Papillomavirus E2 proteins and the host BRD4 protein associate with transcriptionally active cellular chromatin.

abstract：:Adenovirus class B (Ad3 and Ad7) and class C (Ad1, Ad5, and Ad6) late r-strand mRNA's were found to have segmented 5' leaders. These leaders were very similar among serotype within a class but differed in sequence from the leaders on late mRNA's of a different class. However, the leader components of class B viruses m...

journal_title：Journal of virology

authors： Kilpatrick BA,Gelinas RE,Broker TR,Chow LT

更新日期：1979-06-01 00:00:00

abstract：:Nipah virus (NiV) and Hendra virus (HeV) are emerging zoonotic viruses and the causative agents of severe respiratory disease and encephalitis in humans. Little is known about the mechanisms that govern the development of respiratory and neurological disease. Using a hamster model of lethal NiV and HeV infection, we d...

journal_title：Journal of virology

authors： Rockx B,Brining D,Kramer J,Callison J,Ebihara H,Mansfield K,Feldmann H

更新日期：2011-08-01 00:00:00

abstract：:The E4orf6 protein of group C adenovirus is an oncoprotein that, in association with the E1B 55-kDa protein and by E1B-independent means, promotes virus replication. An arginine-faced amphipathic alpha-helix in the E4orf6 protein is required for the E4orf6 protein to direct nuclear localization of the E1B 55-kDa prote...

journal_title：Journal of virology

authors： Orlando JS,Ornelles DA

更新日期：2002-02-01 00:00:00

abstract：:The Gag-Pol polyprotein of human immunodeficiency virus type 1 (HIV-1) is not required for efficient viral particle production. However, premature termination codons in pol, particularly in the integrase (IN)-coding region, can markedly impair HIV-1 particle formation, apparently due to the premature activation of the...

journal_title：Journal of virology

authors： Popov S,Strack B,Sanchez-Merino V,Popova E,Rosin H,Göttlinger HG

更新日期：2011-04-01 00:00:00

abstract：:The EFII cis element is a 38-bp sequence at the 5' end of the Rous sarcoma virus long terminal repeat, extending from nucleotides -229 to -192 (with respect to the viral transcription start site), which is recognized by sequence-specific DNA-binding proteins in avian fibroblast nuclear extracts (L. Sealy and R. Chalkl...

journal_title：Journal of virology

authors： Sears RC,Sealy L

更新日期：1992-11-01 00:00:00

abstract：:The pattern of induced protein species of the prototype strain of the parvovirus minute virus of mice was determined in permissive A9 mouse fibroblast cells by high-resolution two-dimensional gel electrophoresis. Identities of the viral proteins in the gels were assigned by probing two-dimensional blots with antisera ...

journal_title：Journal of virology

authors： Santarén JF,Ramírez JC,Almendral JM

更新日期：1993-09-01 00:00:00

abstract：:A human lymphoid cell line (F172-D8) excreting a human immunodeficiency virus type 1 (HIV-1) anti-gp41 monoclonal antibody was used to construct a plasmid containing the cDNA of the single-chain variable fragment (scFvD8) corresponding to this antibody. A stable human osteosarcoma cell line was obtained which expresse...

journal_title：Journal of virology

authors： Legastelois I,Desgranges C

更新日期：2000-06-01 00:00:00

abstract：:Human coronaviruses (HCoV) are respiratory pathogens with neuroinvasive, neurotropic, and neurovirulent properties, highlighting the importance of studying the potential implication of these viruses in neurological diseases. The OC43 strain (HCoV-OC43) was reported to induce neuronal cell death, which may participate ...

journal_title：Journal of virology

authors： Meessen-Pinard M,Le Coupanec A,Desforges M,Talbot PJ

更新日期：2016-12-16 00:00:00

abstract：:Mouse-adapted dengue type 4 virus (DEN4) strain H241 is highly neurovirulent for mice, whereas its non-mouse-adapted parent is rarely neurovirulent. The genetic basis for the neurovirulence of the mouse-adapted mutant was studied by comparing intratypic chimeric viruses that contained the three structural protein gene...

journal_title：Journal of virology

authors： Kawano H,Rostapshov V,Rosen L,Lai CJ

更新日期：1993-11-01 00:00:00

abstract：:To study the variability of human immunodeficiency virus type 1 (HIV-1), we used immunotoxins to select for variants within a population of H9 cells persistently infected with a molecular clone of HIV-1 designated NL4-3. Chimeric immunotoxin CD4-PE40 (a chimeric fusion protein consisting of the amino-terminal two doma...

journal_title：Journal of virology

authors： Fang H,Pincus SH

更新日期：1995-01-01 00:00:00

abstract：:A virus (M-7) isolated from baboon placental tissue demonstrates many similarities to endogenous feline virus RD-114. Immunodiffusion analysis shows a group-specific antigen (gs-1) line of identity between M-7 and RD-114. Anti-RD-114 DNA polymerase IgG inhibits M-7 polymerase by 57% compared to 97% for RD-114. M-7 vir...

