A second neutralizing epitope of B19 parvovirus implicates the spike region in the immune response.

abstract：:DNA sequences encoding the surface envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) were amplified by PCR from uncultured peripheral blood mononuclear cells obtained from patients with serologically defined HIV-1/HIV-2 mixed infections from Bombay, India. HIV-1-specific PCR prod...

journal_title：Journal of virology

authors： Grez M,Dietrich U,Balfe P,von Briesen H,Maniar JK,Mahambre G,Delwart EL,Mullins JI,Rübsamen-Waigmann H

更新日期：1994-04-01 00:00:00

abstract：:Analyses of the breadth and specificity of virus-specific CD8(+) T cell responses associated with control of HIV have largely relied on measurement of cytokine secretion by effector T cells. These have resulted in the identification of HIV elite controllers with low or absent responses in which non-T-cell mechanisms o...

journal_title：Journal of virology

authors： Ndhlovu ZM,Proudfoot J,Cesa K,Alvino DM,McMullen A,Vine S,Stampouloglou E,Piechocka-Trocha A,Walker BD,Pereyra F

更新日期：2012-06-01 00:00:00

abstract：:Chikungunya virus (CHIKV), a mosquito-borne alphavirus, has traditionally circulated in Africa and Asia, causing human febrile illness accompanied by severe, chronic joint pain. In Africa, epidemic emergence of CHIKV involves the transition from an enzootic, sylvatic cycle involving arboreal mosquito vectors and nonhu...

journal_title：Journal of virology

authors： Volk SM,Chen R,Tsetsarkin KA,Adams AP,Garcia TI,Sall AA,Nasar F,Schuh AJ,Holmes EC,Higgs S,Maharaj PD,Brault AC,Weaver SC

更新日期：2010-07-01 00:00:00

abstract：:An immunological hierarchy among three H-2Db-restricted cytotoxic T lymphocyte (CTL) determinants in simian virus 40 (SV40) large T antigen (Tag) was described previously: determinants I and II/III are immunodominant, whereas determinant V is immunorecessive. To assess the immunogenicity of each determinant individual...

journal_title：Journal of virology

authors： Fu TM,Mylin LM,Schell TD,Bacik I,Russ G,Yewdell JW,Bennink JR,Tevethia SS

更新日期：1998-02-01 00:00:00

abstract：:Recently we showed that the membrane-proximal stem region of the vesicular stomatitis virus (VSV) G protein ectodomain (G stem [GS]), together with the transmembrane and cytoplasmic domains, was sufficient to mediate efficient VSV budding (C. S. Robison and M. A. Whitt, J. Virol. 74:2239-2246, 2000). Here, we show tha...

journal_title：Journal of virology

authors： Jeetendra E,Robison CS,Albritton LM,Whitt MA

更新日期：2002-12-01 00:00:00

abstract：:Epstein-Barr Virus (EBV) generates a variety of viral microRNAs (miRNAs) by processing the BHRF1 and BamHI A rightward (BART) transcripts. BART miRNAs are expressed in all cells latently infected with EBV, but the functions of most BART miRNAs remain unknown. The results of a cell proliferation assay revealed that miR...

journal_title：Journal of virology

authors： Choi H,Lee H,Kim SR,Gho YS,Lee SK

更新日期：2013-07-01 00:00:00

abstract：:The effect of guanidine on the replication of the group A arboviruses, Sindbis virus, and Semliki Forest virus (SFV) was studied. Guanidine rapidly, but reversibly, inhibited SFV ribonucleic acid (RNA) synthesis. The synthesis of all species of viral RNA was inhibited, but that of ribonuclease-resistant forms was leas...

journal_title：Journal of virology

authors： Friedman RM

更新日期：1970-11-01 00:00:00

abstract：:We studied the effect of booster injections and the long-term immune response after injections of an anti-human immunodeficiency virus type 1 (HIV-1) lipopeptide vaccine. This vaccine was injected alone or with QS21 adjuvant to 28 HIV-uninfected volunteers. One month later, after a fourth injection of the vaccine, B- ...

journal_title：Journal of virology

authors： Gahéry-Ségard H,Pialoux G,Figueiredo S,Igéa C,Surenaud M,Gaston J,Gras-Masse H,Lévy JP,Guillet JG

更新日期：2003-10-01 00:00:00

abstract：:To date, no vaccine that is safe and effective against herpes simplex virus 2 (HSV-2) disease has been licensed. In this study, we evaluated a DNA prime-formalin-inactivated-HSV-2 (FI-HSV2) boost vaccine approach in the guinea pig model of acute and recurrent HSV-2 genital disease. Five groups of guinea pigs were immu...

journal_title：Journal of virology

authors： Morello CS,Levinson MS,Kraynyak KA,Spector DH

更新日期：2011-04-01 00:00:00

abstract：:The ribonucleoprotein (RNP) internal components of influenza virus were separated into distinct size classes by sedimentation in glycerol gradients and examined by electron microscopy by using positive staining with uranyl acetate. The large RNP have a peak in length distribution at 90 to 110 nm, the medium, at 60 to ...

