Structural organization of poliovirus RNA replication is mediated by viral proteins of the P2 genomic region.

abstract：:We have characterized by T1 fingerprint analysis several defective interfering (DI) double-stranded RNAs of the simple yeast virus ScV. A common sequence of about 0.5 to 0.6 kilobase pairs, including both 3' termini of the parental RNA, was present in each DI RNA. Several DI RNAs had novel T1 oligonucleotides not pres...

journal_title：Journal of virology

authors： Kane WP,Pietras DF,Bruenn JA

更新日期：1979-11-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is the infectious cause of Kaposi's sarcoma, primary effusion lymphoma, and plasmablastic multicentric Castleman's disease. STAT3 has been shown to be important for the maintenance of primary effusion lymphoma cells in culture and is chronically activated in many tumor ce...

journal_title：Journal of virology

authors： Punjabi AS,Carroll PA,Chen L,Lagunoff M

更新日期：2007-03-01 00:00:00

abstract：UNLABELLED:The HIV-1 envelope protein (Env) is heavily glycosylated, with approximately 50% of the Env molecular mass being contributed by N-glycans. HIV-1 Env N-glycans shield the protein backbone and have been shown to play key roles in determining Env structure, surface exposure, and, consequently, antigenicity, inf...

journal_title：Journal of virology

authors： Shen R,Raska M,Bimczok D,Novak J,Smith PD

更新日期：2014-12-01 00:00:00

abstract：:The mammalian APOBEC3 family of cytidine deaminases includes members that can act as potent inhibitors of retroviral infectivity and retrotransposon mobility. Here, we have examined whether the alpharetrovirus Rous sarcoma virus (RSV) is susceptible to inhibition by a range of human APOBEC3 proteins. We report that RS...

journal_title：Journal of virology

authors： Wiegand HL,Cullen BR

更新日期：2007-12-01 00:00:00

abstract：:APOBEC3G (APO3G) is a cytidine deaminase that restricts replication of vif-defective human immunodeficiency virus type 1 (HIV-1). Like other members of the cellular deaminase family, APO3G has the propensity to form homo-multimers. In the current study, we investigated the functional determinants for multimerization o...

journal_title：Journal of virology

authors： Opi S,Takeuchi H,Kao S,Khan MA,Miyagi E,Goila-Gaur R,Iwatani Y,Levin JG,Strebel K

更新日期：2006-05-01 00:00:00

abstract：:A phage, designated CP-51, that carries out generalized transduction in Bacillus cereus 569 was isolated from soil. All auxotrophic mutants tested, those requiring tryptophan, histidine, leucine, isoleucine, methionine, or phenylalanine, were transduced to prototrophy. The phage was extremely unstable when stored at 2...

journal_title：Journal of virology

authors： Thorne CB

更新日期：1968-07-01 00:00:00

abstract：:The influenza A virus (IAV) M2 protein is a multifunctional protein with critical roles in virion entry, assembly, and budding. M2 is targeted to the apical plasma membrane of polarized epithelial cells, and the interaction of the viral proteins M2, M1, HA, and NA near glycolipid rafts in the apical plasma membrane is...

journal_title：Journal of virology

authors： Wohlgemuth N,Lane AP,Pekosz A

更新日期：2018-10-29 00:00:00

abstract：:Development of a vaccine for the common cold has been thwarted by the fact that there are more than 100 serotypes of human rhinovirus (HRV). We previously demonstrated that the HRV14 capsid is dynamic and transiently displays the buried N termini of viral protein 1 (VP1) and VP4. Here, further evidence for this "breat...

journal_title：Journal of virology

authors： Katpally U,Fu TM,Freed DC,Casimiro DR,Smith TJ

更新日期：2009-07-01 00:00:00

abstract：:Since its detection in swine, influenza D virus (IDV) has been shown to be present in multiple animal hosts, and bovines have been identified as its natural reservoir. However, it remains unclear how IDVs emerge, evolve, spread, and maintain in bovine populations. Through multiple years of virological and serological ...

journal_title：Journal of virology

authors： Wan XF,Ferguson L,Oliva J,Rubrum A,Eckard L,Zhang X,Woolums AR,Lion A,Meyer G,Murakami S,Ma W,Horimoto T,Webby R,Ducatez MF,Epperson W

更新日期：2020-08-31 00:00:00

abstract：:AIDS-related human cytomegalovirus retinitis remains the leading cause of blindness among untreated HIV/AIDS patients worldwide. To study mechanisms of this disease, we used a clinically relevant animal model of murine cytomegalovirus (MCMV) retinitis with retrovirus-induced murine AIDS (MAIDS) that mimics the progres...

