Yellow fever/Japanese encephalitis chimeric viruses: construction and biological properties.

abstract：:The Coccolithoviridae are a group of viruses which infect the marine coccolithophorid microalga Emiliania huxleyi. The Emiliania huxleyi viruses (known as EhVs) described herein have 160- to 180-nm diameter icosahedral structures, have genomes of approximately 400 kbp, and consist of more than 450 predicted coding seq...

journal_title：Journal of virology

authors： Nissimov JI,Worthy CA,Rooks P,Napier JA,Kimmance SA,Henn MR,Ogata H,Allen MJ

更新日期：2012-03-01 00:00:00

abstract：:Circulating leukocytes are important in dissemination of cytomegalovirus (CMV) infection in humans. In the mouse model of murine CMV infection (MCMV), it has been shown that infection peaks on days 5 to 7 after experimental infection, when 0.01 to 0.1% of the circulating leukocytes contain viral DNA. In our laboratory...

journal_title：Journal of virology

authors： Collins TM,Quirk MR,Jordan MC

更新日期：1994-10-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is a herpesvirus and is the causative agent of chicken pox (varicella) and shingles (herpes zoster). Active immunization against varicella became possible with the development of live attenuated varicella vaccine. The Oka vaccine strain was isolated in Japan from a child who had typical va...

journal_title：Journal of virology

authors： Tillieux SL,Halsey WS,Thomas ES,Voycik JJ,Sathe GM,Vassilev V

更新日期：2008-11-01 00:00:00

abstract：:Radioimmunoassays were developed for the 19,000, 15,000, and 12,000 molecular weight polypeptides of avian myeloblastosis virus and for the 19,000 and 12,000 polypeptides of RAV-0, a subgroup E avian tumor virus. Each polypeptide was shown to possess both group- and type-specific antigenic determinants, in contrast to...

journal_title：Journal of virology

authors： Stephenson JR,Smith EJ,Crittenden LB,Aaronson SA

更新日期：1975-07-01 00:00:00

abstract：:To examine the cell fusion activity of hepatitis C virus (HCV) envelope proteins (E1 and E2), we have established a sensitive cell fusion assay based on the activation of a reporter gene as described previously (O. Nussbaum, C. C. Broder, and E. A. Berger, J. Virol. 68:5411-5422, 1994). The chimeric HCV E1 and E2 prot...

journal_title：Journal of virology

authors： Takikawa S,Ishii K,Aizaki H,Suzuki T,Asakura H,Matsuura Y,Miyamura T

更新日期：2000-06-01 00:00:00

abstract：:Seneca Valley virus (SVV) is an oncolytic RNA virus belonging to the Picornaviridae family. Its nucleotide sequence is highly similar to those of members of the Cardiovirus genus. SVV is also a neuroendocrine cancer-selective oncolytic picornavirus that can be used for anticancer therapy. However, the interaction betw...

journal_title：Journal of virology

authors： Qian S,Fan W,Liu T,Wu M,Zhang H,Cui X,Zhou Y,Hu J,Wei S,Chen H,Li X,Qian P

更新日期：2017-07-27 00:00:00

abstract：:Human parainfluenza type 2 virus (hPIV-2)-infected HeLa (HeLa-CA) cells and hPIV-2 V-expressing HeLa (HeLa-V) cells show high resistance to alpha/beta interferons (IFN-alpha/beta) irrespective of whether vesicular stomatitis virus or Sindbis virus is used as a challenge virus. When Sindbis virus is used, these cells s...

journal_title：Journal of virology

authors： Nishio M,Tsurudome M,Ito M,Kawano M,Komada H,Ito Y

更新日期：2001-10-01 00:00:00

abstract：:In latent infection, Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen 1 (LANA1)-specific binding to KSHV terminal repeat DNA mediates multicopy episome persistence. We now use electrophoretic mobility shift assays to investigate LANA1 binding to its 20-bp cognate sequence. Mutations at...

journal_title：Journal of virology

authors： Srinivasan V,Komatsu T,Ballestas ME,Kaye KM

更新日期：2004-12-01 00:00:00

abstract：:Adeno-associated virus (AAV) is a member of the Parvoviridae, belonging to the Dependovirus genus. Currently, several distinct isolates of AAV are in development for use in human gene therapy applications due to their ability to transduce different target cells. The need to manipulate AAV capsids for specific tissue d...

journal_title：Journal of virology

authors： Padron E,Bowman V,Kaludov N,Govindasamy L,Levy H,Nick P,McKenna R,Muzyczka N,Chiorini JA,Baker TS,Agbandje-McKenna M

更新日期：2005-04-01 00:00:00

abstract：:The chimpanzee monoclonal antibody (MAb) 5H2 is specific for dengue virus type 4 (DENV-4) and neutralizes the virus at a high titer in vitro. The epitope detected by the antibody was mapped by sequencing neutralization escape variants of the virus. One variant contained a Lys174-Glu substitution and another contained ...