journal_title：Journal of virology

authors： Compans RW,Content J,Duesberg PH

更新日期：1972-10-01 00:00:00

abstract：:The sequences of several hundred nucleotides around the junctions between the L and S components in concatemeric DNA and in mature virion DNA were ascertained. The two ends of the mature genome (which are joined in concatemeric DNA) show no sequence homology. Several directly repeated elements are present near both en...

journal_title：Journal of virology

authors： DeMarchi JM,Lu ZQ,Rall G,Kupershmidt S,Ben-Porat T

更新日期：1990-10-01 00:00:00

abstract：:The affinity of human immunodeficiency virus (HIV) envelope for CD4 and CCR5 appears to be associated with aspects of R5 virus (virus using the CCR5 coreceptor) pathogenicity. However, entry efficiency results from complex interactions between the viral envelope glycoprotein and both CD4 and CCR5, which limits attempt...

journal_title：Journal of virology

authors： Johnston SH,Lobritz MA,Nguyen S,Lassen K,Delair S,Posta F,Bryson YJ,Arts EJ,Chou T,Lee B

更新日期：2009-11-01 00:00:00

abstract：:Nearly 50 years ago, the discovery of interferon prompted the notion that host cells innately respond to viral invasion. Since that time, technological advances have allowed this response to be extensively characterized and dissected in vitro. However, these advances have only recently been applied to highly complex, ...

journal_title：Journal of virology

authors： Hartman ZC,Kiang A,Everett RS,Serra D,Yang XY,Clay TM,Amalfitano A

更新日期：2007-02-01 00:00:00

abstract：:The trans-activator Tat proteins coded by human immunodeficiency virus type 1 (HIV-1) and HIV-2 appear to be similar in structure and function. However, the Tat protein of HIV-2 (Tat2) activates the HIV-1 long terminal repeat (LTR) less efficiently than Tat1 (M. Emerman, M. Guyader, L. Montagnier, D. Baltimore, and M....

journal_title：Journal of virology

authors： Elangovan B,Subramanian T,Chinnadurai G

更新日期：1992-04-01 00:00:00

abstract：:When human A431 cells, which carry high numbers of epidermal growth factor (EGF) receptors, are exposed to EGF, the total content of phosphotyrosine in cell protein is increased, the EGF receptor becomes phosphorylated at tyrosine, and new phosphotyrosine-containing 36,000- and 81,000-dalton proteins are detected. We ...

journal_title：Journal of virology

authors： Cooper JA,Scolnick EM,Ozanne B,Hunter T

更新日期：1983-12-01 00:00:00

abstract：:Enveloped viruses often require cleavage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola virus glycoprotein does not require the furin cleavage motif for virus replication in cell culture. Here, we show that there are no appreciable dif...

journal_title：Journal of virology

authors： Neumann G,Geisbert TW,Ebihara H,Geisbert JB,Daddario-DiCaprio KM,Feldmann H,Kawaoka Y

更新日期：2007-03-01 00:00:00

abstract：:Infectious bursal disease virus (IBDV), a double-stranded RNA (dsRNA) virus belonging to the Birnaviridae family, is an economically important avian pathogen. The IBDV capsid is based on a single-shelled T=13 lattice, and the only structural subunits are VP2 trimers. During capsid assembly, VP2 is synthesized as a pro...

journal_title：Journal of virology

authors： Luque D,Saugar I,Rodríguez JF,Verdaguer N,Garriga D,Martín CS,Velázquez-Muriel JA,Trus BL,Carrascosa JL,Castón JR

更新日期：2007-07-01 00:00:00

abstract：:While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of...

journal_title：Journal of virology

authors： Denkers ND,Hayes-Klug J,Anderson KR,Seelig DM,Haley NJ,Dahmes SJ,Osborn DA,Miller KV,Warren RJ,Mathiason CK,Hoover EA

更新日期：2013-02-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV/human herpesvirus 8 [HHV-8]) is a gamma-2-herpesvirus responsible for Kaposi's sarcoma as well as primary effusion lymphoma (PEL). KSHV is a lymphotropic virus that has pirated many mammalian genes involved in inflammation, cell cycle control, and angiogenesis. Among these...

journal_title：Journal of virology

authors： Cannon M,Philpott NJ,Cesarman E

更新日期：2003-01-01 00:00:00

abstract：:The herpesvirus saimiri genome encodes a complement control protein homolog (CCPH). Stable mammalian cell transfectants expressing a recombinant transmembrane form of CCPH (mCCPH) or a 5'FLAG epitope-tagged mCCPH (5'FLAGmCCPH) conferred resistance to complement-mediated cell damage by inhibiting the lytic activity of ...