journal_title：Journal of virology

authors： Chien H,Alston CI,Dix RD

更新日期：2018-08-29 00:00:00

abstract：:In gene therapy, the innate immune system is a significant barrier to the effective application of adenovirus (Ad) vectors. In kidney epithelium-derived (REC) cells, serotype 5 Ad vectors induce the expression of the chemokine CXCL10 (IP-10), a response that is dependent on NFkappaB. Compared to the parental vector Ad...

journal_title：Journal of virology

authors： Liu Q,White LR,Clark SA,Heffner DJ,Winston BW,Tibbles LA,Muruve DA

更新日期：2005-12-01 00:00:00

abstract：:Papilloma virus DNA from a laryngeal papilloma was cloned in phage lambda L 47 and characterized after cleavage with different restriction enzymes. Hybridization with the DNAs of human papilloma virus types 1, 2, 3, 4, 5, and 8 showed no homology under stringent hybridization conditions. Human papilloma virus type 6 D...

journal_title：Journal of virology

authors： Gissmann L,Diehl V,Schultz-Coulon HJ,zur Hausen H

更新日期：1982-10-01 00:00:00

abstract：UNLABELLED:During hepatitis C virus (HCV) infection, broadly neutralizing antibody (bNAb) responses targeting E1E2 envelope glycoproteins are generated in many individuals. It is unclear if these antibodies play a protective or a pathogenic role during chronic infection. In this study, we investigated whether bNAb resp...

journal_title：Journal of virology

authors： Swann RE,Cowton VM,Robinson MW,Cole SJ,Barclay ST,Mills PR,Thomson EC,McLauchlan J,Patel AH

更新日期：2016-04-14 00:00:00

abstract：:Extracts of competent cells of Bacillus subtilis exhibited nuclease activity on radioactively labeled cell deoxyribonucleic acid (DNA). The activity was not decreased when Mg was omitted from the reaction mixture but was decreased to zero by addition of ethylenediaminetetraacetic acid. Of the other metals tested, only...

journal_title：Journal of virology

authors： Epstein HT

更新日期：1971-06-01 00:00:00

abstract：:Rice yellow mottle virus is classified in five major serotypes; the molecular diversity of the coat protein (CP) is well established, but the amino acids involved in the recognition by discriminant monoclonal antibodies (MAbs) remain unknown. Reconstruction of a phylogenetic tree and sequence alignment of the CP gene ...

journal_title：Journal of virology

authors： Hébrard E,Pinel-Galzi A,Catherinot V,Labesse G,Brugidou C,Fargette D

更新日期：2005-04-01 00:00:00

abstract：UNLABELLED:Cattle have been proposed as the natural reservoir of a novel member of the virus family Orthomyxoviridae, which has been tentatively classified as influenza D virus (IDV). Although isolated from sick animals, it is unclear whether IDV causes any clinical disease in cattle. To address this aspect of Koch's p...

journal_title：Journal of virology

authors： Ferguson L,Olivier AK,Genova S,Epperson WB,Smith DR,Schneider L,Barton K,McCuan K,Webby RJ,Wan XF

更新日期：2016-05-27 00:00:00

abstract：:The herpes simplex virus 2 (HSV-2) viral microRNA (miRNA) designated miR-H6 is located upstream of the latency-associated transcript (LAT) promoter region on the strand opposite the LAT. Deletion of the LAT promoter and part of LAT exon 1 abolished HSV-2 miR-H6 expression in acutely and latently infected guinea pig do...

journal_title：Journal of virology

authors： Tang S,Bertke AS,Patel A,Margolis TP,Krause PR

更新日期：2011-05-01 00:00:00

abstract：:Vif counteracts the host restriction factor APOBEC3G (A3G) and other APOBEC3s by preventing the incorporation of A3G into progeny virions. We previously identified Vif mutants with a dominant-negative (D/N) phenotype that interfered with the function of wild-type Vif, inhibited the degradation of A3G, and reduced the ...

journal_title：Journal of virology

authors： Miyagi E,Welbourn S,Sukegawa S,Fabryova H,Kao S,Strebel K

更新日期：2020-03-17 00:00:00

abstract：:We investigated the effect of HLA class I alleles on clinical parameters for HIV-1 disease progression in the Japanese population, where two strongly protective alleles, HLA-B*57 and HLA-B*27, are virtually nonexistent. HLA-B alleles showed a dominant role, primarily through HLA-B*67:01 and the HLA-B*52:01-C*12:02 hap...

journal_title：Journal of virology

authors： Naruto T,Gatanaga H,Nelson G,Sakai K,Carrington M,Oka S,Takiguchi M

更新日期：2012-10-01 00:00:00

abstract：:White spot syndrome virus (WSSV) is a crustacean-infecting, double-stranded DNA virus and is the most serious viral pathogen in the global shrimp industry. WSSV is the sole recognized member of the family Nimaviridae, and the lack of genomic data on other nimaviruses has obscured the evolutionary history of WSSV. Here...

