins encoded by the avian retroviral pol gene (reverse transcriptase and endonuclease) are formed by the proteolytic processing of a gag-pol fusion protein precursor. Recent studies have predicted that the avian sarcoma-leukosis virus pol precursor protein undergoes a previously undetected processing ev...

journal_title：Journal of virology

authors： Katz RA,Skalka AM

更新日期：1988-02-01 00:00:00

abstract：:Ribonucleic acid extracted from the virions of two human rhinoviruses is infective and is similar in size to poliovirus ribonucleic acid. ...

journal_title：Journal of virology

authors： Nair CN,Lonberg-Holm KK

更新日期：1971-02-01 00:00:00