journal_title：Journal of virology

authors： Fodor WL,Rollins SA,Bianco-Caron S,Rother RP,Guilmette ER,Burton WV,Albrecht JC,Fleckenstein B,Squinto SP

更新日期：1995-06-01 00:00:00

abstract：:The interaction of papillomavirus E2 proteins with cellular Brd4 protein is important for transcriptional regulation of viral genes and partitioning of viral genomes. Bovine papillomavirus type 1 (BPV-1) E2 binds cellular chromatin in complex with Brd4 in both mitotic and interphase cells. To identify specific sites o...

journal_title：Journal of virology

authors： Jang MK,Kwon D,McBride AA

更新日期：2009-03-01 00:00:00

abstract：:Infection of primary or secondary cultures of Chinese hamster embryo cells with simian virus 40 at a multiplicity of 20 to 50 induced synthesis of the virus-specific intranuclear T antigen in 80 to 90% of the cells within 48 to 72 hr. In the infected cultures, 30 to 50% more cells were recruited into deoxyribonucleic ...

journal_title：Journal of virology

authors： Lehman JM,Defendi V

更新日期：1970-12-01 00:00:00

abstract：UNLABELLED:Hepatitis B virus (HBV) infects hundreds of millions of people worldwide and causes acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HBV is an enveloped virus with a relaxed circular (RC) DNA genome. In the nuclei of infected human hepatocytes, conversion of RC DNA from the incoming viri...

journal_title：Journal of virology

authors： Cui X,Clark DN,Liu K,Xu XD,Guo JT,Hu J

更新日期：2015-10-21 00:00:00

abstract：:Koi herpesvirus (KHV) is the causative agent of a lethal disease in koi and common carp. In the present study, we describe the cloning of the KHV genome as a stable and infectious bacterial artificial chromosome (BAC) clone that can be used to produce KHV recombinant strains. This goal was achieved by the insertion of...

journal_title：Journal of virology

authors： Costes B,Fournier G,Michel B,Delforge C,Raj VS,Dewals B,Gillet L,Drion P,Body A,Schynts F,Lieffrig F,Vanderplasschen A

更新日期：2008-05-01 00:00:00

abstract：:The control of human immunodeficiency virus type 1 (HIV-1) associated with particular HLA class I alleles suggests that some CD8(+) T-cell responses may be more effective than others at containing HIV-1. Unfortunately, substantial diversities in the breadth, magnitude, and function of these responses have impaired our...

journal_title：Journal of virology

authors： Wang YE,Li B,Carlson JM,Streeck H,Gladden AD,Goodman R,Schneidewind A,Power KA,Toth I,Frahm N,Alter G,Brander C,Carrington M,Walker BD,Altfeld M,Heckerman D,Allen TM

更新日期：2009-02-01 00:00:00

abstract：:During HIV-1 assembly, Gag polypeptides multimerize to form an immature capsid and also package HIV-1 genomic RNA. Assembling Gag forms immature capsids by progressing through a stepwise pathway of assembly intermediates containing the cellular ATPase ABCE1, which facilitates capsid formation. The NC domain of Gag is ...

journal_title：Journal of virology

authors： Klein KC,Reed JC,Tanaka M,Nguyen VT,Giri S,Lingappa JR

更新日期：2011-07-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) to human immunodeficiency virus type 1 were produced. Two antibodies reacted with the 17-kilodalton core protein (p17) of the virus and with its polyprotein precursor. To various degrees, each MAb neutralized infection by the cell-free virus. With a series of sequential overlapping hexapep...

journal_title：Journal of virology

authors： Papsidero LD,Sheu M,Ruscetti FW

更新日期：1989-01-01 00:00:00

abstract：:The replication of vaccinia virus is thought to take place exclusively in the cytoplasm of host cells. However, using DNA-DNA hybridization techniques, it can be shown that a significant fraction of the synthesis of vaccinia DNA takes place in the nucleus as well as the cytoplasm. The (3H) thymiding pulse-labeled vacc...

journal_title：Journal of virology

authors： LaColla P,Weissbach A

更新日期：1975-02-01 00:00:00

abstract：:The occurrence of genome segment reassortment between two antigenically related orbiviruses was demonstrated in cattle. Individual virus clones were isolated by cell culture plaque assays directly from the blood of a calf infected with two serotypes of bluetongue virus. The majority (89%) of progeny viruses isolated f...

journal_title：Journal of virology

authors： Stott JL,Oberst RD,Channell MB,Osburn BI

更新日期：1987-09-01 00:00:00

abstract：:The effect of monoclonal antibodies on the growth of herpes simplex virus type 1 in trigeminal ganglia was investigated. Four-week-old mice were infected on an abrased cornea with herpes simplex virus type 1. Forty-eight hours after infection, trigeminal ganglia ipsilateral with infected eyes were removed and placed i...

journal_title：Journal of virology

authors： Oakes JE,Lausch RN

更新日期：1984-09-01 00:00:00