journal_title：Journal of virology

authors： Kawato S,Shitara A,Wang Y,Nozaki R,Kondo H,Hirono I

更新日期：2019-01-17 00:00:00

abstract：:The coding region for the hepatitis B virus surface antigens contains three in-phase ATG codons which direct the synthesis of three related polypeptides. The 24-kilodalton major surface (or S) glycoprotein is initiated at the most distal ATG and is a transmembrane protein whose translocation across the bilayer is medi...

journal_title：Journal of virology

authors： Eble BE,Lingappa VR,Ganem D

更新日期：1990-03-01 00:00:00

abstract：:Influenza A(H7N9) viruses have caused a large number of zoonotic infections since their emergence in 2013. They remain a public health concern due to the repeated high levels of infection with these viruses and their perceived pandemic potential. A major factor that determines influenza A virus fitness and therefore t...

journal_title：Journal of virology

authors： Benton DJ,Wharton SA,Martin SR,McCauley JW

更新日期：2017-05-12 00:00:00

abstract：:Human cytomegalovirus (HCMV) glycoprotein B (gB), encoded by the UL55 open reading frame, is an essential envelope glycoprotein involved in cell attachment and entry. Previously, we identified residue serine 900 (Ser900) as a unique site of reversible casein kinase 2 phosphorylation in the cytoplasmic domain of HCMV g...

journal_title：Journal of virology

authors： Jarvis MA,Jones TR,Drummond DD,Smith PP,Britt WJ,Nelson JA,Baldick CJ

更新日期：2004-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are key regulators of gene expression in higher eukaryotes. Recently, miRNAs have been identified from viruses with double-stranded DNA genomes. To attempt to identify miRNAs encoded by herpes simplex virus 1 (HSV-1), we applied a computational method to screen the complete genome of HSV-1 for seque...

journal_title：Journal of virology

authors： Cui C,Griffiths A,Li G,Silva LM,Kramer MF,Gaasterland T,Wang XJ,Coen DM

更新日期：2006-06-01 00:00:00

abstract：:In most prion diseases, infectivity accumulates in lymphoreticular organs early after infection. Defects in hematopoietic compartments, such as impaired B-cell maturation, or in stromal compartments, such as abrogation of follicular dendritic cells, can delay or prevent lymphoreticular prion colonization. However, the...

journal_title：Journal of virology

authors： Kaeser PS,Klein MA,Schwarz P,Aguzzi A

更新日期：2001-08-01 00:00:00

abstract：:The involvement of two bacteriophage T4 gene products in the initiation of T4 tail tube and sheath polymerization on mature baseplates has been studied by radioautography of acrylamide gels of various partially completed tail structures. The products of genes 48 and 54 (P48[the nomenclature P48 refers to the protein p...

journal_title：Journal of virology

authors： Berget PB,Warner HR

更新日期：1975-12-01 00:00:00

abstract：:The oligosaccharide processing and secretion of hepatitis B surface antigen (HBsAg) was studied in Chinese hamster ovary cells stably transfected with the gene coding HBsAg. HBsAg was secreted from cells with a relatively long half time (ca. 5 h). This appeared to be a characteristic of HBsAg itself, since HBsAg-produ...

journal_title：Journal of virology

authors： Patzer EJ,Nakamura GR,Yaffe A

更新日期：1984-08-01 00:00:00

abstract：:The herpes simplex virus type 1 UL28 gene contains a 785-amino-acid open reading frame that codes for an essential protein. Studies with temperature-sensitive mutants which map to the UL28 gene indicate that the UL28 gene product (ICP18.5) is required for packaging of viral DNA and for expression of viral glycoprotein...

journal_title：Journal of virology

authors： Tengelsen LA,Pederson NE,Shaver PR,Wathen MW,Homa FL

更新日期：1993-06-01 00:00:00

abstract：:The functions of delta antigens (HDAgs) in the morphogenesis of hepatitis delta virus (HDV) have been studied previously. The C terminus of large HDAg has been shown to complex with the small surface antigen (HBsAg) of helper hepatitis B virus, whereas the assembly of small HDAg requires interaction with the N terminu...

journal_title：Journal of virology

authors： Chang MF,Chen CH,Lin SL,Chen CJ,Chang SC

更新日期：1995-04-01 00:00:00

abstract：:Two strains of minute virus of mice (MVM) show different host cell specificities. The prototype strain MVM(p) grows in fibroblasts, whereas the immunosuppressive variant MVM(i) grows in T lymphocytes. In this study, we have mapped on the viral genome a cell type-specific determinant: it is located between 69 and 85 ma...

journal_title：Journal of virology

authors： Antonietti JP,Sahli R,Beard P,Hirt B

更新日期：1988-02-01 00:00:00