journal_title：Journal of virology

authors： Lai CJ,Goncalvez AP,Men R,Wernly C,Donau O,Engle RE,Purcell RH

更新日期：2007-12-01 00:00:00

abstract：:Latent Epstein-Barr virus (EBV) infection is associated with several lymphoproliferative disorders, including posttransplant lymphoma, Hodgkin's disease, and Burkitt's lymphoma, as well as nasopharyngeal carcinoma (NPC). Twenty-nine microRNAs (miRNAs) have been identified that are transcribed during latent infection f...

journal_title：Journal of virology

authors： Edwards RH,Marquitz AR,Raab-Traub N

更新日期：2008-09-01 00:00:00

abstract：:We used 18 monoclonal antibodies against B19 parvovirus to identify neutralizing epitopes on the viral capsid. Of the 18 antibodies, 9 had in vitro neutralizing activity in a bone marrow colony culture assay. The overlapping polypeptide fragments spanning the B19 structural proteins were produced in a pMAL-c Escherich...

journal_title：Journal of virology

authors： Yoshimoto K,Rosenfeld S,Frickhofen N,Kennedy D,Hills R,Kajigaya S,Young NS

更新日期：1991-12-01 00:00:00

abstract：:Picornavirus-infected cells contain a double-stranded RNA (replicative form [RF] RNA), composed of viral genomic RNA hydrogen bonded to cRNA of similar nucleotide length. Mengovirus RF RNA reacted with a succinimide ester of biotin was shown by electron microscopy to bind avidin-coupled polymethacrylate spheres. These...

journal_title：Journal of virology

authors： Thornton GB,Robberson DL,Arlinghaus RB

更新日期：1981-07-01 00:00:00

abstract：:The large T antigen encoded by simian virus 40 (SV40) plays essential roles in the infection of permissive cells, leading to production of progeny virions, and in the infection of nonpermissive cells, leading to malignant transformation. Primary mouse embryo fibroblasts (MEFs) are nonpermissive for SV40, and infection...

journal_title：Journal of virology

authors： Zhu JY,Abate M,Rice PW,Cole CN

更新日期：1991-12-01 00:00:00

abstract：:We describe initial genetic and structural characterizations of HK97, a temperate bacteriophage of Escherichia coli. We isolated 28 amber mutants, characterized them with respect to what phage-related structures they make, and mapped many of them to restriction fragments of genomic DNA. Sodium dodecyl sulfate-polyacry...

journal_title：Journal of virology

authors： Popa MP,McKelvey TA,Hempel J,Hendrix RW

更新日期：1991-06-01 00:00:00

abstract：:The hepatitis C virus (HCV) core gene is more conserved at the nucleic acid level than is necessary to preserve the sequence of the core protein, suggesting that it contains information for additional functions. We used a battery of anticore antibodies to test the hypothesis that the core gene directs the synthesis of...

journal_title：Journal of virology

authors： Eng FJ,Walewski JL,Klepper AL,Fishman SL,Desai SM,McMullan LK,Evans MJ,Rice CM,Branch AD

更新日期：2009-04-01 00:00:00

abstract：:After corneal inoculation, herpes simplex virus type 1 replicates in the mouse eye, trigeminal ganglia, and brainstem, producing first an acute and then a latent infection. Previous work from this laboratory focused on the structure of the viral DNA in this system. We have now examined the structure of the viral genom...

journal_title：Journal of virology

authors： Muggeridge MI,Fraser NW

更新日期：1986-09-01 00:00:00

abstract：:The infectious entry pathway of duck hepatitis B virus (DHBV) was investigated with primary duck hepatocytes. Virus uptake was measured by a selective PCR technique which allows for the detection of a successful infection without the need for viral replication or gene expression. To test whether DHBV uptake occurs by ...

journal_title：Journal of virology

authors： Köck J,Borst EM,Schlicht HJ

更新日期：1996-09-01 00:00:00

abstract：:Human herpesvirus 8 (HHV8) open reading frame (ORF) 21 is predicted to encode a protein similar to the thymidine kinase (TK) enzyme of other herpesviruses. Expressed in mammalian cells, ORF 21 was found to have low TK activity, based on poor growth in media containing hypoxanthine-aminopterin-thymidine (HAT) and low i...

journal_title：Journal of virology

authors： Gustafson EA,Schinazi RF,Fingeroth JD

更新日期：2000-01-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) B capsids are composed of seven proteins, designated VP5, VP19C, 21, 22a, VP23, VP24, and VP26 in order of decreasing molecular weight. Three proteins (21, 22a, and VP24) are encoded by a single open reading frame (ORF), UL26, and include a protease whose structure and function have...