journal_title：Journal of virology

authors： Hellman A,Peebles PT,Strickland JE,Fowler AK,Kalter SS,Oroszlan KS,Gilden RV

更新日期：1974-07-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) is transmitted through a viral synapse and enters target cells via interaction with the glucose transporter GLUT1. Here, we show that Neuropilin-1 (NRP1), the receptor for semaphorin-3A and VEGF-A165 and a member of the immune synapse, is also a physical and functional p...

journal_title：Journal of virology

authors： Ghez D,Lepelletier Y,Lambert S,Fourneau JM,Blot V,Janvier S,Arnulf B,van Endert PM,Heveker N,Pique C,Hermine O

更新日期：2006-07-01 00:00:00

abstract：:In an effort to identify host proteins involved in herpes simplex virus type 1 replication, monkey and human cellular protein activities (called OF-1) that bind the viral replication origin, oriS, have been described. We show by mass spectrometry that the DNA-binding component of human OF-1 contains Ku70 and Ku80 prot...

journal_title：Journal of virology

authors： Murata LB,Dodson MS,Hall JD

更新日期：2004-07-01 00:00:00

abstract：:Posttranslational modification-oligomerization, phosphorylation, and proteolytic cleavage-of the human papillomavirus (HPV) E4 protein occurs as the infected keratinocytes migrate up through the suprabasal wart layers. It has been postulated that these events modify E4 function during the virus life cycle. In HPV type...

journal_title：Journal of virology

authors： Knight GL,Grainger JR,Gallimore PH,Roberts S

更新日期：2004-12-01 00:00:00

abstract：:An in vitro method which led to the transformation of hamster embryo fibroblasts after exposure to herpes simplex virus type 2 (HSV-2) inactivated with ultraviolet irradiation is described. The transformed cells (333-8-9) produced tumors when inoculated into newborn Syrian hamsters but not when injected into weanling ...

journal_title：Journal of virology

authors： Duff R,Rapp F

更新日期：1971-10-01 00:00:00

abstract：:GLUT1 has recently been suggested to be a binding receptor for human T-cell leukemia virus type 1 (HTLV-1). We used a novel, short-term assay to define the role of GLUT1 in cell-to-cell transmission. Although increasing cell surface levels of GLUT1 enhanced HTLV-I transfer, efficient virus spread correlated largely wi...

journal_title：Journal of virology

authors： Takenouchi N,Jones KS,Lisinski I,Fugo K,Yao K,Cushman SW,Ruscetti FW,Jacobson S

更新日期：2007-02-01 00:00:00

abstract：:We have recovered a virion from defective cDNA of Sendai virus (SeV) that is capable of self-replication but incapable of transmissible-virion production. This virion delivers and expresses foreign genes in infected cells, and this is the first report of a gene expression vector derived from a defective viral genome o...

journal_title：Journal of virology

authors： Li HO,Zhu YF,Asakawa M,Kuma H,Hirata T,Ueda Y,Lee YS,Fukumura M,Iida A,Kato A,Nagai Y,Hasegawa M

更新日期：2000-07-01 00:00:00

abstract：:A thorough understanding of the diversity of viruses in wildlife provides epidemiological baseline information about potential pathogens. Metagenomic analysis of the enteric viral flora revealed a new anellovirus and bocavirus species in pine martens and a new circovirus-like virus and geminivirus-related DNA virus in...

journal_title：Journal of virology

authors： van den Brand JM,van Leeuwen M,Schapendonk CM,Simon JH,Haagmans BL,Osterhaus AD,Smits SL

更新日期：2012-02-01 00:00:00

abstract：:The Herpesviridae conserved infected-cell protein 27 (ICP27) is essential for cell culture-based replication of most herpesviruses studied. For members of the Alphaherpesvirinae, ICP27 regulates the expression of many viral genes, including expression of pUL44 (gC), pUL47 (VP13/14), and pUL48 (VP16). These three viral...

journal_title：Journal of virology

authors： Ponnuraj N,Tien YT,Vega-Rodriguez W,Krieter A,Jarosinski KW

更新日期：2019-02-05 00:00:00

abstract：:Transgenic (Tg) mice expressing full-length bovine prion protein (BoPrP) serially propagate bovine spongiform encephalopathy (BSE) prions without posing a transmission barrier. These mice also posed no transmission barrier for Suffolk sheep scrapie prions, suggesting that cattle may be highly susceptible to some sheep...

journal_title：Journal of virology

authors： Scott MR,Peretz D,Nguyen HO,Dearmond SJ,Prusiner SB

更新日期：2005-05-01 00:00:00

abstract：:The structure of VRC01 in complex with the HIV-1 gp120 core reveals that this broadly neutralizing CD4 binding site (CD4bs) antibody partially mimics the interaction of the primary virus receptor, CD4, with gp120. Here, we extended the investigation of the VRC01-gp120 core interaction to the biologically relevant vira...