journal_title：Journal of virology

authors： Desai P,Watkins SC,Person S

更新日期：1994-09-01 00:00:00

abstract：:Human papillomavirus (HPV) type 16 E6 (16E6) is an oncogenic, multifunctional nuclear protein that induces p53 degradation and perturbs normal cell cycle control, leading to immortalization and transformation of infected keratinocytes and epithelial cells. Although it is unclear how 16E6 disrupts the epigenetic profil...

journal_title：Journal of virology

authors： Tao M,Kruhlak M,Xia S,Androphy E,Zheng ZM

更新日期：2003-12-01 00:00:00

abstract：:We examined the 5' ends of Hantaan virus (HTN) genomes and mRNAs to gain insight into the manner in which these chains were initiated. Like those of all members of the family Bunyaviridae described so far, the HTN mRNAs contained 5' terminal extensions that were heterogeneous in both length and sequence, presumably be...

journal_title：Journal of virology

authors： Garcin D,Lezzi M,Dobbs M,Elliott RM,Schmaljohn C,Kang CY,Kolakofsky D

更新日期：1995-09-01 00:00:00

abstract：UNLABELLED:Antibodies against the fusion (F) protein of respiratory syncytial virus (RSV) play an important role in the protective immune response to this important respiratory virus. Little is known, however, about antibody levels against multiple F-specific epitopes induced by infection or after vaccination against R...

journal_title：Journal of virology

authors： Widjaja I,Wicht O,Luytjes W,Leenhouts K,Rottier PJM,van Kuppeveld FJM,Haijema BJ,de Haan CAM

更新日期：2016-06-10 00:00:00

abstract：:Transcriptionally active replication complexes bound to smooth membrane vesicles were isolated from poliovirus-infected cells. In electron microscopic, negatively stained preparations, the replication complex appeared as an irregularly shaped, oblong structure attached to several virus-induced vesicles of a rosettelik...

journal_title：Journal of virology

authors： Bienz K,Egger D,Troxler M,Pasamontes L

更新日期：1990-03-01 00:00:00

abstract：:A malignant glioma cell line was infected with the human T-lymphotropic virus type IIIB isolate of the human immunodeficiency virus. Infection appeared to be latent rather than productive. Through contact with monocytic or lymphoid cells, the virus present in the glioma cells could be transmitted and gave rise to a fu...

journal_title：Journal of virology

authors： Chiodi F,Fuerstenberg S,Gidlund M,Asjö B,Fenyö EM

更新日期：1987-04-01 00:00:00

abstract：:Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of alpha/beta interferons (IFN-alpha/beta). However, recombinant HRSV lacking the NS1 and NS2 genes (Delta NS1/2) induced high levels of IFN-alpha and -beta in human pulmonary epithelial cells (A549) as well as in macrophages derived from primary hum...

journal_title：Journal of virology

authors： Spann KM,Tran KC,Chi B,Rabin RL,Collins PL

更新日期：2004-04-01 00:00:00

abstract：:Phosphorylation of the βC1 protein encoded by the betasatellite of tomato yellow leaf curl China virus (TYLCCNB-βC1) by SNF1-related protein kinase 1 (SnRK1) plays a critical role in defense of host plants against geminivirus infection in Nicotiana benthamiana However, how phosphorylation of TYLCCNB-βC1 impacts its pa...

journal_title：Journal of virology

authors： Zhong X,Wang ZQ,Xiao R,Cao L,Wang Y,Xie Y,Zhou X

更新日期：2017-07-27 00:00:00

abstract：:The herpes simplex virus 1 (HSV-1) infected-cell protein 0 (ICP0) has the characteristics of a promiscuous transactivator of genes introduced into cells by infection or transfection. To identify cellular proteins interacting with ICP0, we used a domain of exon II of ICP0 that is known to be crucial for regulatory func...

journal_title：Journal of virology

authors： Kawaguchi Y,Van Sant C,Roizman B

更新日期：1997-10-01 00:00:00

abstract：:Changes in the envelope glycoprotein ectodomains of a nonpathogenic simian-human immunodeficiency virus (SHIV-89.6) that was serially passaged in vivo have been shown to be responsible for the increased pathogenicity of the resulting virus, SHIV-KB9 (G. B. Karlsson, et al., J. Exp. Med. 188:1159-1171, 1998). The 12 am...

journal_title：Journal of virology

authors： Etemad-Moghadam B,Sun Y,Nicholson EK,Fernandes M,Liou K,Gomila R,Lee J,Sodroski J

更新日期：2000-05-01 00:00:00

abstract：:9-([2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) is more potent and has a more prolonged inhibitory effect against Epstein-Barr virus (EBV) in vitro than does acyclovir (ACV). To assess the mechanism of this difference, we first compared the extent of phosphorylation of the two drugs in superinfected Ra...

journal_title：Journal of virology

authors： Lin JC,Nelson DJ,Lambe CU,Choi EI

更新日期：1986-11-01 00:00:00