journal_title：Journal of virology

authors： Li Y,O'Dell S,Walker LM,Wu X,Guenaga J,Feng Y,Schmidt SD,McKee K,Louder MK,Ledgerwood JE,Graham BS,Haynes BF,Burton DR,Wyatt RT,Mascola JR

更新日期：2011-09-01 00:00:00

abstract：:To examine the pathway of the coreceptor switching of CCR5-using (R5) virus to CXCR4-using (X4) virus in simian-human immunodeficiency virus SHIV(SF162P3N)-infected rhesus macaque BR24, analysis was performed on variants present at 20 weeks postinfection, the time when the signature gp120 V3 loop sequence of the X4 sw...

journal_title：Journal of virology

authors： Tasca S,Ho SH,Cheng-Mayer C

更新日期：2008-07-01 00:00:00

abstract：:Previous work demonstrated that a herpes simplex virus type 1 (HSV-1) immediate-early function up-regulates beta interferon but not chloramphenicol acetyltransferase reporter genes driven by the strong simian virus 40 (SV40) or cytomegalovirus promoter-enhancer regions in both transient assays and stable cell lines. T...

journal_title：Journal of virology

authors： Brown CR,Nakamura MS,Mosca JD,Hayward GS,Straus SE,Perera LP

更新日期：1995-11-01 00:00:00

abstract：:Broad and potent neutralizing antibodies (bnAbs) with multiple epitope specificities evolve in HIV-1-infected children. Herein, we studied two antiretroviral-naive chronically HIV-1 clade C-infected monozygotic pediatric twins, AIIMS_329 and AIIMS_330, with potent plasma bnAbs. Elite plasma neutralizing activity was o...

journal_title：Journal of virology

authors： Mishra N,Makhdoomi MA,Sharma S,Kumar S,Dobhal A,Kumar D,Chawla H,Singh R,Kanga U,Das BK,Lodha R,Kabra SK,Luthra K

更新日期：2019-08-13 00:00:00

abstract：UNLABELLED:The cellular response to virus infection is initiated when pathogen recognition receptors (PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results in induction of downstream signaling pathways that activate the transcription factor interferon regulatory factor 3 (IRF3). IRF3 pl...

journal_title：Journal of virology

authors： Pattabhi S,Wilkins CR,Dong R,Knoll ML,Posakony J,Kaiser S,Mire CE,Wang ML,Ireton RC,Geisbert TW,Bedard KM,Iadonato SP,Loo YM,Gale M Jr

更新日期：2015-12-16 00:00:00

abstract：:HTG2 hamster cells produce a defective murine sarcoma virus lacking gp70 and, consequently, viral surface projections (knobs), but the lack of knobs appears to have no effect on intramembrane particle distribution. In addition, it has been noted that the core of the virus remains in the "immature" form as a result of ...

journal_title：Journal of virology

authors： Demsey A,Collins F,Kawka D

更新日期：1980-12-01 00:00:00

abstract：:Varicella-zoster virus (VZV), an alphaherpesvirus restricted to humans, infects differentiated cells in vivo, including T lymphocytes, keratinocytes, and neurons, and spreads rapidly in confluent cultured dermal fibroblasts (HFFs). In VZV-infected HFFs, atypical expression of cyclins D3 and B1 occurs along with the in...

journal_title：Journal of virology

authors： Leisenfelder SA,Kinchington PR,Moffat JF

更新日期：2008-12-01 00:00:00

abstract：:Astrovirus is one of the major causes of infant and childhood diarrhea worldwide. Our understanding of astrovirus pathogenesis trails behind our knowledge of its molecular and epidemiologic properties. Using a recently developed small-animal model, we investigated the mechanisms by which astrovirus induces diarrhea an...

journal_title：Journal of virology

authors： Koci MD,Kelley LA,Larsen D,Schultz-Cherry S

更新日期：2004-02-01 00:00:00

abstract：:Two hundred seventeen field isolates of cucumber mosaic cucumovirus (CMV), sampled from 11 natural populations, were typed by RNase protection assay (RPA) using probes from the genomic RNAs of strains in subgroup I and in subgroup II of CMV strains. Most (85%) of the analyzed isolates belonged to subgroup I. For these...

journal_title：Journal of virology

authors： Fraile A,Alonso-Prados JL,Aranda MA,Bernal JJ,Malpica JM,García-Arenal F

更新日期：1997-02-01 00:00:00

abstract：:Regulation of immediate-early gene expression in human cytomegalovirus is subject to complex controls. The major immediate-early (mIE) gene is regulated by both positive and negative regulatory signals, including autoregulation mediated by a cis-repressive sequence. A second immediate-early gene, the US3 gene, is tran...

journal_title：Journal of virology

authors： Biegalke BJ

更新日期：1995-09-01 00:00:00